DK0667864T3 - Tricykliske forbindelser med farmaceutisk virkning - Google Patents

Tricykliske forbindelser med farmaceutisk virkning

Info

Publication number
DK0667864T3
DK0667864T3 DK93924165.9T DK93924165T DK0667864T3 DK 0667864 T3 DK0667864 T3 DK 0667864T3 DK 93924165 T DK93924165 T DK 93924165T DK 0667864 T3 DK0667864 T3 DK 0667864T3
Authority
DK
Denmark
Prior art keywords
alkyl
tetrazol
pct
tricyclic compounds
carbamoyl
Prior art date
Application number
DK93924165.9T
Other languages
English (en)
Inventor
Francis Thomas Boyle
James William Crook
Zbigniew Stanley Matusiak
Original Assignee
Zeneca Ltd
British Tech Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd, British Tech Group filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DK0667864T3 publication Critical patent/DK0667864T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK93924165.9T 1992-11-06 1993-11-04 Tricykliske forbindelser med farmaceutisk virkning DK0667864T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929223352A GB9223352D0 (en) 1992-11-06 1992-11-06 Tricyclic compounds

Publications (1)

Publication Number Publication Date
DK0667864T3 true DK0667864T3 (da) 1998-05-04

Family

ID=10724693

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93924165.9T DK0667864T3 (da) 1992-11-06 1993-11-04 Tricykliske forbindelser med farmaceutisk virkning

Country Status (13)

Country Link
US (1) US5789417A (da)
EP (1) EP0667864B1 (da)
JP (1) JP3271667B2 (da)
AT (1) ATE158578T1 (da)
AU (1) AU5376094A (da)
DE (1) DE69314183T2 (da)
DK (1) DK0667864T3 (da)
ES (1) ES2107688T3 (da)
GB (1) GB9223352D0 (da)
GR (1) GR3024875T3 (da)
IL (1) IL107306A0 (da)
WO (1) WO1994011354A1 (da)
ZA (1) ZA937756B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320113D0 (en) * 1993-09-29 1993-11-17 Zeneca Ltd Tricyclic derivatives
GB9904275D0 (en) 1999-02-24 1999-04-21 Cancer Res Campaign Tech Anti-cancer compounds
US6368818B1 (en) * 2000-10-12 2002-04-09 Qingzhong Kong Methods and compositions for the visualization of cellular organelles using tetrazolium salts
US7524872B2 (en) * 2000-09-15 2009-04-28 Qingzhong Kong Method and composition for treating cancer using cellular organelle crystallizing agents
GB0121214D0 (en) 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
ATE483722T1 (de) 2001-08-31 2010-10-15 Btg Int Ltd Antikrebs-cyclopentaag chinazoline-derivate
ES2373644T3 (es) 2001-08-31 2012-02-07 Btg International Limited Uso de derivados de ciclopenta[g]quinazolina para el tratamiento del c�?ncer.
DE10260877A1 (de) * 2002-12-23 2004-07-01 Beiersdorf Ag Stabile zinkoxidhaltige Öl-in-Wasser-Emulsionen
US8466111B2 (en) 2008-03-18 2013-06-18 Btg International Limited Cyclopenta{G}quinazoline derivatives for the treatment of rheumatoid arthritis or acute myeloid leukaemia
KR20130056887A (ko) 2010-07-19 2013-05-30 오닉스 파마슈티컬즈, 인크. 시클로펜타퀴나졸린의 합성
KR20130132481A (ko) * 2010-12-22 2013-12-04 오닉스 파마슈티컬즈, 인크. 효율적인 펩티드 커플링 및 시클로펜타(g)퀴나졸린 3나트륨 염의 합성 및 단리에서의 이의 용도
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0031237B1 (en) * 1979-12-19 1984-10-17 National Research Development Corporation Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US5187167A (en) * 1986-03-27 1993-02-16 Imperial Chemical Industries Plc Pharmaceutical compositions comprising quinazolin-4-one derivatives
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
US4925939A (en) * 1989-01-05 1990-05-15 Sloan-Kettering Institute For Cancer Research 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives
CA2021042A1 (en) * 1989-07-21 1991-01-22 Fabrizio Marazza Salts of n ,n -methylene-5,6,7,8-tetrahydrofolic acid
US5077404A (en) * 1989-08-29 1991-12-31 Piper James R Cyclized 5,10-dideazaaminopterin compounds
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
IL99500A0 (en) * 1990-09-17 1992-08-18 Agouron Pharma Naphthalene compounds,processes for the preparation thereof and pharmaceutical compositions containing the same
YU155791A (sh) * 1990-09-25 1994-01-20 Agouron Pharmaceuticals Inc. Antiproliferativna supstituisana triciklična jedinjenja
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
AU4632893A (en) * 1992-07-29 1994-03-03 Agouron Pharmaceuticals, Inc. Antiproliferative tricyclic compounds

Also Published As

Publication number Publication date
EP0667864B1 (en) 1997-09-24
WO1994011354A1 (en) 1994-05-26
GB9223352D0 (en) 1992-12-23
EP0667864A1 (en) 1995-08-23
DE69314183T2 (de) 1998-01-15
IL107306A0 (en) 1994-01-25
ES2107688T3 (es) 1997-12-01
GR3024875T3 (en) 1998-01-30
US5789417A (en) 1998-08-04
AU5376094A (en) 1994-06-08
ZA937756B (en) 1994-05-11
DE69314183D1 (de) 1997-10-30
JPH08505838A (ja) 1996-06-25
ATE158578T1 (de) 1997-10-15
JP3271667B2 (ja) 2002-04-02

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