DK0948349T3 - In vitro-fremgangsmåder og anvendelse af farmaceutiske præparater til behandling af indre øre-hårceller - Google Patents
In vitro-fremgangsmåder og anvendelse af farmaceutiske præparater til behandling af indre øre-hårcellerInfo
- Publication number
- DK0948349T3 DK0948349T3 DK97949346T DK97949346T DK0948349T3 DK 0948349 T3 DK0948349 T3 DK 0948349T3 DK 97949346 T DK97949346 T DK 97949346T DK 97949346 T DK97949346 T DK 97949346T DK 0948349 T3 DK0948349 T3 DK 0948349T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- pharmaceutical compositions
- inner ear
- hair cells
- vitro methods
- Prior art date
Links
- 210000003027 ear inner Anatomy 0.000 title 1
- 210000002768 hair cell Anatomy 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2953696P | 1996-11-01 | 1996-11-01 | |
US08/743,267 US6593290B1 (en) | 1996-11-01 | 1996-11-04 | Treatment of inner ear hair cells |
PCT/US1997/019585 WO1998019700A1 (en) | 1996-11-01 | 1997-10-28 | Treatment of inner ear hair cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0948349T3 true DK0948349T3 (da) | 2003-04-07 |
Family
ID=26705049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97949346T DK0948349T3 (da) | 1996-11-01 | 1997-10-28 | In vitro-fremgangsmåder og anvendelse af farmaceutiske præparater til behandling af indre øre-hårceller |
Country Status (15)
Country | Link |
---|---|
US (1) | US6593290B1 (pt) |
EP (1) | EP0948349B1 (pt) |
JP (1) | JP4191252B2 (pt) |
CN (1) | CN1313147C (pt) |
AR (1) | AR009603A1 (pt) |
AT (1) | ATE229815T1 (pt) |
AU (1) | AU724988B2 (pt) |
BR (1) | BR9712468A (pt) |
CA (1) | CA2268331C (pt) |
DE (1) | DE69718053T2 (pt) |
DK (1) | DK0948349T3 (pt) |
ES (1) | ES2189002T3 (pt) |
IL (2) | IL129381A0 (pt) |
WO (1) | WO1998019700A1 (pt) |
ZA (1) | ZA979814B (pt) |
Families Citing this family (40)
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US8039026B1 (en) | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
AUPP785098A0 (en) * | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
EP1471926B8 (en) | 1999-06-01 | 2011-09-21 | Baylor College Of Medicine | Compositions and methods for the therapeutic use of an atonal-associated sequence |
US7053200B1 (en) | 1999-06-01 | 2006-05-30 | Baylor College Of Medicine | Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation |
AU4885500A (en) * | 1999-07-27 | 2001-02-01 | Johnson & Johnson Consumer Companies, Inc. | Reducing hair growth, hair follicle and hair shaft size and hair pigmentation |
AU8821901A (en) * | 2000-07-11 | 2002-01-21 | Otogene Usa Inc | Stimulation of cellular regeneration and differentiation in the inner ear |
US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
JP4533144B2 (ja) | 2002-10-02 | 2010-09-01 | アンジェスMg株式会社 | 聴覚機能障害用医薬 |
EA010055B1 (ru) | 2003-03-19 | 2008-06-30 | Байоджен Айдек Ма Инк. | ВЫДЕЛЕННАЯ НУКЛЕИНОВАЯ КИСЛОТА, КОДИРУЮЩАЯ ПОЛИПЕПТИД Sp35, ПОЛИПЕПТИД Sp35 И СПОСОБЫ ПРИМЕНЕНИЯ НУКЛЕИНОВОЙ КИСЛОТЫ И ПОЛИПЕПТИДА |
KR101239542B1 (ko) | 2004-06-24 | 2013-03-07 | 바이오겐 아이덱 엠에이 인코포레이티드 | 탈수초화를 수반하는 병의 치료 |
US20070082858A1 (en) * | 2004-12-21 | 2007-04-12 | Oregon Health & Science University | Methods and compositions for the prevention of toxic side effects of aminoglycoside medications |
WO2007008547A2 (en) | 2005-07-08 | 2007-01-18 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
US20070213264A1 (en) | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
US20070190127A1 (en) | 2005-12-30 | 2007-08-16 | Mingdong Zhou | Extended release of neuregulin for improved cardiac function |
US20110123553A1 (en) * | 2007-11-08 | 2011-05-26 | Biogen Idec Ma Inc. | Use of LINGO-4 Antagonists in the Treatment of Conditions Involving Demyelination |
NZ590605A (en) | 2008-07-09 | 2012-11-30 | Biogen Idec Inc | Compositions comprising antibodies to lingo or fragments thereof |
US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
US8447409B2 (en) * | 2008-10-15 | 2013-05-21 | Cochlear Limited | Electroneural interface for a medical implant |
US7934558B2 (en) | 2009-03-13 | 2011-05-03 | Halliburton Energy Services, Inc. | System and method for dynamically adjusting the center of gravity of a perforating apparatus |
WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions and methods for treating heart failure |
MX2014013950A (es) | 2012-05-14 | 2015-02-17 | Biogen Idec Inc | Antagonistas de proteina que interactua con el receptor nogo 2 que contiene repeticion rica en leucina y dominio de inmunoglobulina (lingo-2) para el tratamiento de afecciones que involucran neuronas motoras. |
PT2970890T (pt) | 2013-03-14 | 2020-04-24 | Massachusetts Inst Technology | Composições e métodos para expansão e cultura de células estaminais epiteliais |
JP6773645B2 (ja) | 2014-09-03 | 2020-10-21 | ザ ブリガム アンド ウィミンズ ホスピタル,インコーポレイテッド | 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法 |
TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
EP3242893A1 (en) | 2015-01-08 | 2017-11-15 | Biogen MA Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
AU2017205194A1 (en) | 2016-01-08 | 2018-07-19 | Massachusetts Institute Of Technology | Production of differentiated enteroendocrine cells and insulin producing cells |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
CN115814097A (zh) * | 2016-06-03 | 2023-03-21 | 霍夫耳科研究所 | 用于内耳感觉毛细胞再生/替换的联合疗法 |
CN106075392B (zh) * | 2016-07-18 | 2020-07-07 | 滨州医学院 | 促红细胞生成素衍生物在听力保护上的应用 |
BR112019013388A2 (pt) | 2016-12-30 | 2020-03-03 | Frequency Therapeutics, Inc. | Compostos de 1h-pirrol-2,5-diona e métodos de uso dos mesmos para induzir a autorrenovação de células de suporte tronco/progenitoras |
WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
WO2020037323A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
CN109182250A (zh) * | 2018-09-30 | 2019-01-11 | 山东省立医院 | 一种小鼠耳蜗毛细胞培养方法 |
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US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
US4637402A (en) | 1980-04-28 | 1987-01-20 | Adelman Roger A | Method for quantitatively measuring a hearing defect |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
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US6136785A (en) * | 1995-08-08 | 2000-10-24 | University Of Virginia Patent Foundation | Protection from loss of sensory hair cells in the inner ear by administration of insulin-like growth factor and platelet derived growth factor |
-
1996
- 1996-11-04 US US08/743,267 patent/US6593290B1/en not_active Expired - Lifetime
-
1997
- 1997-10-28 CN CNB971994498A patent/CN1313147C/zh not_active Expired - Lifetime
- 1997-10-28 WO PCT/US1997/019585 patent/WO1998019700A1/en active IP Right Grant
- 1997-10-28 IL IL12938197A patent/IL129381A0/xx active IP Right Grant
- 1997-10-28 EP EP97949346A patent/EP0948349B1/en not_active Expired - Lifetime
- 1997-10-28 DE DE69718053T patent/DE69718053T2/de not_active Expired - Lifetime
- 1997-10-28 CA CA2268331A patent/CA2268331C/en not_active Expired - Lifetime
- 1997-10-28 AU AU70006/98A patent/AU724988B2/en not_active Expired
- 1997-10-28 ES ES97949346T patent/ES2189002T3/es not_active Expired - Lifetime
- 1997-10-28 AT AT97949346T patent/ATE229815T1/de active
- 1997-10-28 JP JP52151998A patent/JP4191252B2/ja not_active Expired - Lifetime
- 1997-10-28 DK DK97949346T patent/DK0948349T3/da active
- 1997-10-28 BR BR9712468-0A patent/BR9712468A/pt active Search and Examination
- 1997-10-31 AR ARP970105079A patent/AR009603A1/es not_active Application Discontinuation
- 1997-10-31 ZA ZA979814A patent/ZA979814B/xx unknown
-
1999
- 1999-04-09 IL IL129381A patent/IL129381A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2189002T3 (es) | 2003-07-01 |
ZA979814B (en) | 1999-04-30 |
JP2002514191A (ja) | 2002-05-14 |
JP4191252B2 (ja) | 2008-12-03 |
DE69718053D1 (de) | 2003-01-30 |
DE69718053T2 (de) | 2003-09-11 |
CA2268331C (en) | 2011-07-26 |
US6593290B1 (en) | 2003-07-15 |
WO1998019700A1 (en) | 1998-05-14 |
AU7000698A (en) | 1998-05-29 |
EP0948349A1 (en) | 1999-10-13 |
CN1251531A (zh) | 2000-04-26 |
IL129381A0 (en) | 2000-02-17 |
CA2268331A1 (en) | 1998-05-14 |
EP0948349B1 (en) | 2002-12-18 |
IL129381A (en) | 2006-07-05 |
CN1313147C (zh) | 2007-05-02 |
BR9712468A (pt) | 1999-10-26 |
AU724988B2 (en) | 2000-10-05 |
ATE229815T1 (de) | 2003-01-15 |
AR009603A1 (es) | 2000-04-26 |
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