DK0977736T3 - Fremgangsmåde til fremstilling af rent flupirtin-maleat og dettes modifikation A - Google Patents
Fremgangsmåde til fremstilling af rent flupirtin-maleat og dettes modifikation AInfo
- Publication number
- DK0977736T3 DK0977736T3 DK98920511T DK98920511T DK0977736T3 DK 0977736 T3 DK0977736 T3 DK 0977736T3 DK 98920511 T DK98920511 T DK 98920511T DK 98920511 T DK98920511 T DK 98920511T DK 0977736 T3 DK0977736 T3 DK 0977736T3
- Authority
- DK
- Denmark
- Prior art keywords
- modification
- preparation
- flupirtine maleate
- pure
- pure flupirtine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19716984A DE19716984A1 (de) | 1997-04-23 | 1997-04-23 | Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A |
PCT/EP1998/002118 WO1998047872A1 (de) | 1997-04-23 | 1998-04-11 | Verfahren zur herstellung von reinem flupirtin-maleat und dessen modifikation a |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0977736T3 true DK0977736T3 (da) | 2004-01-19 |
Family
ID=7827393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98920511T DK0977736T3 (da) | 1997-04-23 | 1998-04-11 | Fremgangsmåde til fremstilling af rent flupirtin-maleat og dettes modifikation A |
Country Status (12)
Country | Link |
---|---|
US (1) | US5959115A (da) |
EP (1) | EP0977736B1 (da) |
JP (1) | JP4960538B2 (da) |
AR (1) | AR012597A1 (da) |
AT (1) | ATE250579T1 (da) |
AU (1) | AU7334698A (da) |
DE (2) | DE19716984A1 (da) |
DK (1) | DK0977736T3 (da) |
ES (1) | ES2207832T3 (da) |
PT (1) | PT977736E (da) |
WO (1) | WO1998047872A1 (da) |
ZA (1) | ZA983376B (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6821995B1 (en) | 1999-12-01 | 2004-11-23 | Duke University | Method of treating batten disease |
GB0613928D0 (en) | 2006-07-13 | 2006-08-23 | Pliva Istrazivanje I Razvoj D | Pharmaceutically acceptable salt and polymorphic forms |
WO2008110357A1 (en) * | 2007-03-12 | 2008-09-18 | Elbion Gmbh | Method for preparing a flupirtine maleate of a crystal modification b |
US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
WO2009152168A2 (en) | 2008-06-09 | 2009-12-17 | Awd. Pharma Gmbh & Co. Kg | Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine |
EA019038B1 (ru) | 2008-06-09 | 2013-12-30 | Авд. Фарма Гмбх Унд Ко. Кг | Сульфонатные соли 2-амино-3-карбэтоксиамино-6-(4-фторбензил-амино)пиридина |
DE102009023162B4 (de) * | 2009-05-29 | 2011-07-07 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Flupirtin |
CN102140077A (zh) * | 2010-01-28 | 2011-08-03 | 范扶民 | 氟吡汀a晶型及其制备方法 |
WO2012004391A1 (en) * | 2010-07-09 | 2012-01-12 | K.H.S. Pharma Holding Gmbh | Process for the preparation of flupirtine maleate |
DE102010063612A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamidsäureethylester und 2-[2-[(2,6-Dichlorphenyl)-amino]-phenyl]-essigsäure |
DE102010063609A1 (de) | 2010-12-20 | 2012-06-21 | Awd.Pharma Gmbh & Co. Kg | Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure |
CN102351786A (zh) * | 2011-11-01 | 2012-02-15 | 东南大学 | 一种氟吡汀丙二酸盐及其制备方法 |
WO2013080215A1 (en) | 2011-11-30 | 2013-06-06 | Arch Pharmalabs Limited | An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof |
DE102015013478A1 (de) | 2015-10-17 | 2017-04-20 | Goethe-Universität | Neue Kristallphasen von Flupirtin-Maleat |
DE102017007385A1 (de) | 2017-08-02 | 2019-02-07 | Christoph Hoock | Maleatfreie feste Arzneimittelformen |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4481205A (en) * | 1980-09-13 | 1984-11-06 | Degussa Aktiengesellschaft | 2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate |
DE3133519A1 (de) * | 1980-09-13 | 1982-06-09 | Degussa Ag, 6000 Frankfurt | "2-amino-3-carbethoxyamino-6-(p-fluor-benzylamino)-pyridin-maleat" |
-
1997
- 1997-04-23 DE DE19716984A patent/DE19716984A1/de not_active Withdrawn
-
1998
- 1998-04-11 ES ES98920511T patent/ES2207832T3/es not_active Expired - Lifetime
- 1998-04-11 PT PT98920511T patent/PT977736E/pt unknown
- 1998-04-11 DE DE59809728T patent/DE59809728D1/de not_active Expired - Lifetime
- 1998-04-11 EP EP98920511A patent/EP0977736B1/de not_active Expired - Lifetime
- 1998-04-11 WO PCT/EP1998/002118 patent/WO1998047872A1/de active IP Right Grant
- 1998-04-11 AT AT98920511T patent/ATE250579T1/de active
- 1998-04-11 JP JP54494098A patent/JP4960538B2/ja not_active Expired - Fee Related
- 1998-04-11 AU AU73346/98A patent/AU7334698A/en not_active Abandoned
- 1998-04-11 DK DK98920511T patent/DK0977736T3/da active
- 1998-04-22 ZA ZA9803376A patent/ZA983376B/xx unknown
- 1998-04-23 AR ARP980101893A patent/AR012597A1/es not_active Application Discontinuation
- 1998-04-23 US US09/064,790 patent/US5959115A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT977736E (pt) | 2004-02-27 |
DE59809728D1 (de) | 2003-10-30 |
DE19716984A1 (de) | 1998-10-29 |
AR012597A1 (es) | 2000-11-08 |
ES2207832T3 (es) | 2004-06-01 |
US5959115A (en) | 1999-09-28 |
ATE250579T1 (de) | 2003-10-15 |
ZA983376B (en) | 1998-07-03 |
JP4960538B2 (ja) | 2012-06-27 |
EP0977736B1 (de) | 2003-09-24 |
JP2001523236A (ja) | 2001-11-20 |
EP0977736A1 (de) | 2000-02-09 |
WO1998047872A1 (de) | 1998-10-29 |
AU7334698A (en) | 1998-11-13 |
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