DK0798298T3 - Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel - Google Patents

Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel

Info

Publication number
DK0798298T3
DK0798298T3 DK95940418T DK95940418T DK0798298T3 DK 0798298 T3 DK0798298 T3 DK 0798298T3 DK 95940418 T DK95940418 T DK 95940418T DK 95940418 T DK95940418 T DK 95940418T DK 0798298 T3 DK0798298 T3 DK 0798298T3
Authority
DK
Denmark
Prior art keywords
group
alkyl group
angina pectoris
atom
formula
Prior art date
Application number
DK95940418T
Other languages
Danish (da)
English (en)
Inventor
Sadao Ishihara
Fujio Saito
Yasuo Ohhata
Shigeki Miyake
Ryosuke Yorikane
Norio Fukuda
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of DK0798298T3 publication Critical patent/DK0798298T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK95940418T 1994-12-15 1995-12-13 Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel DK0798298T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31151194 1994-12-15
PCT/JP1995/002545 WO1996018620A1 (fr) 1994-12-15 1995-12-13 Composes thiazolidinone ou medicament pour prevenir ou guerir l'angine de poitrine contenant ces composes en tant qu'ingredient actif

Publications (1)

Publication Number Publication Date
DK0798298T3 true DK0798298T3 (da) 2001-10-22

Family

ID=18018119

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95940418T DK0798298T3 (da) 1994-12-15 1995-12-13 Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel

Country Status (21)

Country Link
US (1) US5843973A (zh)
EP (1) EP0798298B1 (zh)
KR (1) KR100312471B1 (zh)
CN (1) CN1092649C (zh)
AT (1) ATE203987T1 (zh)
AU (1) AU692334B2 (zh)
CA (1) CA2207794A1 (zh)
CZ (1) CZ292626B6 (zh)
DE (1) DE69522118T2 (zh)
DK (1) DK0798298T3 (zh)
ES (1) ES2161916T3 (zh)
FI (1) FI972510A (zh)
GR (1) GR3036704T3 (zh)
HK (1) HK1000494A1 (zh)
HU (1) HUT77131A (zh)
MX (1) MX9704435A (zh)
NO (1) NO309475B1 (zh)
NZ (1) NZ297095A (zh)
PT (1) PT798298E (zh)
RU (1) RU2139283C1 (zh)
WO (1) WO1996018620A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200524849A (en) * 2003-07-02 2005-08-01 Hoffmann La Roche Hydroxyalkylamide derivatives
EP1692121A1 (en) 2003-11-18 2006-08-23 University of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof
TR201903981T4 (tr) 2008-06-16 2019-04-22 Univ Ohio State Res Found Kanser tedavisi için bileşikler.
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
EP2290114A1 (de) 2009-08-04 2011-03-02 Gebr. Kemper GmbH + Co. KG Metallwerke Wasserführendes Bauteil
JP5879273B2 (ja) 2010-03-01 2016-03-08 ジーティーエックス・インコーポレイテッド 癌を処置するための化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5213910A (en) * 1975-07-19 1977-02-02 Toshinori Kawabuchi Photogravure printing press
GB8717068D0 (en) * 1987-07-20 1987-08-26 Fujisawa Pharmaceutical Co Nitric ester derivative
AU647599B2 (en) * 1991-03-27 1994-03-24 Sankyo Company Limited New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators
CZ290989B6 (cs) * 1995-03-02 2002-11-13 Sankyo Company, Limited Opticky aktivní thiazolidinonový derivát, prostředek jej obsahující, pouľití tohoto derivátu a způsob jeho přípravy

Also Published As

Publication number Publication date
CN1092649C (zh) 2002-10-16
NO972731L (no) 1997-08-14
GR3036704T3 (en) 2001-12-31
RU2139283C1 (ru) 1999-10-10
FI972510A (fi) 1997-08-07
EP0798298B1 (en) 2001-08-08
ATE203987T1 (de) 2001-08-15
EP0798298A1 (en) 1997-10-01
US5843973A (en) 1998-12-01
DE69522118D1 (de) 2001-09-13
KR100312471B1 (ko) 2002-02-28
FI972510A0 (fi) 1997-06-13
CZ183497A3 (en) 1997-12-17
CN1175250A (zh) 1998-03-04
DE69522118T2 (de) 2002-04-25
AU692334B2 (en) 1998-06-04
AU4187996A (en) 1996-07-03
PT798298E (pt) 2001-11-30
NO309475B1 (no) 2001-02-05
HK1000494A1 (en) 2002-03-15
EP0798298A4 (en) 1998-03-25
WO1996018620A1 (fr) 1996-06-20
CA2207794A1 (en) 1996-06-20
HUT77131A (hu) 1998-03-02
NO972731D0 (no) 1997-06-13
CZ292626B6 (cs) 2003-11-12
NZ297095A (en) 1998-09-24
ES2161916T3 (es) 2001-12-16
MX9704435A (es) 1997-10-31

Similar Documents

Publication Publication Date Title
MX9306831A (es) Nuevos compuestos heterociclicos.
DK0976748T3 (da) Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
DK0790987T3 (da) Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
NO20000722L (no) 2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater
PT842923E (pt) Derivados do pirrolo e composicoes medicinais
CA2080917A1 (en) New pharmacologically active catechol derivatives
DE69725585D1 (de) Phenylalkylcarbonsäure-derivate
DK0798298T3 (da) Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel
DK0506434T3 (da) Thiazolidinon- og oxazolidinon-derivater, fremstilling deraf og deres anvendelse som vasodilaterende midler
DE69612967T2 (de) Optisch aktive thiazolidinonderivate
DE60045821D1 (de) Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
DK1106614T3 (da) 5-leddede, heteroarylsubstituerede 1,4-dihydropyridinforbindelser som bradykininantagonister
DK369289D0 (da) Anvendelse af imidazopyrazolderivater som analgetica og antiinflammatoriske midler
NO944888L (no) 5-(1,2,4-triazol-1-ylmetyl)-3H-isobenzofuran-1-on derivater, deres fremstilling og anvendelse som aromataseinhibitorer