DK0832063T3 - Vitamin D-derivater med substituenter på C-25, fremgangsmåde til deres fremstilling, mellemprodukter samt deres anvendelse - Google Patents

Vitamin D-derivater med substituenter på C-25, fremgangsmåde til deres fremstilling, mellemprodukter samt deres anvendelse

Info

Publication number
DK0832063T3
DK0832063T3 DK96915001T DK96915001T DK0832063T3 DK 0832063 T3 DK0832063 T3 DK 0832063T3 DK 96915001 T DK96915001 T DK 96915001T DK 96915001 T DK96915001 T DK 96915001T DK 0832063 T3 DK0832063 T3 DK 0832063T3
Authority
DK
Denmark
Prior art keywords
intermediates
vitamin
substituents
derivatives
preparation
Prior art date
Application number
DK96915001T
Other languages
Danish (da)
English (en)
Inventor
Gerald Kirsch
Martin Haberey
Andreas Steinmeyer
Guenter Neef
Katica Schwarz
Ruth Thieroff-Ekerdt
Herbert Wiesinger
Andreas Menrad
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0832063T3 publication Critical patent/DK0832063T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK96915001T 1995-06-14 1996-04-30 Vitamin D-derivater med substituenter på C-25, fremgangsmåde til deres fremstilling, mellemprodukter samt deres anvendelse DK0832063T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19522797 1995-06-14
PCT/EP1996/001788 WO1997000242A1 (de) 1995-06-14 1996-04-30 Neue vitamin d-derivate mit substituenten an c-25, verfahren zu ihrer herstellung, zwischenprodukte und die verwendung zur herstellung von arzneimitteln

Publications (1)

Publication Number Publication Date
DK0832063T3 true DK0832063T3 (da) 2000-06-13

Family

ID=7765061

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96915001T DK0832063T3 (da) 1995-06-14 1996-04-30 Vitamin D-derivater med substituenter på C-25, fremgangsmåde til deres fremstilling, mellemprodukter samt deres anvendelse

Country Status (19)

Country Link
US (2) US6372731B1 (cs)
EP (1) EP0832063B1 (cs)
JP (1) JPH11507649A (cs)
AT (1) ATE189888T1 (cs)
AU (1) AU707942B2 (cs)
CA (1) CA2224440A1 (cs)
CZ (1) CZ291915B6 (cs)
DE (1) DE59604498D1 (cs)
DK (1) DK0832063T3 (cs)
ES (1) ES2144239T3 (cs)
GR (1) GR3033459T3 (cs)
HU (1) HUP9801059A3 (cs)
IL (1) IL118366A (cs)
NO (1) NO317059B1 (cs)
NZ (1) NZ307549A (cs)
PT (1) PT832063E (cs)
TW (1) TW351714B (cs)
WO (1) WO1997000242A1 (cs)
ZA (1) ZA965098B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
DE19619036A1 (de) * 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
CA2303248A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
DE19744127B4 (de) 1997-10-01 2006-10-05 Schering Ag Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln
EP0927721A1 (de) * 1997-12-17 1999-07-07 Schering Aktiengesellschaft Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
EP1042335A1 (de) * 1997-12-17 2000-10-11 Schering Aktiengesellschaft Vitamin d-derivate mit phosphoratomen in den seitenketten
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US20040019024A1 (en) * 2000-08-23 2004-01-29 Seiichi Ishizuka Use of vitamin d derivatives as bone resorption inhibitors
US7491711B2 (en) * 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
DE10156596A1 (de) * 2001-11-13 2003-05-28 Schering Ag Vitamin D-Derivate mit Acyloxygruppen in der Seitenkette, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US7351869B2 (en) * 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
US7915242B2 (en) * 2004-02-17 2011-03-29 Wisconsin Alumni Research Foundation Vitamin D receptor antagonists and their use in treating asthma
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
JP2008521941A (ja) * 2005-10-05 2008-06-26 シコール インコーポレイティド フルベストラント異性体の分離
EP2056791A2 (en) * 2006-08-29 2009-05-13 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions including vitamin d and corticosteroid
WO2009108388A2 (en) * 2008-02-28 2009-09-03 University Of Tennessee Research Foundation Enzymatic production or chemical synthesis and uses for 5,7-dienes and uvb conversion products thereof
EP2363390A4 (en) 2008-11-04 2012-06-13 Teijin Pharma Ltd DERIVATIVE LACTAM OF VITAMIN D3
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
CA2770683C (en) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamin d3 and analogs thereof for treating alopecia
WO2012166938A2 (en) * 2011-06-03 2012-12-06 Wisconsin Alumni Research Foundation (22e)-2-methylene-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin d3 derivatives
US10479764B2 (en) 2011-06-28 2019-11-19 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2022078877A1 (en) * 2020-10-12 2022-04-21 Universite De Strasbourg A calcium normalizer targeting the vitamin d receptor and therapeutic uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182396A (en) * 1991-03-29 1993-01-26 Nisshin Flour Milling Co., Ltd. 1-hydroxyvitamin d derivatives
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
HUP9801059A2 (hu) 1998-08-28
EP0832063B1 (de) 2000-02-23
IL118366A0 (en) 1996-09-12
WO1997000242A1 (de) 1997-01-03
AU707942B2 (en) 1999-07-22
ATE189888T1 (de) 2000-03-15
HUP9801059A3 (en) 1999-05-28
DE59604498D1 (de) 2000-03-30
PT832063E (pt) 2000-06-30
NZ307549A (en) 1999-11-29
GR3033459T3 (en) 2000-09-29
IL118366A (en) 2004-12-15
EP0832063A1 (de) 1998-04-01
CA2224440A1 (en) 1997-01-03
ZA965098B (en) 1997-01-22
NO317059B1 (no) 2004-08-02
ES2144239T3 (es) 2000-06-01
TW351714B (en) 1999-02-01
US6376480B1 (en) 2002-04-23
US6372731B1 (en) 2002-04-16
AU5693096A (en) 1997-01-15
CZ291915B6 (cs) 2003-06-18
CZ403197A3 (cs) 1998-07-15
NO975852D0 (no) 1997-12-12
NO975852L (no) 1998-02-16
JPH11507649A (ja) 1999-07-06

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