DK0688315T3 - Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer - Google Patents
Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorerInfo
- Publication number
- DK0688315T3 DK0688315T3 DK94908350T DK94908350T DK0688315T3 DK 0688315 T3 DK0688315 T3 DK 0688315T3 DK 94908350 T DK94908350 T DK 94908350T DK 94908350 T DK94908350 T DK 94908350T DK 0688315 T3 DK0688315 T3 DK 0688315T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- pyrrolidine
- preparation
- platelet aggregation
- aggregation inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4308034A DE4308034A1 (de) | 1993-03-13 | 1993-03-13 | Neue Heterocyclen, ihre Herstellung und ihre Verwendung |
PCT/EP1994/000481 WO1994021607A1 (fr) | 1993-03-13 | 1994-02-19 | Nouveaux heterocycles, preparation et utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0688315T3 true DK0688315T3 (da) | 1999-11-01 |
Family
ID=6482724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94908350T DK0688315T3 (da) | 1993-03-13 | 1994-02-19 | Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer |
Country Status (15)
Country | Link |
---|---|
US (1) | US5658935A (fr) |
EP (1) | EP0688315B1 (fr) |
JP (1) | JP3547745B2 (fr) |
KR (1) | KR100379051B1 (fr) |
AT (1) | ATE179698T1 (fr) |
AU (1) | AU678438B2 (fr) |
CA (1) | CA2155842A1 (fr) |
DE (2) | DE4308034A1 (fr) |
DK (1) | DK0688315T3 (fr) |
ES (1) | ES2133543T3 (fr) |
GR (1) | GR3030699T3 (fr) |
HU (1) | HUT72756A (fr) |
IL (1) | IL108943A (fr) |
WO (1) | WO1994021607A1 (fr) |
ZA (1) | ZA941714B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4427979A1 (de) | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
ES2171768T3 (es) | 1996-03-20 | 2002-09-16 | Hoechst Ag | Inhibidores de la resorcion osea y antagonistas de receptores de vitronectina. |
US5925635A (en) * | 1996-04-17 | 1999-07-20 | Dupont Pharmaceuticals Company | N-(amidinophenyl) cyclourea analogs as factor XA inhibitors |
DE19622489A1 (de) | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) * | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
EP1151994A1 (fr) * | 2000-05-01 | 2001-11-07 | Ethyl Corporation | Acides de succinimide et leurs derivatives |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10137595A1 (de) * | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
US20060045902A1 (en) * | 2004-09-01 | 2006-03-02 | Serbousek Jon C | Polymeric wrap for in vivo delivery of osteoinductive formulations |
US20060057184A1 (en) * | 2004-09-16 | 2006-03-16 | Nycz Jeffrey H | Process to treat avascular necrosis (AVN) with osteoinductive materials |
US9119901B2 (en) * | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
US8414907B2 (en) | 2005-04-28 | 2013-04-09 | Warsaw Orthopedic, Inc. | Coatings on medical implants to guide soft tissue healing |
US20070179615A1 (en) * | 2006-01-31 | 2007-08-02 | Sdgi Holdings, Inc. | Intervertebral prosthetic disc |
US20070280986A1 (en) * | 2006-06-01 | 2007-12-06 | Carlos Gil | Intra-operative coating of implants |
US8133553B2 (en) | 2007-06-18 | 2012-03-13 | Zimmer, Inc. | Process for forming a ceramic layer |
US8309521B2 (en) | 2007-06-19 | 2012-11-13 | Zimmer, Inc. | Spacer with a coating thereon for use with an implant device |
US8608049B2 (en) | 2007-10-10 | 2013-12-17 | Zimmer, Inc. | Method for bonding a tantalum structure to a cobalt-alloy substrate |
EP2247320B1 (fr) * | 2008-01-29 | 2013-05-29 | Zimmer Inc. | Dispositif d'implant destiné à être utilisé dans un système d'implant |
US11020160B2 (en) | 2016-03-21 | 2021-06-01 | Warsaw Orthopedic, Inc. | Surgical injection system and method |
US10709814B2 (en) | 2016-04-22 | 2020-07-14 | Warsaw Orthopedic, Inc. | Osteoimplant comprising an insoluble fibrous polymer |
EP3886853A4 (fr) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Composés diarylhydantoine et leurs procédés d'utilisation |
WO2020113094A1 (fr) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Composés pyrrole et pyrazole et leurs procédés d'utilisation |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1539817A (en) * | 1976-10-22 | 1979-02-07 | Ucb Sa | N-substituted lactams |
GB2032419B (en) * | 1978-09-05 | 1983-01-19 | Wellcome Found | Hydantoin prostaglandin analogues |
AU561156B2 (en) * | 1983-02-18 | 1987-04-30 | Wellcome Foundation Limited, The | Hydantoin derivatives |
CA1279643C (fr) * | 1985-02-07 | 1991-01-29 | Hiroyuki Kouji | Composes de phenylteraconimide n-subtitues, compose herbicide, et methode de destructions des herbes indesirables |
DE4009506A1 (de) * | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
HUT68769A (en) * | 1991-05-07 | 1995-07-28 | Merck & Co Inc | FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE |
DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
DE4213634A1 (de) * | 1992-04-24 | 1993-10-28 | Cassella Ag | 2,4-Dioxo-imidazolidin-Derivate |
DE4224414A1 (de) * | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
-
1993
- 1993-03-13 DE DE4308034A patent/DE4308034A1/de not_active Withdrawn
-
1994
- 1994-02-19 DK DK94908350T patent/DK0688315T3/da active
- 1994-02-19 AT AT94908350T patent/ATE179698T1/de not_active IP Right Cessation
- 1994-02-19 HU HU9502660A patent/HUT72756A/hu unknown
- 1994-02-19 AU AU61423/94A patent/AU678438B2/en not_active Ceased
- 1994-02-19 EP EP94908350A patent/EP0688315B1/fr not_active Expired - Lifetime
- 1994-02-19 KR KR1019950703843A patent/KR100379051B1/ko not_active IP Right Cessation
- 1994-02-19 US US08/513,897 patent/US5658935A/en not_active Expired - Lifetime
- 1994-02-19 ES ES94908350T patent/ES2133543T3/es not_active Expired - Lifetime
- 1994-02-19 CA CA002155842A patent/CA2155842A1/fr not_active Abandoned
- 1994-02-19 WO PCT/EP1994/000481 patent/WO1994021607A1/fr active IP Right Grant
- 1994-02-19 JP JP52055994A patent/JP3547745B2/ja not_active Expired - Fee Related
- 1994-02-19 DE DE59408213T patent/DE59408213D1/de not_active Expired - Lifetime
- 1994-03-11 IL IL10894394A patent/IL108943A/en active IP Right Grant
- 1994-03-11 ZA ZA941714A patent/ZA941714B/xx unknown
-
1999
- 1999-07-07 GR GR990401782T patent/GR3030699T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0688315A1 (fr) | 1995-12-27 |
AU678438B2 (en) | 1997-05-29 |
JP3547745B2 (ja) | 2004-07-28 |
AU6142394A (en) | 1994-10-11 |
DE59408213D1 (de) | 1999-06-10 |
KR100379051B1 (ko) | 2003-08-21 |
ES2133543T3 (es) | 1999-09-16 |
JPH08509209A (ja) | 1996-10-01 |
HU9502660D0 (en) | 1995-11-28 |
HUT72756A (en) | 1996-05-28 |
GR3030699T3 (en) | 1999-11-30 |
CA2155842A1 (fr) | 1994-09-29 |
EP0688315B1 (fr) | 1999-05-06 |
DE4308034A1 (de) | 1994-09-15 |
WO1994021607A1 (fr) | 1994-09-29 |
KR960701008A (ko) | 1996-02-24 |
IL108943A0 (en) | 1994-06-24 |
IL108943A (en) | 2001-04-30 |
US5658935A (en) | 1997-08-19 |
ATE179698T1 (de) | 1999-05-15 |
ZA941714B (en) | 1994-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0688315T3 (da) | Pyrrolidin- og oxazolidinderivater, deres fremstilling og deres anvendelse som trombocytaggregationsinhibitorer | |
AP2001002204A0 (en) | Pyrazole derivatives. | |
DK41193D0 (da) | Ionkanalaabnere | |
TR199901765T2 (xx) | S�lfomid-metalloproteaz inhibit�rleri | |
DK0766696T3 (da) | Thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse forbindelser | |
DE60230127D1 (de) | Inhibitoren von integrin alpha-v-beta-6 | |
DK0689549T3 (da) | Nye urinstofderivater, deres fremstilling og anvendelse | |
BRPI0407841A (pt) | inibidores heterocìclicos de quinase | |
IL116231A (en) | Dipeptide p-amidinobenzylamides with n-terminal sulfonyl or aminosulfonyl radicals as thrombin inhibitors | |
AU2001263278A1 (en) | Cyclic gmp-specific phosphodiesterase inhibitors | |
DK0490816T3 (da) | Fluorforbindelser som aromatase-inhibitorer. | |
TR200100133T2 (tr) | FKBP İnhibitörleri | |
AU2001296699A1 (en) | Condensed pyrazindione derivatives as pde inhibitors | |
DK0775113T3 (da) | N-substituerede azabicycloheptan-derivater som neuroleptika osv. | |
AU6876896A (en) | Carbamoylcarboxamides | |
ATE149159T1 (de) | Heteroarylmethylbenzole-aromatasehemmer | |
DK0687257T3 (da) | 4-amino-2-(hetero)aryl-butanamider anvendelige som 5HT1A-antagonister | |
MXPA04001442A (es) | Derivados de m-aminofenol y agentes colorantes que contienen estos compuestos. | |
ZA955052B (en) | Pyrrolidine derivatives their preparation and compositions containing them |