BR9712468A - Método para aumentar o número de células pilosas do ouvido interno de mamìferos, composição de proliferação das células de suporte do ouvido interno de mamìferos, método para o tratamento de um distúrbio relacionado com as células pilosas do ouvido interno em um mamìfero kit e sou de igf-1 - Google Patents
Método para aumentar o número de células pilosas do ouvido interno de mamìferos, composição de proliferação das células de suporte do ouvido interno de mamìferos, método para o tratamento de um distúrbio relacionado com as células pilosas do ouvido interno em um mamìfero kit e sou de igf-1Info
- Publication number
- BR9712468A BR9712468A BR9712468-0A BR9712468A BR9712468A BR 9712468 A BR9712468 A BR 9712468A BR 9712468 A BR9712468 A BR 9712468A BR 9712468 A BR9712468 A BR 9712468A
- Authority
- BR
- Brazil
- Prior art keywords
- inner ear
- treatment
- mammals
- cells
- hair cells
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 210000003027 ear inner Anatomy 0.000 title abstract 5
- 241000124008 Mammalia Species 0.000 title abstract 4
- 210000002768 hair cell Anatomy 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 title abstract 3
- 230000035755 proliferation Effects 0.000 title abstract 3
- 101150088952 IGF1 gene Proteins 0.000 title 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 2
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 abstract 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 abstract 1
- 208000027601 Inner ear disease Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 230000006727 cell loss Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<B>"MéTODO PARA AUMENTAR O NúMERO DE CéLULAS PILOSAS DO OUVIDO INTERNO DE MAMìFEROS, COMPOSIçãO PARA USO NA PROMOçãO DE PROLIFERAçãO DAS CéLULAS DE SUPORTE DO OUVIDO INTERNO DE MAMìFEROS, MéTODO PARA O TRATAMENTO DE UM DISTúRBIO RELACIONADO COM AS CéLULAS PILOSAS DO OUVIDO INTERNO EM UM MAMìFERO, KIT E USO DE IGF-1"<D>. A presente invenção se refere a composições, métodos e dispositivos para a indução ou aumento do crescimento, proliferação, regeneração do tecido do ouvido interno, em particular as células pilosas do ouvido interno. Além disso, a presente invenção se refere a composições e métodos para o tratamento profiláctico ou terapêutico de um mamífero afetado com um distúrbio ou condição do ouvido interno, em particular para diminuições da audição envolvendo o dano, perda ou degeneração das células pilosas, mediante a administração de uma quantidade aceitável do ponto de vista terapêutico de IGF-1 ou FGF-2, ou seus agonistas, isolados ou em combinação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2953696P | 1996-11-01 | 1996-11-01 | |
US08/743,267 US6593290B1 (en) | 1996-11-01 | 1996-11-04 | Treatment of inner ear hair cells |
PCT/US1997/019585 WO1998019700A1 (en) | 1996-11-01 | 1997-10-28 | Treatment of inner ear hair cells |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712468A true BR9712468A (pt) | 1999-10-26 |
Family
ID=26705049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712468-0A BR9712468A (pt) | 1996-11-01 | 1997-10-28 | Método para aumentar o número de células pilosas do ouvido interno de mamìferos, composição de proliferação das células de suporte do ouvido interno de mamìferos, método para o tratamento de um distúrbio relacionado com as células pilosas do ouvido interno em um mamìfero kit e sou de igf-1 |
Country Status (15)
Country | Link |
---|---|
US (1) | US6593290B1 (pt) |
EP (1) | EP0948349B1 (pt) |
JP (1) | JP4191252B2 (pt) |
CN (1) | CN1313147C (pt) |
AR (1) | AR009603A1 (pt) |
AT (1) | ATE229815T1 (pt) |
AU (1) | AU724988B2 (pt) |
BR (1) | BR9712468A (pt) |
CA (1) | CA2268331C (pt) |
DE (1) | DE69718053T2 (pt) |
DK (1) | DK0948349T3 (pt) |
ES (1) | ES2189002T3 (pt) |
IL (2) | IL129381A0 (pt) |
WO (1) | WO1998019700A1 (pt) |
ZA (1) | ZA979814B (pt) |
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RU2457854C2 (ru) * | 2005-12-30 | 2012-08-10 | Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи Лимитед | Длительное высвобождение нейрегулина для улучшения сердечной функции |
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-
1996
- 1996-11-04 US US08/743,267 patent/US6593290B1/en not_active Expired - Lifetime
-
1997
- 1997-10-28 EP EP97949346A patent/EP0948349B1/en not_active Expired - Lifetime
- 1997-10-28 JP JP52151998A patent/JP4191252B2/ja not_active Expired - Lifetime
- 1997-10-28 AT AT97949346T patent/ATE229815T1/de active
- 1997-10-28 CN CNB971994498A patent/CN1313147C/zh not_active Expired - Lifetime
- 1997-10-28 WO PCT/US1997/019585 patent/WO1998019700A1/en active IP Right Grant
- 1997-10-28 AU AU70006/98A patent/AU724988B2/en not_active Expired
- 1997-10-28 IL IL12938197A patent/IL129381A0/xx active IP Right Grant
- 1997-10-28 BR BR9712468-0A patent/BR9712468A/pt active Search and Examination
- 1997-10-28 DK DK97949346T patent/DK0948349T3/da active
- 1997-10-28 ES ES97949346T patent/ES2189002T3/es not_active Expired - Lifetime
- 1997-10-28 CA CA2268331A patent/CA2268331C/en not_active Expired - Lifetime
- 1997-10-28 DE DE69718053T patent/DE69718053T2/de not_active Expired - Lifetime
- 1997-10-31 ZA ZA979814A patent/ZA979814B/xx unknown
- 1997-10-31 AR ARP970105079A patent/AR009603A1/es not_active Application Discontinuation
-
1999
- 1999-04-09 IL IL129381A patent/IL129381A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1313147C (zh) | 2007-05-02 |
DE69718053D1 (de) | 2003-01-30 |
ES2189002T3 (es) | 2003-07-01 |
AR009603A1 (es) | 2000-04-26 |
ATE229815T1 (de) | 2003-01-15 |
CA2268331A1 (en) | 1998-05-14 |
CN1251531A (zh) | 2000-04-26 |
DK0948349T3 (da) | 2003-04-07 |
IL129381A (en) | 2006-07-05 |
JP4191252B2 (ja) | 2008-12-03 |
AU724988B2 (en) | 2000-10-05 |
CA2268331C (en) | 2011-07-26 |
EP0948349B1 (en) | 2002-12-18 |
WO1998019700A1 (en) | 1998-05-14 |
JP2002514191A (ja) | 2002-05-14 |
DE69718053T2 (de) | 2003-09-11 |
EP0948349A1 (en) | 1999-10-13 |
IL129381A0 (en) | 2000-02-17 |
US6593290B1 (en) | 2003-07-15 |
AU7000698A (en) | 1998-05-29 |
ZA979814B (en) | 1999-04-30 |
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