DK0788480T3 - Krystallisering af levobupivacain og analoger deraf - Google Patents

Krystallisering af levobupivacain og analoger deraf

Info

Publication number
DK0788480T3
DK0788480T3 DK95934738T DK95934738T DK0788480T3 DK 0788480 T3 DK0788480 T3 DK 0788480T3 DK 95934738 T DK95934738 T DK 95934738T DK 95934738 T DK95934738 T DK 95934738T DK 0788480 T3 DK0788480 T3 DK 0788480T3
Authority
DK
Denmark
Prior art keywords
pct
levobupivacaine
analogues
crystallization
sec
Prior art date
Application number
DK95934738T
Other languages
Danish (da)
English (en)
Inventor
Marianne Langston
Benjamin Mark Skead
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421476A external-priority patent/GB9421476D0/en
Priority claimed from GBGB9504926.8A external-priority patent/GB9504926D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of DK0788480T3 publication Critical patent/DK0788480T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK95934738T 1994-10-25 1995-10-23 Krystallisering af levobupivacain og analoger deraf DK0788480T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9421476A GB9421476D0 (en) 1994-10-25 1994-10-25 Process and salt
GBGB9504926.8A GB9504926D0 (en) 1995-03-10 1995-03-10 Crystallisation
PCT/GB1995/002513 WO1996012699A1 (en) 1994-10-25 1995-10-23 Crystallisation of levobupivacaine and analogues thereof

Publications (1)

Publication Number Publication Date
DK0788480T3 true DK0788480T3 (da) 2003-09-29

Family

ID=26305863

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95934738T DK0788480T3 (da) 1994-10-25 1995-10-23 Krystallisering af levobupivacain og analoger deraf

Country Status (16)

Country Link
US (1) US5994548A (fi)
EP (1) EP0788480B1 (fi)
JP (1) JP3911545B2 (fi)
AT (1) ATE245629T1 (fi)
AU (1) AU698637B2 (fi)
CA (1) CA2200355C (fi)
DE (1) DE69531356T2 (fi)
DK (1) DK0788480T3 (fi)
ES (1) ES2202375T3 (fi)
FI (1) FI117438B (fi)
HU (1) HU227420B1 (fi)
MX (1) MX9703024A (fi)
NO (1) NO309266B1 (fi)
PL (1) PL183210B1 (fi)
PT (1) PT788480E (fi)
WO (1) WO1996012699A1 (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0002246A (pt) * 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
SI1575569T1 (sl) 2002-12-13 2010-12-31 Durect Corp Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale
US6790267B1 (en) * 2003-04-24 2004-09-14 Xerox Corporation Colorant compositions
US7094812B2 (en) * 2003-04-24 2006-08-22 Xerox Corporations Colorant compositions
EP2415484B1 (en) 2004-09-17 2014-06-18 Durect Corporation Sustained local anesthetic composition containing SAIB
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
EP2010491A1 (en) * 2006-04-25 2009-01-07 Disham Pharmaceuticals and Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
DK2117521T3 (da) 2006-11-03 2012-09-03 Durect Corp Transdermale indgivelsessystemer omfattende bupivacain
CA2706931C (en) 2007-12-06 2015-05-12 Durect Corporation Oral pharmaceutical dosage forms
EP2234974B1 (en) * 2008-01-15 2012-04-25 Pharmathen S.A. Process for the preparation of (s)-1-alkyl-2',6'-pipecoloxylidide compound
US20100260844A1 (en) * 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN103073484B (zh) * 2013-01-28 2014-10-22 山东诚创医药技术开发有限公司 一种甲哌卡因及其光学对映体的制备方法
EP2983468A4 (en) 2013-03-15 2016-09-07 Durect Corp COMPOSITIONS WITH RHEOLOGY MODIFIER TO REDUCE RESOLUTION VARIABILITY
CA3048485C (en) * 2016-12-26 2022-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE341404B (fi) * 1967-05-18 1971-12-27 Sterling Drug Inc
US4695576A (en) * 1984-07-09 1987-09-22 Astra Lake Medel Aktiebolag L-N-n-propylpipecolic acid-2,6-xylidide

Also Published As

Publication number Publication date
FI117438B (fi) 2006-10-13
DE69531356D1 (de) 2003-08-28
US5994548A (en) 1999-11-30
WO1996012699A1 (en) 1996-05-02
PT788480E (pt) 2003-12-31
HUT77631A (hu) 1998-06-29
ES2202375T3 (es) 2004-04-01
NO971903L (no) 1997-04-24
FI971711A0 (fi) 1997-04-22
AU3704895A (en) 1996-05-15
AU698637B2 (en) 1998-11-05
HU227420B1 (en) 2011-05-30
CA2200355C (en) 2007-03-06
MX9703024A (es) 1997-10-31
JPH10507464A (ja) 1998-07-21
FI971711A (fi) 1997-04-22
PL183210B1 (pl) 2002-06-28
ATE245629T1 (de) 2003-08-15
PL319829A1 (en) 1997-09-01
NO971903D0 (no) 1997-04-24
EP0788480A1 (en) 1997-08-13
NO309266B1 (no) 2001-01-08
JP3911545B2 (ja) 2007-05-09
DE69531356T2 (de) 2004-05-27
EP0788480B1 (en) 2003-07-23
CA2200355A1 (en) 1996-05-02

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