DK0820473T4 - Biologisk nedbrydelige polyacetalpolymerer og dannelse og anvendelse - Google Patents

Biologisk nedbrydelige polyacetalpolymerer og dannelse og anvendelse

Info

Publication number
DK0820473T4
DK0820473T4 DK96912522T DK96912522T DK0820473T4 DK 0820473 T4 DK0820473 T4 DK 0820473T4 DK 96912522 T DK96912522 T DK 96912522T DK 96912522 T DK96912522 T DK 96912522T DK 0820473 T4 DK0820473 T4 DK 0820473T4
Authority
DK
Denmark
Prior art keywords
biodegradable biocompatible
polyacetals
biodegradable
formation
administration
Prior art date
Application number
DK96912522T
Other languages
Danish (da)
English (en)
Other versions
DK0820473T3 (da
Inventor
Mikhail Papisov
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23671966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0820473(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of DK0820473T3 publication Critical patent/DK0820473T3/da
Publication of DK0820473T4 publication Critical patent/DK0820473T4/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L59/00Compositions of polyacetals; Compositions of derivatives of polyacetals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G4/00Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK96912522T 1995-04-14 1996-04-01 Biologisk nedbrydelige polyacetalpolymerer og dannelse og anvendelse DK0820473T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/421,766 US5811510A (en) 1995-04-14 1995-04-14 Biodegradable polyacetal polymers and methods for their formation and use
PCT/US1996/004476 WO1996032419A1 (fr) 1995-04-14 1996-04-01 Polymeres de polyacetals biodegradables, formation et utilisation

Publications (2)

Publication Number Publication Date
DK0820473T3 DK0820473T3 (da) 2001-10-22
DK0820473T4 true DK0820473T4 (da) 2008-05-13

Family

ID=23671966

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96912522T DK0820473T4 (da) 1995-04-14 1996-04-01 Biologisk nedbrydelige polyacetalpolymerer og dannelse og anvendelse

Country Status (10)

Country Link
US (3) US5811510A (fr)
EP (1) EP0820473B2 (fr)
JP (1) JP4187265B2 (fr)
AT (1) ATE202573T1 (fr)
AU (1) AU5531296A (fr)
CA (1) CA2215997C (fr)
DE (1) DE69613569T3 (fr)
DK (1) DK0820473T4 (fr)
GR (1) GR3036696T3 (fr)
WO (1) WO1996032419A1 (fr)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW527183B (en) * 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
EP0988550A1 (fr) * 1997-06-18 2000-03-29 Elvira Schecklies Formulation pour systemes reactionnels immunologiques
EP1037642B9 (fr) * 1997-12-09 2010-10-13 Biomedical Frontiers, Inc. Polysaccharides a reconnaissance biologique modifiee
US6958148B1 (en) * 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
EP1206285A2 (fr) * 1999-08-09 2002-05-22 The General Hospital Corporation Complexes vecteurs de medicament et technique d'utilisation de ceux-ci
US8106098B2 (en) * 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
WO2002020663A2 (fr) * 2000-09-06 2002-03-14 Ap Pharma, Inc. Polymeres degradables de polyacetal
US7250048B2 (en) 2001-04-26 2007-07-31 Medtronic, Inc. Ablation system and method of use
US6648883B2 (en) 2001-04-26 2003-11-18 Medtronic, Inc. Ablation system and method of use
DE60323936D1 (de) 2002-01-14 2008-11-20 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
EP1585817B1 (fr) * 2002-02-20 2009-09-02 The General Hospital Corporation Conjugues contenant un polymere biodegradable, et leurs utilisations
JP4925581B2 (ja) * 2002-07-05 2012-04-25 旭化成株式会社 体液適合性および生体適合性を有する樹脂
CA2492803C (fr) * 2002-07-19 2013-11-05 The General Hospital Corporation Conjugats d'oximes, procedes de synthese de ces produits et leurs usages
WO2004009774A2 (fr) * 2002-07-19 2004-01-29 Amgen Inc. Conjugues de proteines avec un polymere biodegradable, biocompatible soluble dans l'eau
US7045589B2 (en) 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US6878374B2 (en) * 2003-02-25 2005-04-12 Nitto Denko Corporation Biodegradable polyacetals
US7048925B2 (en) 2003-08-28 2006-05-23 Nitto Denko Corporation Acid-sensitive polyacetals and methods
US7790150B2 (en) * 2003-09-05 2010-09-07 The General Hospital Corporation Dual phase drug release system
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
JP4586022B2 (ja) * 2003-09-29 2010-11-24 日東電工株式会社 インビボポリヌクレオチド送達用生分解性ポリアセタール
DE102004023117A1 (de) * 2004-05-11 2005-12-08 A. u. K. Müller GmbH & Co KG Elektromagnetventil für flüssige Medien, insbesondere Heißwasser
US7358223B2 (en) * 2004-10-04 2008-04-15 Nitto Denko Corporation Biodegradable cationic polymers
WO2006044986A1 (fr) * 2004-10-18 2006-04-27 Nitto Denko Corporation Relargage intracellulaire de peptides
AU2005314426A1 (en) 2004-12-10 2006-06-15 Talima Therapeutics, Inc. Compositions and methods for treating conditions of the nail unit
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
US7674452B2 (en) * 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
US7341720B2 (en) * 2005-04-06 2008-03-11 Genzyme Corporation Targeting of glycoprotein therapeutics
US20060229585A1 (en) * 2005-04-11 2006-10-12 Minu, L.L.C. Drug delivery to the crystalline lens and other ocular structures
US7722581B2 (en) * 2005-04-11 2010-05-25 Gholam A. Peyman Crystalline lens drug delivery
US7588754B2 (en) * 2005-05-10 2009-09-15 Nitto Denko Corporation Biodegradable polyacetals and methods
US20060263328A1 (en) * 2005-05-19 2006-11-23 Sang Van Hydrophilic polymers with pendant functional groups and method thereof
WO2007098041A1 (fr) * 2006-02-17 2007-08-30 Medtronic, Inc. Polymeres de polycetal et leurs procedes de fabrication et d'utilisation
US7700541B2 (en) * 2006-04-06 2010-04-20 Nitto Denko Corporation Biodegradable cationic polymers
US7458953B2 (en) * 2006-06-20 2008-12-02 Gholam A. Peyman Ocular drainage device
US20090061515A1 (en) * 2007-08-29 2009-03-05 Michael Eric Benz Methods of inhibiting or suppressing cellular proliferation
MX2010005857A (es) * 2007-11-28 2010-11-22 Mersana Therapeutics Inc Conjugados de analogos de fumagillina biodegradables biocompatibles.
US8101706B2 (en) 2008-01-11 2012-01-24 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
PA8853201A1 (es) * 2008-12-10 2010-07-27 Mersana Therapeutics Inc Formulaciones farmaceuticas de conjugados de camtotecina-polimero biocompatibles biodegradables
SI2889043T1 (sl) 2008-12-16 2019-08-30 Genzyme Corporation Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein
WO2010138719A1 (fr) 2009-05-28 2010-12-02 Mersana Therapeutics, Inc. Conjugués de médicament/polyal comprenant des liants à taux de libération variable
JP2013528665A (ja) 2010-03-26 2013-07-11 メルサナ セラピューティックス, インコーポレイテッド ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法
WO2012129070A2 (fr) 2011-03-24 2012-09-27 Unversity Of Florida Research Foundation, Inc. Polymérisation par métathèse d'acétal
EP3228325A1 (fr) 2011-06-10 2017-10-11 Mersana Therapeutics, Inc. Conjugués protéine-polymère-médicament
US20140017265A1 (en) * 2012-07-05 2014-01-16 Mersana Therapeutics, Inc. Terminally Modified Polymers and Conjugates Thereof
CA2892863C (fr) 2012-12-10 2022-03-15 Mersana Therapeutics, Inc. Echafaudage polymere fonde sur des filaments helicoidaux apparies (phf) pour l'administration ciblee de medicaments
US10226535B2 (en) 2012-12-10 2019-03-12 Mersana Therapeutics, Inc. Auristatin compounds and conjugates thereof
CN105377355A (zh) 2013-03-14 2016-03-02 拇趾公司 治疗甲单元的感染、疾病或病症的方法
JP6427564B2 (ja) 2013-10-11 2018-11-21 アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー タンパク質−ポリマー−薬物共役体
EP3054991B1 (fr) 2013-10-11 2019-04-03 Mersana Therapeutics, Inc. Conjugués de médicament-protéine-polymère
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗her2表位之單株抗體及其使用之方法
CN104877127B (zh) 2015-06-23 2017-11-10 厦门赛诺邦格生物科技股份有限公司 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质
US11324827B2 (en) 2014-10-01 2022-05-10 Xiamen Sinopeg Biotech Co., Ltd. Multifunctionalized polyethylene glycol derivative and preparation method therefor
ES2941897T3 (es) 2014-11-12 2023-05-26 Seagen Inc Compuestos que interaccionan con glicanos y procedimientos de uso
IL258768B2 (en) 2015-11-12 2023-11-01 Siamab Therapeutics Inc Compounds interacting with glycans and methods of use
EP4302782A3 (fr) 2016-03-15 2024-03-27 Mersana Therapeutics, Inc. Conjugués anticorps-médicament ciblant napi2b et leurs procédés d'utilisation
EP3541847A4 (fr) 2016-11-17 2020-07-08 Seattle Genetics, Inc. Composés interagissant avec le glycane et méthodes d'utilisation
WO2018160538A1 (fr) 2017-02-28 2018-09-07 Mersana Therapeutics, Inc. Polythérapies de conjugués anticorps-médicament ciblant her2
KR20240044544A (ko) 2017-03-03 2024-04-04 씨젠 인크. 글리칸-상호작용 화합물 및 사용 방법
CN111315414A (zh) 2017-06-22 2020-06-19 梅尔莎纳医疗公司 产生载药聚合物支架和蛋白-聚合物-药物缀合物的方法
WO2023012798A2 (fr) 2021-08-02 2023-02-09 Yeda Research And Development Co. Ltd. Anticorps pour le traitement du cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
US4303767A (en) * 1976-12-02 1981-12-01 Basf Wyandotte Corporation Flame retardant antistatic additives and antistatic fibers
US4304767A (en) * 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
EP0051707A1 (fr) * 1980-11-12 1982-05-19 Thomas Clemens Usher Acides polycarboxyliques de dextrane, leurs complexes avec l'hydroxyde de fer trivalent; compositions pharmaceutiques les contenant et procédé pour leur fabrication
JPS59124901A (ja) * 1982-12-29 1984-07-19 Dai Ichi Seiyaku Co Ltd 多糖誘導体
US4549010A (en) * 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4863964A (en) * 1985-07-02 1989-09-05 Biomedical Frontiers, Inc. Method for the stabilization of deferoxamine to chelate free ions in physiological fluid
US4713441A (en) * 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4793986A (en) * 1987-02-25 1988-12-27 Johnson Matthey, Inc. Macromolecular platinum antitumor compounds
JPH01190636A (ja) * 1988-01-22 1989-07-31 Green Cross Corp:The 制癌作用物質複合体
US4975519A (en) * 1989-05-12 1990-12-04 Hoechst Celanese Corporation Novel polyacetal terpolymers of trioxane and alpha, alpha- and alpha, beta-isomers of glycerol formal and functional derivatives thereof
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
EP0581752B1 (fr) * 1992-07-15 1998-12-09 The Procter & Gamble Company Compositions pour éviter le transfert de colorant contenant des adjuvants
US5393737A (en) * 1992-08-20 1995-02-28 Health Research, Inc. Cytotoxic drug conjugates for treatment of neoplastic diseases
US5359071A (en) * 1993-03-12 1994-10-25 Merck & Co., Inc. 15-substituted 4-azasteroids

Also Published As

Publication number Publication date
EP0820473B1 (fr) 2001-06-27
ATE202573T1 (de) 2001-07-15
AU5531296A (en) 1996-10-30
US5811510A (en) 1998-09-22
CA2215997A1 (fr) 1996-10-17
EP0820473A1 (fr) 1998-01-28
DE69613569D1 (de) 2001-08-02
DK0820473T3 (da) 2001-10-22
CA2215997C (fr) 2009-03-24
US5958398A (en) 1999-09-28
DE69613569T2 (de) 2002-05-16
EP0820473B2 (fr) 2008-01-30
GR3036696T3 (en) 2001-12-31
JP4187265B2 (ja) 2008-11-26
JPH11503481A (ja) 1999-03-26
WO1996032419A1 (fr) 1996-10-17
DE69613569T3 (de) 2008-07-24
US5863990A (en) 1999-01-26

Similar Documents

Publication Publication Date Title
DK0820473T3 (da) Biologisk nedbrydelige polyacetalpolymerer og dannelse og anvendelse
DE69508938T2 (de) Transdermales arzneistoff-abgabesystem
WO1996032419B1 (fr) Polymeres de polyacetals biodegradables, formation et utilisation
DE69839251D1 (de) Alpha interferon-polymer konjugate mit erhöhter biologischer wirksamkeit sowie verfahren zu deren herstellung
CA2355293A1 (fr) Solutions de sel d'hydroxybutyrate stables et saines au plan microbiologique, pour le traitement de la narcolepsie
DE69634009D1 (de) Implantierbare vorrichtung zur kontrollierten abgabe von arzneimitteln unmittelbar an einen inneren teil des körpers
KR900700089A (ko) 전신성 피부 투과적 투여를 위한 약학적 조성물
ES2184800T3 (es) Uso de agentes anti-vegf en el tratamiento de la endometriosis.
TR199701490A2 (xx) 3-Hidroksipiridin-2-karbonasitamidester ve bunlar�n imalat�.
ATE198152T1 (de) Oral anzuwendende arzneizubereitung mit verzögerter wirkstoffabgabe
Hamilton Announced Entrances in Greek Tragedy
EE9900428A (et) Köhavastased ravimkoostised
WO2001024783A3 (fr) Utilisation de (+)-tramadol, de o-demethyltramadol ou de (+)-o-demethyltramadol, de o-desmethyle-n-mono-desmethyl-tramadol ou de (+)o-desmethyl-n-mono-desmethyl-tramadol pour traiter l'incontinence urinaire
SE9202208D0 (sv) Vaevnadsfoerstaerkning
ATE422893T1 (de) Mannose-rezeptor tragende zellinie und antigen zusammensetzung
CO5280202A1 (es) Metodos de tratamiento y metodos de rastreo de farmacos
BR0115882A (pt) Emprego de compostos de 1-fenil-3-dimetilaminopropano no tratamento da incontinência urinária
HUP9902415A2 (hu) Azonnal felszabaduló szilárd beadási formák és eljárás azok előállítására
PT1058544E (pt) Inibicao da actividade do tnf
FR2734724B1 (fr) Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'alcoolisme
WO2001042205A3 (fr) Traitement de maladies enteriques inflammatoires avec des composes de la vitamine d
TR200000890T2 (tr) Topik ilacın üretilmesi için -amino levülozik asidin kullanılması
CA2118997A1 (fr) Derives du benzimidazole, leur preparation et leur utilisation
SE9700617D0 (sv) New composition
UA31955A (uk) Спосіб лікування гіпогалактії у породіль групи ризику