ATE244254T1 - Phosphatidyloligoglycerine - Google Patents

Phosphatidyloligoglycerine

Info

Publication number
ATE244254T1
ATE244254T1 AT97903308T AT97903308T ATE244254T1 AT E244254 T1 ATE244254 T1 AT E244254T1 AT 97903308 T AT97903308 T AT 97903308T AT 97903308 T AT97903308 T AT 97903308T AT E244254 T1 ATE244254 T1 AT E244254T1
Authority
AT
Austria
Prior art keywords
phosphatidyloligoglycerins
blood
life
order
longer half
Prior art date
Application number
AT97903308T
Other languages
German (de)
English (en)
Inventor
Hans-Joerg Eibl
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19622224A external-priority patent/DE19622224A1/de
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE244254T1 publication Critical patent/ATE244254T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C07C43/135—Saturated ethers containing hydroxy or O-metal groups having more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97903308T 1996-02-16 1997-02-17 Phosphatidyloligoglycerine ATE244254T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19605833 1996-02-16
DE19622224A DE19622224A1 (de) 1996-02-16 1996-06-03 Phosphatidyloligoglycerine
PCT/EP1997/000749 WO1997030058A1 (de) 1996-02-16 1997-02-17 Phosphatidyloligoglycerine

Publications (1)

Publication Number Publication Date
ATE244254T1 true ATE244254T1 (de) 2003-07-15

Family

ID=26022970

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97903308T ATE244254T1 (de) 1996-02-16 1997-02-17 Phosphatidyloligoglycerine

Country Status (9)

Country Link
US (4) US20020090383A1 (enExample)
EP (1) EP0880530B1 (enExample)
JP (1) JP2000506121A (enExample)
AT (1) ATE244254T1 (enExample)
AU (1) AU715208B2 (enExample)
CA (1) CA2246568C (enExample)
DK (1) DK0880530T3 (enExample)
ES (1) ES2202576T3 (enExample)
WO (1) WO1997030058A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19622224A1 (de) 1996-02-16 1997-08-21 Max Planck Gesellschaft Phosphatidyloligoglycerine
ES2202576T3 (es) * 1996-02-16 2004-04-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Fosfatidil-oligogliceroles.
EP1019417B1 (de) 1997-08-18 2002-10-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Phospholipidanaloge verbindungen
DE19835611A1 (de) 1998-08-06 2000-02-10 Max Planck Gesellschaft Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten
JP2000169520A (ja) * 1998-10-01 2000-06-20 Dai Ichi Kogyo Seiyaku Co Ltd 新規分解型反応性乳化剤、及びこれを用いたポリマ―改質方法
DE10015814A1 (de) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Arzneimittel zur Stimulierung der Leukopoese, zur Behandlung von Tumor- und Protozoenerkrankungen und Verfahren zu seiner Herstellung
DE10122855A1 (de) * 2001-05-11 2002-11-14 Max Planck Gesellschaft Mittel zur Verbesserung der Gewebepenetration
DE10148066A1 (de) * 2001-09-28 2003-04-24 Max Planck Gesellschaft Liposome enthaltend (Ether)-Lysolecithine
DE10148065A1 (de) * 2001-09-28 2003-04-17 Max Planck Gesellschaft (Ester)-Lysolecithine in Liposomen
GB0205327D0 (en) * 2002-03-06 2002-04-17 Glaxo Group Ltd compounds
DE10242367A1 (de) * 2002-09-12 2004-03-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Thermolabiles Liposom mit geregelter Freigabetemperatur
EP2536414B1 (en) 2010-02-18 2016-07-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for preventing cancer metastasis
US9663432B2 (en) * 2012-12-28 2017-05-30 Dow Corning Toray Co., Ltd. High-purity monoalkenyl-containing glycerin derivative and method of manufacturing same
JP6501765B2 (ja) * 2013-06-18 2019-04-17 サーモソーム ゲゼルシャフト ミット べシュレンクテル ハフツングＴｈｅｒｍｏｓｏｍｅ ＧｍｂＨ 長時間循環する刺激応答性ナノキャリア系での局所領域的治療のための立体特異性脂質
CN111971066B (zh) * 2018-01-18 2025-03-11 伊泽阿恩埃免疫疗法股份有限公司 脂质纳米颗粒
WO2022008471A1 (en) 2020-07-07 2022-01-13 THERMOSOME GmbH Liposome formulations
JPWO2022154055A1 (enExample) * 2021-01-13 2022-07-21
EP4527380A1 (en) 2023-09-19 2025-03-26 Thermosome Gmbh Lipid nanoparticles
EP4527843A1 (en) 2023-09-19 2025-03-26 Thermosome Gmbh Stereoisomeric phosphatidyloligoglycerol
EP4527379A1 (en) 2023-09-19 2025-03-26 Thermosome Gmbh Lipids containing an oligoglycerol group
WO2025061874A1 (en) 2023-09-19 2025-03-27 THERMOSOME GmbH Novel lipid nanoparticles
WO2025061835A1 (en) 2023-09-19 2025-03-27 THERMOSOME GmbH Lipids containing an oligoglycerol group

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE240020C (enExample)
JPS5813530A (ja) * 1981-07-20 1983-01-26 Kao Corp ２，３−ジアルコキシプロピルグリセリルエ−テル及びその製造法並びにこれを含有する化粧料
JPS6028944A (ja) * 1983-07-25 1985-02-14 Kao Corp 新規なポリオ−ルエ−テル化合物およびその製造方法ならびにこれを含有する化粧料
LU85952A1 (fr) * 1985-06-14 1987-01-13 Oreal Nouveaux composes hemiacetaliques et leurs applications
DD240020A1 (de) * 1985-08-02 1986-10-15 Univ Leipzig Verfahren zur herstellung neuer, pharmakologisch hochwirksamer phospholipide
US5290565A (en) * 1989-04-06 1994-03-01 L'oreal Composition for promoting healing
FR2668366B1 (fr) * 1990-10-30 1993-01-29 Oreal Utilisation cosmetique d'une composition ayant une activite antierythemale et composition correspondante.
JP3008131B2 (ja) 1990-11-14 2000-02-14 ロレアル グリセリンから誘導される非イオン両親媒性化合物、その調製方法、相応する中間体化合物及び前記化合物を含有する組成物
JP2898768B2 (ja) 1991-02-25 1999-06-02 花王株式会社 洗浄剤組成物
JPH0812519A (ja) 1994-06-24 1996-01-16 Kao Corp 皮膚外用剤組成物
ES2202576T3 (es) * 1996-02-16 2004-04-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Fosfatidil-oligogliceroles.
JPH1180749A (ja) 1997-08-29 1999-03-26 Ishikawajima Harima Heavy Ind Co Ltd 油分の分離方法およびその装置

Also Published As

Publication number Publication date
AU715208B2 (en) 2000-01-20
US20040213836A1 (en) 2004-10-28
EP0880530A1 (de) 1998-12-02
CA2246568A1 (en) 1997-08-21
ES2202576T3 (es) 2004-04-01
DK0880530T3 (da) 2003-10-27
US7351428B2 (en) 2008-04-01
EP0880530B1 (de) 2003-07-02
US20020090383A1 (en) 2002-07-11
US6413543B1 (en) 2002-07-02
JP2000506121A (ja) 2000-05-23
WO1997030058A1 (de) 1997-08-21
AU1791297A (en) 1997-09-02
CA2246568C (en) 2007-08-07
US20030053978A1 (en) 2003-03-20

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Legal Events

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REN Ceased due to non-payment of the annual fee