AU8821901A - Stimulation of cellular regeneration and differentiation in the inner ear - Google Patents

Stimulation of cellular regeneration and differentiation in the inner ear

Info

Publication number
AU8821901A
AU8821901A AU8821901A AU8821901A AU8821901A AU 8821901 A AU8821901 A AU 8821901A AU 8821901 A AU8821901 A AU 8821901A AU 8821901 A AU8821901 A AU 8821901A AU 8821901 A AU8821901 A AU 8821901A
Authority
AU
Australia
Prior art keywords
differentiation
stimulation
inner ear
cellular regeneration
regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU8821901A
Inventor
Jonathan Kil
Rendu Gu
Corinne Grigeur
Hubert Lowenheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otogene AG
Otogene USA Inc
Original Assignee
Otogene AG
Otogene USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otogene AG, Otogene USA Inc filed Critical Otogene AG
Publication of AU8821901A publication Critical patent/AU8821901A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU8821901A 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear Pending AU8821901A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61409900A 2000-07-11 2000-07-11
PCT/US2001/021793 WO2002004605A2 (en) 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear

Publications (1)

Publication Number Publication Date
AU8821901A true AU8821901A (en) 2002-01-21

Family

ID=24459860

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001288219A Ceased AU2001288219C1 (en) 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear
AU8821901A Pending AU8821901A (en) 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001288219A Ceased AU2001288219C1 (en) 2000-07-11 2001-07-10 Stimulation of cellular regeneration and differentiation in the inner ear

Country Status (7)

Country Link
EP (1) EP1307542A2 (en)
JP (1) JP2004502785A (en)
KR (1) KR100896489B1 (en)
CN (1) CN1441841B (en)
AU (2) AU2001288219C1 (en)
CA (1) CA2412764C (en)
WO (1) WO2002004605A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
CA2669693C (en) 2006-11-15 2018-06-12 Massachusetts Eye & Ear Infirmary Generation of inner ear cells
JP5366820B2 (en) 2006-12-07 2013-12-11 ウィルソン ウォルフ マニュファクチャリング コーポレイション Apparatus and method effective for cell culture
DE102010007281A1 (en) * 2010-02-08 2011-08-11 EMC microcollections GmbH, 72070 Novel aminoalkyl-oxazole and aminoalkyl-thiazolecarboxamides and their application to stimulate the endogenous regeneration of hair cells in the internal organ Corti organ in the mammal
EP2739637A4 (en) * 2011-08-03 2015-04-22 Quark Pharmaceuticals Inc Double-stranded oligonucleotide compounds for treating hearing and balance disorders
BR112014016937A2 (en) * 2012-01-12 2017-06-13 Quark Pharmaceuticals Inc combination therapy for the treatment of hearing and balance disorders
EP3943090A1 (en) 2016-01-29 2022-01-26 Massachusetts Eye & Ear Infirmary Expansion and differentiation of inner ear supporting cells and methods of use thereof
CN114736924A (en) * 2021-01-07 2022-07-12 中国科学院脑科学与智能技术卓越创新中心 Ectopic combined overexpression of Atoh1 and Ikzf2 for regeneration of cochlear outer hair cells and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593290B1 (en) * 1996-11-01 2003-07-15 Genentech, Inc. Treatment of inner ear hair cells
DE19807426A1 (en) * 1998-02-23 1999-10-14 Otogene Biotechnologische Fors Procedure for the treatment of diseases or disorders of the inner ear
AU1223500A (en) * 1998-10-21 2000-05-08 Jonathan Kil Methods for stimulating the regeneration of inner ear cells

Also Published As

Publication number Publication date
WO2002004605A2 (en) 2002-01-17
KR100896489B1 (en) 2009-05-08
CA2412764C (en) 2014-06-03
JP2004502785A (en) 2004-01-29
CA2412764A1 (en) 2002-01-17
WO2002004605A3 (en) 2003-02-27
CN1441841A (en) 2003-09-10
AU2001288219B9 (en) 2009-11-19
AU2001288219B2 (en) 2006-11-23
AU2001288219C1 (en) 2009-12-03
EP1307542A2 (en) 2003-05-07
KR20030046386A (en) 2003-06-12
CN1441841B (en) 2013-03-20

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