DK0863776T3 - Et biologisk materiale, der omfatter en effektiv kultur af knoglemarvsstamceller, der er differentieret delvist eller fuldstændigt til bindevævsceller og en tredimensionel biokompatibel og biologisk nedbrydelig matrix bestående af en hyaluronsyrederivat - Google Patents
Et biologisk materiale, der omfatter en effektiv kultur af knoglemarvsstamceller, der er differentieret delvist eller fuldstændigt til bindevævsceller og en tredimensionel biokompatibel og biologisk nedbrydelig matrix bestående af en hyaluronsyrederivatInfo
- Publication number
- DK0863776T3 DK0863776T3 DK96939845T DK96939845T DK0863776T3 DK 0863776 T3 DK0863776 T3 DK 0863776T3 DK 96939845 T DK96939845 T DK 96939845T DK 96939845 T DK96939845 T DK 96939845T DK 0863776 T3 DK0863776 T3 DK 0863776T3
- Authority
- DK
- Denmark
- Prior art keywords
- connective tissue
- biological material
- bone marrow
- hyaluronic acid
- partially
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
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- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Developmental Biology & Embryology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95PD000225A IT1282207B1 (it) | 1995-11-20 | 1995-11-20 | Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico |
PCT/EP1996/005093 WO1997018842A1 (en) | 1995-11-20 | 1996-11-19 | A biologic material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0863776T3 true DK0863776T3 (da) | 2003-05-26 |
Family
ID=11391180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96939845T DK0863776T3 (da) | 1995-11-20 | 1996-11-19 | Et biologisk materiale, der omfatter en effektiv kultur af knoglemarvsstamceller, der er differentieret delvist eller fuldstændigt til bindevævsceller og en tredimensionel biokompatibel og biologisk nedbrydelig matrix bestående af en hyaluronsyrederivat |
Country Status (13)
Country | Link |
---|---|
US (1) | US6596274B1 (pt) |
EP (1) | EP0863776B1 (pt) |
JP (1) | JP3808900B2 (pt) |
AT (1) | ATE231730T1 (pt) |
AU (1) | AU709236B2 (pt) |
CA (1) | CA2238011C (pt) |
DE (1) | DE69626035T2 (pt) |
DK (1) | DK0863776T3 (pt) |
ES (1) | ES2189890T3 (pt) |
IL (1) | IL124450A (pt) |
IT (1) | IT1282207B1 (pt) |
PT (1) | PT863776E (pt) |
WO (1) | WO1997018842A1 (pt) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5594651A (en) | 1995-02-14 | 1997-01-14 | St. Ville; James A. | Method and apparatus for manufacturing objects having optimized response characteristics |
CA2198978A1 (en) * | 1996-03-01 | 1997-09-01 | Clemens Antoni Van Blitterswijk | Method for the in vitro production of bone |
US7767452B2 (en) | 1997-02-20 | 2010-08-03 | Kleinsek Don A | Tissue treatments with adipocyte cells |
BR9815713A (pt) * | 1997-02-20 | 2002-11-05 | Gerigene Medical Corp | Método para aumento e reparo de defeitos de tecido dérmico, subcutâneo e das cordas vocais |
IT1293484B1 (it) * | 1997-06-11 | 1999-03-01 | Fidia Advanced Biopolymers Srl | Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile |
FR2771102B1 (fr) * | 1997-11-14 | 2000-12-15 | Biocoral Inc | Procede pour induire la differenciation osteoblastique de cellules de tissu adipeux extramedullaire humain |
WO1999031222A1 (en) * | 1997-12-18 | 1999-06-24 | Willem Frederik Van Eelen | Industrial scale production of meat from in vitro cell cultures |
US20030147860A1 (en) | 2002-02-07 | 2003-08-07 | Marchosky J. Alexander | Compositions and methods for forming and strengthening bone |
US6872819B1 (en) | 1998-05-27 | 2005-03-29 | Fidia Advanced Biopolymers S.R.L. | Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells |
ITPD980149A1 (it) * | 1998-06-17 | 1999-12-17 | Fidia Advanced Biopolymers Srl | Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la |
ITPD980168A1 (it) * | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Composizioni biocompatibili e biodegradabili comprendenti acido ialuronico e suoi derivati per il trattamento delle ulcere dell'appara |
DE19855890A1 (de) | 1998-12-03 | 2000-06-08 | Nerlich Michael | Poröse Kompositmatrix, deren Herstellung und Verwendung |
EP1203074A4 (en) | 1999-06-29 | 2003-09-10 | J Alexander Marchosky | BONE FORMATION AND STRENGTHENING COMPOSITIONS AND METHOD |
RU2305864C2 (ru) * | 1999-08-23 | 2007-09-10 | ВИЛЛЕ Джеймс А. СТ. | Система и способ изготовления |
EP1242578B1 (en) * | 1999-12-28 | 2004-04-14 | Iso Tis N.V. | Cell culture medim containing growth factors and l-glutamine |
US20040037810A1 (en) * | 2000-05-03 | 2004-02-26 | Dennis Von Heimburg | Biomaterials comprised of preadipocyte cells for soft tissue repair |
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1995
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1996
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- 1996-11-19 JP JP51938597A patent/JP3808900B2/ja not_active Expired - Fee Related
- 1996-11-19 US US09/041,287 patent/US6596274B1/en not_active Expired - Lifetime
- 1996-11-19 EP EP96939845A patent/EP0863776B1/en not_active Expired - Lifetime
- 1996-11-19 PT PT96939845T patent/PT863776E/pt unknown
- 1996-11-19 AU AU76934/96A patent/AU709236B2/en not_active Expired
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- 1996-11-19 ES ES96939845T patent/ES2189890T3/es not_active Expired - Lifetime
- 1996-11-19 DK DK96939845T patent/DK0863776T3/da active
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ITPD950225A1 (it) | 1997-05-20 |
CA2238011A1 (en) | 1997-05-29 |
ES2189890T3 (es) | 2003-07-16 |
EP0863776B1 (en) | 2003-01-29 |
DE69626035T2 (de) | 2004-01-22 |
IT1282207B1 (it) | 1998-03-16 |
PT863776E (pt) | 2003-06-30 |
JP2000500372A (ja) | 2000-01-18 |
ATE231730T1 (de) | 2003-02-15 |
DE69626035D1 (de) | 2003-03-06 |
AU7693496A (en) | 1997-06-11 |
EP0863776A1 (en) | 1998-09-16 |
IL124450A0 (en) | 1998-12-06 |
WO1997018842A1 (en) | 1997-05-29 |
ITPD950225A0 (pt) | 1995-11-20 |
US6596274B1 (en) | 2003-07-22 |
CA2238011C (en) | 2007-01-09 |
IL124450A (en) | 2004-02-19 |
JP3808900B2 (ja) | 2006-08-16 |
AU709236B2 (en) | 1999-08-26 |
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