DK0914146T3 - Morfogenbehandling af kronisk nyresvigt - Google Patents

Morfogenbehandling af kronisk nyresvigt

Info

Publication number
DK0914146T3
DK0914146T3 DK97922726T DK97922726T DK0914146T3 DK 0914146 T3 DK0914146 T3 DK 0914146T3 DK 97922726 T DK97922726 T DK 97922726T DK 97922726 T DK97922726 T DK 97922726T DK 0914146 T3 DK0914146 T3 DK 0914146T3
Authority
DK
Denmark
Prior art keywords
renal failure
chronic renal
treatment
morphogen treatment
risk
Prior art date
Application number
DK97922726T
Other languages
Danish (da)
English (en)
Inventor
Kuber T Sampath
Charles M Cohen
Slobodan Vukicevic
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of DK0914146T3 publication Critical patent/DK0914146T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK97922726T 1996-05-06 1997-05-06 Morfogenbehandling af kronisk nyresvigt DK0914146T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/643,321 US6498142B1 (en) 1996-05-06 1996-05-06 Morphogen treatment for chronic renal failure
EP97922726A EP0914146B1 (de) 1996-05-06 1997-05-06 Morphogenische behandlung des chronischen nierenversagens

Publications (1)

Publication Number Publication Date
DK0914146T3 true DK0914146T3 (da) 2005-01-31

Family

ID=24580305

Family Applications (2)

Application Number Title Priority Date Filing Date
DK97922726T DK0914146T3 (da) 1996-05-06 1997-05-06 Morfogenbehandling af kronisk nyresvigt
DK97923567T DK0910400T3 (da) 1996-05-06 1997-05-06 Terapier for kronisk nyresvigt

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK97923567T DK0910400T3 (da) 1996-05-06 1997-05-06 Terapier for kronisk nyresvigt

Country Status (11)

Country Link
US (5) US6498142B1 (de)
EP (2) EP0910400B1 (de)
JP (4) JP2000510835A (de)
AT (2) ATE277629T1 (de)
AU (2) AU2832297A (de)
CA (2) CA2254953C (de)
DE (2) DE69723845T2 (de)
DK (2) DK0914146T3 (de)
ES (2) ES2230604T3 (de)
PT (2) PT914146E (de)
WO (2) WO1997041881A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
CA2104678C (en) * 1991-03-11 2002-05-14 Charles M. Cohen Protein-induced morphogenesis
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
EP0980252B1 (de) 1997-05-05 2004-10-06 Curis, Inc. Therapien zur behandlung von akutem nierenversagen
WO1998050061A1 (en) * 1997-05-07 1998-11-12 Biogen, Inc. Novel therapies for cystic kidney disease
DE69714035T2 (de) 1997-08-14 2003-03-06 Sulzer Innotec Ag, Winterthur Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
US6203788B1 (en) * 1997-09-29 2001-03-20 Adherex Inc. Compounds and methods for regulating cell adhesion
CA2314423A1 (en) * 1997-12-04 1999-06-10 Creative Biomolecules, Inc. Maintenance of smooth muscle integrity by morphogenic proteins
NZ509609A (en) * 1998-07-28 2003-11-28 Univ Johns Hopkins Med Disrupting growth differentiation factor-11 (GDF-11) to increase the muscle and bone tissue in animals
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
ATE325623T1 (de) * 1999-09-14 2006-06-15 Biogen Idec Inc Therapien für chronische niereninsuffizienz unter verwendung von einem oder mehreren integrinantagonist(en)
US20020173453A1 (en) * 2000-12-15 2002-11-21 Rama Akella Method of treating renal injury
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
EP1578360A4 (de) * 2002-08-28 2009-10-21 Curis Inc Gleichzeitige verabreichung von morphogenen und ace-hemmern bei der behandlung von chronischer niereninsuffizienz
EP1677735B1 (de) 2003-10-17 2014-07-23 Joslin Diabetes Center, Inc. Verfahren und zusammensetzungen zur modulierung der adipozyten-funktion
US7844367B2 (en) 2003-12-23 2010-11-30 Rain Bird Corporation Code replacement for irrigation controllers
KR101228233B1 (ko) 2004-03-30 2013-01-31 리립사, 인크. 이온 결합 중합체 및 이의 용도
US7459527B2 (en) * 2004-03-31 2008-12-02 Xencor, Inc. BMP-7 variants with improved properties
WO2006130690A2 (en) 2005-06-01 2006-12-07 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
US7771995B2 (en) * 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
CA2629522A1 (en) * 2005-11-14 2007-05-18 Merial Limited Gene therapy for renal failure
WO2007087570A2 (en) * 2006-01-24 2007-08-02 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US20080090765A1 (en) * 2006-05-25 2008-04-17 The Trustees Of Columbia University In The City Of New York Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage
EP2035835B1 (de) * 2006-05-30 2011-12-28 Antibodyshop A/S Verfahren zur schnellen beurteilung der schwere eines traumas
US7722665B2 (en) * 2006-07-07 2010-05-25 Graft Technologies, Inc. System and method for providing a graft in a vascular environment
EP2047862B9 (de) 2006-07-21 2013-04-10 Chugai Seiyaku Kabushiki Kaisha Mittel zur behandlung von nierenerkrankungen
WO2008075173A2 (en) * 2006-12-15 2008-06-26 Ruprecht-Karls-Universität Heidelberg Methods for treating podocyte-related disorders
EP2148706A2 (de) * 2007-04-24 2010-02-03 Advanced Technologies and Regenerative Medicine, LLC Gentechnisch hergestelltes nierengewebe
DE102007034580B4 (de) * 2007-07-13 2012-11-08 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Biomaterial basierend auf einem hydrophilen polymeren Träger
US20090155245A1 (en) * 2007-12-18 2009-06-18 Fang Carrie H Treatment for Organ Regeneration with Combination of Drug and Biologics
EP2283119B1 (de) * 2008-05-06 2015-01-07 Joslin Diabetes Center, Inc. Verfahren und zusammensetzungen zur einleitung von brauner adipogenese
WO2009157165A1 (ja) * 2008-06-24 2009-12-30 株式会社根本杏林堂 薬液注入装置、この薬液注入装置を有する透視撮像システム、薬液注入装置のコンピュータプログラムおよびデータ処理方法
KR20110073471A (ko) * 2008-08-28 2011-06-29 아스튜트 메디컬 인코포레이티드 신손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물
EP2324354B1 (de) * 2008-08-29 2014-07-16 Astute Medical, Inc. Verfahren zur prognose von akuter niereninsuffizienz
EP2347260A4 (de) * 2008-10-21 2012-09-26 Astute Medical Inc Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
EP3246707B1 (de) 2008-10-21 2020-09-30 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
CN104330574B (zh) 2008-11-10 2017-04-12 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
NZ592552A (en) * 2008-11-22 2013-12-20 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011017654A1 (en) 2009-08-07 2011-02-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
MX2011008323A (es) * 2009-02-06 2011-09-21 Astute Medical Inc Metodos y composiciones para diagnosis y prognosis de lesion renal y falla renal.
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2010213591B2 (en) * 2009-02-12 2013-11-21 Stryker Corporation Compositions and methods for minimally-invasive systemic delivery of proteins including TGF-beta superfamily members
JP5819733B2 (ja) * 2009-02-12 2015-11-24 ストライカー コーポレイションStryker Corporation 障害および疾患に対する全身治療のためのTGF−βスーパーファミリーメンバー含有タンパク質の末梢投与
AU2010223268B2 (en) * 2009-03-12 2015-04-23 Haase Investments Gmbh Bone morphogenetic protein 2 (BMP2 ) variants with reduced BMP antagonist sensitivity
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
ES2387379T3 (es) 2009-09-17 2012-09-21 Stryker Corporation Tampones para controlar el pH de las proteínas morfogenéticas óseas
JP2013510322A (ja) 2009-11-07 2013-03-21 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
CN102725636B (zh) 2009-12-20 2015-04-01 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
WO2011087768A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
BR112012019542A2 (pt) 2010-02-05 2018-03-27 Astute Medical Inc "método para avaliar o estado renal em um indivíduo, medição de um ou mais biomarcadores, e, kit"
EA201290711A1 (ru) 2010-02-26 2013-10-30 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
WO2011149962A1 (en) 2010-05-24 2011-12-01 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
NZ703055A (en) 2010-06-23 2016-07-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ605698A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
CN103079585B (zh) 2010-08-20 2015-09-30 惠氏有限责任公司 经设计的成骨蛋白
EP2788759B1 (de) 2011-12-08 2019-02-20 Astute Medical, Inc. Verfahren und verwendungen zur diagnose von nierenverletzungen und niereninsuffizienz
KR20150088243A (ko) 2012-10-08 2015-07-31 리립사, 인크. 고혈압 및 고칼륨혈증을 치료하기 위한 칼륨-결합제
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
ES2681955T3 (es) 2013-01-17 2018-09-17 Astute Medical, Inc. Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
EP2784083A1 (de) 2013-03-28 2014-10-01 Charité - Universitätsmedizin Berlin Knochenmorphogenetische Protein (BMP)-Varianten mit hoch reduzierter Antagonisten-Sensibilität und erweiterter spezifischer biologischer Aktivität
EP3069149B1 (de) * 2013-11-11 2022-05-18 General Electric Company Verfahren zur verringerung von fehlern bei rotordrehzahlmessungen
EP2944326B1 (de) 2014-05-16 2018-11-21 Cyanagen Srl Tricarbocyanin-cyclodextrin-konjugate und deren verwendung zur diagnose von nierenkrankheiten
EP4406585A3 (de) 2015-02-13 2024-10-23 Factor Bioscience Inc. Nukleinsäureprodukte und verfahren zur verabreichung davon
US11243217B2 (en) 2016-06-06 2022-02-08 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
CA3033788A1 (en) 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
JP2019039673A (ja) * 2017-08-22 2019-03-14 セイコーエプソン株式会社 時間デジタル変換回路、回路装置、物理量測定装置、電子機器及び移動体

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156741B (it) * 1978-05-15 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi
US4342828A (en) 1979-07-20 1982-08-03 Morinaga Milk Industry Co., Ltd. Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
US4627839A (en) 1985-11-21 1986-12-09 American Hospital Supply Corporation Patient controlled analgesia conversion
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
WO1990011366A1 (en) 1989-03-28 1990-10-04 Genetics Institute, Inc. Osteoinductive compositions
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5045452A (en) * 1988-09-02 1991-09-03 Brigham And Women's Hospital Method for evaluating nephrotoxicity
ES2168091T3 (es) 1990-05-16 2002-06-01 Genetics Inst Proteinas de induccion osea y cartilaginosa.
JPH0426624A (ja) * 1990-05-18 1992-01-29 Tsumura & Co 慢性腎不全改善剤
DK0533840T3 (da) 1990-06-22 1996-12-30 Du Pont Behandling af kronisk nyresvigt med imidazol-angiotensin-II-receptor-antagonister
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
CA2104678C (en) 1991-03-11 2002-05-14 Charles M. Cohen Protein-induced morphogenesis
WO1992015323A1 (en) 1991-03-11 1992-09-17 Creative Biomolecules, Inc. Protein-induced morphogenesis
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
ATE192931T1 (de) 1991-08-30 2000-06-15 Creative Biomolecules Inc Morphogen-induzierte modulation von entzündlichen antworten
ATE197611T1 (de) 1991-08-30 2000-12-15 Creative Biomolecules Inc Screeningverfahren von morphogenischen proteinen
ES2253736T3 (es) 1991-08-30 2006-06-01 Curis, Inc. Tratamiento para prevenir la perdida y/o aumentar la masa osea en transtornos metabolicos del hueso.
US6120760A (en) * 1992-02-12 2000-09-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Growth/differentiation factors of the TGF-β family
CA2141555C (en) 1992-07-31 2007-03-27 William K. Jones Morphogenic protein soluble complex and composition thereof
AU681594B2 (en) 1992-07-31 1997-09-04 Stryker Corporation Morphogen-induced nerve regeneration and repair
ES2118253T3 (es) 1992-07-31 1998-09-16 Creative Biomolecules Inc Composicion dietetica enriquecida con morfogen.
CA2144514C (en) 1992-09-16 2002-03-26 Thangavel Kuberasampath Morphogen-induced liver regeneration
EP0672064A1 (de) 1992-11-03 1995-09-20 Creative Biomolecules, Inc. Op 3 - induzierte morphogenese
US5372335A (en) 1992-12-18 1994-12-13 Scott H. Yenzer Aerial marker ball and method of placement
AU682176B2 (en) 1993-03-04 1997-09-25 Stryker Corporation Method and compositions for recombinant osteogenic protein production
US5631159A (en) 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
US5585237A (en) 1993-10-25 1996-12-17 Creative Biomolecules, Inc. Methods and compositions for high protein production from recombinant DNA
CA2176709A1 (en) * 1993-11-15 1995-05-26 Howard R. Higley Method of treating renal disease by administering igf-i and igfbp-3
US5525621A (en) * 1994-05-20 1996-06-11 Cytos Pharmaceuticals Llc Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses
US5714511A (en) * 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
US5723411A (en) * 1995-10-31 1998-03-03 E. I. Du Pont De Nemours And Company Herbicidal pyridazinones
AU734312B2 (en) 1996-03-22 2001-06-07 General Hospital Corporation, The Administration of polypeptide growth factors following central nervous system ischemia or trauma
US5820589A (en) 1996-04-30 1998-10-13 Medtronic, Inc. Implantable non-invasive rate-adjustable pump
US6498142B1 (en) * 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
US5879908A (en) * 1997-04-30 1999-03-09 Smithkline Beecham Corporation CRFG-1a, a target and marker for chronic renal failure
US7147839B2 (en) * 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity

Also Published As

Publication number Publication date
EP0914146A1 (de) 1999-05-12
AU2933997A (en) 1997-11-26
DE69730966D1 (de) 2004-11-04
US20050143304A1 (en) 2005-06-30
US6498142B1 (en) 2002-12-24
CA2254954C (en) 2010-01-12
DK0910400T3 (da) 2003-11-24
PT910400E (pt) 2003-12-31
US20100291170A1 (en) 2010-11-18
DE69723845T2 (de) 2004-06-03
JP2009185076A (ja) 2009-08-20
CA2254953C (en) 2006-09-26
DE69730966T2 (de) 2006-02-23
ATE245997T1 (de) 2003-08-15
AU2832297A (en) 1997-11-26
US8017580B2 (en) 2011-09-13
JP4766722B2 (ja) 2011-09-07
EP0910400A1 (de) 1999-04-28
ATE277629T1 (de) 2004-10-15
US20120004171A1 (en) 2012-01-05
WO1997041880A1 (en) 1997-11-13
US8377878B2 (en) 2013-02-19
WO1997041881A1 (en) 1997-11-13
CA2254953A1 (en) 1997-11-13
ES2230604T3 (es) 2005-05-01
DE69723845D1 (de) 2003-09-04
EP0914146B1 (de) 2004-09-29
EP0910400B1 (de) 2003-07-30
PT914146E (pt) 2005-02-28
US7524817B2 (en) 2009-04-28
JP2000510124A (ja) 2000-08-08
JP5247593B2 (ja) 2013-07-24
JP2000510835A (ja) 2000-08-22
ES2203803T3 (es) 2004-04-16
US6861404B1 (en) 2005-03-01
CA2254954A1 (en) 1997-11-13
JP2012229268A (ja) 2012-11-22

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