DK0683166T3 - 3-Indolylpiperidiner - Google Patents

3-Indolylpiperidiner

Info

Publication number
DK0683166T3
DK0683166T3 DK95105227T DK95105227T DK0683166T3 DK 0683166 T3 DK0683166 T3 DK 0683166T3 DK 95105227 T DK95105227 T DK 95105227T DK 95105227 T DK95105227 T DK 95105227T DK 0683166 T3 DK0683166 T3 DK 0683166T3
Authority
DK
Denmark
Prior art keywords
indolylpiperidines
cona2
indolylalkyl
conha
cooa
Prior art date
Application number
DK95105227T
Other languages
Danish (da)
English (en)
Inventor
Henning Dr Boettcher
Joachim Dr Morz
Christoph Dr Seyfreid
Harmut Dr Greiner
Gerd Bartoszyk
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0683166T3 publication Critical patent/DK0683166T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
DK95105227T 1994-04-22 1995-04-07 3-Indolylpiperidiner DK0683166T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4414113A DE4414113A1 (de) 1994-04-22 1994-04-22 3-Indolylpiperidine

Publications (1)

Publication Number Publication Date
DK0683166T3 true DK0683166T3 (da) 1999-07-12

Family

ID=6516183

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95105227T DK0683166T3 (da) 1994-04-22 1995-04-07 3-Indolylpiperidiner

Country Status (20)

Country Link
US (1) US5693655A (hu)
EP (1) EP0683166B1 (hu)
JP (1) JPH07291969A (hu)
KR (1) KR100361950B1 (hu)
CN (1) CN1047385C (hu)
AT (1) ATE172730T1 (hu)
AU (1) AU697749B2 (hu)
CA (1) CA2147451C (hu)
CZ (1) CZ285369B6 (hu)
DE (2) DE4414113A1 (hu)
DK (1) DK0683166T3 (hu)
ES (1) ES2125508T3 (hu)
HU (1) HUT74096A (hu)
NO (1) NO307831B1 (hu)
PL (1) PL180781B1 (hu)
RU (1) RU2151148C1 (hu)
SK (1) SK280881B6 (hu)
TW (1) TW401416B (hu)
UA (1) UA41333C2 (hu)
ZA (1) ZA953260B (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
ES2206963T3 (es) * 1997-07-25 2004-05-16 H. Lundbeck A/S Derivados de indol y de 2,3-dihidroindol, su preparacion y uso.
CN1265660A (zh) * 1997-08-15 2000-09-06 辉瑞产品公司 2－(4－芳基或杂芳基－哌嗪－1－基甲基)－1h－吲哚衍生物
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
KR20010034605A (ko) 1998-03-18 2001-04-25 우에하라 아끼라 방향족 복소환 유도체
EP1070715A4 (en) 1998-03-19 2002-10-17 Nihon Nohyaku Co Ltd ARYLPIPERIDINE AND THEIR USE
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
JP2003521443A (ja) * 1998-06-19 2003-07-15 ハー・ルンドベック・アクチエゼルスカベット ４，５，６及び７−インドール及びインドリン誘導体、その製造方法及びその使用方法
BR9911843A (pt) 1998-06-19 2001-03-20 Lundbeck & Co As H 4 5 6 7-indol e derivados de indolina, preparação e utilização dos mesmos
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
AR020773A1 (es) * 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
AU4552200A (en) * 1999-05-12 2000-12-05 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
JP4919565B2 (ja) 1999-08-23 2012-04-18 アボツト・ヘルスケア・プロダクツ・ベー・ブイ 新規なフェニルピペラジン
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
WO2003010169A1 (en) * 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
US7235569B2 (en) * 2003-05-02 2007-06-26 Wyeth Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2675801A (en) * 1954-04-20 Intramedbllary nail
FR2349331A1 (fr) * 1976-04-30 1977-11-25 Roussel Uclaf Nouveaux derives de 2,3 dihydro a/4-(3-indolyl) 1-piperidinyl/methyl 1,4-benzodioxin-2-methanol, un procede pour leur preparation et leur application comme medicaments
GB2044254B (en) 1979-01-26 1983-01-26 Wyeth John & Brother Ltd Piperidine derivatives
US4359468A (en) * 1981-02-25 1982-11-16 Boehringer Ingelheim Ltd. Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US5256673A (en) * 1983-11-25 1993-10-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8531665D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
JP2860688B2 (ja) * 1990-03-14 1999-02-24 第一製薬株式会社 インドール誘導体
FR2675801A1 (fr) 1991-04-24 1992-10-30 Rhone Poulenc Rorer Sa Piperidines, leur preparation et les medicaments les contenant.
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
KR102044254B1 (ko) * 2018-01-18 2019-11-13 (주)우신에이펙 배광제어가 가능한 led 탐조등

Also Published As

Publication number Publication date
PL180781B1 (pl) 2001-04-30
RU95106675A (ru) 1997-03-20
SK280881B6 (sk) 2000-08-14
KR950032176A (ko) 1995-12-20
EP0683166B1 (de) 1998-10-28
NO951529D0 (no) 1995-04-21
CA2147451A1 (en) 1995-10-23
CN1047385C (zh) 1999-12-15
KR100361950B1 (ko) 2003-02-05
HUT74096A (en) 1996-11-28
RU2151148C1 (ru) 2000-06-20
HU9501139D0 (en) 1995-06-28
DE59504032D1 (de) 1998-12-03
TW401416B (en) 2000-08-11
JPH07291969A (ja) 1995-11-07
PL308287A1 (en) 1995-10-30
EP0683166A1 (de) 1995-11-22
ZA953260B (en) 1996-01-09
AU1648895A (en) 1995-11-02
AU697749B2 (en) 1998-10-15
US5693655A (en) 1997-12-02
CZ103595A3 (en) 1995-12-13
NO951529L (no) 1995-10-23
CA2147451C (en) 2006-03-28
CZ285369B6 (cs) 1999-07-14
UA41333C2 (uk) 2001-09-17
CN1114651A (zh) 1996-01-10
ES2125508T3 (es) 1999-03-01
ATE172730T1 (de) 1998-11-15
DE4414113A1 (de) 1995-10-26
NO307831B1 (no) 2000-06-05
SK50895A3 (en) 1995-11-08

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