ZA965098B - New vitamin d derivatives with substituents at c-25 process for their production intermediate products and use for the production of pharmaceutical agents - Google Patents

New vitamin d derivatives with substituents at c-25 process for their production intermediate products and use for the production of pharmaceutical agents

Info

Publication number
ZA965098B
ZA965098B ZA965098A ZA965098A ZA965098B ZA 965098 B ZA965098 B ZA 965098B ZA 965098 A ZA965098 A ZA 965098A ZA 965098 A ZA965098 A ZA 965098A ZA 965098 B ZA965098 B ZA 965098B
Authority
ZA
South Africa
Prior art keywords
production
substituents
derivatives
pharmaceutical agents
intermediate products
Prior art date
Application number
ZA965098A
Other languages
English (en)
Inventor
Gerald Kirsch
Guenter Neef
Ruth Thieroff-Ekerdt
Andreas Menrad
Andreas Steinmeyer
Katica Schwarz
Herbert Wiesinger
Martin Haberey
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA965098B publication Critical patent/ZA965098B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
ZA965098A 1995-06-14 1996-06-14 New vitamin d derivatives with substituents at c-25 process for their production intermediate products and use for the production of pharmaceutical agents ZA965098B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19522797 1995-06-14

Publications (1)

Publication Number Publication Date
ZA965098B true ZA965098B (en) 1997-01-22

Family

ID=7765061

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA965098A ZA965098B (en) 1995-06-14 1996-06-14 New vitamin d derivatives with substituents at c-25 process for their production intermediate products and use for the production of pharmaceutical agents

Country Status (19)

Country Link
US (2) US6372731B1 (cs)
EP (1) EP0832063B1 (cs)
JP (1) JPH11507649A (cs)
AT (1) ATE189888T1 (cs)
AU (1) AU707942B2 (cs)
CA (1) CA2224440A1 (cs)
CZ (1) CZ291915B6 (cs)
DE (1) DE59604498D1 (cs)
DK (1) DK0832063T3 (cs)
ES (1) ES2144239T3 (cs)
GR (1) GR3033459T3 (cs)
HU (1) HUP9801059A3 (cs)
IL (1) IL118366A (cs)
NO (1) NO317059B1 (cs)
NZ (1) NZ307549A (cs)
PT (1) PT832063E (cs)
TW (1) TW351714B (cs)
WO (1) WO1997000242A1 (cs)
ZA (1) ZA965098B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
JP4219553B2 (ja) * 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
DE19744127B4 (de) * 1997-10-01 2006-10-05 Schering Ag Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln
JP2002508383A (ja) * 1997-12-17 2002-03-19 シエーリング アクチエンゲゼルシャフト 側鎖中にリン原子を有するビタミンｄ誘導体
EP0927721A1 (de) * 1997-12-17 1999-07-07 Schering Aktiengesellschaft Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US20040019024A1 (en) * 2000-08-23 2004-01-29 Seiichi Ishizuka Use of vitamin d derivatives as bone resorption inhibitors
US7491711B2 (en) * 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
DE10156596A1 (de) * 2001-11-13 2003-05-28 Schering Ag Vitamin D-Derivate mit Acyloxygruppen in der Seitenkette, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
WO2004046097A1 (en) * 2002-11-18 2004-06-03 Teva Pharmaceutical Industries Ltd. A crystallization method for purification of calcipotriene
WO2005079464A2 (en) * 2004-02-17 2005-09-01 Wisconsin Alumni Research Foundation Vitamin d receptor antagonists and their use in treating asthma
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
TW200804408A (en) * 2005-10-05 2008-01-16 Sicor Inc Separation of fulvestrant isomers
BRPI0715636A2 (pt) * 2006-08-29 2013-07-02 Teva Pharma composiÇÕes farmacologicamente ativas estÁveis incluindo compostos contendo vitamina d e corticosteràide com compatibilidade para ph baixo
WO2009108388A2 (en) * 2008-02-28 2009-09-03 University Of Tennessee Research Foundation Enzymatic production or chemical synthesis and uses for 5,7-dienes and uvb conversion products thereof
US20110207944A1 (en) 2008-11-04 2011-08-25 Teijin Pharma Limited Vitamin d3 lactam derivative
US20100196308A1 (en) 2009-01-27 2010-08-05 Jimenez Joaquin J Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
WO2011019617A2 (en) 2009-08-14 2011-02-17 Cytotech Labs, Llc Vitamin d3 and analogs thereof for treating alopecia
US9834512B2 (en) 2011-06-03 2017-12-05 Wisconsin Alumni Research Foundation (22E)-2-methylene-26,27-cyclo-22-dehydro-1α-hydroxy-19-norvitamin D3 derivatives
US10479764B2 (en) 2011-06-28 2019-11-19 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
HK1222819A1 (zh) 2013-05-29 2017-07-14 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
WO2022078877A1 (en) * 2020-10-12 2022-04-21 Universite De Strasbourg A calcium normalizer targeting the vitamin d receptor and therapeutic uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182396A (en) * 1991-03-29 1993-01-26 Nisshin Flour Milling Co., Ltd. 1-hydroxyvitamin d derivatives
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
WO1997000242A1 (de) 1997-01-03
US6376480B1 (en) 2002-04-23
EP0832063A1 (de) 1998-04-01
JPH11507649A (ja) 1999-07-06
HUP9801059A2 (hu) 1998-08-28
NO975852L (no) 1998-02-16
ATE189888T1 (de) 2000-03-15
DK0832063T3 (da) 2000-06-13
AU707942B2 (en) 1999-07-22
US6372731B1 (en) 2002-04-16
IL118366A0 (en) 1996-09-12
PT832063E (pt) 2000-06-30
ES2144239T3 (es) 2000-06-01
GR3033459T3 (en) 2000-09-29
IL118366A (en) 2004-12-15
DE59604498D1 (de) 2000-03-30
AU5693096A (en) 1997-01-15
CZ403197A3 (cs) 1998-07-15
NZ307549A (en) 1999-11-29
CZ291915B6 (cs) 2003-06-18
NO975852D0 (no) 1997-12-12
NO317059B1 (no) 2004-08-02
CA2224440A1 (en) 1997-01-03
HUP9801059A3 (en) 1999-05-28
EP0832063B1 (de) 2000-02-23
TW351714B (en) 1999-02-01

Similar Documents

Publication Publication Date Title
ZA965098B (en) New vitamin d derivatives with substituents at c-25 process for their production intermediate products and use for the production of pharmaceutical agents
NZ306664A (en) Intermediates of camptothecin (CPT-11) or mappicine and their manufacture
AU1416095A (en) Phenyl acetic acid derivatives, process and intermediate products for their production and agents containing them
HUT68029A (en) New 11-benzaldoxim-estradiene derivatives, pharmaceutical compositions containing them and process for producing them
HUT37418A (en) Process for producing new 2,2'-imino-bis/ethanol/ derivatives and pharmaceutical compositions sontaining them as active agents
ES8802228A1 (es) Un procedimiento para la preparacion de nuevas piranopiridinas
MY102038A (en) 4-substituted androstendione derivatives and process for their preparation
AU4712396A (en) Chiral methylphenyloxazolidinones
IL112622A (en) Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them
MY110747A (en) Quinolone-and naphthyridonecarboxylic acid derivatives
AU7035194A (en) 11-benzaldoxime-17beta-methoxy-17alpha- methoxymethylestradiene-derivatives, methods for their production and pharmaceuticals containing these substances
UA35607C2 (uk) Похідні оксазолідинонкарбонової кислоти, спосіб їх одержання, фармацевтична композиція і спосіб її одержання
AU4677785A (en) New dopamine derivatives, process for their production, and their use as medicinal products
MX9803672A (es) Nuevos derivados de fenilamidina, procedimiento para su preparacion y su utilizacion como medicamentos.
IL112098A0 (en) Sulfamate derivatives and pharmaceutical compositions containing them
HUT46224A (en) Process for producing pharmaceutical compositions containing prostaglandin e1-derivatives
NZ322318A (en) Method for preparing camptothecin derivatives
IL135364A (en) Vitamin d derivatives, processes for the production thereof and for producing pharmaceutical compositions conataining the same
HUT57774A (en) Process for producing triacetate derivative of antibiotic bu-3420t, as well as pharmaceutical compositions comprising bu-3420t triacetate
AU4347389A (en) Novel s-timolol derivative and process for its preparation
AU665866B2 (en) Androstane derivatives substituted by a quaternary ammonium group in 16-position, pharmaceutical compositions containing them and process for preparing same
IL110553A (en) Process for the preparation of 9-amino camptothecin from the 12-nitro derivative, pharmaceutical compositions containing it and certain intermediates
GR3036868T3 (en) Amino alcohol derivatives, methods of producing said derivatives and medicaments containing them
IL140863A0 (en) Novel 2,3,3a,4,9,9a hexahydro-8-hydroxy-1h-benz [f] indoles, a method for the production thereof and their use as medicaments
HU913693D0 (en) Bicyclo(3.30)octane derivatives, method for producing them and pharmaceutical application of said compounds