DK0869965T3 - Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler - Google Patents
Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidlerInfo
- Publication number
- DK0869965T3 DK0869965T3 DK96943560T DK96943560T DK0869965T3 DK 0869965 T3 DK0869965 T3 DK 0869965T3 DK 96943560 T DK96943560 T DK 96943560T DK 96943560 T DK96943560 T DK 96943560T DK 0869965 T3 DK0869965 T3 DK 0869965T3
- Authority
- DK
- Denmark
- Prior art keywords
- ester derivatives
- inflammatory drugs
- derivatives useful
- nitrite ester
- steroid nitrite
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/569,269 US5792758A (en) | 1995-12-08 | 1995-12-08 | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
PCT/US1996/019220 WO1997021724A1 (fr) | 1995-12-08 | 1996-12-06 | Derives d'esters de nitrites steroides, utiles comme medicaments anti-inflammatoires |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0869965T3 true DK0869965T3 (da) | 2000-10-16 |
Family
ID=24274729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96943560T DK0869965T3 (da) | 1995-12-08 | 1996-12-06 | Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler |
Country Status (12)
Country | Link |
---|---|
US (1) | US5792758A (fr) |
EP (1) | EP0869965B1 (fr) |
JP (1) | JP2000501733A (fr) |
AT (1) | ATE195528T1 (fr) |
AU (1) | AU1277397A (fr) |
CA (1) | CA2239964C (fr) |
DE (1) | DE69609864T2 (fr) |
DK (1) | DK0869965T3 (fr) |
ES (1) | ES2150705T3 (fr) |
GR (1) | GR3034575T3 (fr) |
PT (1) | PT869965E (fr) |
WO (1) | WO1997021724A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
US6598603B1 (en) * | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
CA2330611A1 (fr) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Molecules bifonctionnelles et therapies basees sur celles-ci |
AU3703900A (en) * | 1999-02-24 | 2000-09-14 | Nitromed, Inc. | Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders |
GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
DK1305329T4 (da) | 2000-08-05 | 2015-06-15 | Glaxo Group Ltd | 6alpha, 9alpha-difluor-17alpha-(2-furanylcarboxyl)oxy-11beta-hydroxy-16alpha-methyl-3-oxo-androst-1,4-dien-17-carbothiosyre-S-fluormethylester som et antiinflammatorisk middel |
EP1554572B1 (fr) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique |
EP1336602A1 (fr) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Prodrogues nitrées capable de libérer du monoxyde d'azote de manière controlée et sélective ainsi que leur utilisation pour la prévention et le traitement de maladies inflammatoires, ischémiques et proliferatives |
GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
EP2671508B1 (fr) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Système pharma-informatique |
US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
PE20190622A1 (es) | 2016-06-02 | 2019-04-26 | Abbvie Inc | Agonista del receptor de glucocorticoides e inmunoconjugados del mismo |
PL3658192T3 (pl) | 2017-12-01 | 2021-10-18 | Abbvie Inc. | Agonista receptora glukokortykoidowego i jego immunokoniugaty |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3215713A (en) * | 1960-04-04 | 1965-11-02 | Schering Corp | Steroid nitrite esters |
US3298941A (en) * | 1961-05-29 | 1967-01-17 | Schering Corp | Photochemical process for rearranging organic hypohalite and nitrite compounds |
US3218340A (en) * | 1962-06-27 | 1965-11-16 | Abbott Lab | Steroid nitrite ester and process therefor |
GB1082573A (en) * | 1965-02-12 | 1967-09-06 | Boots Pure Drug Co Ltd | Improvements in the preparation of steroid esters |
US3639434A (en) * | 1967-02-02 | 1972-02-01 | Boots Pure Drug Co Ltd | 17-acyloxysteroids and their manufacture |
DE1643036B2 (de) * | 1967-08-16 | 1976-04-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung |
US3494941A (en) * | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
GB1272179A (en) * | 1969-05-19 | 1972-04-26 | Dresden Arzneimittel | Nitrates of steroid aglycones and steroid glycosides |
NL7007906A (fr) * | 1969-06-11 | 1970-12-15 | ||
US3980681A (en) * | 1969-11-21 | 1976-09-14 | Peter Job Sykes | Process for the preparation of 11-β-nitro-oxysteroids |
HU164115B (fr) * | 1971-05-07 | 1973-12-28 | ||
HU163145B (fr) * | 1971-09-23 | 1973-06-28 | ||
US3781312A (en) * | 1971-10-27 | 1973-12-25 | Glaxo Lab Ltd | Process for preparing 3-hydroxy-9alpha-hydrogen-11alpha-hydroxy-ring a-aromatic steroids |
DE2264001C2 (de) * | 1972-12-22 | 1982-08-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 11β-Hydroxy-2',2'-dimethyl-1,4-pregnadieno[17,16α-d]-1',3'-oxathiolan-3,20-dion |
GB1458372A (en) * | 1973-03-05 | 1976-12-15 | Leo Ab | Steroid carbamates and allophanates |
GB1446126A (en) * | 1974-05-16 | 1976-08-18 | Res Inst For Medicine Chemistr | Photolytic preparation of diol mononitrates |
DE2625306C2 (de) * | 1976-06-02 | 1978-06-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Pregnan-Derivaten |
US4201778A (en) * | 1977-11-08 | 1980-05-06 | Schering Corporation | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates |
DE3004508C2 (de) * | 1980-02-05 | 1981-12-10 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Verfahren zur Herstellung von 6-Methylensteroiden |
DE4223800A1 (de) * | 1992-07-20 | 1994-01-27 | Cassella Farbwerke Mainkur Ag | Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen |
CA2141435A1 (fr) * | 1992-07-30 | 1994-02-17 | William Byrne | Ester d'un nitrate organique et d'un salicylate |
IT1256345B (it) * | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
-
1995
- 1995-12-08 US US08/569,269 patent/US5792758A/en not_active Expired - Fee Related
-
1996
- 1996-12-06 DK DK96943560T patent/DK0869965T3/da active
- 1996-12-06 CA CA002239964A patent/CA2239964C/fr not_active Expired - Fee Related
- 1996-12-06 ES ES96943560T patent/ES2150705T3/es not_active Expired - Lifetime
- 1996-12-06 JP JP09522082A patent/JP2000501733A/ja not_active Abandoned
- 1996-12-06 PT PT96943560T patent/PT869965E/pt unknown
- 1996-12-06 DE DE69609864T patent/DE69609864T2/de not_active Expired - Fee Related
- 1996-12-06 EP EP96943560A patent/EP0869965B1/fr not_active Expired - Lifetime
- 1996-12-06 AT AT96943560T patent/ATE195528T1/de not_active IP Right Cessation
- 1996-12-06 WO PCT/US1996/019220 patent/WO1997021724A1/fr active IP Right Grant
- 1996-12-06 AU AU12773/97A patent/AU1277397A/en not_active Abandoned
-
2000
- 2000-10-06 GR GR20000402264T patent/GR3034575T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69609864T2 (de) | 2001-01-04 |
EP0869965B1 (fr) | 2000-08-16 |
PT869965E (pt) | 2001-01-31 |
GR3034575T3 (en) | 2001-01-31 |
US5792758A (en) | 1998-08-11 |
CA2239964C (fr) | 2005-02-01 |
WO1997021724A1 (fr) | 1997-06-19 |
CA2239964A1 (fr) | 1997-06-19 |
JP2000501733A (ja) | 2000-02-15 |
ATE195528T1 (de) | 2000-09-15 |
AU1277397A (en) | 1997-07-03 |
EP0869965A1 (fr) | 1998-10-14 |
DE69609864D1 (de) | 2000-09-21 |
ES2150705T3 (es) | 2000-12-01 |
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