ES2196057T3 - Aparato de electroporacion e iontoforesis para la insercion de medicamentos y genes dentro de celulas. - Google Patents

Aparato de electroporacion e iontoforesis para la insercion de medicamentos y genes dentro de celulas.

Info

Publication number
ES2196057T3
ES2196057T3 ES95908090T ES95908090T ES2196057T3 ES 2196057 T3 ES2196057 T3 ES 2196057T3 ES 95908090 T ES95908090 T ES 95908090T ES 95908090 T ES95908090 T ES 95908090T ES 2196057 T3 ES2196057 T3 ES 2196057T3
Authority
ES
Spain
Prior art keywords
electrodes
cells
drugs
blood vessel
catheter device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95908090T
Other languages
English (en)
Inventor
Gunter A Hofmann
Lois J Crandell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ES2196057T3 publication Critical patent/ES2196057T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02—Dilators made of swellable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Electrotherapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN DISPOSITIVO DE CATETER QUE LLEVA UNA PLURALIDAD DE ELECTRODOS SEPARADOS CIRCUNFERENCIALMENTE, QUE SE EXTIENDEN AXIALMENTE, MEDIOS DE INFUSION PARA INFUNDIR UN MEDIO DE INFUSION PARA LLEVAR DROGAS Y GENES, Y MEDIOS DE SELLADO EXPANDIBLE EN CADA EXTREMO DEL ELECTRODO PARA SELLAR Y CONFINAR EL MEDIO TERAPEUTICO EN EL AREA A TRATAR SE INSERTA DENTRO DE UN VASO SANGUINEO SELECCIONADO DE UN PACIENTE Y SE AVANZA A UN LUGAR PRESELECCIONADO DENTRO DEL VASO SANGUINEO DONDE LAS CELULAS SOBRE O CERCA DE LA PARED DEL VASO HAN DE SER TRATADAS. UNA VEZ EN SU SITIO, EL DISPOSITIVO DE CATETER SE EXPANDE DE MANERA QUE LA PLURALIDAD DE ELECTRODO SEPARADOS CIRCUNFERENCIALMENTE, LLEVADOS Y QUE SE EXTIENDEN CIRCUNFERENCIALMENTE ESTAN EN CONTACTO CON LA PARED INTERNA DEL VASO SANGUINEO Y SELLA A CADA EXTREMO DE LOS ELECTRODOS QUE SE EXPANDEN Y SELLAN EL DISPOSITIVO DE CATETER EN EL LUGAR PRESELECCIONADO. UNA CANTIDAD DE GENES Y DROGAS TERAPEUTICAS SE INFUNDE DENTRO DEL AREA DE LOS ELECTRODOS POR UN TUBO Y UNABOMBA CONVENCIONAL. UNA BATERIA CONECTADA A LOS ELECTRODOS SE PONE BAJO TENSION SOMETIENDO LAS CELULAS A CAMPOS ELECTRICOS DE AMPLITUD Y DURACION PREDETERMINADA HACIENDO QUE LAS PAREDES DE LAS CELULAS ELASTICAMENTE PERMEABLES PERMITAN QUE LAS DROGAS Y GENERA TERAPEUTICOS LLEVADOS POR EL MEDIO FLUIDO ENTRE EN LAS CELULAS SIN MATARLAS.
ES95908090T 1994-01-21 1995-01-20 Aparato de electroporacion e iontoforesis para la insercion de medicamentos y genes dentro de celulas. Expired - Lifetime ES2196057T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/183,963 US5507724A (en) 1992-07-01 1994-01-21 Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells

Publications (1)

Publication Number Publication Date
ES2196057T3 true ES2196057T3 (es) 2003-12-16

Family

ID=22675037

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95908090T Expired - Lifetime ES2196057T3 (es) 1994-01-21 1995-01-20 Aparato de electroporacion e iontoforesis para la insercion de medicamentos y genes dentro de celulas.

Country Status (11)

Country Link
US (1) US5507724A (es)
EP (1) EP0740564B1 (es)
JP (1) JP3223321B2 (es)
AT (1) ATE236681T1 (es)
AU (1) AU1605295A (es)
CA (1) CA2177655C (es)
DE (1) DE69530283T2 (es)
DK (1) DK0740564T3 (es)
ES (1) ES2196057T3 (es)
PT (1) PT740564E (es)
WO (1) WO1995019805A1 (es)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4253493A (en) * 1992-05-21 1993-12-13 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Targeting gene expression to living tissue using jet injection
US5728068A (en) * 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5836905A (en) * 1994-06-20 1998-11-17 Lemelson; Jerome H. Apparatus and methods for gene therapy
US5810762A (en) * 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US5983131A (en) * 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
KR19990064209A (ko) * 1995-10-13 1999-07-26 트랜스바스큘라, 인코포레이티드 간질성 경혈관 개입을 위한 장치, 시스템 및 방법
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6747133B1 (en) 1995-12-08 2004-06-08 University Technologies International Inc. Antibodies against the tumor suppressor gene ING1
US6117633A (en) 1995-12-08 2000-09-12 University Technologies International Inc. DNA sequence encoding the tumor suppressor gene ING1
US6143522A (en) * 1995-12-08 2000-11-07 University Technologies International, Inc. Methods of modulating apoptosis
EP0780139A1 (en) * 1995-12-22 1997-06-25 PHYSION S.r.l. Device for the combined electropharmacological treatment of the bladder and the prostatic urethra
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5869326A (en) * 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5704908A (en) * 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US5999847A (en) * 1997-10-21 1999-12-07 Elstrom; John A. Apparatus and method for delivery of surgical and therapeutic agents
US6775569B2 (en) * 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
EP0993297A4 (en) * 1998-04-27 2009-05-06 Artemis Medical Inc EXPANSION AND SUPPORT DEVICE COMPRISING DISEASE INHIBITORS AND METHOD OF USE
US6450989B2 (en) * 1998-04-27 2002-09-17 Artemis Medical, Inc. Dilating and support apparatus with disease inhibitors and methods for use
US20100036481A1 (en) * 1998-04-27 2010-02-11 Artemis Medical, Inc. Cardiovascular Devices and Methods
US6347247B1 (en) 1998-05-08 2002-02-12 Genetronics Inc. Electrically induced vessel vasodilation
US8177743B2 (en) 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
US6206283B1 (en) 1998-12-23 2001-03-27 At&T Corp. Method and apparatus for transferring money via a telephone call
US6280411B1 (en) 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
AU760619B2 (en) * 1998-06-26 2003-05-22 Genetronics, Inc. Synergism of photodynamic and electropermeation effects on cell vitality as a novel cytotoxic agent
JP2003505114A (ja) 1998-07-13 2003-02-12 ジェネトロニクス、インコーポレーテッド パルス電場による皮膚および筋肉を標的とした遺伝子治療
US6302874B1 (en) 1998-07-13 2001-10-16 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6634364B2 (en) 2000-12-15 2003-10-21 Cardiac Pacemakers, Inc. Method of deploying a ventricular lead containing a hemostasis mechanism
US6240321B1 (en) 1998-08-12 2001-05-29 Cardiac Pacemakers, Inc. Expandable seal for use with medical device and system
NZ513404A (en) * 1999-02-10 2003-01-31 Gmp Drug Delivery Inc Iontophoresis, electroporation and combination patches for local drug delivery
US6593130B1 (en) 1999-04-16 2003-07-15 The Regents Of The University Of California Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy
WO2000067825A1 (en) * 1999-05-07 2000-11-16 Microheart, Inc. Apparatus and method for delivering therapeutic and diagnostic agents
ATE342089T1 (de) 1999-06-02 2006-11-15 Boston Scient Ltd Arzneimittelabgabevorrichtungen
US7147633B2 (en) * 1999-06-02 2006-12-12 Boston Scientific Scimed, Inc. Method and apparatus for treatment of atrial fibrillation
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
WO2001032088A2 (en) * 1999-11-05 2001-05-10 Microheart, Inc. Method and apparatus for demand injury in stimulating angiogenesis
US6748258B1 (en) * 1999-11-05 2004-06-08 Scimed Life Systems, Inc. Method and devices for heart treatment
US6676679B1 (en) 1999-11-05 2004-01-13 Boston Scientific Corporation Method and apparatus for recurrent demand injury in stimulating angiogenesis
AU2495801A (en) * 1999-12-22 2001-07-09 Innovation And Development Corporation Method and apparatus for targeting localised electroporation
CA2401239A1 (en) * 2000-03-03 2001-09-13 Valentis, Inc. Improved poloxamer and poloxamine compositions for nucleic acid delivery
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
WO2001070117A2 (en) * 2000-03-23 2001-09-27 Microheart, Inc. Pressure sensor for therapeutic delivery device and method
US7214223B2 (en) * 2000-03-24 2007-05-08 Boston Scientific Scimed, Inc. Photoatherolytic catheter apparatus and method
AU6475901A (en) 2000-05-22 2001-12-03 Merck And Company Inc System and method for assessing the performance of a pharmaceutical agent delivery system
US7588554B2 (en) 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
US6584362B1 (en) 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
US20040009940A1 (en) * 2000-10-20 2004-01-15 Coleman Michael E. Gene delivery formulations and methods for treatment of ischemic conditions
AU2002254212A1 (en) * 2001-03-12 2002-09-24 Irm, Llc Identification of cellular targets for biologically active molecules
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US6936469B2 (en) 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20030186390A1 (en) * 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
CN100417419C (zh) 2001-10-26 2008-09-10 贝勒医学院 改变个体的瘦体重和骨特性的组合物和方法
US7488313B2 (en) * 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
US20040219660A1 (en) * 2001-12-14 2004-11-04 Dev Sukhendu B. Electroporation-mediated intravascular delivery
US6740081B2 (en) * 2002-01-25 2004-05-25 Applied Medical Resources Corporation Electrosurgery with improved control apparatus and method
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US8131371B2 (en) * 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8145317B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
CA2495787A1 (en) * 2002-05-01 2003-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
AU2003299471A1 (en) 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20040034336A1 (en) * 2002-08-08 2004-02-19 Neal Scott Charged liposomes/micelles with encapsulted medical compounds
US7517342B2 (en) * 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
US7361642B2 (en) 2003-08-04 2008-04-22 Vgx Pharmaceuticals, Inc. Canine specific growth hormone releasing hormone
US7330851B2 (en) * 2003-08-18 2008-02-12 Eaglehawk, Limited Data security through dissembly of data elements or connections between elements
EP1711187B1 (en) 2003-12-31 2010-05-12 VGX Pharmaceuticals, LLC Reducing arthritis and lameness in subjects by growth hormone releasing hormone (ghrh) supplementation
ATE507239T1 (de) 2004-01-20 2011-05-15 VGX Pharmaceuticals LLC Erhöhte sekretion/retention von wachstumshormonfreisetzendem hormon (ghrh) aus muskelzellen durch speziesspezifisches signalpeptid
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7775087B2 (en) * 2004-03-16 2010-08-17 Northwestern University Microchannel forming method and nanotipped dispensing device having a microchannel
US20050209548A1 (en) * 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7729761B2 (en) * 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US20060111704A1 (en) * 2004-11-22 2006-05-25 Rox Medical, Inc. Devices, systems, and methods for energy assisted arterio-venous fistula creation
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7608275B2 (en) 2005-07-22 2009-10-27 The Foundry, Llc Systems and methods for delivery of a therapeutic agent
US20070054048A1 (en) * 2005-09-07 2007-03-08 Suvi Haukka Extended deposition range by hot spots
US8058253B2 (en) 2006-07-06 2011-11-15 Vgx Pharmaceuticals, Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
US20090088827A1 (en) * 2007-10-02 2009-04-02 Cardiac Pacemakers, Inc Lead assembly providing sensing or stimulation of spaced-apart myocardial contact areas
WO2009111709A2 (en) * 2008-03-06 2009-09-11 Boston Scientific Scimed, Inc. Balloon catheter devices with solvent-swellable polymer
US8849395B2 (en) 2008-05-30 2014-09-30 Boston Scientific Scimed, Inc. Guide catheter having vasomodulating electrodes
US9597145B2 (en) 2008-08-20 2017-03-21 Prostacare Pty Ltd Non-thermal ablation system for treating tissue
US20100125238A1 (en) * 2008-11-14 2010-05-20 Therawire, Inc. Iontophoretic Therapeutic Agent Delivery System
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
EP2376011B1 (en) 2009-01-09 2019-07-03 ReCor Medical, Inc. Apparatus for treatment of mitral valve insufficiency
WO2010137021A2 (en) 2009-05-27 2010-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method of generating connective tissue
US20110054396A1 (en) * 2009-08-27 2011-03-03 Boston Scientific Scimed, Inc. Balloon Catheter Devices With Drug-Coated Sheath
CN103313671B (zh) 2010-10-25 2017-06-06 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
ITTO20110203A1 (it) * 2011-03-08 2012-09-09 Cesare Quarante Srl Unipersonale Gestione combinata e/o alternata di elettronica per elettroporazione e iontoforesi per ottimizzare la veicolazione transdermica.
ITCO20120004A1 (it) * 2012-02-07 2013-08-08 Giuseppe Caccia Apparecchio per elettroporazzione dinamica vaginale e anale
WO2013134548A2 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
JP6195856B2 (ja) 2012-03-08 2017-09-13 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10918840B2 (en) 2014-05-06 2021-02-16 Hydra Vascular Llc Drug device electroporation system
WO2017062753A1 (en) 2015-10-07 2017-04-13 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
JP7287888B2 (ja) 2016-06-27 2023-06-06 ギャラリー，インコーポレイテッド ジェネレータ、電極付きのカテーテル、及び肺通路の治療方法
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
US11035983B2 (en) 2016-09-26 2021-06-15 Verily Life Sciences Llc Cast-moldable, high refractive index, rigid, gas permeable polymer formulations for an accommodating contact lens
DE202018106744U1 (de) 2017-11-27 2019-05-13 Prostacare Pty Ltd Vorrichtung für die Behandlung einer Prostataerkrankung
US11224474B2 (en) 2018-02-28 2022-01-18 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for BPH
WO2020209961A1 (en) * 2019-04-08 2020-10-15 Udayan Patel Inflatable balloon over catheter with bypass passageway

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE315982C (es) *
US3680544A (en) * 1970-09-09 1972-08-01 James P Shinnick Transthoracic cannula-type device for cardiopulmonary resuscitation
SU1069826A1 (ru) * 1982-09-17 1984-01-30 Запорожский медицинский институт Эндотрахеальна трубка
US4709698A (en) * 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US5098843A (en) * 1987-06-04 1992-03-24 Calvin Noel M Apparatus for the high efficiency transformation of living cells
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
GB8813395D0 (en) * 1988-06-07 1988-07-13 Elliott T S J Medical devices
US5117828A (en) * 1989-09-25 1992-06-02 Arzco Medical Electronics, Inc. Expandable esophageal catheter
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
DE69110467T2 (de) * 1990-06-15 1996-02-01 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
EP0481799B1 (en) * 1990-10-19 1997-03-05 Stork Protecon-Langen B.V. Apparatus for conditioning divided or particulate material
WO1992007605A1 (en) * 1990-11-05 1992-05-14 Ravi Xavier Implantable drug dispensing multielectrode catheter
US5256141A (en) * 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus

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US5507724A (en) 1996-04-16
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DE69530283D1 (de) 2003-05-15
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AU1605295A (en) 1995-08-08
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PT740564E (pt) 2003-08-29
DK0740564T3 (da) 2003-07-28
CA2177655A1 (en) 1995-07-27
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EP0740564A1 (en) 1996-11-06

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