DK0981525T3 - (2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling - Google Patents
(2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstillingInfo
- Publication number
- DK0981525T3 DK0981525T3 DK98921668T DK98921668T DK0981525T3 DK 0981525 T3 DK0981525 T3 DK 0981525T3 DK 98921668 T DK98921668 T DK 98921668T DK 98921668 T DK98921668 T DK 98921668T DK 0981525 T3 DK0981525 T3 DK 0981525T3
- Authority
- DK
- Denmark
- Prior art keywords
- thienyl
- acetonitriles
- ethylamino
- preparation
- intermediates
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- -1 2- (2-Thienyl) -ethylamino Chemical group 0.000 title 1
- HVLUYXIJZLDNIS-UHFFFAOYSA-N 2-thiophen-2-ylethanamine Chemical compound NCCC1=CC=CS1 HVLUYXIJZLDNIS-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700886A HU225504B1 (en) | 1997-05-13 | 1997-05-13 | Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them |
PCT/HU1998/000046 WO1998051682A1 (fr) | 1997-05-13 | 1998-05-11 | Nouveaux produits intermediaires et procede de preparation de ces derniers |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0981525T3 true DK0981525T3 (da) | 2004-05-10 |
Family
ID=89995121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98921668T DK0981525T3 (da) | 1997-05-13 | 1998-05-11 | (2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling |
Country Status (14)
Country | Link |
---|---|
US (1) | US6215005B1 (fr) |
EP (1) | EP0981525B1 (fr) |
JP (1) | JP4279903B2 (fr) |
AT (1) | ATE258551T1 (fr) |
AU (1) | AU7444698A (fr) |
BR (1) | BR9809113B1 (fr) |
CA (1) | CA2288637C (fr) |
DE (1) | DE69821347T2 (fr) |
DK (1) | DK0981525T3 (fr) |
ES (1) | ES2213900T3 (fr) |
HU (1) | HU225504B1 (fr) |
NO (1) | NO325305B1 (fr) |
PT (1) | PT981525E (fr) |
WO (1) | WO1998051682A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU226421B1 (en) | 1998-11-09 | 2008-12-29 | Sanofi Aventis | Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides |
US6495691B1 (en) | 2001-07-06 | 2002-12-17 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
HUP0200438A3 (en) * | 2002-02-06 | 2003-10-28 | Egis Gyogyszergyar Nyilvanosan | Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them |
IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
US6800759B2 (en) | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
EP1603920A1 (fr) | 2003-03-12 | 2005-12-14 | Cadila Healthcare Ltd. | Polymorphes et forme amorphe de bisulfate de (s) - (+) -clopidogrel |
US20040250673A1 (en) * | 2003-06-10 | 2004-12-16 | Salerno Paul Michael | Ergonomic pedal board |
GB0321256D0 (en) | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
ATE455778T1 (de) | 2003-11-03 | 2010-02-15 | Cadila Healthcare Ltd | Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat |
US20060154957A1 (en) * | 2004-09-21 | 2006-07-13 | Nina Finkelstein | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
US20060223845A1 (en) * | 2005-02-24 | 2006-10-05 | Eran Turgeman | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
US8063217B2 (en) | 2005-07-12 | 2011-11-22 | Rpg Life Sciences Limited | Process for preparation of methyl-(+)-(S)-alpha-(2-chlorophenyl)-6, 7-dihydrothieno[3,2-C]pyridine-5(4H) -acetic acid methyl ester or salts thereof having higher chiral purity and products thereof |
RU2008146758A (ru) * | 2006-04-27 | 2010-06-10 | Инд-Свифт Лэборетриз Лимитед (In) | Способ получения полиморфных форм клопидогрела гидросульфата |
KR20080055860A (ko) * | 2006-08-03 | 2008-06-19 | 테바 파마슈티컬 인더스트리즈 리미티드 | 클로피도그렐 바이설페이트의 제조 방법 |
EP1980563A1 (fr) | 2007-04-09 | 2008-10-15 | BATTULA, Srinivasa Reddy | Procédure pour la préparation d'acétate de méthyle (+)-(S)-alpha-(O-chlorophényl)-6,7-dihydrothiéno-[3,2-C]pyridine-5(4H) |
CN102186858A (zh) * | 2008-10-24 | 2011-09-14 | 桑多斯股份公司 | 制备s-氯吡格雷的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2508455A1 (fr) | 1981-06-30 | 1982-12-31 | Sanofi Sa | Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines |
FR2530247B1 (fr) | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
FR2608607B1 (fr) | 1986-12-23 | 1989-04-28 | Sanofi Sa | Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues |
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2614619B1 (fr) | 1987-04-29 | 1989-09-15 | Sanofi Sa | Procede de preparation de n-((chloro-2)-benzyl) (thienyl-2)-2 ethylamine |
FR2652575B1 (fr) * | 1989-09-29 | 1992-01-24 | Sanofi Sa | Procede de preparation d'acides alpha-bromo phenylacetiques. |
FR2664596B1 (fr) * | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
AU732332B2 (en) * | 1996-09-12 | 2001-04-12 | Aventis Pharmaceuticals Inc. | Stereospecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines |
-
1997
- 1997-05-13 HU HU9700886A patent/HU225504B1/hu unknown
-
1998
- 1998-05-11 JP JP54895498A patent/JP4279903B2/ja not_active Expired - Lifetime
- 1998-05-11 DK DK98921668T patent/DK0981525T3/da active
- 1998-05-11 EP EP98921668A patent/EP0981525B1/fr not_active Expired - Lifetime
- 1998-05-11 DE DE69821347T patent/DE69821347T2/de not_active Expired - Lifetime
- 1998-05-11 CA CA002288637A patent/CA2288637C/fr not_active Expired - Lifetime
- 1998-05-11 AT AT98921668T patent/ATE258551T1/de active
- 1998-05-11 WO PCT/HU1998/000046 patent/WO1998051682A1/fr active IP Right Grant
- 1998-05-11 AU AU74446/98A patent/AU7444698A/en not_active Abandoned
- 1998-05-11 ES ES98921668T patent/ES2213900T3/es not_active Expired - Lifetime
- 1998-05-11 US US09/423,548 patent/US6215005B1/en not_active Expired - Lifetime
- 1998-05-11 PT PT98921668T patent/PT981525E/pt unknown
- 1998-05-11 BR BRPI9809113-1A patent/BR9809113B1/pt not_active IP Right Cessation
-
1999
- 1999-11-12 NO NO19995531A patent/NO325305B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO995531L (no) | 1999-12-13 |
AU7444698A (en) | 1998-12-08 |
BR9809113A (pt) | 2000-08-01 |
HUP9700886A3 (en) | 2000-06-28 |
ES2213900T3 (es) | 2004-09-01 |
WO1998051682A1 (fr) | 1998-11-19 |
BR9809113B1 (pt) | 2010-03-09 |
CA2288637A1 (fr) | 1998-11-19 |
DE69821347T2 (de) | 2004-12-02 |
HUP9700886A2 (hu) | 1999-09-28 |
HU225504B1 (en) | 2007-01-29 |
PT981525E (pt) | 2004-05-31 |
DE69821347D1 (de) | 2004-03-04 |
EP0981525B1 (fr) | 2004-01-28 |
EP0981525A1 (fr) | 2000-03-01 |
CA2288637C (fr) | 2005-11-15 |
HU9700886D0 (en) | 1997-07-28 |
NO325305B1 (no) | 2008-03-25 |
ATE258551T1 (de) | 2004-02-15 |
US6215005B1 (en) | 2001-04-10 |
NO995531D0 (no) | 1999-11-12 |
JP4279903B2 (ja) | 2009-06-17 |
JP2001525817A (ja) | 2001-12-11 |
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