MXPA04000162A - Metodos para incrementar la eficacia in vivo de oligonucleotidos e inhibir la inflamacion en mamiferos. - Google Patents

Metodos para incrementar la eficacia in vivo de oligonucleotidos e inhibir la inflamacion en mamiferos.

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Publication number
MXPA04000162A
MXPA04000162A MXPA04000162A MXPA04000162A MXPA04000162A MX PA04000162 A MXPA04000162 A MX PA04000162A MX PA04000162 A MXPA04000162 A MX PA04000162A MX PA04000162 A MXPA04000162 A MX PA04000162A MX PA04000162 A MXPA04000162 A MX PA04000162A
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Mexico
Prior art keywords
mammals
increasing
vivo efficacy
inhibiting inflammation
nucleic acid
Prior art date
Application number
MXPA04000162A
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English (en)
Inventor
Zoulfia Allakhverdi
Original Assignee
Topigen Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Topigen Pharma Inc filed Critical Topigen Pharma Inc
Publication of MXPA04000162A publication Critical patent/MXPA04000162A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/333—Modified A

Abstract

La presente invencion se refiere al uso de sustitutos de nucleotidos para incrementar la eficacia in vivo de moleculas de acido nucleico y tambien para inhibir la inflamacion en mamiferos. Mas particularmente, la presente invencion se refiere al uso de 2??6?? diaminopurina (DAP) y analogos del mismo per se, en composiciones anti-inflamatorias, y tambien a la preparacion de moleculas de acido nucleico que tienen una eficacia fisiologica in vivo incrementada y una toxicidad reducida tal como se compara con oligos convencionales. La presente invencion es particularmente util para la preparacion de oligonucleotidos antisentido para tratar enfermedades pulmonares/respiratorias tales como fibrosis quistica, asma, bronquitis cronica, enfermedad del pulmon de obstruccion cronica, bronquitis eosinofilica, alergias, rinitis alergica, fibrosis pulmonar, sindrome de distension respiratoria de adulto, sinusitis, virus sincitial respiratorio y otras infecciones virales del tracto respiratorio y cancer.
MXPA04000162A 2001-07-06 2002-07-08 Metodos para incrementar la eficacia in vivo de oligonucleotidos e inhibir la inflamacion en mamiferos. MXPA04000162A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30307101P 2001-07-06 2001-07-06
PCT/CA2002/001046 WO2003004511A2 (en) 2001-07-06 2002-07-08 Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals

Publications (1)

Publication Number Publication Date
MXPA04000162A true MXPA04000162A (es) 2006-05-22

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Family Applications (1)

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MXPA04000162A MXPA04000162A (es) 2001-07-06 2002-07-08 Metodos para incrementar la eficacia in vivo de oligonucleotidos e inhibir la inflamacion en mamiferos.

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US (2) US7745420B2 (es)
EP (1) EP1406667B1 (es)
JP (1) JP4903984B2 (es)
AT (1) ATE386548T1 (es)
AU (1) AU2002319033B2 (es)
CA (1) CA2451738C (es)
DE (1) DE60225141T2 (es)
DK (1) DK1406667T3 (es)
ES (1) ES2301659T3 (es)
MX (1) MXPA04000162A (es)
NZ (1) NZ530360A (es)
PT (1) PT1406667E (es)
WO (1) WO2003004511A2 (es)

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AU2007282224B2 (en) 2006-08-11 2013-08-29 Vico Therapeutics B.V. Methods and means for treating DNA repeat instability associated genetic disorders
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
AU2008317566B2 (en) 2007-10-26 2014-05-01 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
AU2009246000B2 (en) * 2008-05-15 2014-09-04 Topigen Pharmaceuticals Inc. Oligonucleotides for treating inflammation and neoplastic cell proliferation
WO2010048731A1 (en) * 2008-10-31 2010-05-06 Christopher John Ong Aminoacyl trna-synthetase inhibitors as broad-spectrum immunosuppressive agents
US9622909B2 (en) 2009-02-26 2017-04-18 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
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US8231664B2 (en) * 2009-02-26 2012-07-31 Advanced Cooling Therapy, Llc Devices and methods for controlling patient temperature
US9326890B2 (en) 2009-02-26 2016-05-03 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
JP2014511181A (ja) * 2011-02-24 2014-05-15 ファーマキシス リミテッド キメラ骨格および２−アミノ−２’−デオキシアデノシンを有するオリゴヌクレオチド阻害剤
BR112014018427B1 (pt) 2012-01-27 2021-11-03 Biomarin Technologies B.V. Oligonucleotídeos moduladores de rna com características melhoradas para o tratamento da distrofia muscular de duchenne e becker
US9272016B2 (en) * 2012-04-20 2016-03-01 University Of Iowa Research Foundation Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells
CN104271741A (zh) * 2012-04-23 2015-01-07 普罗森萨科技有限公司 用于治疗神经肌肉障碍的具有改善特性的rna调节寡核苷酸
FR3057774A1 (fr) * 2016-10-21 2018-04-27 Museum National D'histoire Naturelle Derives de la purine pour leur utilisation dans le traitement ou la prevention de maladies dues a une mutation non-sens

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Publication number Publication date
US20100286235A1 (en) 2010-11-11
NZ530360A (en) 2006-01-27
US7745420B2 (en) 2010-06-29
WO2003004511A3 (en) 2003-07-10
DK1406667T3 (da) 2008-06-16
CA2451738A1 (en) 2003-01-16
US20050032723A1 (en) 2005-02-10
DE60225141T2 (de) 2009-03-05
ES2301659T3 (es) 2008-07-01
EP1406667A2 (en) 2004-04-14
CA2451738C (en) 2013-09-17
PT1406667E (pt) 2008-05-23
EP1406667B1 (en) 2008-02-20
DE60225141D1 (de) 2008-04-03
AU2002319033B2 (en) 2008-01-10
JP2004532900A (ja) 2004-10-28
JP4903984B2 (ja) 2012-03-28
WO2003004511A2 (en) 2003-01-16
ATE386548T1 (de) 2008-03-15

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