ATE212992T1 - Plättchen aktivierender faktor (paf)-antagonist: imidazopyridin - indole - Google Patents

Plättchen aktivierender faktor (paf)-antagonist: imidazopyridin - indole

Info

Publication number
ATE212992T1
ATE212992T1 AT95904287T AT95904287T ATE212992T1 AT E212992 T1 ATE212992 T1 AT E212992T1 AT 95904287 T AT95904287 T AT 95904287T AT 95904287 T AT95904287 T AT 95904287T AT E212992 T1 ATE212992 T1 AT E212992T1
Authority
AT
Austria
Prior art keywords
paf
platele
imidazopyridine
indole
antagonist
Prior art date
Application number
AT95904287T
Other languages
English (en)
Inventor
James B Summers Jr
Steven K Davidsen
Michael L Curtin
H Robin Heyman
George S Sheppard
Lianhong Xu
George M Carrera Jr
Robert B Garland
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE212992T1 publication Critical patent/ATE212992T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95904287T 1993-12-16 1994-12-08 Plättchen aktivierender faktor (paf)-antagonist: imidazopyridin - indole ATE212992T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16856493A 1993-12-16 1993-12-16
US32463194A 1994-10-18 1994-10-18
US08/347,528 US5486525A (en) 1993-12-16 1994-12-05 Platelet activating factor antagonists: imidazopyridine indoles
PCT/US1994/014112 WO1995016687A1 (en) 1993-12-16 1994-12-08 Platelet activating factor antagonists: imidazopyridine indoles

Publications (1)

Publication Number Publication Date
ATE212992T1 true ATE212992T1 (de) 2002-02-15

Family

ID=27389538

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95904287T ATE212992T1 (de) 1993-12-16 1994-12-08 Plättchen aktivierender faktor (paf)-antagonist: imidazopyridin - indole

Country Status (13)

Country Link
US (1) US5486525A (de)
EP (1) EP0734386B1 (de)
JP (1) JPH09507474A (de)
KR (1) KR960706494A (de)
AT (1) ATE212992T1 (de)
AU (1) AU690620B2 (de)
CA (1) CA2176247A1 (de)
DE (1) DE69429827T2 (de)
DK (1) DK0734386T3 (de)
ES (1) ES2173171T3 (de)
IL (1) IL111963A0 (de)
PT (1) PT734386E (de)
WO (1) WO1995016687A1 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2990042B2 (ja) 1994-06-06 1999-12-13 吉富製薬株式会社 新規縮合環カルボン酸誘導体またはその塩、およびその医薬用途
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
US5633388A (en) * 1996-03-29 1997-05-27 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
AU4400597A (en) * 1996-10-08 1998-05-05 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives
US5811425A (en) * 1997-03-04 1998-09-22 Abbott Laboratories Heterocyclic compounds as COX-2 inhibitors
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
WO2001012600A1 (en) * 1999-08-12 2001-02-22 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
WO2001032621A1 (fr) * 1999-10-29 2001-05-10 Wakunaga Pharmaceutical Co., Ltd. Nouveaux derives d'indole, et medicaments contenant lesdits derives comme principe actif
US7067539B2 (en) * 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
US7507767B2 (en) * 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
US7071213B2 (en) * 2001-11-14 2006-07-04 Schering Corporation Cannabinoid receptor ligands
US7632955B2 (en) * 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) * 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
TWI317634B (en) * 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
ATE327236T1 (de) * 2002-01-07 2006-06-15 Eisai Co Ltd Desazapurine und deren verwendung
SE0201635D0 (sv) * 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) * 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
MXPA04012704A (es) 2002-06-19 2005-03-23 Schering Corp Agonistas de los receptores canabinoides.
US6906096B2 (en) * 2002-06-28 2005-06-14 Irm Llc 4,7-Disubstituted indoles and methods of making
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
TW200505902A (en) * 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
SE0301569D0 (sv) * 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) * 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
AU2004283139A1 (en) * 2003-10-14 2005-05-06 Oxagen Limited Compounds having CRTH2 antagonist activity
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
DK2161273T3 (en) * 2003-12-22 2015-07-20 Leuven K U Res & Dev Imidazo [4,5-C] pyridine compounds and methods for antiviral therapy
US20090208456A1 (en) * 2004-07-27 2009-08-20 Gilead Sciences, Inc. Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
PT1841765E (pt) * 2004-12-21 2009-05-14 Gilead Sciences Inc Anticorpos para mcp-1 humano
US7456289B2 (en) * 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
GB0500604D0 (en) * 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
US7863288B2 (en) * 2005-06-22 2011-01-04 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
WO2007084841A2 (en) 2006-01-13 2007-07-26 Wyeth Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors
EP2125722A2 (de) * 2006-05-26 2009-12-02 AstraZeneca AB Biaryl- oder arylheteroaryl-substituierte indole
DK2038275T3 (da) * 2006-07-07 2010-05-10 Gilead Sciences Inc Ny pyridazinforbindelse og anvendelse heraf
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
NZ582772A (en) 2007-07-17 2012-06-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
EA031116B1 (ru) * 2009-04-03 2018-11-30 Ф. Хоффманн-Ля Рош Аг КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
BR112012010041A2 (pt) 2009-10-30 2016-05-24 Janssen Pharmaceutica Nv derivados de imidazo [1,2-b] piridazina e seu uso como inibidores de pde10
UA105813C2 (uk) 2009-11-06 2014-06-25 Плексікон, Інк. Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти)
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
ES2646834T3 (es) 2010-08-20 2017-12-18 Amira Pharmaceuticals, Inc. Inhibidores de autotaxina y usos de los mismos
EP2672967B1 (de) 2011-02-07 2018-10-17 Plexxikon Inc. Verbindungen und verfahren zur kinase-modulation und anzeigen dafür
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP2714680B1 (de) 2011-05-27 2015-11-25 Amira Pharmaceuticals, Inc. Heterocyclische autotaxin-inhibitoren und ihre verwendungen
CN103619846B (zh) 2011-06-27 2016-08-17 詹森药业有限公司 1-芳基-4-甲基-[1,2,4]三唑[4,3-a]喹喔啉衍生物
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US9669035B2 (en) 2012-06-26 2017-06-06 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders
MX362197B (es) 2012-07-09 2019-01-08 Janssen Pharmaceutica Nv Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos.
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
GB201321735D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
EP3310773B1 (de) 2015-06-18 2020-12-02 89Bio Ltd. Substituierte 4-benzyl-und 4-benzoylpiperidinderivate
CA3014554A1 (en) 2015-06-18 2016-12-22 Cephalon, Inc. 1,4-substituted piperidine derivative for treating a disorder mediated by fatty acid synthase
US10392358B2 (en) * 2015-09-17 2019-08-27 Micromidas, Inc. Oxidation chemistry on furan aldehydes
WO2019195682A1 (en) 2018-04-05 2019-10-10 Beth Israel Deaconess Medical Center, Inc. Aryl hydrocarbon receptor modulators and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH574441A5 (de) * 1973-06-14 1976-04-15 Ciba Geigy Ag
DE3200705A1 (de) * 1982-01-13 1983-07-21 Agfa-Gevaert Ag, 5090 Leverkusen Farbfotografisches aufzeichnungsmaterial
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
IL102494A0 (en) * 1991-07-17 1993-01-14 Abbott Lab Platelet activating factor antagonists

Also Published As

Publication number Publication date
ES2173171T3 (es) 2002-10-16
DK0734386T3 (da) 2002-05-27
EP0734386B1 (de) 2002-02-06
AU690620B2 (en) 1998-04-30
DE69429827D1 (de) 2002-03-21
KR960706494A (ko) 1996-12-09
EP0734386A1 (de) 1996-10-02
IL111963A0 (en) 1995-03-15
PT734386E (pt) 2002-07-31
US5486525A (en) 1996-01-23
AU1303695A (en) 1995-07-03
DE69429827T2 (de) 2002-11-21
CA2176247A1 (en) 1995-06-22
JPH09507474A (ja) 1997-07-29
WO1995016687A1 (en) 1995-06-22

Similar Documents

Publication Publication Date Title
ATE212992T1 (de) Plättchen aktivierender faktor (paf)-antagonist: imidazopyridin - indole
IL117723A0 (en) Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
CA2434277A1 (en) Substituted alkylamine derivatives and methods of use
CA2534571A1 (en) Substituted isoquinoline derivatives and methods of use
YU90901A (sh) Biciklični heterocikli, lekovi koji sadrže ta jedinjenja, njihova primena i postupci za njihovo pripremanje
DE60128258D1 (de) Indanylderivate zur Behandlung von Atemwegserkrankungen
ME02777B (de) Chinazolinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
MXPA03005464A (es) Agentes antivirales.
CA2498047A1 (en) Novel imidazole compounds as transforming growth factor (tgf) inhibitors
RU2005134230A (ru) Ацилированные производные спиропиперидина как агонисты рецептора меланокортина-4
MY110108A (en) Imidazolyl or imidazolylalkyl substituted with a four or five membered nitrigen containing heterocyclic ring
EP2165708A3 (de) Neue Pyrazol-Verbindungen als Hemmer des transformierenden Wachstumsfaktors (TGF)
CA2386799A1 (en) Fused cycloheptane and fused azacycloheptane compounds and their as integrin receptor antagonists
SI0773943T1 (en) Compounds useful as antiproliferative agents and garft inhibitors
NO962855D0 (no) Nye piperidin-derivater med PAF-antagonist-aktivitet
DK0984019T3 (da) C11-carbamater fra antibakterielle macrolider
ES2090081T3 (es) Derivados de indolocarbazol, procedimientos para su obtencion y su empleo.
CA2264005A1 (en) Piperazino derivatives as neurokinin antagonists
CA2218887A1 (en) Piperazino derivatives as neurokinin antagonists
ATE178796T1 (de) Antagonisten des plättchen aktivierenden faktors
CA2436537A1 (en) Pharmaceutical compositions comprising tiotropium salts and antihistamines
MX9207216A (es) Aductos de etanol de 3-hidroxicromanos 6-sulfonil sustituidos y su empleo como agentes de inhalacion de enfermedades.
EP0244088A3 (de) 1-Phenyl-3-benzazepin-Verbindungen und diese enthaltende Arzneimittel zur Behandlung von Störungen des gastrointestinalen Bewegungsvermögens
BG105080A (en) Substituted beta-diketones and their use
RU93004405A (ru) Производные хинолон- и нафтиридонкарбоновой кислоты в виде смеси изомеров или отдельных изомеров, их гидраты и соли, способ их получения и содержащее их лекарственное средство

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee