DK0832096T3 - Syntese af proteiner ved nativ kemisk ligering - Google Patents

Syntese af proteiner ved nativ kemisk ligering

Info

Publication number
DK0832096T3
DK0832096T3 DK95919029T DK95919029T DK0832096T3 DK 0832096 T3 DK0832096 T3 DK 0832096T3 DK 95919029 T DK95919029 T DK 95919029T DK 95919029 T DK95919029 T DK 95919029T DK 0832096 T3 DK0832096 T3 DK 0832096T3
Authority
DK
Denmark
Prior art keywords
ligation
native
proteins
full length
native chemical
Prior art date
Application number
DK95919029T
Other languages
Danish (da)
English (en)
Inventor
B H Kent Stephen
W Muir Tom
Philip E Dawson
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0832096T3 publication Critical patent/DK0832096T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
DK95919029T 1995-05-04 1995-05-04 Syntese af proteiner ved nativ kemisk ligering DK0832096T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/005668 WO1996034878A1 (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation
CA002218620A CA2218620C (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation

Publications (1)

Publication Number Publication Date
DK0832096T3 true DK0832096T3 (da) 2001-10-01

Family

ID=25679740

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95919029T DK0832096T3 (da) 1995-05-04 1995-05-04 Syntese af proteiner ved nativ kemisk ligering

Country Status (13)

Country Link
EP (1) EP0832096B1 (ja)
JP (1) JP3599346B2 (ja)
AT (1) ATE203248T1 (ja)
AU (1) AU711451B2 (ja)
CA (1) CA2218620C (ja)
DE (1) DE69521815T2 (ja)
DK (1) DK0832096T3 (ja)
ES (1) ES2161885T3 (ja)
GR (1) GR3036895T3 (ja)
MX (1) MX9708500A (ja)
PT (1) PT832096E (ja)
SI (1) SI0832096T1 (ja)
WO (1) WO1996034878A1 (ja)

Families Citing this family (65)

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US6184344B1 (en) * 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US6307018B1 (en) * 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
AU6020998A (en) 1997-01-08 1998-08-03 Life Technologies, Inc. Methods for production of proteins
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WO1998056807A1 (en) 1997-06-13 1998-12-17 Gryphon Sciences Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution
US6168784B1 (en) 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use
WO1999011655A1 (en) 1997-09-04 1999-03-11 Gryphon Sciences Modular protein libraries and methods of preparation
US6875594B2 (en) * 1997-11-13 2005-04-05 The Rockefeller University Methods of ligating expressed proteins
JP2002527358A (ja) 1998-08-31 2002-08-27 グリフォン サイエンシーズ 脂質マトリックス介助化学連結方法および膜ポリペプチドの合成
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AU3719500A (en) 1999-03-05 2000-09-21 Maxygen, Inc. Recombination of insertion modified nucleic acids
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
US6277957B1 (en) * 2000-03-23 2001-08-21 Derek Hudson Method for production of acylthio derivatives
AU2001269906A1 (en) * 2000-06-19 2002-01-02 Zyomyx, Inc. Methods for immobilizing polypeptides
EP1313754A4 (en) * 2000-09-01 2006-09-27 Gryphon Therapeutics Inc COMPOSITIONS PRODUCING STABLE THIOESTERS WITH OPHILIC NUCL, PROCESSES FOR PRODUCTION AND USE
HUP0303854A2 (hu) 2000-09-08 2004-03-01 Gryhon Therapeutics, Inc. Szintetikus erythropoiesis-stimuláló proteinek
GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components
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US8034900B2 (en) 2002-12-30 2011-10-11 Amylin Pharmaceuticals, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
DE10335584B4 (de) * 2003-07-31 2006-06-29 Philipps-Universität Marburg Verfahren zur Herstellung zyklischer Moleküle
JP2007527864A (ja) 2003-09-05 2007-10-04 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 自然に起こる化学的連結による、多官能化ペプチドおよび／またはタンパク質の調製方法
PL2332968T3 (pl) 2003-11-05 2017-08-31 Dana-Farber Cancer Institute, Inc. Stabilizowane alfa-helikalne peptydy i ich zastosowania
WO2007120614A2 (en) 2006-04-11 2007-10-25 Sloan-Kettering Institute For Cancer Research Homogeneous erythropoietin and other peptides and proteins, methods and intermediates for their preparation
EP2089426B1 (en) * 2006-06-20 2016-04-20 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Antimicrobial kinocidin compositions and methods of use
CA2686827C (en) 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP3301108A1 (en) 2007-02-23 2018-04-04 Aileron Therapeutics, Inc. Triazole macrocycle systems
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
EP2184290B1 (en) 2007-07-31 2015-02-18 Glytech, Inc. Method for producing peptide
WO2010011313A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides
KR20110067097A (ko) 2008-08-19 2011-06-21 오츠카 가가쿠 가부시키가이샤 당단백질의 제조방법 및 스크리닝 방법
CN104961795A (zh) 2008-09-22 2015-10-07 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
CA2744088A1 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
EP2450364B1 (en) * 2009-06-26 2016-11-09 Glytech, Inc. Process for production of peptide thioester
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
WO2011007747A1 (ja) 2009-07-16 2011-01-20 大塚化学株式会社 糖鎖付加ａｉｌｉｍ細胞外ドメイン及びその製造方法
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
FR2952058B1 (fr) 2009-10-29 2013-10-04 Centre Nat Rech Scient Procede de ligation native de polypeptides
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
FR2971509B1 (fr) 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
RU2586524C2 (ru) 2011-03-10 2016-06-10 Глитек, Инк. Способ получения гликопептида, имеющего сиалированную сахарную цепь, и способ получения производного сиалилгликоаспарагина
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
IN2014CN02854A (ja) 2011-09-26 2015-07-03 Glytech Inc
FR2981352B1 (fr) 2011-10-17 2015-07-03 Centre Nat Rech Scient Procede de synthese de proteines
JP6342808B2 (ja) 2011-10-18 2018-06-13 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
AU2013221433B2 (en) 2012-02-15 2018-01-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN107216380A (zh) 2012-02-15 2017-09-29 爱勒让治疗公司 拟肽大环化合物
FR2988392B1 (fr) 2012-03-21 2014-04-11 Centre Nat Rech Scient Procede de ligation native
HUE054444T2 (hu) 2012-09-26 2021-09-28 Harvard College Prolinnal lezárt kapcsos peptidek és felhasználásuk
CA2887285A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
JP6759109B2 (ja) 2014-05-21 2020-09-23 プレジデント アンド フェローズ オブ ハーバード カレッジ Ｒａｓ抑制性ペプチドおよびその使用
CN112245565A (zh) 2014-09-24 2021-01-22 艾瑞朗医疗公司 拟肽大环化合物及其用途
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
AU2018228182B2 (en) 2017-03-02 2024-04-11 Glytech, Inc. Production method for amino-acid polymer

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IT1228537B (it) * 1987-07-30 1991-06-20 Magis Farmaceutici Derivati della cisteina ad azione espettorante
EP0396116B1 (en) * 1989-05-02 1997-02-05 Abbott Laboratories Covalent attachment of specific binding members to a solid phase

Also Published As

Publication number Publication date
JP3599346B2 (ja) 2004-12-08
EP0832096B1 (en) 2001-07-18
ATE203248T1 (de) 2001-08-15
DE69521815T2 (de) 2002-04-04
CA2218620C (en) 2007-02-27
WO1996034878A1 (en) 1996-11-07
ES2161885T3 (es) 2001-12-16
JPH11508874A (ja) 1999-08-03
SI0832096T1 (en) 2001-12-31
AU2474095A (en) 1996-11-21
PT832096E (pt) 2002-01-30
GR3036895T3 (en) 2002-01-31
EP0832096A4 (en) 1998-08-05
AU711451B2 (en) 1999-10-14
DE69521815D1 (de) 2001-08-23
EP0832096A1 (en) 1998-04-01
CA2218620A1 (en) 1996-11-07
MX9708500A (es) 1998-02-28

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