DK0804548T3 - Patched-gener og deres anvendelse - Google Patents

Patched-gener og deres anvendelse

Info

Publication number
DK0804548T3
DK0804548T3 DK95938749T DK95938749T DK0804548T3 DK 0804548 T3 DK0804548 T3 DK 0804548T3 DK 95938749 T DK95938749 T DK 95938749T DK 95938749 T DK95938749 T DK 95938749T DK 0804548 T3 DK0804548 T3 DK 0804548T3
Authority
DK
Denmark
Prior art keywords
patched
genes
gene
ligands
isolation
Prior art date
Application number
DK95938749T
Other languages
Danish (da)
English (en)
Inventor
Matthew P Scott
Lisa V Goodrich
Ronald L Johnson
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of DK0804548T3 publication Critical patent/DK0804548T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK95938749T 1994-10-07 1995-10-06 Patched-gener og deres anvendelse DK0804548T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31974594A 1994-10-07 1994-10-07

Publications (1)

Publication Number Publication Date
DK0804548T3 true DK0804548T3 (da) 2005-11-07

Family

ID=23243482

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95938749T DK0804548T3 (da) 1994-10-07 1995-10-06 Patched-gener og deres anvendelse

Country Status (10)

Country Link
US (6) US5837538A (fr)
EP (2) EP0804548B1 (fr)
JP (1) JP3776454B2 (fr)
AT (1) ATE299529T1 (fr)
AU (1) AU4001195A (fr)
CA (1) CA2201887C (fr)
DE (1) DE69534310T2 (fr)
DK (1) DK0804548T3 (fr)
ES (1) ES2245454T3 (fr)
WO (1) WO1996011260A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6027882A (en) * 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
US6429354B1 (en) * 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto
JP3776454B2 (ja) 1994-10-07 2006-05-17 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ パッチド遺伝子及びそれらの使用
AU752969B2 (en) * 1994-10-07 2002-10-03 Board Of Trustees Of The Leland Stanford Junior University Patched genes and their use
WO1997043414A2 (fr) * 1996-05-17 1997-11-20 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Gene suppresseur du carcinome basocellulaire
JP2002504805A (ja) * 1996-05-17 2002-02-12 アメリカ合衆国 基底細胞癌腫瘍抑制遺伝子
US6552181B1 (en) * 1996-05-17 2003-04-22 The United States Of America As Represented By The Department Of Health And Human Services Basal cell carcinoma tumor supressor gene
WO1998012326A1 (fr) * 1996-09-20 1998-03-26 President And Fellows Of Harvard College Proteines d'interaction de type herisson et utilisations s'y rapportant
WO1998035020A2 (fr) * 1997-02-10 1998-08-13 The Presidents And Fellows Of Harvard College Procedes destines a moduler l'hematopoiese et la croissance vasculaire
CA2280896A1 (fr) * 1997-02-14 1998-08-20 Incyte Pharmaceuticals, Inc. Nouvelle proteine humaine mago nashi
EP0879888A3 (fr) * 1997-05-23 1999-07-14 Smithkline Beecham Plc Polypeptides patched-2 et polynucléotides et leurs procédés de fabrication
WO1999000117A2 (fr) 1997-06-27 1999-01-07 Ontogeny, Inc. Procedes et reactifs neuroprotecteurs
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
EP1037982A1 (fr) 1997-12-08 2000-09-27 Ontogeny, Inc. Genes et proteines ptc humains, et leurs utilisations
US6709838B1 (en) 1998-04-15 2004-03-23 Genentech, Inc. Nucleic acid encoding patched-2
US6348575B1 (en) 1998-04-15 2002-02-19 Genentech, Inc. Patched-2
CA2336220A1 (fr) * 1998-07-24 2000-02-03 The Carnegie Institution Of Washington Procede de preservation et de reproduction de cellules souches de germen a l'aide de membres de la famille tgf-.beta. des facteurs de croissance
AU761298C (en) * 1998-09-11 2005-04-21 President And Fellows Of Harvard College Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto
AU773044B2 (en) * 1998-09-11 2004-05-13 Curis, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US20040060568A1 (en) * 2000-10-13 2004-04-01 Henryk Dudek Hedgehog antagonists, methods and uses related thereto
US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
AU2002308557A1 (en) * 2001-05-01 2002-11-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
JP2007521333A (ja) * 2003-12-19 2007-08-02 キュアリス・インコーポレーテッド 中枢神経系の活動を調節するための組成物および方法
WO2005097207A2 (fr) * 2004-03-26 2005-10-20 Curis, Inc. Modulateurs d'interference d'arn de signalisation hedgehog et leurs utilisations
US7999940B2 (en) * 2006-06-30 2011-08-16 Asml Netherlands B.V. Apparatus for angular-resolved spectroscopic lithography characterization
US20090285819A1 (en) * 2006-11-15 2009-11-19 Functional Genetics, Inc. Methods and compositions for treating influenza
CA2824863A1 (fr) * 2011-01-18 2012-07-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procedes d'amplification et de detection de prions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US66A (en) * 1836-10-20 Machinery for forming webs of cloth of wool
US5023180A (en) * 1986-06-17 1991-06-11 Lubrizol Genetics, Inc. Bradyrhizobium japonicum nodulation regulatory protein and gene
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US6610656B1 (en) * 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US5750367A (en) * 1993-11-08 1998-05-12 Baylor College Of Medicine Human and mouse very low density lipoprotein receptors and methods for use of such receptors
US6384192B1 (en) * 1993-12-30 2002-05-07 President & Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins
US6165747A (en) * 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6884775B1 (en) * 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US6261786B1 (en) * 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6946257B1 (en) * 1994-10-07 2005-09-20 Regents Of The University Of California Patched genes and uses related thereto
US6027882A (en) 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
JP3776454B2 (ja) * 1994-10-07 2006-05-17 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ パッチド遺伝子及びそれらの使用
US6429354B1 (en) * 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto

Also Published As

Publication number Publication date
US6172200B1 (en) 2001-01-09
AU4001195A (en) 1996-05-02
ATE299529T1 (de) 2005-07-15
EP0804548A4 (fr) 1999-07-21
US7659371B2 (en) 2010-02-09
ES2245454T3 (es) 2006-01-01
US20030032085A1 (en) 2003-02-13
CA2201887C (fr) 2009-04-14
CA2201887A1 (fr) 1996-04-18
EP1616942A3 (fr) 2006-11-22
JPH10507349A (ja) 1998-07-21
EP0804548A1 (fr) 1997-11-05
US20030148388A1 (en) 2003-08-07
US5837538A (en) 1998-11-17
DE69534310D1 (de) 2005-08-18
EP1616942A2 (fr) 2006-01-18
US6610507B2 (en) 2003-08-26
EP0804548B1 (fr) 2005-07-13
US6921646B2 (en) 2005-07-26
WO1996011260A1 (fr) 1996-04-18
JP3776454B2 (ja) 2006-05-17
US20100221724A1 (en) 2010-09-02
US8178298B2 (en) 2012-05-15
US20080300167A1 (en) 2008-12-04
DE69534310T2 (de) 2006-04-27

Similar Documents

Publication Publication Date Title
DK0804548T3 (da) Patched-gener og deres anvendelse
DE60044004D1 (de) Verwendung von Omega-Carboxyaryl-substituierten Diphenylharnstoffen als raf-Kinase-Inhibitoren
DE59905858D1 (de) Verwendung von pit-emulsionen
DE60023936D1 (de) Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
PT1049767E (pt) Coelho transgenico que expressa uma lipoproteina (a) humana funcional
TR199900781T2 (xx) H�cre yap��ma inhibit�rleri
EA200501772A1 (ru) Способы измерения экспрессии генов из фиксированного и залитого в парафин образца ткани
DE69027431T2 (de) Kumarinderivate zur verwendung als nukleotidvernetzungsreagenzien
DE69918072D1 (de) P53-regulierte gene
ATE217865T1 (de) Verbindungen zur hemmung von phosphodiesrerase iv
BR0308339A (pt) Indazóis substituìdos com uma atividade anticancerosa
DE69905041D1 (de) Zusammensetzung auf basis von modifiziertem gellangummi, verfahren zu dessen herstellung und seine verwendung
Lupo et al. Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age‐associated neurogenic decline
FI20020176A0 (fi) Menetelmõ ja reagenssipakkaus geneettisen yhtõlõisyyden osoittamiseksi
DK0760010T3 (da) Fremgangsmåder til screening for Crohn's sygdom under anvendelse af TNF-mikrosatellit-alleler
MXPA02009613A (es) Marcadores geneticos para caracteristicas de carne mejoradas en animales.
DE60228609D1 (de) Identifizierung und charakterisierung von genen
ATE230414T1 (de) Mimetika von beta-faltblatt und verfahren zur verwendung davon
WO2001085980A3 (fr) Tests enzymatiques destines au criblage d'agents anticancereux
DE60028196D1 (de) Verwendung von 13c-nmr zum nachweis von bindungen
DE60005440D1 (de) Anordnung zur Herstellung von Matrixen von Proben
NO960715D0 (no) Fremgangsmåter for sceening av anti-östrogen forbindelser
ATE283703T1 (de) Neurodegenerative-erkrankung verwandtes gen
DE69502855D1 (de) (Pyrrolidinyl)phenylcarbamate und Zwischenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente
ATE294853T1 (de) Verwendung von pit-emulsionen in fermentationsverfahren