DK0730587T3 - 3-phenyl-2-isoxazoliner som anti-inflammatoriske midler - Google Patents

3-phenyl-2-isoxazoliner som anti-inflammatoriske midler

Info

Publication number
DK0730587T3
DK0730587T3 DK94927778T DK94927778T DK0730587T3 DK 0730587 T3 DK0730587 T3 DK 0730587T3 DK 94927778 T DK94927778 T DK 94927778T DK 94927778 T DK94927778 T DK 94927778T DK 0730587 T3 DK0730587 T3 DK 0730587T3
Authority
DK
Denmark
Prior art keywords
pct
date
isoxazolines
sec
aryl
Prior art date
Application number
DK94927778T
Other languages
Danish (da)
English (en)
Inventor
Edward F Kleinman
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0730587T3 publication Critical patent/DK0730587T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
DK94927778T 1993-11-26 1994-10-12 3-phenyl-2-isoxazoliner som anti-inflammatoriske midler DK0730587T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15724193A 1993-11-26 1993-11-26
PCT/IB1994/000313 WO1995014680A1 (fr) 1993-11-26 1994-10-12 3-aryl-2-isoxazolines utiles comme agents anti-inflammatoires

Publications (1)

Publication Number Publication Date
DK0730587T3 true DK0730587T3 (da) 2000-04-10

Family

ID=22562909

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94927778T DK0730587T3 (da) 1993-11-26 1994-10-12 3-phenyl-2-isoxazoliner som anti-inflammatoriske midler

Country Status (12)

Country Link
US (1) US5686434A (fr)
EP (1) EP0730587B1 (fr)
JP (1) JP2818820B2 (fr)
AT (1) ATE187447T1 (fr)
CA (1) CA2177375A1 (fr)
DE (1) DE69422061T2 (fr)
DK (1) DK0730587T3 (fr)
ES (1) ES2139754T3 (fr)
FI (1) FI945556A (fr)
GR (1) GR3032506T3 (fr)
PT (1) PT730587E (fr)
WO (1) WO1995014680A1 (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT920421E (pt) * 1996-08-21 2003-03-31 Upjohn Co Derivados de isoxazolina uteis como agentes antimicrobianos
WO1998021209A1 (fr) * 1996-11-11 1998-05-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouvelles imidazopyridines et oxazolopyridines
DE59808163D1 (de) * 1997-01-17 2003-06-05 Basf Ag Verfahren zur herstellung von schwefelhaltigen 2-chlor-3-(4,5-dihydroisoxazol-3-yl)-benzoesäuren
US6022977A (en) * 1997-03-26 2000-02-08 Dupont Pharmaceuticals Company Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
WO1999041244A1 (fr) * 1998-02-13 1999-08-19 Pharmacia & Upjohn Company Derives d'isoxazoline aminophenyle substitues utilises comme agents antimicrobiens
NZ508648A (en) * 1998-05-11 2003-09-26 Basf Ag Method for producing isoxazoline-3-yl-acyl benzene
DE19852095A1 (de) 1998-11-12 2000-05-18 Basf Ag Verfahren zur Herstellung von 2-Alkyl-3-(4,5-dihydroisoxazol-3-yl)-acylbenzolen
CA2346396C (fr) 1998-10-09 2009-04-28 Janssen Pharmaceutica N.V. Derives de 4-5-dihydro-isoxazole et leur utilisation pharmaceutique
IL147688A0 (en) 1999-08-21 2002-08-14 Byk Gulden Lomberg Chem Fab Synergistic combination
KR100399361B1 (ko) 1999-11-04 2003-09-26 주식회사 엘지생명과학 캐스파제 억제제 함유 치료제 조성물
CA2388564C (fr) * 1999-09-17 2007-11-06 Lg Chem Investment Ltd. Inhibiteur de caspases
DE19953024A1 (de) * 1999-11-04 2001-05-10 Merck Patent Gmbh Isoxazolderivate als Phosphodiesterase VII-Hemmer
EP1554572B1 (fr) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BRPI0409229A (pt) 2003-04-01 2006-03-28 Applied Research Systems inibidores das fosfodiesterases na infertilidade
KR100594544B1 (ko) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 이소옥사졸린 구조를 갖는 캐스파제 저해제
AR045536A1 (es) 2003-08-29 2005-11-02 Ranbaxy Lab Ltd Inhibidores de la fosfodiesterasa tipo -iv
US20070259874A1 (en) * 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
US20050250826A1 (en) * 2004-03-26 2005-11-10 Thais Sielecki-Dzurdz Compounds, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
PT1768966E (pt) * 2004-06-17 2012-05-23 Infinity Discovery Inc Compostos e métodos para inibir a interacção de proteínas bcl com parceiros de ligação
ES2370788T3 (es) * 2005-02-07 2011-12-22 Aerocrine Ab Controlar flujo de aliento exhalado durante análisis.
JP5336175B2 (ja) * 2005-03-15 2013-11-06 ガニアル・イミュノセラピューティクス・インコーポレーテッド 免疫調整剤活性を有する化合物
EP2671508B1 (fr) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Système pharma-informatique
EP2275095A3 (fr) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese par modulation des recepteurs muscariniques
EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
WO2007029077A1 (fr) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Indazoles substitues utilises en tant qu'inhibiteurs de phosphodiesterase de type-iv
AU2006305620A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
EP2377530A3 (fr) 2005-10-21 2012-06-20 Braincells, Inc. Modulation de neurogénèse par inhibition PDE
EP2314289A1 (fr) 2005-10-31 2011-04-27 Braincells, Inc. Modulation de la neurogenese dont la médiation est assurée par récepteur gaba
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenese induite par le recepteur 5ht
WO2007134136A2 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenèse par modulation de l'angiotensine
JP2010502722A (ja) * 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
EP2063905B1 (fr) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2066661A2 (fr) * 2006-09-22 2009-06-10 Ranbaxy Laboratories Limited Inhibiteurs de phosphodiesterase
KR20090069309A (ko) * 2006-09-22 2009-06-30 랜박시 래보러터리스 리미티드 포스포디에스터라제 타입-ⅳ의 저해제
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951B1 (fr) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
CA2969926C (fr) 2009-02-20 2018-05-15 2-Bbb Medicines B.V. Systeme d'administration de medicament a base de glutathionne
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
EP4218718A3 (fr) 2009-05-06 2024-04-24 Laboratory Skin Care, Inc. Compositions pour libération dermique comprenant des complexes principe actif-particule de phosphate de calcium et procédés d'utilisation associés
CN101781294B (zh) * 2010-03-10 2012-02-01 天津药物研究院 一类咪唑的衍生物、其制备方法和用途
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
CA2831704C (fr) 2011-03-31 2019-10-01 Bayer Intellectual Property Gmbh 3-phneylisoxazoline-5-carboxamides et 3-phenylisoxazoline-5-thioamides actifs comme herbicides et fongicides
WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
JP6285937B2 (ja) * 2012-09-25 2018-02-28 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 除草性および殺真菌性の５−オキシ置換３−フェニルイソオキサゾリン−５−カルボキサミドおよび５−オキシ置換３−フェニルイソオキサゾリン−５−チオアミド
ES2747483T3 (es) * 2012-09-25 2020-03-10 Bayer Cropscience Ag Derivados de 3-fenilisoxazolina con acción herbicida
EP3718557A3 (fr) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Agoniste du récepteur de la guanylate cyclase sp-333 à utiliser lors du nettoyage du côlon
WO2014151200A2 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
CA2905438A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
EP3030252B1 (fr) 2013-08-09 2018-11-07 Ardelyx, Inc. Composés et procédés d'inhibition du transport de phosphate
US11613522B2 (en) 2017-06-13 2023-03-28 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of tetrahydro- and dihydrofurancarboxamides
US11597724B2 (en) 2017-06-13 2023-03-07 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of tetrahydro and dihydrofuran carboxylic acids and esters
WO2019034602A1 (fr) 2017-08-17 2019-02-21 Bayer Aktiengesellschaft 3-phényl-5-trifluorométhylisoxazoline-5-carboxamides d'acides carboxyliques et d'esters de cyclopentyle efficaces en tant qu'herbicides
DK3743411T3 (da) 2018-01-25 2023-02-13 Bayer Ag Herbicidt virksomt 3-phenylisoxazolin-5-carboxamider af cyclopentenylcarbonsyrederivater
BR112021017924A2 (pt) 2019-03-12 2021-11-16 Bayer Ag 3-fenilisoxazolina-5-carboxamidas herbicidamente ativas de ésteres de ácido ciclopentenil- carboxílico contendo s
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
JPS62103070A (ja) * 1985-10-29 1987-05-13 Mitsui Toatsu Chem Inc イソオキサゾリン誘導体および植物生長調節剤
US4912120A (en) * 1986-03-14 1990-03-27 Syntex (U.S.A.) Inc. 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors
HU215433B (hu) * 1986-04-29 2000-05-28 Pfizer Inc. Eljárás új 2-oxo-5-fenil-pirimidin-származékok előállítására
ZA872997B (en) * 1986-05-09 1988-12-28 Warner Lambert Co Novel styryl pyrazoles,isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors,pharmaceutical compositions and methods of use therefor
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
DE3736113A1 (de) * 1987-10-26 1989-05-03 Hoechst Ag Arzneimittel, darin enthaltene phosphorhaltige 2-isoxazoline und isoxazole, sowie herstellungsverfahren fuer diese heterocyclischen verbindungen
US4952700A (en) * 1988-04-25 1990-08-28 W.R. Grace & Co.-Conn. Preparation of isoxazolines and isoxazoles
US4933464A (en) * 1988-04-25 1990-06-12 W. R. Grace & Co.-Conn. Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles
CA2017383A1 (fr) * 1989-06-08 1990-12-08 Raymond R. Martodam Utilisation de vanilloides pour le traitement des affections ou des troubles respiratoires
WO1991007177A1 (fr) * 1989-11-13 1991-05-30 Pfizer Inc. Derives de pyrimidone et analogues pour le traitement de l'asthme et de certaines maladies de la peau
GB9007762D0 (en) * 1990-04-05 1990-06-06 Beecham Group Plc Novel compounds
EP0451790A1 (fr) * 1990-04-12 1991-10-16 Hoechst Aktiengesellschaft 2-isoxazolines et isoxazoles 3,5-disubstitués, procédé pour leur préparation,médicaments les contenant et leur utilisation
DE4026018A1 (de) * 1990-08-17 1992-02-20 Hoechst Ag Isoxazoline oder isothiazoline enthaltende pflanzenschuetzende mittel und neue isoxazoline und isothiazoline
IE913855A1 (en) * 1990-11-06 1992-05-22 Smithkline Beecham Corp Imidazolidinone compounds
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
WO1993007141A1 (fr) * 1991-10-11 1993-04-15 Smithkline Beecham Corporation 3-phenylpyrrolidine-2-ones heterocycliques, leurs preparation et utilisation pour la fabrication d'un medicament permettant d'inhiber la production du facteur de necrose tumorale

Also Published As

Publication number Publication date
ATE187447T1 (de) 1999-12-15
WO1995014680A1 (fr) 1995-06-01
FI945556A0 (fi) 1994-11-25
FI945556A (fi) 1995-05-27
EP0730587A1 (fr) 1996-09-11
US5686434A (en) 1997-11-11
ES2139754T3 (es) 2000-02-16
JPH09500146A (ja) 1997-01-07
GR3032506T3 (en) 2000-05-31
EP0730587B1 (fr) 1999-12-08
PT730587E (pt) 2000-05-31
JP2818820B2 (ja) 1998-10-30
DE69422061D1 (de) 2000-01-13
DE69422061T2 (de) 2000-03-30
CA2177375A1 (fr) 1995-06-01

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