DK0835115T3 - 4-(2-(N-2-carboxamidoindo)aminoethyl)-benzensulfonamider eller -sulfonylurinstoffer som PDGF-antagonister - Google Patents
4-(2-(N-2-carboxamidoindo)aminoethyl)-benzensulfonamider eller -sulfonylurinstoffer som PDGF-antagonisterInfo
- Publication number
- DK0835115T3 DK0835115T3 DK96916719T DK96916719T DK0835115T3 DK 0835115 T3 DK0835115 T3 DK 0835115T3 DK 96916719 T DK96916719 T DK 96916719T DK 96916719 T DK96916719 T DK 96916719T DK 0835115 T3 DK0835115 T3 DK 0835115T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzenesulfonamides
- sulfonylureas
- aminoethyl
- intimal hyperplasia
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74395P | 1995-06-30 | 1995-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0835115T3 true DK0835115T3 (da) | 2004-08-02 |
Family
ID=21692834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96916719T DK0835115T3 (da) | 1995-06-30 | 1996-05-29 | 4-(2-(N-2-carboxamidoindo)aminoethyl)-benzensulfonamider eller -sulfonylurinstoffer som PDGF-antagonister |
Country Status (9)
Country | Link |
---|---|
US (1) | US5731326A (ja) |
EP (1) | EP0835115B1 (ja) |
JP (1) | JP3195363B2 (ja) |
AT (1) | ATE265855T1 (ja) |
AU (1) | AU5938696A (ja) |
DE (1) | DE69632402T2 (ja) |
DK (1) | DK0835115T3 (ja) |
ES (1) | ES2217313T3 (ja) |
WO (1) | WO1997002036A1 (ja) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US8236048B2 (en) * | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US20040243097A1 (en) * | 2000-05-12 | 2004-12-02 | Robert Falotico | Antiproliferative drug and delivery device |
US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
US20020111590A1 (en) * | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
US20020051730A1 (en) * | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
US7261735B2 (en) * | 2001-05-07 | 2007-08-28 | Cordis Corporation | Local drug delivery devices and methods for maintaining the drug coatings thereon |
AU2001294869B2 (en) | 2000-09-29 | 2006-06-15 | Cardinal Health 529, Llc | Coated medical devices |
AU2002318377B2 (en) * | 2001-06-21 | 2008-06-19 | Beth Israel Deaconess Medical Center, Inc. | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
US7195640B2 (en) * | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
US7108701B2 (en) * | 2001-09-28 | 2006-09-19 | Ethicon, Inc. | Drug releasing anastomosis devices and methods for treating anastomotic sites |
US20030065377A1 (en) * | 2001-09-28 | 2003-04-03 | Davila Luis A. | Coated medical devices |
US20030065345A1 (en) * | 2001-09-28 | 2003-04-03 | Kevin Weadock | Anastomosis devices and methods for treating anastomotic sites |
EA200401070A1 (ru) * | 2002-02-13 | 2005-02-24 | Бет Изрейэл Диконисс Медикал Сентер, Инк. | Способы лечения сосудистых заболеваний |
WO2003088981A1 (en) * | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
RS91004A (en) * | 2002-04-15 | 2007-02-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education, | Methods of treating ileus |
JP2005522521A (ja) | 2002-04-15 | 2005-07-28 | ベス イスラエル デアコネス メディカル センター | ヘムオキシゲナーゼ−1およびヘム分解産物の使用法 |
RS99304A (en) * | 2002-05-17 | 2007-04-10 | Yale University, | Methods of treating hepatitis |
UA87438C2 (ru) * | 2002-06-05 | 2009-07-27 | Йельский Университет | Способы лечения или профилактики рака, способ проведения хирургической операции по удалению рака и применения монооксида углерода |
RS20050344A (en) * | 2002-11-07 | 2007-11-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education, | Treatment for hemorrhagic shock |
EP3168304A1 (en) | 2003-08-27 | 2017-05-17 | Ophthotech Corporation | Combination therapy for the treatment of ocular neovascular disorders |
WO2009057733A1 (ja) * | 2007-10-31 | 2009-05-07 | Santen Pharmaceutical Co., Ltd. | 血管新生阻害活性を有する新規インドール誘導体 |
WO2010099139A2 (en) | 2009-02-25 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Combination anti-cancer therapy |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670700B2 (de) * | 1966-05-14 | 1978-06-22 | Hoechst Ag, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
US5280016A (en) * | 1991-03-29 | 1994-01-18 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
CA2094858C (en) * | 1992-04-28 | 2004-06-15 | Robert D. Mitchell | Method of treating hyperproliferative vascular disease |
JP3465247B2 (ja) * | 1992-12-28 | 2003-11-10 | アベンティス ファーマ株式会社 | 動脈硬化症の予防および治療剤 |
US5976534A (en) * | 1993-02-25 | 1999-11-02 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin |
-
1996
- 1996-05-29 JP JP50513097A patent/JP3195363B2/ja not_active Expired - Fee Related
- 1996-05-29 DK DK96916719T patent/DK0835115T3/da active
- 1996-05-29 AU AU59386/96A patent/AU5938696A/en not_active Abandoned
- 1996-05-29 WO PCT/US1996/007881 patent/WO1997002036A1/en active IP Right Grant
- 1996-05-29 US US08/657,470 patent/US5731326A/en not_active Expired - Fee Related
- 1996-05-29 AT AT96916719T patent/ATE265855T1/de not_active IP Right Cessation
- 1996-05-29 EP EP96916719A patent/EP0835115B1/en not_active Expired - Lifetime
- 1996-05-29 DE DE69632402T patent/DE69632402T2/de not_active Expired - Fee Related
- 1996-05-29 ES ES96916719T patent/ES2217313T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0835115A1 (en) | 1998-04-15 |
US5731326A (en) | 1998-03-24 |
JP2001502292A (ja) | 2001-02-20 |
ES2217313T3 (es) | 2004-11-01 |
DE69632402D1 (en) | 2004-06-09 |
AU5938696A (en) | 1997-02-05 |
JP3195363B2 (ja) | 2001-08-06 |
WO1997002036A1 (en) | 1997-01-23 |
EP0835115B1 (en) | 2004-05-06 |
ATE265855T1 (de) | 2004-05-15 |
DE69632402T2 (de) | 2005-05-19 |
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