MX9709978A - Terapia de combinacion de antagonista de aldosterona epoxi-esteroidal y antagonista de angiotensina ii para tratamiento de insuficiencia cardiaca congestiva. - Google Patents

Terapia de combinacion de antagonista de aldosterona epoxi-esteroidal y antagonista de angiotensina ii para tratamiento de insuficiencia cardiaca congestiva.

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Publication number
MX9709978A
MX9709978A MX9709978A MX9709978A MX9709978A MX 9709978 A MX9709978 A MX 9709978A MX 9709978 A MX9709978 A MX 9709978A MX 9709978 A MX9709978 A MX 9709978A MX 9709978 A MX9709978 A MX 9709978A
Authority
MX
Mexico
Prior art keywords
angiotensin
epoxy
combination therapy
antagonist
receptor antagonist
Prior art date
Application number
MX9709978A
Other languages
English (en)
Inventor
John C Alenxander
Joseph R Schuh
Richard J Gorczynski
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of MX9709978A publication Critical patent/MX9709978A/es

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Abstract

Se describe una terapia de combinacion que comprende una cantidad terapéuticamente efectiva de un antagonista de receptor de aldosterona epoxi-esteroidal y una cantidad terapéuticamente efectiva de antagonista de receptor de angiotensina II para el tratamiento de trastornos circulatorios, incluyendo enfermedades cardiovasculares tales como hipertension, insuficiencia cardiaca congestiva, cirrosis y ascitis, los antagonistas de receptor de angiotensina II son aquellos compuestos que tiene potencia y biodisponibilidad elevadas y que se caracterizan porque tienen una porcion imidazol o triazol unida a una porcion bifenilmetilo o piridinilo/fenilmetilo; los antagonistas de receptor de aldosterona epoxi-esteroidal son compuestos de espiroxano esteroidales caracterizados por la presencia de una porcion epoxi 9a-,11a-substituida; una terapia de combinacion preferida incluye el antagonista de receptor de angiotensina II 5-[2-[5-[(3,5-dibutil-1H-1,2,4-triazol-1-il)metil] -2-piridinil]fenil-1H-tetrazol y el antagonista de receptor de aldosterona epoximexrenona.
MX9709978A 1995-06-07 1997-12-08 Terapia de combinacion de antagonista de aldosterona epoxi-esteroidal y antagonista de angiotensina ii para tratamiento de insuficiencia cardiaca congestiva. MX9709978A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60933595A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
MX9709978A true MX9709978A (es) 1998-03-31

Family

ID=39427973

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709978A MX9709978A (es) 1995-06-07 1997-12-08 Terapia de combinacion de antagonista de aldosterona epoxi-esteroidal y antagonista de angiotensina ii para tratamiento de insuficiencia cardiaca congestiva.

Country Status (1)

Country Link
MX (1) MX9709978A (es)

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees