DK0831911T3 - Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonist - Google Patents
Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonistInfo
- Publication number
- DK0831911T3 DK0831911T3 DK96919173T DK96919173T DK0831911T3 DK 0831911 T3 DK0831911 T3 DK 0831911T3 DK 96919173 T DK96919173 T DK 96919173T DK 96919173 T DK96919173 T DK 96919173T DK 0831911 T3 DK0831911 T3 DK 0831911T3
- Authority
- DK
- Denmark
- Prior art keywords
- angiotensin
- receptor antagonist
- spironolactone
- combination therapy
- heart failure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48608995A | 1995-06-07 | 1995-06-07 | |
PCT/US1996/009342 WO1996040258A2 (fr) | 1995-06-07 | 1996-06-05 | Therapie mixte a base de spironolactone et d'un antagoniste de l'angiotensine ii pour le traitement de l'insuffisance cardiaque globale |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0831911T3 true DK0831911T3 (da) | 2002-07-22 |
Family
ID=23930539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96919173T DK0831911T3 (da) | 1995-06-07 | 1996-06-05 | Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonist |
Country Status (16)
Country | Link |
---|---|
US (1) | US20040102423A1 (fr) |
EP (1) | EP0831911B1 (fr) |
JP (1) | JPH11509838A (fr) |
KR (1) | KR19990022723A (fr) |
CN (1) | CN1192696A (fr) |
AT (1) | ATE216261T1 (fr) |
AU (1) | AU6158096A (fr) |
BR (1) | BR9608505A (fr) |
CA (1) | CA2224222A1 (fr) |
CZ (1) | CZ291268B6 (fr) |
DE (1) | DE69620756T2 (fr) |
DK (1) | DK0831911T3 (fr) |
ES (1) | ES2175098T3 (fr) |
IL (1) | IL122246A (fr) |
PT (1) | PT831911E (fr) |
WO (1) | WO1996040258A2 (fr) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306826B1 (en) | 1997-06-04 | 2001-10-23 | The Regents Of The University Of California | Treatment of heart failure with growth hormone |
US6211217B1 (en) | 1999-03-16 | 2001-04-03 | Novartis Ag | Method for reducing pericardial fibrosis and adhesion formation |
HUP0301057A3 (en) * | 2000-02-18 | 2004-01-28 | Takeda Pharmaceutical | Angiotenzin ii antagonist heterocyclic compound an their use for preparation of tnf-alpha inhibitors |
EP1465869B1 (fr) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulateurs de lxr |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
DE10335027A1 (de) * | 2003-07-31 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Angiotensin II Rezeptor Antagonisten |
AU2004228028B2 (en) | 2003-04-03 | 2009-12-10 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
CA2559665A1 (fr) | 2004-03-16 | 2005-09-29 | The Regents Of The University Of California | Reduction de la nephropathie au moyen d'inhibiteurs d'hydrolase d'epoxyde soluble et d'epoxyeicosanoides |
EP1814875A4 (fr) * | 2004-10-20 | 2010-02-17 | Univ California | Inhibiteurs ameliores de l'epoxyde hydrolase soluble |
US9512125B2 (en) * | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
US20080032960A1 (en) * | 2006-04-04 | 2008-02-07 | Regents Of The University Of California | PI3 kinase antagonists |
EP2051696A2 (fr) * | 2006-08-18 | 2009-04-29 | Morton Grove Pharmaceuticals, Inc. | Compositions liquides stables de lévétiracétam et procédés |
WO2009046448A1 (fr) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Entités chimiques et leurs utilisations thérapeutiques |
NZ613219A (en) * | 2008-01-04 | 2014-11-28 | Intellikine Llc | Heterocyclic containing entities, compositions and methods |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
JP5547099B2 (ja) * | 2008-03-14 | 2014-07-09 | インテリカイン, エルエルシー | キナーゼ阻害剤および使用方法 |
WO2009114874A2 (fr) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Inhibiteurs de kinases (benzothiazole) et procédés d’utilisation associés |
US20110224223A1 (en) * | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
CN102124009B (zh) | 2008-07-08 | 2014-07-23 | 因特利凯公司 | 激酶抑制剂及其使用方法 |
WO2010036380A1 (fr) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Inhibiteurs hétérocycliques de kinases |
AU2009305669A1 (en) | 2008-10-16 | 2010-04-22 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
TW201444848A (zh) | 2009-01-30 | 2014-12-01 | Takeda Pharmaceutical | 稠環化合物及其用途 |
EP2427195B1 (fr) | 2009-05-07 | 2019-05-01 | Intellikine, LLC | Composés hétérocycliques et leurs utilisations |
US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
ES2593256T3 (es) | 2010-05-21 | 2016-12-07 | Infinity Pharmaceuticals, Inc. | Compuestos químicos, composiciones y métodos para las modulaciones de cinasas |
CA2817577A1 (fr) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Composes heterocycliques et utilisations de ceux-ci |
UA115767C2 (uk) | 2011-01-10 | 2017-12-26 | Інфініті Фармасьютікалз, Інк. | Способи отримання ізохінолінонів і тверді форми ізохінолінонів |
WO2012094703A1 (fr) | 2011-01-11 | 2012-07-19 | Dimerix Bioscience Pty Ltd | Polythérapie |
CN106619647A (zh) | 2011-02-23 | 2017-05-10 | 因特利凯有限责任公司 | 激酶抑制剂的组合及其用途 |
CN102816126A (zh) * | 2011-06-07 | 2012-12-12 | 中国药科大学 | 具有心血管活性的胺磺酰芳基取代的三氮唑类衍生物、其制备方法及用途 |
US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
PE20141371A1 (es) | 2011-08-29 | 2014-10-13 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
EP2751112B1 (fr) | 2011-09-02 | 2019-10-09 | The Regents of The University of California | Pyrazolo[3,4-d]pyrimidines substituées et utilisations de celles-ci |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
JP2015532287A (ja) | 2012-09-26 | 2015-11-09 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ire1の調節 |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
WO2015051241A1 (fr) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
EA201690713A1 (ru) | 2013-10-04 | 2016-08-31 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
DK3119397T3 (da) | 2014-03-19 | 2022-03-28 | Infinity Pharmaceuticals Inc | Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser |
WO2015160975A2 (fr) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Polythérapies |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
WO2016141182A1 (fr) | 2015-03-03 | 2016-09-09 | Yee Richard W | Compositions et méthodes de traitement de maladies oculaires |
AU2016322552B2 (en) | 2015-09-14 | 2021-03-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
WO2017161116A1 (fr) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues de composés isoquinolinone et quinazolinone et leurs utilisations comme inhibiteurs de la kinase pi3k |
WO2017214269A1 (fr) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
KR20190033526A (ko) | 2016-06-24 | 2019-03-29 | 인피니티 파마슈티칼스, 인코포레이티드 | 병용 요법 |
BR112018077075A2 (pt) | 2016-06-29 | 2019-04-30 | Universite De Montreal | heterociclos de biarilmetila |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3257390A (en) * | 1963-06-12 | 1966-06-21 | Merck & Co Inc | Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents |
DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
DE3506100A1 (de) * | 1985-02-18 | 1986-08-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1(alpha).7(alpha)-dithiosubstituierte spirolactone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
EP0517812A4 (en) * | 1990-02-13 | 1995-10-18 | Merck & Co Inc | Angiotensin ii antagonists incorporating a substituted benzyl element |
WO1991015206A1 (fr) * | 1990-04-05 | 1991-10-17 | E.I. Du Pont De Nemours And Company | Traitement du glaucome et de l'hypertension oculaire a l'aide d'imidazoles en tant qu'antagonistes de recepteur d'angiotensine-ii |
CA2053148A1 (fr) * | 1990-10-16 | 1992-04-17 | Karnail Atwal | Derives de la dihydropyrimidine |
US5049565A (en) * | 1990-12-07 | 1991-09-17 | Merck & Co., Inc. | Microbial transformation process for preparing anti-hypertensive products |
EP0586513A1 (fr) * | 1991-05-10 | 1994-03-16 | Merck & Co. Inc. | Derives acides d'aralkyltriazole actifs en tant qu'antagonistes de l'angiotensine ii |
US5529992A (en) * | 1992-04-21 | 1996-06-25 | Curators Of The University Of Missouri | Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors |
US5264447A (en) * | 1992-09-01 | 1993-11-23 | Merck & Co., Inc. | Angiotensin II antagonist |
AU5449194A (en) * | 1992-10-26 | 1994-05-24 | Merck & Co., Inc. | Combinations of angiotensin-ii receptor antagonists and diuretics |
CA2125251C (fr) * | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | Composition pharmaceutique pour le traitement des affections mediees par l'angiotensine ii |
-
1996
- 1996-06-05 EP EP96919173A patent/EP0831911B1/fr not_active Expired - Lifetime
- 1996-06-05 AU AU61580/96A patent/AU6158096A/en not_active Abandoned
- 1996-06-05 DE DE69620756T patent/DE69620756T2/de not_active Expired - Fee Related
- 1996-06-05 CZ CZ19973848A patent/CZ291268B6/cs not_active IP Right Cessation
- 1996-06-05 WO PCT/US1996/009342 patent/WO1996040258A2/fr not_active Application Discontinuation
- 1996-06-05 BR BR9608505A patent/BR9608505A/pt not_active Application Discontinuation
- 1996-06-05 ES ES96919173T patent/ES2175098T3/es not_active Expired - Lifetime
- 1996-06-05 CN CN96196086A patent/CN1192696A/zh active Pending
- 1996-06-05 IL IL12224696A patent/IL122246A/en not_active IP Right Cessation
- 1996-06-05 DK DK96919173T patent/DK0831911T3/da active
- 1996-06-05 AT AT96919173T patent/ATE216261T1/de not_active IP Right Cessation
- 1996-06-05 KR KR1019970709165A patent/KR19990022723A/ko not_active Application Discontinuation
- 1996-06-05 PT PT96919173T patent/PT831911E/pt unknown
- 1996-06-05 CA CA002224222A patent/CA2224222A1/fr not_active Abandoned
- 1996-06-05 JP JP9501683A patent/JPH11509838A/ja not_active Abandoned
-
2002
- 2002-10-15 US US10/271,362 patent/US20040102423A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0831911B1 (fr) | 2002-04-17 |
JPH11509838A (ja) | 1999-08-31 |
DE69620756D1 (de) | 2002-05-23 |
CZ291268B6 (cs) | 2003-01-15 |
EP0831911A2 (fr) | 1998-04-01 |
WO1996040258A3 (fr) | 1997-01-23 |
IL122246A (en) | 2004-06-01 |
KR19990022723A (ko) | 1999-03-25 |
PT831911E (pt) | 2002-09-30 |
AU6158096A (en) | 1996-12-30 |
CZ384897A3 (cs) | 1998-05-13 |
BR9608505A (pt) | 1999-07-06 |
US20040102423A1 (en) | 2004-05-27 |
ES2175098T3 (es) | 2002-11-16 |
CA2224222A1 (fr) | 1996-12-19 |
IL122246A0 (en) | 1998-04-05 |
WO1996040258A2 (fr) | 1996-12-19 |
DE69620756T2 (de) | 2002-11-14 |
CN1192696A (zh) | 1998-09-09 |
ATE216261T1 (de) | 2002-05-15 |
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