DK0804548T3 - Patched-gener og deres anvendelse - Google Patents

Patched-gener og deres anvendelse

Info

Publication number
DK0804548T3
DK0804548T3 DK95938749T DK95938749T DK0804548T3 DK 0804548 T3 DK0804548 T3 DK 0804548T3 DK 95938749 T DK95938749 T DK 95938749T DK 95938749 T DK95938749 T DK 95938749T DK 0804548 T3 DK0804548 T3 DK 0804548T3
Authority
DK
Denmark
Prior art keywords
patched
genes
gene
ligands
isolation
Prior art date
Application number
DK95938749T
Other languages
English (en)
Inventor
Matthew P Scott
Lisa V Goodrich
Ronald L Johnson
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of DK0804548T3 publication Critical patent/DK0804548T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Insects & Arthropods (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95938749T 1994-10-07 1995-10-06 Patched-gener og deres anvendelse DK0804548T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31974594A 1994-10-07 1994-10-07

Publications (1)

Publication Number Publication Date
DK0804548T3 true DK0804548T3 (da) 2005-11-07

Family

ID=23243482

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95938749T DK0804548T3 (da) 1994-10-07 1995-10-06 Patched-gener og deres anvendelse

Country Status (10)

Country Link
US (6) US5837538A (da)
EP (2) EP0804548B1 (da)
JP (1) JP3776454B2 (da)
AT (1) ATE299529T1 (da)
AU (1) AU4001195A (da)
CA (1) CA2201887C (da)
DE (1) DE69534310T2 (da)
DK (1) DK0804548T3 (da)
ES (1) ES2245454T3 (da)
WO (1) WO1996011260A1 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6429354B1 (en) 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto
AU752969B2 (en) * 1994-10-07 2002-10-03 Board Of Trustees Of The Leland Stanford Junior University Patched genes and their use
US6027882A (en) * 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
JP3776454B2 (ja) * 1994-10-07 2006-05-17 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ パッチド遺伝子及びそれらの使用
US6552181B1 (en) * 1996-05-17 2003-04-22 The United States Of America As Represented By The Department Of Health And Human Services Basal cell carcinoma tumor supressor gene
AU725404B2 (en) * 1996-05-17 2000-10-12 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The A basal cell carcinoma tumor suppressor gene
WO1997043414A2 (en) * 1996-05-17 1997-11-20 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services A basal cell carcinoma tumor suppressor gene
EP0935656B1 (en) 1996-09-20 2006-08-09 President And Fellows Of Harvard College Hedgehog interacting proteins and uses related thereto
DE69841320D1 (de) 1997-02-10 2010-01-07 Harvard College Verfahren zur modulation von hämatopoese und vaskulärem wachstum
EP0979275A1 (en) * 1997-02-14 2000-02-16 Incyte Pharmaceuticals, Inc. Novel human mago nashi protein
US6051400A (en) * 1997-05-23 2000-04-18 Smithkline Beecham Plc Patched-2 polypeptides and polynucleotides
AU8173098A (en) 1997-06-27 1999-01-19 Ontogeny, Inc. Neuroprotective methods and reagents
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
EP1037982A1 (en) 1997-12-08 2000-09-27 Ontogeny, Inc. Human patched genes and proteins, and uses related thereto
US6348575B1 (en) 1998-04-15 2002-02-19 Genentech, Inc. Patched-2
US6709838B1 (en) 1998-04-15 2004-03-23 Genentech, Inc. Nucleic acid encoding patched-2
WO2000005344A1 (en) * 1998-07-24 2000-02-03 The Carnegie Institution Of Washington METHOD FOR MAINTENANCE AND PROPAGATION OF GERMLINE STEM CELLS USING MEMBERS OF THE TGF-β FAMILY OF GROWTH FACTORS
JP2002524528A (ja) * 1998-09-11 2002-08-06 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法
CA2343335C (en) 1998-09-11 2014-05-27 Biogen, Inc. Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor
US6884770B1 (en) 1998-11-06 2005-04-26 Curis, Inc. Methods and compositions for treating or preventing peripheral neuropathies
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US7708998B2 (en) * 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
AU9684401A (en) * 2000-10-13 2002-04-22 Curis Inc Hedgehog antagonists, methods and uses related thereto
US7682607B2 (en) * 2001-05-01 2010-03-23 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
MXPA06006659A (es) * 2003-12-19 2006-08-31 Curis Inc Composicion y metodos para modular la actividad del sistema nervioso central.
AU2005231692B2 (en) * 2004-03-26 2011-01-27 Curis, Inc. RNA interference modulators of Hedgehog signaling and uses thereof
US7999940B2 (en) * 2006-06-30 2011-08-16 Asml Netherlands B.V. Apparatus for angular-resolved spectroscopic lithography characterization
AU2007353317B2 (en) * 2006-11-15 2012-09-06 Eli Lilly And Company Methods and compositions for treating influenza
EP2666020A1 (en) * 2011-01-18 2013-11-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for amplification and detection of prions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US66A (en) * 1836-10-20 Machinery for forming webs of cloth of wool
US5023180A (en) 1986-06-17 1991-06-11 Lubrizol Genetics, Inc. Bradyrhizobium japonicum nodulation regulatory protein and gene
US6610656B1 (en) 1993-12-30 2003-08-26 President And Fellows Of Harvard College Method of promoting chondrocyte differentiation with hedgehog related polypeptides
US5789543A (en) 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US5750367A (en) * 1993-11-08 1998-05-12 Baylor College Of Medicine Human and mouse very low density lipoprotein receptors and methods for use of such receptors
US6884775B1 (en) 1993-12-30 2005-04-26 President And Fellows Of Harvard College Methods and compositions for regulating skeletogenic formation
US6165747A (en) 1993-12-30 2000-12-26 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US6271363B1 (en) 1993-12-30 2001-08-07 President & Fellows Of Harvard College Nucleic acids encoding hedgehog proteins
US7060450B1 (en) 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US6261786B1 (en) 1993-12-30 2001-07-17 Imperial Cancer Res. Technology Screening assays for hedgehog agonists and antagonists
US20030186357A1 (en) 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
JP3776454B2 (ja) * 1994-10-07 2006-05-17 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ パッチド遺伝子及びそれらの使用
US6027882A (en) 1994-10-07 2000-02-22 The Regents Of The University Of California Patched genes and their use for diagnostics
US6429354B1 (en) 1994-10-07 2002-08-06 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and uses related thereto
US6946257B1 (en) 1994-10-07 2005-09-20 Regents Of The University Of California Patched genes and uses related thereto

Also Published As

Publication number Publication date
US8178298B2 (en) 2012-05-15
EP1616942A3 (en) 2006-11-22
EP1616942A2 (en) 2006-01-18
CA2201887C (en) 2009-04-14
EP0804548A1 (en) 1997-11-05
US20100221724A1 (en) 2010-09-02
JPH10507349A (ja) 1998-07-21
DE69534310T2 (de) 2006-04-27
ATE299529T1 (de) 2005-07-15
US20030032085A1 (en) 2003-02-13
US20030148388A1 (en) 2003-08-07
DE69534310D1 (de) 2005-08-18
US6172200B1 (en) 2001-01-09
AU4001195A (en) 1996-05-02
WO1996011260A1 (en) 1996-04-18
EP0804548B1 (en) 2005-07-13
US20080300167A1 (en) 2008-12-04
EP0804548A4 (en) 1999-07-21
ES2245454T3 (es) 2006-01-01
US5837538A (en) 1998-11-17
US7659371B2 (en) 2010-02-09
US6610507B2 (en) 2003-08-26
CA2201887A1 (en) 1996-04-18
US6921646B2 (en) 2005-07-26
JP3776454B2 (ja) 2006-05-17

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