ATE195528T1 - Steroidnitritesterderivate und ihre verwendung als entzündungshemmende medikamente - Google Patents
Steroidnitritesterderivate und ihre verwendung als entzündungshemmende medikamenteInfo
- Publication number
- ATE195528T1 ATE195528T1 AT96943560T AT96943560T ATE195528T1 AT E195528 T1 ATE195528 T1 AT E195528T1 AT 96943560 T AT96943560 T AT 96943560T AT 96943560 T AT96943560 T AT 96943560T AT E195528 T1 ATE195528 T1 AT E195528T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- nitritester
- steroid
- inflammatory medications
- medications
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/569,269 US5792758A (en) | 1995-12-08 | 1995-12-08 | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
PCT/US1996/019220 WO1997021724A1 (en) | 1995-12-08 | 1996-12-06 | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE195528T1 true ATE195528T1 (de) | 2000-09-15 |
Family
ID=24274729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96943560T ATE195528T1 (de) | 1995-12-08 | 1996-12-06 | Steroidnitritesterderivate und ihre verwendung als entzündungshemmende medikamente |
Country Status (12)
Country | Link |
---|---|
US (1) | US5792758A (de) |
EP (1) | EP0869965B1 (de) |
JP (1) | JP2000501733A (de) |
AT (1) | ATE195528T1 (de) |
AU (1) | AU1277397A (de) |
CA (1) | CA2239964C (de) |
DE (1) | DE69609864T2 (de) |
DK (1) | DK0869965T3 (de) |
ES (1) | ES2150705T3 (de) |
GR (1) | GR3034575T3 (de) |
PT (1) | PT869965E (de) |
WO (1) | WO1997021724A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
US6598603B1 (en) * | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
AU3703900A (en) * | 1999-02-24 | 2000-09-14 | Nitromed, Inc. | Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders |
CA2417825C (en) | 2000-08-05 | 2008-07-22 | Glaxo Group Limited | 6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyl)oxy!-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fluoromethyl ester as an anti-inflammatory agent |
US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
EP1336602A1 (de) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrat-Prodrugs zur Freisetzung von Stickstoffmonoxid in kontrollierter und selektiver Weise sowie deren Verwendung zur Prävention und Behandlung inflammatorischer, ischämischer und proliferativer Erkrankungen |
GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
EP2671508B1 (de) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
KR20220119529A (ko) | 2016-06-02 | 2022-08-29 | 애브비 인코포레이티드 | 글루코코르티코이드 수용체 작용제 및 이의 면역접합체 |
AU2018374634A1 (en) | 2017-12-01 | 2020-05-28 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3215713A (en) * | 1960-04-04 | 1965-11-02 | Schering Corp | Steroid nitrite esters |
US3298941A (en) * | 1961-05-29 | 1967-01-17 | Schering Corp | Photochemical process for rearranging organic hypohalite and nitrite compounds |
US3218340A (en) * | 1962-06-27 | 1965-11-16 | Abbott Lab | Steroid nitrite ester and process therefor |
GB1082573A (en) * | 1965-02-12 | 1967-09-06 | Boots Pure Drug Co Ltd | Improvements in the preparation of steroid esters |
US3639434A (en) * | 1967-02-02 | 1972-02-01 | Boots Pure Drug Co Ltd | 17-acyloxysteroids and their manufacture |
DE1643036B2 (de) * | 1967-08-16 | 1976-04-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung |
US3494941A (en) * | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
GB1272179A (en) * | 1969-05-19 | 1972-04-26 | Dresden Arzneimittel | Nitrates of steroid aglycones and steroid glycosides |
NL7007906A (de) * | 1969-06-11 | 1970-12-15 | ||
US3980681A (en) * | 1969-11-21 | 1976-09-14 | Peter Job Sykes | Process for the preparation of 11-β-nitro-oxysteroids |
HU164115B (de) * | 1971-05-07 | 1973-12-28 | ||
HU163145B (de) * | 1971-09-23 | 1973-06-28 | ||
US3781312A (en) * | 1971-10-27 | 1973-12-25 | Glaxo Lab Ltd | Process for preparing 3-hydroxy-9alpha-hydrogen-11alpha-hydroxy-ring a-aromatic steroids |
DE2264001C2 (de) * | 1972-12-22 | 1982-08-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 11β-Hydroxy-2',2'-dimethyl-1,4-pregnadieno[17,16α-d]-1',3'-oxathiolan-3,20-dion |
GB1458372A (en) * | 1973-03-05 | 1976-12-15 | Leo Ab | Steroid carbamates and allophanates |
GB1446126A (en) * | 1974-05-16 | 1976-08-18 | Res Inst For Medicine Chemistr | Photolytic preparation of diol mononitrates |
DE2625306C2 (de) * | 1976-06-02 | 1978-06-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Pregnan-Derivaten |
US4201778A (en) * | 1977-11-08 | 1980-05-06 | Schering Corporation | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates |
DE3004508C2 (de) * | 1980-02-05 | 1981-12-10 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Verfahren zur Herstellung von 6-Methylensteroiden |
DE4223800A1 (de) * | 1992-07-20 | 1994-01-27 | Cassella Farbwerke Mainkur Ag | Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen |
DE69321596T2 (de) * | 1992-07-30 | 1999-04-22 | Cal International Ltd., Dublin | Ester und kombinationen von einem organischen nitrat und einem salicyclat |
IT1256345B (it) * | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
-
1995
- 1995-12-08 US US08/569,269 patent/US5792758A/en not_active Expired - Fee Related
-
1996
- 1996-12-06 DE DE69609864T patent/DE69609864T2/de not_active Expired - Fee Related
- 1996-12-06 JP JP09522082A patent/JP2000501733A/ja not_active Abandoned
- 1996-12-06 AT AT96943560T patent/ATE195528T1/de not_active IP Right Cessation
- 1996-12-06 CA CA002239964A patent/CA2239964C/en not_active Expired - Fee Related
- 1996-12-06 EP EP96943560A patent/EP0869965B1/de not_active Expired - Lifetime
- 1996-12-06 WO PCT/US1996/019220 patent/WO1997021724A1/en active IP Right Grant
- 1996-12-06 DK DK96943560T patent/DK0869965T3/da active
- 1996-12-06 PT PT96943560T patent/PT869965E/pt unknown
- 1996-12-06 ES ES96943560T patent/ES2150705T3/es not_active Expired - Lifetime
- 1996-12-06 AU AU12773/97A patent/AU1277397A/en not_active Abandoned
-
2000
- 2000-10-06 GR GR20000402264T patent/GR3034575T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0869965B1 (de) | 2000-08-16 |
DE69609864D1 (de) | 2000-09-21 |
DK0869965T3 (da) | 2000-10-16 |
GR3034575T3 (en) | 2001-01-31 |
PT869965E (pt) | 2001-01-31 |
CA2239964A1 (en) | 1997-06-19 |
ES2150705T3 (es) | 2000-12-01 |
DE69609864T2 (de) | 2001-01-04 |
WO1997021724A1 (en) | 1997-06-19 |
AU1277397A (en) | 1997-07-03 |
EP0869965A1 (de) | 1998-10-14 |
US5792758A (en) | 1998-08-11 |
CA2239964C (en) | 2005-02-01 |
JP2000501733A (ja) | 2000-02-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE195128T1 (de) | Steroidnitrit/nitratesterderivate und ihre verwendung als entzündungshemmende medikamente | |
ATE195528T1 (de) | Steroidnitritesterderivate und ihre verwendung als entzündungshemmende medikamente | |
TR199902626T2 (xx) | Enflamasyon tedavisi i�in ikameli benzopiran t�revleri. | |
DK1053239T3 (da) | Gluccocorticoid-selektive, anti-inflammatoriske midler | |
NO20032254L (no) | Forbindelser for inhibering av ekspresjon av VACM-I | |
TR199901174T2 (xx) | Yeni heterosiklilmetil-ikameli pirazol t�revleri. | |
PT839154E (pt) | Peptidos e composicoes biologicamente activos sua utilizacao | |
NO965516D0 (no) | Sterolderivater anvendt til regulering av meiose | |
IT1285770B1 (it) | Composti corticoidei | |
DK1053240T3 (da) | Glucocorticoid-selektiv antiinflammatoriske midler | |
TR199801579T2 (xx) | Polimerlere dayanan b�cek �ld�r�c� bile�imler. | |
DE69723863D1 (de) | Chinoline und deren therapeutische verwendung | |
AU8330898A (en) | Substituted heterocycles and their use in medicaments | |
DE69720996D1 (de) | Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer | |
AP2000001761A0 (en) | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. | |
TR199902257T2 (xx) | Tetrahidropirido bile�ikleri | |
ES2192610T3 (es) | Aminouracilos substituidos. | |
NZ330244A (en) | Isoxazole derivatives useful in the treatment of inflammatory diseases | |
DE59605796D1 (de) | Oximether- und acrylsäurederivate und ihre verwendung als fungizide | |
HUP9902417A2 (hu) | Alfa-ketoészterek, és alfa-ketoamidok acilezett enol-származékai | |
ATE206055T1 (de) | Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren | |
ES2160969T3 (es) | Derivados anticonvulsivos utiles en el tratamiento de la psoriasis. | |
TR199701605A2 (xx) | S�lfonamid-substit�e edilmi� bile�ikler | |
GR1001497B (el) | Οπτικώς δραστικά ισοϊνδολινο παράγωγα, η παραγωγή και η χρησιμοποίηση αυτών. | |
GR1001393B (el) | Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |