DK0939769T3 - Vertebrat-Smoothened-proteiner - Google Patents
Vertebrat-Smoothened-proteinerInfo
- Publication number
- DK0939769T3 DK0939769T3 DK97944533T DK97944533T DK0939769T3 DK 0939769 T3 DK0939769 T3 DK 0939769T3 DK 97944533 T DK97944533 T DK 97944533T DK 97944533 T DK97944533 T DK 97944533T DK 0939769 T3 DK0939769 T3 DK 0939769T3
- Authority
- DK
- Denmark
- Prior art keywords
- vertebrate
- smoothened
- vertebrate smoothened
- smoothened proteins
- proteins
- Prior art date
Links
- 241000251539 Vertebrata <Metazoa> Species 0.000 title abstract 5
- 102000013380 Smoothened Receptor Human genes 0.000 title 1
- 108010090739 Smoothened Receptor Proteins 0.000 title 1
- 101000708627 Rattus norvegicus Smoothened homolog Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/720,484 US5990281A (en) | 1996-09-30 | 1996-09-30 | Vertebrate smoothened proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0939769T3 true DK0939769T3 (da) | 2006-03-13 |
Family
ID=24894172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97944533T DK0939769T3 (da) | 1996-09-30 | 1997-09-29 | Vertebrat-Smoothened-proteiner |
Country Status (12)
Country | Link |
---|---|
US (2) | US5990281A (fr) |
EP (1) | EP0939769B1 (fr) |
JP (1) | JP4671371B2 (fr) |
AT (1) | ATE309270T1 (fr) |
AU (1) | AU725701B2 (fr) |
CA (1) | CA2267181A1 (fr) |
DE (1) | DE69734596T2 (fr) |
DK (1) | DK0939769T3 (fr) |
ES (1) | ES2252795T3 (fr) |
IL (1) | IL129139A (fr) |
WO (1) | WO1998014475A1 (fr) |
ZA (1) | ZA978503B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999000117A2 (fr) | 1997-06-27 | 1999-01-07 | Ontogeny, Inc. | Procedes et reactifs neuroprotecteurs |
US7144997B2 (en) | 1997-07-24 | 2006-12-05 | Curis, Inc. | Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto |
US7361336B1 (en) | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
US6639051B2 (en) | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
EP1037982A1 (fr) | 1997-12-08 | 2000-09-27 | Ontogeny, Inc. | Genes et proteines ptc humains, et leurs utilisations |
US6884770B1 (en) | 1998-11-06 | 2005-04-26 | Curis, Inc. | Methods and compositions for treating or preventing peripheral neuropathies |
EP2783700A1 (fr) * | 2006-09-07 | 2014-10-01 | Stemline Therapeutics, Inc. | Thérapie du cancer ciblant des cellules souches cancéreuses |
JP5887270B2 (ja) | 2009-09-02 | 2016-03-16 | ジェネンテック, インコーポレイテッド | 突然変異体smoothenedおよびその使用方法 |
KR102254905B1 (ko) * | 2018-07-11 | 2021-05-24 | 주식회사 헤지호그 | Smo 단백질의 특이적 에피토프, 이를 인지하는 항체 및 이를 포함하는 조성물 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2413974A1 (fr) * | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
US4342566A (en) * | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
US4399216A (en) * | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
WO1981002798A1 (fr) | 1980-03-21 | 1981-10-01 | Concurrent Processing Systems | Systeme d'ordinateur et interface pour celui-ci |
ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
US4419446A (en) * | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4870009A (en) * | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4601978A (en) * | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
AU2353384A (en) * | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
US4713339A (en) * | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4736866B1 (en) * | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
JPS63502716A (ja) * | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
GB8724885D0 (en) * | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
WO1989005859A1 (fr) * | 1987-12-21 | 1989-06-29 | The Upjohn Company | Transformation par l'agrobacterium de graines de plantes de germination |
ES2096590T3 (es) * | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
DK168302B1 (da) * | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
US5206161A (en) * | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
CA2102511A1 (fr) * | 1991-05-14 | 1992-11-15 | Paul J. Higgins | Anticorps heteroconjugues pour le traitement de l'infection a vih |
WO1994004679A1 (fr) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Procede pour fabriquer des anticorps humanises |
WO1993008829A1 (fr) * | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions induisant la destruction de cellules infectees par l'hiv |
CA2140280A1 (fr) * | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Immunoadhesines bispecifiques |
RU2139092C1 (ru) * | 1993-06-03 | 1999-10-10 | Терапьютик Антибодиз Инк. | Фрагменты антител в терапии |
US6136958A (en) * | 1996-09-30 | 2000-10-24 | Genentech, Inc. | Antibodies to vertebrate smoothened proteins |
-
1996
- 1996-09-30 US US08/720,484 patent/US5990281A/en not_active Expired - Lifetime
-
1997
- 1997-09-22 ZA ZA978503A patent/ZA978503B/xx unknown
- 1997-09-29 DE DE69734596T patent/DE69734596T2/de not_active Revoked
- 1997-09-29 ES ES97944533T patent/ES2252795T3/es not_active Expired - Lifetime
- 1997-09-29 WO PCT/US1997/017433 patent/WO1998014475A1/fr active IP Right Grant
- 1997-09-29 CA CA002267181A patent/CA2267181A1/fr not_active Abandoned
- 1997-09-29 AU AU46005/97A patent/AU725701B2/en not_active Expired
- 1997-09-29 EP EP97944533A patent/EP0939769B1/fr not_active Revoked
- 1997-09-29 JP JP51672198A patent/JP4671371B2/ja not_active Expired - Lifetime
- 1997-09-29 DK DK97944533T patent/DK0939769T3/da active
- 1997-09-29 IL IL129139A patent/IL129139A/en not_active IP Right Cessation
- 1997-09-29 AT AT97944533T patent/ATE309270T1/de active
-
1999
- 1999-09-20 US US09/398,239 patent/US6407216B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5990281A (en) | 1999-11-23 |
AU4600597A (en) | 1998-04-24 |
US6407216B1 (en) | 2002-06-18 |
CA2267181A1 (fr) | 1998-04-09 |
ES2252795T3 (es) | 2006-05-16 |
JP2001501476A (ja) | 2001-02-06 |
EP0939769B1 (fr) | 2005-11-09 |
ATE309270T1 (de) | 2005-11-15 |
DE69734596T2 (de) | 2006-07-20 |
ZA978503B (en) | 1999-03-23 |
DE69734596D1 (de) | 2005-12-15 |
IL129139A (en) | 2007-12-03 |
EP0939769A1 (fr) | 1999-09-08 |
IL129139A0 (en) | 2000-02-17 |
AU725701B2 (en) | 2000-10-19 |
WO1998014475A1 (fr) | 1998-04-09 |
JP4671371B2 (ja) | 2011-04-13 |
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