DK0902027T5 - Indol- og indazol-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterne - Google Patents
Indol- og indazol-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterneInfo
- Publication number
- DK0902027T5 DK0902027T5 DK98402154T DK98402154T DK0902027T5 DK 0902027 T5 DK0902027 T5 DK 0902027T5 DK 98402154 T DK98402154 T DK 98402154T DK 98402154 T DK98402154 T DK 98402154T DK 0902027 T5 DK0902027 T5 DK 0902027T5
- Authority
- DK
- Denmark
- Prior art keywords
- derivatives
- indazole
- preparation
- indole
- methods
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000019695 Migraine disease Diseases 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- -1 1-Substituted indole Chemical class 0.000 abstract 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- HLDVKIKLLBOOPW-UHFFFAOYSA-N 2-methyl-1h-indol-3-ol Chemical class C1=CC=C2C(O)=C(C)NC2=C1 HLDVKIKLLBOOPW-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- JXZZHCVPKCNLHP-UHFFFAOYSA-N N1C=NN=C1.N1N=CC2=CC=CC=C12 Chemical class N1C=NN=C1.N1N=CC2=CC=CC=C12 JXZZHCVPKCNLHP-UHFFFAOYSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- AYTAYKXVFZPRAF-KQQUZDAGSA-N n'-[(e)-dimethylaminomethylideneamino]-n,n-dimethylmethanimidamide Chemical compound CN(C)\C=N\N=C\N(C)C AYTAYKXVFZPRAF-KQQUZDAGSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 150000003852 triazoles Chemical group 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
- 201000002282 venous insufficiency Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9710939A FR2767827A1 (fr) | 1997-09-03 | 1997-09-03 | Nouveaux derives de l'indole et de l'indazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK0902027T3 DK0902027T3 (da) | 2001-10-15 |
| DK0902027T5 true DK0902027T5 (da) | 2001-12-03 |
Family
ID=9510710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98402154T DK0902027T5 (da) | 1997-09-03 | 1998-09-01 | Indol- og indazol-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterne |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6020336A (da) |
| EP (1) | EP0902027B1 (da) |
| JP (1) | JPH11130773A (da) |
| CN (2) | CN1510034A (da) |
| AT (1) | ATE203531T1 (da) |
| AU (1) | AU736602B2 (da) |
| BR (1) | BR9803318A (da) |
| CA (1) | CA2246485C (da) |
| DE (1) | DE69801196T2 (da) |
| DK (1) | DK0902027T5 (da) |
| ES (1) | ES2162404T3 (da) |
| FR (1) | FR2767827A1 (da) |
| GR (1) | GR3036678T3 (da) |
| HU (1) | HUP9801977A1 (da) |
| NO (1) | NO316271B1 (da) |
| NZ (1) | NZ331683A (da) |
| PL (1) | PL328323A1 (da) |
| PT (1) | PT902027E (da) |
| ZA (1) | ZA988072B (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6380242B1 (en) * | 1998-12-23 | 2002-04-30 | Nps Allelix Corp. | N-alkylamino-indoles for the treatment of migraine |
| YU54202A (sh) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| BR0110302A (pt) | 2000-04-18 | 2003-01-14 | Agouron Pharma | Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase |
| US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| US20070105841A1 (en) * | 2000-08-14 | 2007-05-10 | Breitenbucher J G | Method for treating allergies using substituted pyrazoles |
| EP1309591B1 (en) | 2000-08-14 | 2007-01-24 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| FR2829134B1 (fr) | 2001-08-28 | 2006-11-24 | Atofina | Procede de preparation de (meth) acrylates d'alkylimidazolidone |
| US20030073672A1 (en) * | 2001-09-05 | 2003-04-17 | Breitenbucher J. Guy | Method for treating allergies using substituted pyrazoles |
| RU2295326C1 (ru) * | 2005-10-05 | 2007-03-20 | Елена Николаевна Лаптева | Комплексный способ снижения избыточной массы тела |
| JPWO2012086735A1 (ja) * | 2010-12-22 | 2014-06-05 | 大正製薬株式会社 | 縮合複素環化合物 |
| CN102617548A (zh) * | 2011-01-31 | 2012-08-01 | 北京赛林泰医药技术有限公司 | 作为gpr受体激动剂的双环杂芳基化合物及其组合物和应用 |
| WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
| US9963458B2 (en) | 2012-12-27 | 2018-05-08 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| US20150252051A1 (en) * | 2014-03-10 | 2015-09-10 | Innov17 Llc | Retinoic acid receptor-related orphan receptor modulators and uses thereof |
| WO2015138276A2 (en) * | 2014-03-10 | 2015-09-17 | Innov17 Llc | Retinoic acid receptor-related orphan receptor modulators and uses thereof |
| WO2018106667A1 (en) * | 2016-12-05 | 2018-06-14 | Microbiotix, Inc. | Broad-spectrum inhibitors of filoviruses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU198036B (en) * | 1983-08-22 | 1989-07-28 | Hoechst Roussel Pharma | Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them |
| TW203049B (da) * | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
| EP0597112A4 (en) * | 1992-03-27 | 1994-06-22 | Kyoto Pharma Ind | Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor. |
| IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
| GB9402016D0 (en) * | 1994-02-02 | 1994-03-30 | Merck Sharp & Dohme | Therapeutic agents |
| EP0759918A1 (en) * | 1994-05-19 | 1997-03-05 | MERCK SHARP & DOHME LTD. | Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists |
| GB2289465A (en) * | 1994-05-19 | 1995-11-22 | Merck Sharp & Dohme | Five-membered heteroaromatic 5-HT receptor agonists |
| JPH10503768A (ja) * | 1994-08-02 | 1998-04-07 | メルク シヤープ エンド ドーム リミテツド | アゼチジン、ピロリジンおよびピペリジン誘導体 |
| ZA965837B (en) * | 1995-07-11 | 1997-01-31 | Merck & Co Inc | A triazolylmethyl-indole ethylamine bisulfate salt |
| WO1997006159A1 (en) * | 1995-08-07 | 1997-02-20 | Merck Sharp & Dohme Limited | Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives |
-
1997
- 1997-09-03 FR FR9710939A patent/FR2767827A1/fr not_active Withdrawn
-
1998
- 1998-09-01 DE DE69801196T patent/DE69801196T2/de not_active Expired - Fee Related
- 1998-09-01 EP EP98402154A patent/EP0902027B1/fr not_active Expired - Lifetime
- 1998-09-01 BR BR9803318-2A patent/BR9803318A/pt not_active IP Right Cessation
- 1998-09-01 PT PT98402154T patent/PT902027E/pt unknown
- 1998-09-01 DK DK98402154T patent/DK0902027T5/da active
- 1998-09-01 ES ES98402154T patent/ES2162404T3/es not_active Expired - Lifetime
- 1998-09-01 AT AT98402154T patent/ATE203531T1/de not_active IP Right Cessation
- 1998-09-02 CN CNA021184682A patent/CN1510034A/zh active Pending
- 1998-09-02 PL PL98328323A patent/PL328323A1/xx unknown
- 1998-09-02 NZ NZ331683A patent/NZ331683A/xx unknown
- 1998-09-02 CN CN98124581A patent/CN1087741C/zh not_active Expired - Fee Related
- 1998-09-02 HU HU9801977A patent/HUP9801977A1/hu unknown
- 1998-09-02 NO NO19984033A patent/NO316271B1/no not_active IP Right Cessation
- 1998-09-02 US US09/146,009 patent/US6020336A/en not_active Expired - Fee Related
- 1998-09-03 ZA ZA988072A patent/ZA988072B/xx unknown
- 1998-09-03 AU AU83068/98A patent/AU736602B2/en not_active Ceased
- 1998-09-03 CA CA002246485A patent/CA2246485C/fr not_active Expired - Fee Related
- 1998-09-03 JP JP10249314A patent/JPH11130773A/ja active Pending
-
1999
- 1999-04-26 US US09/299,314 patent/US6046205A/en not_active Expired - Fee Related
-
2001
- 2001-09-20 GR GR20010401535T patent/GR3036678T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2767827A1 (fr) | 1999-02-26 |
| CA2246485A1 (fr) | 1999-03-03 |
| US6020336A (en) | 2000-02-01 |
| HK1019738A1 (en) | 2000-02-25 |
| PT902027E (pt) | 2001-11-30 |
| ZA988072B (en) | 1999-03-09 |
| NO984033L (no) | 1999-03-04 |
| AU736602B2 (en) | 2001-08-02 |
| NO984033D0 (no) | 1998-09-02 |
| DE69801196D1 (de) | 2001-08-30 |
| HU9801977D0 (en) | 1998-10-28 |
| NO316271B1 (no) | 2004-01-05 |
| CA2246485C (fr) | 2004-04-20 |
| DE69801196T2 (de) | 2002-03-14 |
| JPH11130773A (ja) | 1999-05-18 |
| PL328323A1 (en) | 1999-03-15 |
| GR3036678T3 (en) | 2001-12-31 |
| AU8306898A (en) | 1999-03-18 |
| CN1218052A (zh) | 1999-06-02 |
| ATE203531T1 (de) | 2001-08-15 |
| US6046205A (en) | 2000-04-04 |
| CN1510034A (zh) | 2004-07-07 |
| BR9803318A (pt) | 2000-02-08 |
| EP0902027B1 (fr) | 2001-07-25 |
| CN1087741C (zh) | 2002-07-17 |
| NZ331683A (en) | 2000-01-28 |
| EP0902027A1 (fr) | 1999-03-17 |
| ES2162404T3 (es) | 2001-12-16 |
| DK0902027T3 (da) | 2001-10-15 |
| HUP9801977A1 (hu) | 2000-11-28 |
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