DK0839146T3 - Piperazinderivater og deres anvendelse som 5-HT1A-antagonister - Google Patents

Piperazinderivater og deres anvendelse som 5-HT1A-antagonister

Info

Publication number
DK0839146T3
DK0839146T3 DK96924983T DK96924983T DK0839146T3 DK 0839146 T3 DK0839146 T3 DK 0839146T3 DK 96924983 T DK96924983 T DK 96924983T DK 96924983 T DK96924983 T DK 96924983T DK 0839146 T3 DK0839146 T3 DK 0839146T3
Authority
DK
Denmark
Prior art keywords
piperazine derivatives
ht1a antagonists
ht1a
antagonists
piperazine
Prior art date
Application number
DK96924983T
Other languages
Danish (da)
English (en)
Inventor
Andrew Fensome
Michael Gerard Kelly
Howard Langham Mansell
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0839146T3 publication Critical patent/DK0839146T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96924983T 1995-07-20 1996-07-19 Piperazinderivater og deres anvendelse som 5-HT1A-antagonister DK0839146T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514901.9A GB9514901D0 (en) 1995-07-20 1995-07-20 Piperazine derivatives
PCT/GB1996/001714 WO1997003982A1 (en) 1995-07-20 1996-07-19 Piperazine derivatives and their use as 5-ht1a antagonists

Publications (1)

Publication Number Publication Date
DK0839146T3 true DK0839146T3 (da) 2000-11-20

Family

ID=10778004

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96924983T DK0839146T3 (da) 1995-07-20 1996-07-19 Piperazinderivater og deres anvendelse som 5-HT1A-antagonister

Country Status (21)

Country Link
EP (1) EP0839146B1 (zh)
JP (1) JP4166824B2 (zh)
KR (1) KR100447002B1 (zh)
CN (2) CN1077889C (zh)
AR (1) AR003451A1 (zh)
AT (1) ATE196294T1 (zh)
AU (1) AU700546B2 (zh)
BR (1) BR9609694A (zh)
CA (1) CA2227386C (zh)
DE (1) DE69610316T2 (zh)
DK (1) DK0839146T3 (zh)
ES (1) ES2150684T3 (zh)
GB (1) GB9514901D0 (zh)
GR (1) GR3034408T3 (zh)
HU (1) HUP9802447A3 (zh)
IL (1) IL122981A (zh)
MX (1) MX9800483A (zh)
NZ (1) NZ313231A (zh)
PT (1) PT839146E (zh)
WO (1) WO1997003982A1 (zh)
ZA (1) ZA966048B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US6271234B1 (en) * 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
US20060223824A1 (en) 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US20060287335A1 (en) 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US6469007B2 (en) 2000-11-28 2002-10-22 Wyeth Serotonergic agents
ES2323451T7 (es) 2001-07-20 2011-08-01 Psychogenics Inc. Tratamiento para el trastorno de hiperactividad con deficit de atencion.
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
CA2477892C (en) * 2002-03-12 2010-11-23 Gregg Brian Feigelson Process for synthesizing chiral n-aryl piperazines
EP1483256A2 (en) 2002-03-12 2004-12-08 Wyeth Process for making chiral 1,4-disubstituted piperazines
IL163829A0 (en) * 2002-03-12 2005-12-18 Wyeth Corp Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
PA8626301A1 (es) * 2004-03-19 2006-12-07 Wyeth Wyeth Proceso para preparar derivados de n-aril-piperazina
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
CN101243091A (zh) 2005-06-17 2008-08-13 惠氏公司 用作5－羟色胺抑制剂和5－ht1a激动剂和拮抗剂的三环化合物
TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
EP0763024B1 (en) * 1994-06-03 2002-08-14 JOHN WYETH & BROTHER LIMITED Processes and intermediates for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
WO1997003982A1 (en) 1997-02-06
BR9609694A (pt) 1999-03-23
CN1077889C (zh) 2002-01-16
JP4166824B2 (ja) 2008-10-15
KR100447002B1 (ko) 2004-12-04
IL122981A0 (en) 1998-08-16
KR19990029067A (ko) 1999-04-15
CN1190968A (zh) 1998-08-19
HUP9802447A3 (en) 1999-11-29
AU6524996A (en) 1997-02-18
PT839146E (pt) 2000-12-29
AU700546B2 (en) 1999-01-07
CN1309127A (zh) 2001-08-22
CN1131861C (zh) 2003-12-24
ATE196294T1 (de) 2000-09-15
HUP9802447A2 (hu) 1999-08-30
DE69610316D1 (de) 2000-10-19
GR3034408T3 (en) 2000-12-29
NZ313231A (en) 2001-03-30
CA2227386A1 (en) 1997-02-06
MX9800483A (es) 1998-04-30
IL122981A (en) 2001-01-28
AR003451A1 (es) 1998-08-05
EP0839146A1 (en) 1998-05-06
GB9514901D0 (en) 1995-09-20
EP0839146B1 (en) 2000-09-13
ES2150684T3 (es) 2000-12-01
CA2227386C (en) 2006-05-16
JPH11509544A (ja) 1999-08-24
ZA966048B (en) 1998-01-16
DE69610316T2 (de) 2001-03-29

Similar Documents

Publication Publication Date Title
DK0832082T3 (da) N-heteroaryl-pyridinsulfonamidderivater og deres anvendelse som endotelinantagonister
NO990551D0 (no) Piperidin- og piperazinderivater, og deres anvendelse som muskarine antagonister
DK0832061T3 (da) Benzamidderivater og anvendelse deraf som vasopressin-antagonister
NO942977D0 (no) Piperazin og piperidinderivater og anvendelse derav som antipsykotiske midler
DK0847388T3 (da) Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider
DK1000039T3 (da) Substituerede quinazolinderivater og anvendelse deraf som tyrosinkinaseinhibitorer
DK0839146T3 (da) Piperazinderivater og deres anvendelse som 5-HT1A-antagonister
NO960371D0 (no) Piperazinderivater som ter
NO980720D0 (no) Pyridazin-3-on-derivater, deres anvendelse og mellomprodukter for deres fremstilling
NO975710D0 (no) Nye Dolastatinderivater, deres fremstilling og anvendelse
NO984761D0 (no) Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler
DK1131308T3 (da) Piperazin- og piperidinderivater
NO971811D0 (no) Bicykliske tetrahydropyrazolopyridiner og deres anvendelse som legemidler
NO996115D0 (no) Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister
NO981522L (no) Aminosyrederivater, deres fremstilling og anvendelse som endotelinantagonister
ATE321042T1 (de) Piperazin-derivate
NO995513L (no) N-triazolyl-2-indolkarboksamider og deres anvendelse som CCK-
NO985891D0 (no) Substituerte benzamid-derivater og deres anvendelse som antikonvulsjonsmidler
NO951418D0 (no) Peptidderivater, deres fremstilling og anvendelse som terapeutika
NO20001934D0 (no) 3-Substituerte tetrahydropyridopyrimidinon-derivater, deres fremstilling og anvendelse
NO954763D0 (no) Piperidinderivater, deres fremstilling og anvendelse
NO992066D0 (no) Piperazinoderivater som neurokininantagonister
NO972256D0 (no) O-Benzyloksimeterderivater og deres anvendelse som pesticider
NO20003142D0 (no) Substituerte isokinolin-derivater og anvendelse derav som antikrampemidler
NO971424D0 (no) Nye heterocyklisk substituerte imidazolo-kinoksalidoner, deres fremstilling og anvendelse