ZA983376B - Process for the preparation of flupirtine maleate. - Google Patents

Process for the preparation of flupirtine maleate.

Info

Publication number
ZA983376B
ZA983376B ZA9803376A ZA983376A ZA983376B ZA 983376 B ZA983376 B ZA 983376B ZA 9803376 A ZA9803376 A ZA 9803376A ZA 983376 A ZA983376 A ZA 983376A ZA 983376 B ZA983376 B ZA 983376B
Authority
ZA
South Africa
Prior art keywords
preparation
flupirtine maleate
flupirtine
maleate
Prior art date
Application number
ZA9803376A
Other languages
English (en)
Inventor
Alfred Dr Olbrich
Peter Dr Emig
Bernhard Prof Kutscher
Karl-Friedrich Dr Landgraf
Siegfried Pauluhn
Hans Dr Stange
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7827393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA983376(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of ZA983376B publication Critical patent/ZA983376B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9803376A 1997-04-23 1998-04-22 Process for the preparation of flupirtine maleate. ZA983376B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19716984A DE19716984A1 (de) 1997-04-23 1997-04-23 Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A

Publications (1)

Publication Number Publication Date
ZA983376B true ZA983376B (en) 1998-07-03

Family

ID=7827393

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9803376A ZA983376B (en) 1997-04-23 1998-04-22 Process for the preparation of flupirtine maleate.

Country Status (12)

Country Link
US (1) US5959115A (xx)
EP (1) EP0977736B1 (xx)
JP (1) JP4960538B2 (xx)
AR (1) AR012597A1 (xx)
AT (1) ATE250579T1 (xx)
AU (1) AU7334698A (xx)
DE (2) DE19716984A1 (xx)
DK (1) DK0977736T3 (xx)
ES (1) ES2207832T3 (xx)
PT (1) PT977736E (xx)
WO (1) WO1998047872A1 (xx)
ZA (1) ZA983376B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
GB0613928D0 (en) 2006-07-13 2006-08-23 Pliva Istrazivanje I Razvoj D Pharmaceutically acceptable salt and polymorphic forms
WO2008110357A1 (en) * 2007-03-12 2008-09-18 Elbion Gmbh Method for preparing a flupirtine maleate of a crystal modification b
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
WO2009152142A1 (en) 2008-06-09 2009-12-17 Awd. Pharma Gmbh & Co. Kg Sulfonate salts of flupirtine
EP2346826A2 (en) 2008-06-09 2011-07-27 AWD.pharma GmbH & Co.KG Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine
DE102009023162B4 (de) 2009-05-29 2011-07-07 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Flupirtin
CN102140077A (zh) * 2010-01-28 2011-08-03 范扶民 氟吡汀a晶型及其制备方法
WO2012004391A1 (en) * 2010-07-09 2012-01-12 K.H.S. Pharma Holding Gmbh Process for the preparation of flupirtine maleate
DE102010063612A1 (de) 2010-12-20 2012-06-21 Awd.Pharma Gmbh & Co. Kg Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamidsäureethylester und 2-[2-[(2,6-Dichlorphenyl)-amino]-phenyl]-essigsäure
DE102010063609A1 (de) 2010-12-20 2012-06-21 Awd.Pharma Gmbh & Co. Kg Neue Multikomponentenkristalle aus ([2-Amino-6-(4-fluoro-benzylamino)-pyridin-3yl)-carbamidsäureethylester und einer Arylpropionsäure
CN102351786A (zh) * 2011-11-01 2012-02-15 东南大学 一种氟吡汀丙二酸盐及其制备方法
WO2013080215A1 (en) 2011-11-30 2013-06-06 Arch Pharmalabs Limited An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof
DE102015013478A1 (de) 2015-10-17 2017-04-20 Goethe-Universität Neue Kristallphasen von Flupirtin-Maleat
DE102017007385A1 (de) 2017-08-02 2019-02-07 Christoph Hoock Maleatfreie feste Arzneimittelformen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3133519A1 (de) * 1980-09-13 1982-06-09 Degussa Ag, 6000 Frankfurt "2-amino-3-carbethoxyamino-6-(p-fluor-benzylamino)-pyridin-maleat"
US4481205A (en) * 1980-09-13 1984-11-06 Degussa Aktiengesellschaft 2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate

Also Published As

Publication number Publication date
PT977736E (pt) 2004-02-27
WO1998047872A1 (de) 1998-10-29
US5959115A (en) 1999-09-28
JP2001523236A (ja) 2001-11-20
EP0977736B1 (de) 2003-09-24
AU7334698A (en) 1998-11-13
JP4960538B2 (ja) 2012-06-27
DE59809728D1 (de) 2003-10-30
DK0977736T3 (da) 2004-01-19
ATE250579T1 (de) 2003-10-15
DE19716984A1 (de) 1998-10-29
EP0977736A1 (de) 2000-02-09
ES2207832T3 (es) 2004-06-01
AR012597A1 (es) 2000-11-08

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