DK0880530T3 - Phosphatidyloligoglyceroler - Google Patents

Phosphatidyloligoglyceroler

Info

Publication number
DK0880530T3
DK0880530T3 DK97903308T DK97903308T DK0880530T3 DK 0880530 T3 DK0880530 T3 DK 0880530T3 DK 97903308 T DK97903308 T DK 97903308T DK 97903308 T DK97903308 T DK 97903308T DK 0880530 T3 DK0880530 T3 DK 0880530T3
Authority
DK
Denmark
Prior art keywords
phosphatidyloligoglycerols
blood
life
order
longer half
Prior art date
Application number
DK97903308T
Other languages
Danish (da)
English (en)
Inventor
Hans-Joerg Eibl
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19622224A external-priority patent/DE19622224A1/de
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK0880530T3 publication Critical patent/DK0880530T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/03Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04Saturated ethers
    • C07C43/13Saturated ethers containing hydroxy or O-metal groups
    • C07C43/135Saturated ethers containing hydroxy or O-metal groups having more than one ether bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/03Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14Unsaturated ethers
    • C07C43/178Unsaturated ethers containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97903308T 1996-02-16 1997-02-17 Phosphatidyloligoglyceroler DK0880530T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19605833 1996-02-16
DE19622224A DE19622224A1 (de) 1996-02-16 1996-06-03 Phosphatidyloligoglycerine
PCT/EP1997/000749 WO1997030058A1 (de) 1996-02-16 1997-02-17 Phosphatidyloligoglycerine

Publications (1)

Publication Number Publication Date
DK0880530T3 true DK0880530T3 (da) 2003-10-27

Family

ID=26022970

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97903308T DK0880530T3 (da) 1996-02-16 1997-02-17 Phosphatidyloligoglyceroler

Country Status (9)

Country Link
US (4) US20020090383A1 (enExample)
EP (1) EP0880530B1 (enExample)
JP (1) JP2000506121A (enExample)
AT (1) ATE244254T1 (enExample)
AU (1) AU715208B2 (enExample)
CA (1) CA2246568C (enExample)
DK (1) DK0880530T3 (enExample)
ES (1) ES2202576T3 (enExample)
WO (1) WO1997030058A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU715208B2 (en) * 1996-02-16 2000-01-20 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Phosphatidyl oligoglycerols
DE19622224A1 (de) 1996-02-16 1997-08-21 Max Planck Gesellschaft Phosphatidyloligoglycerine
DE59805997D1 (de) 1997-08-18 2002-11-21 Max Planck Gesellschaft Phospholipidanaloge verbindungen
DE19835611A1 (de) 1998-08-06 2000-02-10 Max Planck Gesellschaft Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten
JP2000169520A (ja) * 1998-10-01 2000-06-20 Dai Ichi Kogyo Seiyaku Co Ltd 新規分解型反応性乳化剤、及びこれを用いたポリマ―改質方法
DE10015814A1 (de) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung
DE10122855A1 (de) * 2001-05-11 2002-11-14 Max Planck Gesellschaft Mittel zur Verbesserung der Gewebepenetration
DE10148065A1 (de) * 2001-09-28 2003-04-17 Max Planck Gesellschaft (Ester)-Lysolecithine in Liposomen
DE10148066A1 (de) * 2001-09-28 2003-04-24 Max Planck Gesellschaft Liposome enthaltend (Ether)-Lysolecithine
GB0205327D0 (en) * 2002-03-06 2002-04-17 Glaxo Group Ltd compounds
DE10242367A1 (de) * 2002-09-12 2004-03-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Thermolabiles Liposom mit geregelter Freigabetemperatur
ES2594927T3 (es) 2010-02-18 2016-12-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos para prevenir las metástasis cancerosas
US9663432B2 (en) * 2012-12-28 2017-05-30 Dow Corning Toray Co., Ltd. High-purity monoalkenyl-containing glycerin derivative and method of manufacturing same
HUE054713T2 (hu) * 2013-06-18 2021-09-28 THERMOSOME GmbH Sztereospecifikus lipidek hosszantartó keringésû stimulus-érzékeny nanohordozó rendszerrel történõ lokoregionális terápiára
JP7333563B2 (ja) * 2018-01-18 2023-08-25 イーザアールエヌーエー イムノセラピーズ エンヴェー 脂質ナノ粒子
TW202216122A (zh) 2020-07-07 2022-05-01 德商塞摩斯桑股份有限公司 微脂體製劑
WO2022154055A1 (ja) * 2021-01-13 2022-07-21 地方独立行政法人神奈川県立産業技術総合研究所 ポリグリセロール、該ポリグリセロールを含む複合ゲル組成物、該複合ゲル組成物を含む薬剤送達マイクロニードルおよびそれらの製造方法
EP4527843A1 (en) 2023-09-19 2025-03-26 Thermosome Gmbh Stereoisomeric phosphatidyloligoglycerol
EP4527380A1 (en) 2023-09-19 2025-03-26 Thermosome Gmbh Lipid nanoparticles
EP4527379A1 (en) 2023-09-19 2025-03-26 Thermosome Gmbh Lipids containing an oligoglycerol group
AU2024345757A1 (en) 2023-09-19 2026-03-26 THERMOSOME GmbH Lipids containing an oligoglycerol group
WO2025061856A1 (en) 2023-09-19 2025-03-27 THERMOSOME GmbH Lipid nanoparticles

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE240020C (enExample)
JPS5813530A (ja) * 1981-07-20 1983-01-26 Kao Corp 2,3−ジアルコキシプロピルグリセリルエ−テル及びその製造法並びにこれを含有する化粧料
JPS6028944A (ja) * 1983-07-25 1985-02-14 Kao Corp 新規なポリオ−ルエ−テル化合物およびその製造方法ならびにこれを含有する化粧料
LU85952A1 (fr) * 1985-06-14 1987-01-13 Oreal Nouveaux composes hemiacetaliques et leurs applications
DD240020A1 (de) * 1985-08-02 1986-10-15 Univ Leipzig Verfahren zur herstellung neuer, pharmakologisch hochwirksamer phospholipide
US5290565A (en) * 1989-04-06 1994-03-01 L'oreal Composition for promoting healing
FR2668366B1 (fr) * 1990-10-30 1993-01-29 Oreal Utilisation cosmetique d'une composition ayant une activite antierythemale et composition correspondante.
ES2067255T3 (es) * 1990-11-14 1995-03-16 Oreal Compuestos anfifilos no ionicos derivados del glicerol, su procedimiento de preparacion, compuestos intermedios correspondientes y composiciones que contienen dichos compuestos.
JP2898768B2 (ja) 1991-02-25 1999-06-02 花王株式会社 洗浄剤組成物
JPH0812519A (ja) 1994-06-24 1996-01-16 Kao Corp 皮膚外用剤組成物
AU715208B2 (en) * 1996-02-16 2000-01-20 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Phosphatidyl oligoglycerols
JPH1180749A (ja) 1997-08-29 1999-03-26 Ishikawajima Harima Heavy Ind Co Ltd 油分の分離方法およびその装置

Also Published As

Publication number Publication date
ES2202576T3 (es) 2004-04-01
WO1997030058A1 (de) 1997-08-21
EP0880530B1 (de) 2003-07-02
CA2246568A1 (en) 1997-08-21
US7351428B2 (en) 2008-04-01
AU1791297A (en) 1997-09-02
ATE244254T1 (de) 2003-07-15
AU715208B2 (en) 2000-01-20
US20020090383A1 (en) 2002-07-11
CA2246568C (en) 2007-08-07
US6413543B1 (en) 2002-07-02
US20030053978A1 (en) 2003-03-20
EP0880530A1 (de) 1998-12-02
JP2000506121A (ja) 2000-05-23
US20040213836A1 (en) 2004-10-28

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