DK0744961T3 - Gasholdige mikropartikler, midler indeholdende disse, deres anvendelse i ultralydsdiagnostikken samt fremgangsmåder til fremstilling af partiklerne og midlerne - Google Patents
Gasholdige mikropartikler, midler indeholdende disse, deres anvendelse i ultralydsdiagnostikken samt fremgangsmåder til fremstilling af partiklerne og midlerneInfo
- Publication number
- DK0744961T3 DK0744961T3 DK95909702T DK95909702T DK0744961T3 DK 0744961 T3 DK0744961 T3 DK 0744961T3 DK 95909702 T DK95909702 T DK 95909702T DK 95909702 T DK95909702 T DK 95909702T DK 0744961 T3 DK0744961 T3 DK 0744961T3
- Authority
- DK
- Denmark
- Prior art keywords
- poe
- fatty acid
- iii
- acid ester
- agents
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 238000002604 ultrasonography Methods 0.000 title 1
- -1 polyoxyethylene Polymers 0.000 abstract 5
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 4
- 229930195729 fatty acid Natural products 0.000 abstract 4
- 239000000194 fatty acid Substances 0.000 abstract 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 3
- 239000002961 echo contrast media Substances 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 229930182558 Sterol Natural products 0.000 abstract 2
- 150000002191 fatty alcohols Chemical class 0.000 abstract 2
- 150000003432 sterols Chemical class 0.000 abstract 2
- 235000003702 sterols Nutrition 0.000 abstract 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 229930186217 Glycolipid Natural products 0.000 abstract 1
- 229920001214 Polysorbate 60 Polymers 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001451 polypropylene glycol Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C19/00—Acyclic saturated compounds containing halogen atoms
- C07C19/08—Acyclic saturated compounds containing halogen atoms containing fluorine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4406474A DE4406474A1 (de) | 1994-02-23 | 1994-02-23 | Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel |
| PCT/EP1995/000484 WO1995022994A1 (de) | 1994-02-23 | 1995-02-10 | Gas enthaltende mikropartikel, diese enthaltende mittel, deren verwendung in der ultraschalldiagnostik, sowie verfahren zur herstellung der partikel und mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0744961T3 true DK0744961T3 (da) | 2001-12-10 |
Family
ID=6511397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95909702T DK0744961T3 (da) | 1994-02-23 | 1995-02-10 | Gasholdige mikropartikler, midler indeholdende disse, deres anvendelse i ultralydsdiagnostikken samt fremgangsmåder til fremstilling af partiklerne og midlerne |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6306366B1 (sv) |
| EP (2) | EP0744961B1 (sv) |
| JP (1) | JP4242448B2 (sv) |
| KR (1) | KR970701067A (sv) |
| CN (1) | CN1141595A (sv) |
| AT (1) | ATE205727T1 (sv) |
| AU (1) | AU701797B2 (sv) |
| CA (1) | CA2183968A1 (sv) |
| CZ (1) | CZ287115B6 (sv) |
| DE (2) | DE4406474A1 (sv) |
| DK (1) | DK0744961T3 (sv) |
| ES (1) | ES2162912T3 (sv) |
| FI (1) | FI963279A (sv) |
| HU (1) | HUT74516A (sv) |
| IL (1) | IL112617A (sv) |
| MX (1) | MX9603619A (sv) |
| NO (1) | NO312497B1 (sv) |
| NZ (1) | NZ281212A (sv) |
| PL (1) | PL315972A1 (sv) |
| PT (1) | PT744961E (sv) |
| RU (1) | RU2137502C1 (sv) |
| SK (1) | SK108696A3 (sv) |
| WO (1) | WO1995022994A1 (sv) |
| ZA (1) | ZA951498B (sv) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| DE19602930A1 (de) * | 1996-01-18 | 1997-07-24 | Schering Ag | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
| HU224218B1 (hu) | 1996-10-21 | 2005-06-28 | Amersham Health As | Továbbfejlesztett kontrasztanyagok |
| DE19805012A1 (de) * | 1998-02-07 | 1999-08-12 | Thomas Gieselmann | Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung |
| US7838034B2 (en) * | 2002-07-30 | 2010-11-23 | Grunenthal Gmbh | Intravenous pharmaceutical form of administration |
| RU2344833C2 (ru) * | 2004-06-04 | 2009-01-27 | Экьюсфиэр, Инк. | Контрастное средство для ультразвуковой визуализации |
| US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| US10369343B2 (en) | 2006-06-30 | 2019-08-06 | Biocompatibles Uk Limited | Apparatus and method to convey a fluid |
| JP5196896B2 (ja) * | 2007-07-13 | 2013-05-15 | 花王株式会社 | 微細気泡前駆体の製造方法 |
| WO2009082618A2 (en) * | 2007-12-20 | 2009-07-02 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Frozen lonic liquid microparticles and nanoparticles, and methods for their synthesis and use |
| CN101721719B (zh) * | 2008-10-28 | 2011-09-28 | 温州医学院 | 超声造影剂及其制备方法 |
| JP2011140527A (ja) * | 2011-04-20 | 2011-07-21 | Acusphere Inc | 超音波造影剤の投薬処方物 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3834705A1 (de) * | 1988-10-07 | 1990-04-12 | Schering Ag | Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln |
| DE3313947A1 (de) * | 1983-04-15 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel |
| US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
| DE3313946A1 (de) * | 1983-04-15 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel |
| JPS61275420A (ja) | 1985-05-31 | 1986-12-05 | Toray Ind Inc | ポリエステル糸条の直接紡糸延伸方法 |
| DE3529195A1 (de) | 1985-08-14 | 1987-02-26 | Max Planck Gesellschaft | Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung |
| DE3741199A1 (de) * | 1987-12-02 | 1989-08-17 | Schering Ag | Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie |
| US5425366A (en) | 1988-02-05 | 1995-06-20 | Schering Aktiengesellschaft | Ultrasonic contrast agents for color Doppler imaging |
| EP0586875A1 (de) * | 1988-02-05 | 1994-03-16 | Schering Aktiengesellschaft | Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika |
| DE4004430A1 (de) | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
| IN172208B (sv) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| US5055119A (en) | 1990-09-13 | 1991-10-08 | Owens-Corning Fiberglas Corporation | Method and apparatus for forming migration free glass fiber packages |
| US5147631A (en) | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
| ATE151992T1 (de) | 1991-06-03 | 1997-05-15 | Nycomed Imaging As | Verbesserungen im bezug auf kontrastmittel |
| GB9200388D0 (en) | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| GB9200391D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| GB9200387D0 (en) | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| US5302372A (en) | 1992-07-27 | 1994-04-12 | National Science Council | Method to opacify left ventricle in echocardiography |
| EP0679066A4 (en) | 1992-11-02 | 1996-04-03 | Univ Drexel | TENSIDE-STABILIZED MICROBUBBLE MIXTURES, METHOD FOR THEIR PRODUCTION AND USE. |
| US5362478A (en) | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
| WO1995001187A1 (en) * | 1993-07-02 | 1995-01-12 | Molecular Biosystems, Inc. | Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents |
| EP1550464A1 (en) * | 1993-07-30 | 2005-07-06 | IMCOR Pharmaceutical Co. | Stabilized microbubble composition for ultrasound |
| US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| JPH1193037A (ja) | 1997-09-12 | 1999-04-06 | Asahi Chem Ind Co Ltd | 撚糸織物 |
| JPH11172526A (ja) | 1997-11-26 | 1999-06-29 | Asahi Chem Ind Co Ltd | 低熱応力ポリエステル繊維及びその紡糸方法 |
| JPH11189925A (ja) | 1997-12-22 | 1999-07-13 | Toray Ind Inc | 芯鞘複合繊維の製造方法 |
| JP3167677B2 (ja) | 1998-04-23 | 2001-05-21 | 旭化成株式会社 | ポリエステル異形断面繊維 |
-
1994
- 1994-02-23 DE DE4406474A patent/DE4406474A1/de not_active Withdrawn
-
1995
- 1995-02-10 PT PT95909702T patent/PT744961E/pt unknown
- 1995-02-10 RU RU96119318A patent/RU2137502C1/ru active
- 1995-02-10 DE DE59509618T patent/DE59509618D1/de not_active Revoked
- 1995-02-10 DK DK95909702T patent/DK0744961T3/da active
- 1995-02-10 NZ NZ281212A patent/NZ281212A/en unknown
- 1995-02-10 KR KR1019960704607A patent/KR970701067A/ko not_active Application Discontinuation
- 1995-02-10 CZ CZ19962421A patent/CZ287115B6/cs not_active IP Right Cessation
- 1995-02-10 ES ES95909702T patent/ES2162912T3/es not_active Expired - Lifetime
- 1995-02-10 CA CA002183968A patent/CA2183968A1/en not_active Abandoned
- 1995-02-10 EP EP95909702A patent/EP0744961B1/de not_active Revoked
- 1995-02-10 WO PCT/EP1995/000484 patent/WO1995022994A1/de not_active Application Discontinuation
- 1995-02-10 JP JP52209995A patent/JP4242448B2/ja not_active Expired - Fee Related
- 1995-02-10 PL PL95315972A patent/PL315972A1/xx unknown
- 1995-02-10 EP EP98250140A patent/EP0855186A3/de not_active Ceased
- 1995-02-10 CN CN95191752A patent/CN1141595A/zh active Pending
- 1995-02-10 AU AU18087/95A patent/AU701797B2/en not_active Ceased
- 1995-02-10 MX MX9603619A patent/MX9603619A/es unknown
- 1995-02-10 SK SK1086-96A patent/SK108696A3/sk unknown
- 1995-02-10 HU HU9602300A patent/HUT74516A/hu unknown
- 1995-02-10 AT AT95909702T patent/ATE205727T1/de not_active IP Right Cessation
- 1995-02-12 IL IL11261795A patent/IL112617A/xx not_active IP Right Cessation
- 1995-02-23 ZA ZA951498A patent/ZA951498B/xx unknown
-
1996
- 1996-08-22 FI FI963279A patent/FI963279A/sv unknown
- 1996-08-22 NO NO19963501A patent/NO312497B1/no not_active IP Right Cessation
-
1998
- 1998-08-06 US US09/129,953 patent/US6306366B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE59509618D1 (de) | 2001-10-25 |
| CN1141595A (zh) | 1997-01-29 |
| CZ287115B6 (en) | 2000-09-13 |
| EP0744961A1 (de) | 1996-12-04 |
| ES2162912T3 (es) | 2002-01-16 |
| HU9602300D0 (en) | 1996-10-28 |
| WO1995022994A1 (de) | 1995-08-31 |
| EP0855186A3 (de) | 1999-01-27 |
| EP0744961B1 (de) | 2001-09-19 |
| NO963501D0 (no) | 1996-08-22 |
| SK108696A3 (en) | 1997-05-07 |
| PT744961E (pt) | 2002-03-28 |
| NO963501L (no) | 1996-10-22 |
| IL112617A0 (en) | 1995-05-26 |
| ATE205727T1 (de) | 2001-10-15 |
| NZ281212A (en) | 1998-06-26 |
| US6306366B1 (en) | 2001-10-23 |
| DE4406474A1 (de) | 1995-08-24 |
| RU2137502C1 (ru) | 1999-09-20 |
| AU701797B2 (en) | 1999-02-04 |
| JP4242448B2 (ja) | 2009-03-25 |
| FI963279A0 (sv) | 1996-08-22 |
| AU1808795A (en) | 1995-09-11 |
| ZA951498B (en) | 1995-12-07 |
| KR970701067A (ko) | 1997-03-17 |
| FI963279A (sv) | 1996-08-22 |
| EP0855186A2 (de) | 1998-07-29 |
| IL112617A (en) | 1999-12-22 |
| HUT74516A (en) | 1997-01-28 |
| JPH09509186A (ja) | 1997-09-16 |
| NO312497B1 (no) | 2002-05-21 |
| MX9603619A (es) | 1997-04-30 |
| PL315972A1 (en) | 1996-12-23 |
| CZ242196A3 (en) | 1996-11-13 |
| CA2183968A1 (en) | 1995-08-31 |
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