DK0981534T3 - Dinukleotider og deres anvendelser - Google Patents
Dinukleotider og deres anvendelserInfo
- Publication number
- DK0981534T3 DK0981534T3 DK98907435T DK98907435T DK0981534T3 DK 0981534 T3 DK0981534 T3 DK 0981534T3 DK 98907435 T DK98907435 T DK 98907435T DK 98907435 T DK98907435 T DK 98907435T DK 0981534 T3 DK0981534 T3 DK 0981534T3
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- useful
- treatment
- well
- present
- Prior art date
Links
- 206010036790 Productive cough Diseases 0.000 abstract 2
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 201000003883 Cystic fibrosis Diseases 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010033078 Otitis media Diseases 0.000 abstract 1
- 102100037601 P2X purinoceptor 4 Human genes 0.000 abstract 1
- 206010048705 Paraneoplastic cerebellar degeneration Diseases 0.000 abstract 1
- 208000017787 Paraneoplastic neurologic syndrome Diseases 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- 108010080192 Purinergic Receptors Proteins 0.000 abstract 1
- 206010038848 Retinal detachment Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000035559 beat frequency Effects 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 230000001886 ciliary effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 208000000617 lacrimal duct obstruction Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003097 mucus Anatomy 0.000 abstract 1
- 208000032307 premature centromere division Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000009266 primary ciliary dyskinesia Diseases 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 230000004264 retinal detachment Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 201000009890 sinusitis Diseases 0.000 abstract 1
- 210000003802 sputum Anatomy 0.000 abstract 1
- 208000024794 sputum Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/797,472 US5900407A (en) | 1997-02-06 | 1997-02-06 | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US08/798,508 US5837861A (en) | 1997-02-10 | 1997-02-10 | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0981534T3 true DK0981534T3 (da) | 2006-09-04 |
Family
ID=27121880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98907435T DK0981534T3 (da) | 1997-02-06 | 1998-02-06 | Dinukleotider og deres anvendelser |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6348589B1 (https=) |
| EP (1) | EP0981534B1 (https=) |
| JP (1) | JP4531867B2 (https=) |
| KR (1) | KR100606131B1 (https=) |
| CN (1) | CN1262556C (https=) |
| AT (1) | ATE325129T1 (https=) |
| AU (1) | AU738907C (https=) |
| BR (1) | BR9807169A (https=) |
| CA (1) | CA2279963C (https=) |
| DE (1) | DE69834392T2 (https=) |
| DK (1) | DK0981534T3 (https=) |
| ES (1) | ES2264197T3 (https=) |
| NO (1) | NO326718B1 (https=) |
| NZ (1) | NZ337225A (https=) |
| PT (1) | PT981534E (https=) |
| WO (1) | WO1998034942A2 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673779B2 (en) * | 1996-03-27 | 2004-01-06 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| CN1262556C (zh) | 1997-02-06 | 2006-07-05 | 印斯拜尔药品股份有限公司 | 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 |
| US6596725B2 (en) * | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
| US6818629B2 (en) * | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
| US7223744B2 (en) | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| US7078391B2 (en) | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
| US6548658B2 (en) * | 1997-07-25 | 2003-04-15 | Inspire Pharmaceuticals, Inc. | Di-(uridine 5′)-tetraphosphate and salts thereof |
| WO1999005155A2 (en) * | 1997-07-25 | 1999-02-04 | Inspire Pharmaceuticals, Inc. | Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof |
| US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| EP1011688B1 (en) * | 1997-08-29 | 2005-02-02 | The University of North Carolina at Chapel Hill | Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases |
| JP4633927B2 (ja) * | 1998-05-22 | 2011-02-16 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 治療用ジヌクレオチドおよび誘導体 |
| CA2355227A1 (en) * | 1998-12-23 | 2000-07-06 | Richard C. Boucher, Jr. | Targeted gene transfer using g protein coupled receptors |
| DE60015734D1 (de) | 1999-02-26 | 2004-12-16 | Inspire Pharmaceuticals Durham | Verwendung von dinukleotidtriphosphaten, cytidindiphosphaten und adenindiphosphaten zur herstellung einer pharmazeutischen zubereitung zur förderung der schleimauthydratation |
| ATE255123T1 (de) * | 1999-06-30 | 2003-12-15 | Yamasa Corp | Dinucleotid-kristalle |
| AU6551800A (en) * | 1999-08-17 | 2001-03-13 | Adani, Alexander | Dinucleoside 5',5'-tetraphosphates as inhibitors of viral reverse transcriptasesand viruses |
| JP2003524636A (ja) * | 1999-12-22 | 2003-08-19 | インスパイアー ファーマシューティカルズ，インコーポレイティド | プリン性受容体アゴニストによる胃腸管の処置方法 |
| RU2161982C1 (ru) * | 2000-01-20 | 2001-01-20 | Общество с ограниченной ответственностью "Клиника Института биорегуляции и геронтологии" | Тетрапептид, стимулирующий функцию сетчатой оболочки глаза, фармакологическое средство на его основе и способ его применения |
| US6864243B1 (en) | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
| AU2001260643B9 (en) | 2000-05-30 | 2006-10-19 | Merck Sharp & Dohme Corp. | Ectocornea extension promoters |
| US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
| US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
| US6555675B2 (en) * | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
| US7132408B2 (en) * | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| WO2002048165A2 (en) * | 2000-12-15 | 2002-06-20 | Pharmasset Ltd. | Antiviral agents for treatment of flaviviridae infections |
| US20040122223A1 (en) * | 2001-02-07 | 2004-06-24 | Davis Jeremy Martin | Non-natural nucleotides and dinucleotides |
| JP2005508297A (ja) | 2001-06-25 | 2005-03-31 | インスパイアー ファーマシューティカルズ，インコーポレイティド | Ｐ２ｙプリン受容体作用物質による関節潤滑 |
| WO2003011885A1 (en) * | 2001-07-25 | 2003-02-13 | Celltech R & D Limited | Non-natural carbon-linked nucleotides and dinucleotides |
| WO2003030892A1 (en) * | 2001-10-11 | 2003-04-17 | Alcon, Inc. | Methods for treating dry eye |
| JP2005532254A (ja) | 2001-11-06 | 2005-10-27 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 炎症性疾患を治療又は予防する方法 |
| US7084128B2 (en) * | 2002-01-18 | 2006-08-01 | Inspire Pharmaceuticals, Inc. | Method for reducing intraocular pressure |
| JP2006505585A (ja) * | 2002-10-18 | 2006-02-16 | モリケム メディシンズ， インコーポレイテッド | ランチビオティクスで眼乾燥症を処置する方法 |
| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
| EP1753445A4 (en) * | 2004-05-06 | 2009-05-20 | Molichem Medicines Inc | TREATMENT OF EYE DISEASES AND EYE TREATMENTS WITH LANTIBIOTIC COMPOSITIONS |
| WO2005107787A1 (en) * | 2004-05-06 | 2005-11-17 | Molichem Medicines, Inc. | Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions |
| GB0417886D0 (en) * | 2004-08-11 | 2004-09-15 | Univ Cardiff | Method and means for enhanced pulmonary delivery |
| GB0502250D0 (en) * | 2005-02-03 | 2005-03-09 | Ic Vec Ltd | Use |
| US7368439B2 (en) * | 2005-06-15 | 2008-05-06 | Bar - Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
| US7851456B2 (en) * | 2005-06-29 | 2010-12-14 | Inspire Pharmaceuticals, Inc. | P2Y6 receptor agonists for treating lung diseases |
| EP2036567A3 (en) | 2005-12-06 | 2009-12-09 | P2-Science APS | Modulation of the P2Y2 receptor pathway |
| US20070249556A1 (en) * | 2006-04-21 | 2007-10-25 | Brubaker Kurt E | Method of treating inflammation |
| JP5193040B2 (ja) * | 2006-07-26 | 2013-05-08 | ヤマサ醤油株式会社 | ジ（ピリミジンヌクレオシド５’−）ポリホスフェートの製造法 |
| US8304529B2 (en) * | 2006-07-28 | 2012-11-06 | Life Technologies Corporation | Dinucleotide MRNA cap analogs |
| US8551534B2 (en) | 2007-10-10 | 2013-10-08 | Parion Sciences, Inc. | Inhaled hypertonic saline delivered by a heated nasal cannula |
| US8168597B2 (en) * | 2008-10-22 | 2012-05-01 | Inspire Pharmaceuticals, Inc. | Method for treating cystic fibrosis |
| EP2376518A4 (en) | 2008-12-18 | 2013-12-04 | Avaris Ab | COMPLEX AND METHOD FOR AMPLIFYING NUCLEAR RELEASE |
| US9011909B2 (en) | 2010-09-03 | 2015-04-21 | Wisconsin Pharmacal Company, Llc | Prebiotic suppositories |
| CN106729718A (zh) * | 2010-09-10 | 2017-05-31 | 参天制药株式会社 | 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂 |
| US8778383B2 (en) | 2011-06-07 | 2014-07-15 | Parion Sciences, Inc. | Methods of treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| KR101536885B1 (ko) | 2012-03-26 | 2015-07-14 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 함유 점안액 |
| MX2014014648A (es) | 2012-05-29 | 2015-09-04 | Parion Sciences Inc | Aminoamidas tipo dendrimero que poseen actividad bloqueadora del canal de sodio para el tratamiento de ojo reseco y otras enfermedades mucosas. |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| SG10201708931XA (en) | 2012-12-17 | 2017-12-28 | Parion Sciences Inc | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| RU2018138195A (ru) | 2012-12-17 | 2018-12-18 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
| CN106715454B (zh) | 2014-07-24 | 2020-06-16 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| KR102629310B1 (ko) | 2015-03-09 | 2024-01-24 | 더블유.알. 그레이스 앤드 캄파니-콘. | 니코틴아미드 리보사이드의 결정 형태 |
| US20180125876A1 (en) * | 2015-05-20 | 2018-05-10 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages |
| EP3727400A4 (en) | 2017-12-22 | 2021-10-20 | Elysium Health, Inc. | CRYSTALLINE FORMS OF NICOTINAMIDE RIBOSIDE CHLORIDE |
| EP4157288A2 (en) | 2020-06-02 | 2023-04-05 | Institut Gustave-Roussy | Modulators of purinergic receptors and related immune checkpoint for treating acute respiratory distress syndrom |
| EP3919062A1 (en) | 2020-06-02 | 2021-12-08 | Institut Gustave-Roussy | Modulators of purinergic receptors and related immune checkpoint for treating acute respiratory distress syndrom |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855304A (en) | 1985-01-10 | 1989-08-08 | Repligen Corporation | Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals |
| US5049550A (en) | 1987-11-05 | 1991-09-17 | Worcester Foundation For Experimental Biology | Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| ES2129893T3 (es) * | 1994-07-15 | 1999-06-16 | Biosearch Italia Spa | Dinucleosido-5',5'-pirofosfatos. |
| US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
| US5681823A (en) | 1996-05-02 | 1997-10-28 | Prp Inc. | P1, P4 -dithio-P2 -P3 -monochloromethylene 5', 5'"-diadenosine P1, P4 -tetraphosphate as antithrombotic agent |
| US5789391A (en) | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| US5763447C1 (en) * | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| BR9712285A (pt) * | 1996-10-09 | 2001-11-20 | Pharmasset Ltd | Tetrafosfonato bicìclico de trianidridas |
| CN1262556C (zh) | 1997-02-06 | 2006-07-05 | 印斯拜尔药品股份有限公司 | 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用 |
-
1998
- 1998-02-06 CN CNB988032597A patent/CN1262556C/zh not_active Expired - Fee Related
- 1998-02-06 BR BR9807169-6A patent/BR9807169A/pt active Search and Examination
- 1998-02-06 JP JP53505598A patent/JP4531867B2/ja not_active Expired - Fee Related
- 1998-02-06 US US09/101,395 patent/US6348589B1/en not_active Expired - Lifetime
- 1998-02-06 AT AT98907435T patent/ATE325129T1/de active
- 1998-02-06 DE DE69834392T patent/DE69834392T2/de not_active Expired - Lifetime
- 1998-02-06 DK DK98907435T patent/DK0981534T3/da active
- 1998-02-06 CA CA002279963A patent/CA2279963C/en not_active Expired - Fee Related
- 1998-02-06 NZ NZ337225A patent/NZ337225A/en not_active IP Right Cessation
- 1998-02-06 PT PT98907435T patent/PT981534E/pt unknown
- 1998-02-06 EP EP98907435A patent/EP0981534B1/en not_active Expired - Lifetime
- 1998-02-06 AU AU63242/98A patent/AU738907C/en not_active Ceased
- 1998-02-06 ES ES98907435T patent/ES2264197T3/es not_active Expired - Lifetime
- 1998-02-06 KR KR1019997007070A patent/KR100606131B1/ko not_active Expired - Fee Related
- 1998-02-06 WO PCT/US1998/002702 patent/WO1998034942A2/en not_active Ceased
-
1999
- 1999-08-04 NO NO19993776A patent/NO326718B1/no not_active IP Right Cessation
-
2001
- 2001-11-06 US US10/007,451 patent/US6977246B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO993776L (no) | 1999-10-06 |
| ATE325129T1 (de) | 2006-06-15 |
| WO1998034942A2 (en) | 1998-08-13 |
| AU6324298A (en) | 1998-08-26 |
| BR9807169A (pt) | 2000-06-06 |
| US6348589B1 (en) | 2002-02-19 |
| JP2001526635A (ja) | 2001-12-18 |
| NO993776D0 (no) | 1999-08-04 |
| US20020082417A1 (en) | 2002-06-27 |
| CA2279963A1 (en) | 1998-08-13 |
| WO1998034942A3 (en) | 2000-01-06 |
| US6977246B2 (en) | 2005-12-20 |
| JP4531867B2 (ja) | 2010-08-25 |
| NO326718B1 (no) | 2009-02-02 |
| DE69834392T2 (de) | 2007-02-08 |
| CA2279963C (en) | 2008-04-22 |
| KR20000070807A (ko) | 2000-11-25 |
| EP0981534A2 (en) | 2000-03-01 |
| DE69834392D1 (de) | 2006-06-08 |
| AU738907B2 (en) | 2001-09-27 |
| CN1262556C (zh) | 2006-07-05 |
| CN1292795A (zh) | 2001-04-25 |
| ES2264197T3 (es) | 2006-12-16 |
| PT981534E (pt) | 2006-09-29 |
| KR100606131B1 (ko) | 2006-07-31 |
| EP0981534B1 (en) | 2006-05-03 |
| NZ337225A (en) | 2002-03-28 |
| AU738907C (en) | 2002-05-16 |
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