DK0740564T3 - Elektroporerings- og ionoforeseapparat til indføring af lægemidler og gener i celler - Google Patents

Elektroporerings- og ionoforeseapparat til indføring af lægemidler og gener i celler

Info

Publication number
DK0740564T3
DK0740564T3 DK95908090T DK95908090T DK0740564T3 DK 0740564 T3 DK0740564 T3 DK 0740564T3 DK 95908090 T DK95908090 T DK 95908090T DK 95908090 T DK95908090 T DK 95908090T DK 0740564 T3 DK0740564 T3 DK 0740564T3
Authority
DK
Denmark
Prior art keywords
cells
electrodes
drugs
genes
blood vessel
Prior art date
Application number
DK95908090T
Other languages
Danish (da)
English (en)
Inventor
Gunter A Hofmann
Lois J Crandell
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of DK0740564T3 publication Critical patent/DK0740564T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02—Dilators made of swellable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK95908090T 1994-01-21 1995-01-20 Elektroporerings- og ionoforeseapparat til indføring af lægemidler og gener i celler DK0740564T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/183,963 US5507724A (en) 1992-07-01 1994-01-21 Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
PCT/US1995/000799 WO1995019805A1 (fr) 1994-01-21 1995-01-20 Appareil d'electroporation et d'ionophorese et procede d'insertion de medicaments et de genes dans les cellules

Publications (1)

Publication Number Publication Date
DK0740564T3 true DK0740564T3 (da) 2003-07-28

Family

ID=22675037

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95908090T DK0740564T3 (da) 1994-01-21 1995-01-20 Elektroporerings- og ionoforeseapparat til indføring af lægemidler og gener i celler

Country Status (11)

Country Link
US (1) US5507724A (fr)
EP (1) EP0740564B1 (fr)
JP (1) JP3223321B2 (fr)
AT (1) ATE236681T1 (fr)
AU (1) AU1605295A (fr)
CA (1) CA2177655C (fr)
DE (1) DE69530283T2 (fr)
DK (1) DK0740564T3 (fr)
ES (1) ES2196057T3 (fr)
PT (1) PT740564E (fr)
WO (1) WO1995019805A1 (fr)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023552A1 (fr) * 1992-05-21 1993-11-25 Government Of The United States As Represented By Secretary Department Of Health And Human Services Ciblage de l'expression genique sur des tissus vivants par injection a jet
US5728068A (en) * 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5836905A (en) * 1994-06-20 1998-11-17 Lemelson; Jerome H. Apparatus and methods for gene therapy
US5810762A (en) * 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US5983131A (en) * 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
CA2234389A1 (fr) 1995-10-13 1997-04-17 Transvascular, Inc. Dispositif, systeme et procede permettant une intervention interstitielle transvasculaire
US6747133B1 (en) 1995-12-08 2004-06-08 University Technologies International Inc. Antibodies against the tumor suppressor gene ING1
US6143522A (en) * 1995-12-08 2000-11-07 University Technologies International, Inc. Methods of modulating apoptosis
US6117633A (en) * 1995-12-08 2000-09-12 University Technologies International Inc. DNA sequence encoding the tumor suppressor gene ING1
EP0780139A1 (fr) * 1995-12-22 1997-06-25 PHYSION S.r.l. Appareil de traitement combiné de la vessie et de l'urètre prostatique par iontophorèse ou électrophorèse
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5869326A (en) * 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5704908A (en) * 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US5999847A (en) * 1997-10-21 1999-12-07 Elstrom; John A. Apparatus and method for delivery of surgical and therapeutic agents
US6775569B2 (en) * 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6450989B2 (en) * 1998-04-27 2002-09-17 Artemis Medical, Inc. Dilating and support apparatus with disease inhibitors and methods for use
JP2002507930A (ja) * 1998-04-27 2002-03-12 ドゥブルル，ウィリアム，アール 疾患抑制剤を備えた拡張式支持装置とその使用方法
US20100036481A1 (en) * 1998-04-27 2010-02-11 Artemis Medical, Inc. Cardiovascular Devices and Methods
EP1079890A4 (fr) * 1998-05-08 2008-12-03 Genetronics Inc Vasodilatation d'un vaisseau induite electriquement
US8177743B2 (en) 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
US6280411B1 (en) 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
US6206283B1 (en) 1998-12-23 2001-03-27 At&T Corp. Method and apparatus for transferring money via a telephone call
DE69936866T2 (de) * 1998-06-26 2008-04-30 Genetronics, Inc., San Diego Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
JP2003505114A (ja) 1998-07-13 2003-02-12 ジェネトロニクス、インコーポレーテッド パルス電場による皮膚および筋肉を標的とした遺伝子治療
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
CA2337129A1 (fr) 1998-07-13 2000-01-20 Genetronics, Inc. Procede et appareil d'apport topique dote d'une assistance electrique d'agents destines a des applications cosmetiques
US6240321B1 (en) 1998-08-12 2001-05-29 Cardiac Pacemakers, Inc. Expandable seal for use with medical device and system
US6634364B2 (en) 2000-12-15 2003-10-21 Cardiac Pacemakers, Inc. Method of deploying a ventricular lead containing a hemostasis mechanism
MXPA01007996A (es) * 1999-02-10 2004-03-26 Gmp Drug Delivery Inc Parches de iontoforesis, electroporacion y combinacion para entrega local de droga..
US6593130B1 (en) 1999-04-16 2003-07-15 The Regents Of The University Of California Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy
WO2000067825A1 (fr) * 1999-05-07 2000-11-16 Microheart, Inc. Appareil et procede d"administration d"agents therapeutiques et diagnostiques
WO2000072908A1 (fr) * 1999-06-02 2000-12-07 Microheart, Inc. Dispositifs et procedes permettant d'apporter un medicament
US7147633B2 (en) * 1999-06-02 2006-12-12 Boston Scientific Scimed, Inc. Method and apparatus for treatment of atrial fibrillation
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
US6676679B1 (en) 1999-11-05 2004-01-13 Boston Scientific Corporation Method and apparatus for recurrent demand injury in stimulating angiogenesis
US6524324B1 (en) * 1999-11-05 2003-02-25 Scimed Life Systems, Inc. Method and apparatus for demand injury in stimulating angiogenesis
US6748258B1 (en) * 1999-11-05 2004-06-08 Scimed Life Systems, Inc. Method and devices for heart treatment
CA2395492A1 (fr) * 1999-12-22 2001-07-05 Diana Wang Procede et appareil permettant de cibler une electroporation localisee
CA2401239A1 (fr) * 2000-03-03 2001-09-13 Valentis, Inc. Compositions ameliorees de poloxamere et de poloxamine generatrices d'acide nucleique
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
US20010034501A1 (en) 2000-03-23 2001-10-25 Tom Curtis P. Pressure sensor for therapeutic delivery device and method
US7214223B2 (en) * 2000-03-24 2007-05-08 Boston Scientific Scimed, Inc. Photoatherolytic catheter apparatus and method
JP2004532654A (ja) 2000-05-22 2004-10-28 マーク・アンド・カンパニー・インコーポレイテッド 薬剤投与システム性能評価システム及び方法
US7588554B2 (en) 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
US6584362B1 (en) 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
US20040009940A1 (en) * 2000-10-20 2004-01-15 Coleman Michael E. Gene delivery formulations and methods for treatment of ischemic conditions
AU2002254212A1 (en) * 2001-03-12 2002-09-24 Irm, Llc Identification of cellular targets for biologically active molecules
US20030186390A1 (en) * 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US6936469B2 (en) 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
CN100417419C (zh) 2001-10-26 2008-09-10 贝勒医学院 改变个体的瘦体重和骨特性的组合物和方法
US7488313B2 (en) * 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
US20040219660A1 (en) * 2001-12-14 2004-11-04 Dev Sukhendu B. Electroporation-mediated intravascular delivery
US6740081B2 (en) * 2002-01-25 2004-05-25 Applied Medical Resources Corporation Electrosurgery with improved control apparatus and method
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8150519B2 (en) * 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US8131371B2 (en) * 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8145317B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8145316B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
AU2003221584A1 (en) * 2002-05-01 2003-11-17 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
AU2003299471A1 (en) 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20040034336A1 (en) * 2002-08-08 2004-02-19 Neal Scott Charged liposomes/micelles with encapsulted medical compounds
US7517342B2 (en) * 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
EP1660530A2 (fr) 2003-08-04 2006-05-31 Advisys, Inc. Hormone liberant une hormone de croissance specifique du chien
US7330851B2 (en) * 2003-08-18 2008-02-12 Eaglehawk, Limited Data security through dissembly of data elements or connections between elements
CA2592891C (fr) 2003-12-31 2013-05-28 Advisys, Inc. Reduction de l'arthrite et de la boiterie chez des sujets par apport complementaire de somatostatine (srif)
DE602005027661D1 (de) 2004-01-20 2011-06-09 VGX Pharmaceuticals LLC Isetzendem hormon (ghrh) aus muskelzellen durch speziesspezifisches signalpeptid
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7775087B2 (en) * 2004-03-16 2010-08-17 Northwestern University Microchannel forming method and nanotipped dispensing device having a microchannel
US20050209548A1 (en) * 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7729761B2 (en) * 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US20060111704A1 (en) * 2004-11-22 2006-05-25 Rox Medical, Inc. Devices, systems, and methods for energy assisted arterio-venous fistula creation
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
JP5826450B2 (ja) * 2005-07-22 2015-12-02 ザ ファウンドリー， エルエルシー 治療薬の送達のためのシステムおよび方法
US20070054048A1 (en) * 2005-09-07 2007-03-08 Suvi Haukka Extended deposition range by hot spots
US8058253B2 (en) 2006-07-06 2011-11-15 Vgx Pharmaceuticals, Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
US20090088827A1 (en) * 2007-10-02 2009-04-02 Cardiac Pacemakers, Inc Lead assembly providing sensing or stimulation of spaced-apart myocardial contact areas
EP2594311A3 (fr) * 2008-03-06 2013-07-10 Boston Scientific Scimed, Inc. Dispositifs de cathéter à ballonnet avec protection gainée
US8849395B2 (en) 2008-05-30 2014-09-30 Boston Scientific Scimed, Inc. Guide catheter having vasomodulating electrodes
US9597145B2 (en) * 2008-08-20 2017-03-21 Prostacare Pty Ltd Non-thermal ablation system for treating tissue
US20100125238A1 (en) * 2008-11-14 2010-05-20 Therawire, Inc. Iontophoretic Therapeutic Agent Delivery System
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8974445B2 (en) 2009-01-09 2015-03-10 Recor Medical, Inc. Methods and apparatus for treatment of cardiac valve insufficiency
US20120078163A1 (en) 2009-05-27 2012-03-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
WO2011028419A1 (fr) * 2009-08-27 2011-03-10 Boston Scientific Scimed, Inc. Dispositifs de cathéter à ballonnet présentant une gaine enrobée de médicament
CN107007348B (zh) 2010-10-25 2019-05-31 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
ITTO20110203A1 (it) * 2011-03-08 2012-09-09 Cesare Quarante Srl Unipersonale Gestione combinata e/o alternata di elettronica per elettroporazione e iontoforesi per ottimizzare la veicolazione transdermica.
ITCO20120004A1 (it) * 2012-02-07 2013-08-08 Giuseppe Caccia Apparecchio per elettroporazzione dinamica vaginale e anale
WO2013134548A2 (fr) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation ovarienne, systèmes et procédés associés
CA2865242A1 (fr) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg S.A.R.L. Echantillonnage de biomarqueurs dans le contexte de dispositifs de neuromodulation et systemes et procedes associes
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10918840B2 (en) 2014-05-06 2021-02-16 Hydra Vascular Llc Drug device electroporation system
US11337749B2 (en) 2015-10-07 2022-05-24 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
CA3029260A1 (fr) 2016-06-27 2018-01-04 Gala Therapeutics, Inc. Generateur et catheter pourvu d'une electrode et procede pour traiter une voie pulmonaire
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
US11035983B2 (en) 2016-09-26 2021-06-15 Verily Life Sciences Llc Cast-moldable, high refractive index, rigid, gas permeable polymer formulations for an accommodating contact lens
DE202018106744U1 (de) 2017-11-27 2019-05-13 Prostacare Pty Ltd Vorrichtung für die Behandlung einer Prostataerkrankung
WO2019168949A1 (fr) 2018-02-28 2019-09-06 Prostacare Pty Ltd Système de gestion des grandes variations d'impédance dans un système d'ablation non thermique pour hbp
WO2020209961A1 (fr) * 2019-04-08 2020-10-15 Udayan Patel Ballonnet gonflable sur cathéter avec passage de dérivation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE315982C (fr) *
US3680544A (en) * 1970-09-09 1972-08-01 James P Shinnick Transthoracic cannula-type device for cardiopulmonary resuscitation
SU1069826A1 (ru) * 1982-09-17 1984-01-30 Запорожский медицинский институт Эндотрахеальна трубка
US4709698A (en) * 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US5098843A (en) * 1987-06-04 1992-03-24 Calvin Noel M Apparatus for the high efficiency transformation of living cells
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
GB8813395D0 (en) * 1988-06-07 1988-07-13 Elliott T S J Medical devices
US5117828A (en) * 1989-09-25 1992-06-02 Arzco Medical Electronics, Inc. Expandable esophageal catheter
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
EP0533816B1 (fr) * 1990-06-15 1995-06-14 Cortrak Medical, Inc. Appareil d'acheminement de medicament
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
ATE149668T1 (de) * 1990-10-19 1997-03-15 Stork Protecon Langen Bv Vorrichtung zur behandlung von verteiltem oder körnigem material
WO1992007605A1 (fr) * 1990-11-05 1992-05-14 Ravi Xavier Catheter implantable a plusieurs electrodes servant a administrer un medicament
US5256141A (en) * 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus

Also Published As

Publication number Publication date
EP0740564B1 (fr) 2003-04-09
DE69530283D1 (de) 2003-05-15
CA2177655C (fr) 2001-09-25
US5507724A (en) 1996-04-16
EP0740564A1 (fr) 1996-11-06
AU1605295A (en) 1995-08-08
JPH09511385A (ja) 1997-11-18
DE69530283T2 (de) 2004-01-29
JP3223321B2 (ja) 2001-10-29
CA2177655A1 (fr) 1995-07-27
PT740564E (pt) 2003-08-29
WO1995019805A1 (fr) 1995-07-27
ES2196057T3 (es) 2003-12-16
ATE236681T1 (de) 2003-04-15

Similar Documents

Publication Publication Date Title
DK0740564T3 (da) Elektroporerings- og ionoforeseapparat til indføring af lægemidler og gener i celler
US6027488A (en) Flow-through electroporation system for ex vivo gene therapy
EP0788392B1 (fr) Therapie genique et chimique par electroporation au moyen de champs electriques induits
Haberl et al. Cell membrane electroporation-Part 2: the applications
CA2266347A1 (fr) Catheter d'electroporation et d'iontophorese comportant un ballonnet poreux
WO1996012006A3 (fr) Dispositif et procede d'electroporation a circulation
US5869326A (en) Electroporation employing user-configured pulsing scheme
US5304120A (en) Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
WO1989006555A1 (fr) Transport de molecules a travers les tissus par electroporation
US20020155611A1 (en) Method for treatment of an aqueous flux by electropulsation of a field parallel to the flow, pulsation chamber and uses thereof
SU1710071A1 (ru) Устройство дл электрофореза полых органов
JPS59135066A (ja) 腔内用誘電加熱電極構造体
JPS60119963A (ja) 温熱治療用生体内溜置アプリケ−タ装置