DK0734386T3 - Blodpladeaktiveringsfaktor-antagonister:imidazopyridin-indoler - Google Patents
Blodpladeaktiveringsfaktor-antagonister:imidazopyridin-indolerInfo
- Publication number
- DK0734386T3 DK0734386T3 DK95904287T DK95904287T DK0734386T3 DK 0734386 T3 DK0734386 T3 DK 0734386T3 DK 95904287 T DK95904287 T DK 95904287T DK 95904287 T DK95904287 T DK 95904287T DK 0734386 T3 DK0734386 T3 DK 0734386T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazopyridine
- indoles
- activating factor
- platelet activating
- paf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16856493A | 1993-12-16 | 1993-12-16 | |
US32463194A | 1994-10-18 | 1994-10-18 | |
US08/347,528 US5486525A (en) | 1993-12-16 | 1994-12-05 | Platelet activating factor antagonists: imidazopyridine indoles |
PCT/US1994/014112 WO1995016687A1 (en) | 1993-12-16 | 1994-12-08 | Platelet activating factor antagonists: imidazopyridine indoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0734386T3 true DK0734386T3 (da) | 2002-05-27 |
Family
ID=27389538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95904287T DK0734386T3 (da) | 1993-12-16 | 1994-12-08 | Blodpladeaktiveringsfaktor-antagonister:imidazopyridin-indoler |
Country Status (13)
Country | Link |
---|---|
US (1) | US5486525A (da) |
EP (1) | EP0734386B1 (da) |
JP (1) | JPH09507474A (da) |
KR (1) | KR960706494A (da) |
AT (1) | ATE212992T1 (da) |
AU (1) | AU690620B2 (da) |
CA (1) | CA2176247A1 (da) |
DE (1) | DE69429827T2 (da) |
DK (1) | DK0734386T3 (da) |
ES (1) | ES2173171T3 (da) |
IL (1) | IL111963A0 (da) |
PT (1) | PT734386E (da) |
WO (1) | WO1995016687A1 (da) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2990042B2 (ja) | 1994-06-06 | 1999-12-13 | 吉富製薬株式会社 | 新規縮合環カルボン酸誘導体またはその塩、およびその医薬用途 |
US5753664A (en) * | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
US5567711A (en) * | 1995-04-19 | 1996-10-22 | Abbott Laboratories | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
GB9508748D0 (en) * | 1995-04-28 | 1995-06-14 | British Biotech Pharm | Benzimidazole derivatives |
US5633388A (en) * | 1996-03-29 | 1997-05-27 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
AU4400597A (en) * | 1996-10-08 | 1998-05-05 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives |
US5811425A (en) * | 1997-03-04 | 1998-09-22 | Abbott Laboratories | Heterocyclic compounds as COX-2 inhibitors |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
TW526202B (en) * | 1998-11-27 | 2003-04-01 | Shionogi & Amp Co | Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity |
WO2001012600A1 (en) * | 1999-08-12 | 2001-02-22 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
AU7962200A (en) * | 1999-10-29 | 2001-05-14 | Wakunaga Pharmaceutical Co., Ltd | Novel indole derivatives and drugs containing the same as the active ingredient |
US7067539B2 (en) * | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
US7507767B2 (en) * | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
TW200302088A (en) * | 2001-11-14 | 2003-08-01 | Schering Corp | Cannabinoid receptor ligands |
US7528165B2 (en) * | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
US7632955B2 (en) * | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
US6933316B2 (en) * | 2001-12-13 | 2005-08-23 | National Health Research Institutes | Indole compounds |
CN100503608C (zh) * | 2002-01-07 | 2009-06-24 | 卫材R&D管理株式会社 | 脱氮嘌呤及其用途 |
SE0201635D0 (sv) * | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
TW200307542A (en) * | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
CN1662496A (zh) | 2002-06-19 | 2005-08-31 | 先灵公司 | 大麻素受体激动剂 |
US6906096B2 (en) * | 2002-06-28 | 2005-06-14 | Irm Llc | 4,7-Disubstituted indoles and methods of making |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
TW200505902A (en) * | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
SE0301569D0 (sv) * | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
SE0302232D0 (sv) * | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
US20070232681A1 (en) * | 2003-10-14 | 2007-10-04 | Oxagen Limited | Compounds Having Crth2 Antagonist Activity |
SE0303180D0 (sv) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
US20050222198A1 (en) * | 2003-12-22 | 2005-10-06 | K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
JP5014129B2 (ja) * | 2004-07-27 | 2012-08-29 | ギリアード サイエンシーズ, インコーポレイテッド | イミダゾ[4,5−d]ピリミジン、それらの使用および調製方法 |
EP1841765B1 (en) * | 2004-12-21 | 2009-03-25 | Gilead Sciences, Inc. | Imidazo[4,5-c]pyridine compound and method of antiviral treatment |
US7456289B2 (en) * | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
GB0500604D0 (en) * | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
RS52010B (en) * | 2005-06-22 | 2012-04-30 | Plexxikon Inc. | DERIVATI PIROLO [2, 3-B] PIRIDINA KAO INHIBITORI PROTEIN KINAZE |
AU2007206016A1 (en) | 2006-01-13 | 2007-07-26 | Wyeth | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors |
CN101454284A (zh) * | 2006-05-26 | 2009-06-10 | 阿斯利康(瑞典)有限公司 | 联芳基或芳基-杂芳基取代的吲哚类化合物 |
US7754720B2 (en) * | 2006-07-07 | 2010-07-13 | Gilead Sciences, Inc. | Pyridazine compound and use thereof |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
EP2414356B1 (en) * | 2009-04-03 | 2015-09-02 | F.Hoffmann-La Roche Ag | Propane-i-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
MX2012004990A (es) | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
CN106220623A (zh) | 2009-11-06 | 2016-12-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
CN103201262B (zh) | 2010-08-20 | 2016-06-01 | 艾米拉医药股份有限公司 | 自分泌运动因子抑制剂及其用途 |
EA028821B9 (ru) | 2011-02-07 | 2018-10-31 | Плексксикон, Инк. | Соединения и способы для модуляции киназ, а также показания к их применению |
AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
WO2012166415A1 (en) | 2011-05-27 | 2012-12-06 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
WO2013000924A1 (en) | 2011-06-27 | 2013-01-03 | Janssen Pharmaceutica Nv | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
US9669035B2 (en) | 2012-06-26 | 2017-06-06 | Janssen Pharmaceutica Nv | Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders |
RU2667058C2 (ru) | 2012-07-09 | 2018-09-14 | Янссен Фармацевтика Нв | Ингибиторы фермента фосфодиэстеразы 10 |
JP2016145155A (ja) * | 2013-04-30 | 2016-08-12 | 日本農薬株式会社 | フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法 |
GB201321735D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
US10919875B2 (en) | 2015-06-18 | 2021-02-16 | 89Bio Ltd | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
AU2016280255A1 (en) | 2015-06-18 | 2018-02-08 | Cephalon, Inc. | 1, 4-substituted piperidine derivatives |
US10392358B2 (en) * | 2015-09-17 | 2019-08-27 | Micromidas, Inc. | Oxidation chemistry on furan aldehydes |
US11634408B2 (en) | 2018-04-05 | 2023-04-25 | Beth Israel Deaconess Medical Center, Inc. | Aryl hydrocarbon receptor modulators and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH574441A5 (da) * | 1973-06-14 | 1976-04-15 | Ciba Geigy Ag | |
DE3200705A1 (de) * | 1982-01-13 | 1983-07-21 | Agfa-Gevaert Ag, 5090 Leverkusen | Farbfotografisches aufzeichnungsmaterial |
PH23498A (en) * | 1984-08-06 | 1989-08-16 | Sterling Drug Inc | 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof |
US5068234A (en) * | 1990-02-26 | 1991-11-26 | Sterling Drug Inc. | 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles |
US5120749A (en) * | 1991-02-20 | 1992-06-09 | Abbott Laboratories | Platelet activating antagonists |
EP0595924B1 (en) * | 1991-07-17 | 1999-04-14 | Abbott Laboratories | Platelet activating factor antagonists |
-
1994
- 1994-12-05 US US08/347,528 patent/US5486525A/en not_active Expired - Fee Related
- 1994-12-08 DK DK95904287T patent/DK0734386T3/da active
- 1994-12-08 ES ES95904287T patent/ES2173171T3/es not_active Expired - Lifetime
- 1994-12-08 CA CA002176247A patent/CA2176247A1/en not_active Abandoned
- 1994-12-08 AU AU13036/95A patent/AU690620B2/en not_active Ceased
- 1994-12-08 AT AT95904287T patent/ATE212992T1/de not_active IP Right Cessation
- 1994-12-08 JP JP7516840A patent/JPH09507474A/ja not_active Withdrawn
- 1994-12-08 DE DE69429827T patent/DE69429827T2/de not_active Expired - Fee Related
- 1994-12-08 EP EP95904287A patent/EP0734386B1/en not_active Expired - Lifetime
- 1994-12-08 PT PT95904287T patent/PT734386E/pt unknown
- 1994-12-08 KR KR1019960703166A patent/KR960706494A/ko not_active Application Discontinuation
- 1994-12-08 WO PCT/US1994/014112 patent/WO1995016687A1/en active IP Right Grant
- 1994-12-12 IL IL11196394A patent/IL111963A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69429827D1 (de) | 2002-03-21 |
JPH09507474A (ja) | 1997-07-29 |
WO1995016687A1 (en) | 1995-06-22 |
EP0734386A1 (en) | 1996-10-02 |
DE69429827T2 (de) | 2002-11-21 |
IL111963A0 (en) | 1995-03-15 |
AU1303695A (en) | 1995-07-03 |
ATE212992T1 (de) | 2002-02-15 |
AU690620B2 (en) | 1998-04-30 |
EP0734386B1 (en) | 2002-02-06 |
KR960706494A (ko) | 1996-12-09 |
CA2176247A1 (en) | 1995-06-22 |
PT734386E (pt) | 2002-07-31 |
US5486525A (en) | 1996-01-23 |
ES2173171T3 (es) | 2002-10-16 |
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