DK0663391T3 - Svovlsyreestere af sukkeralkoholer til behandling af arteriosklerotiske ændringer i den vaskulære væg - Google Patents

Svovlsyreestere af sukkeralkoholer til behandling af arteriosklerotiske ændringer i den vaskulære væg

Info

Publication number
DK0663391T3
DK0663391T3 DK95100180.9T DK95100180T DK0663391T3 DK 0663391 T3 DK0663391 T3 DK 0663391T3 DK 95100180 T DK95100180 T DK 95100180T DK 0663391 T3 DK0663391 T3 DK 0663391T3
Authority
DK
Denmark
Prior art keywords
treatment
sulfuric acid
acid esters
sugar alcohols
vascular wall
Prior art date
Application number
DK95100180.9T
Other languages
Danish (da)
English (en)
Inventor
Gerard Schmid
Alexander Chucholowski
Juergen Fingerle
Niggi Iberg
Hans Peter Maerki
Rita Mueller
Michael Pech
Marianne Rouge
Thomas Tschopp
Hans Peter Wessel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0663391T3 publication Critical patent/DK0663391T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/06—Hydrogenosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Seasonings (AREA)
  • Laser Surgery Devices (AREA)
  • Steroid Compounds (AREA)
DK95100180.9T 1994-01-14 1995-01-09 Svovlsyreestere af sukkeralkoholer til behandling af arteriosklerotiske ændringer i den vaskulære væg DK0663391T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH11494 1994-01-14
CH331594 1994-11-07

Publications (1)

Publication Number Publication Date
DK0663391T3 true DK0663391T3 (da) 1997-10-20

Family

ID=25683559

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95100180.9T DK0663391T3 (da) 1994-01-14 1995-01-09 Svovlsyreestere af sukkeralkoholer til behandling af arteriosklerotiske ændringer i den vaskulære væg

Country Status (21)

Country Link
US (1) US5521160A (enExample)
EP (1) EP0663391B1 (enExample)
JP (1) JP2862489B2 (enExample)
KR (1) KR950032111A (enExample)
CN (1) CN1043349C (enExample)
AT (1) ATE151416T1 (enExample)
AU (1) AU685196B2 (enExample)
CA (1) CA2139720A1 (enExample)
CZ (1) CZ8395A3 (enExample)
DE (1) DE59500162D1 (enExample)
DK (1) DK0663391T3 (enExample)
ES (1) ES2101583T3 (enExample)
FI (1) FI950127L (enExample)
GR (1) GR3024012T3 (enExample)
HU (1) HUT72412A (enExample)
IL (1) IL112284A (enExample)
NO (1) NO302817B1 (enExample)
NZ (1) NZ270316A (enExample)
RU (1) RU2139854C1 (enExample)
TW (1) TW308598B (enExample)
UA (1) UA42696C2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2174583A1 (en) * 1995-05-05 1996-11-06 Alexander Chucholowski Sulfuric acid esters of sugar alcohols
CA2174582A1 (en) * 1995-05-05 1996-11-06 Alexander Chucholowski Sulphuric acid esters of amino-sugars
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
CN1189166C (zh) * 1998-09-11 2005-02-16 伊来克萨斯独资有限公司 Fc受体调节剂及其应用
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6525093B1 (en) 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
EP1360167A1 (en) * 2001-01-16 2003-11-12 Guilford Pharmaceuticals Inc. Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (adp-ribose) glycohydrolase, and methods for their use
GB0228410D0 (en) 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
JP4466373B2 (ja) * 2002-12-11 2010-05-26 日産化学工業株式会社 新規なジアミノベンゼン誘導体、それを用いたポリイミド前駆体およびポリイミド、並びに液晶配向剤
JP6051998B2 (ja) * 2012-03-30 2016-12-27 日油株式会社 マルチアーム型ポリエチレングリコール誘導体、その中間体及び製造方法
MX2014014174A (es) * 2012-05-22 2015-07-06 Hoffmann La Roche Inhibidores selectivos de celulas no diferenciadas.
CN110092737B (zh) * 2018-01-31 2022-06-17 海思美域(深圳)科技有限公司 一种抗静电化合物、材料的表面处理方法及改性材料

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621796A5 (en) * 1976-06-28 1981-02-27 Hoffmann La Roche Process for the preparation of an antibiotic
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DE3734853A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Bis-aldonsaeureamide und verfahren zu ihrer herstellung
US5298616A (en) * 1990-10-03 1994-03-29 Hoffmann-La Roche Inc. Sulfated O-polysaccharide-trehaloses
CA2061370A1 (en) * 1991-03-13 1992-09-14 Markus Hosang Pharmaceutical preparations

Also Published As

Publication number Publication date
KR950032111A (ko) 1995-12-20
JP2862489B2 (ja) 1999-03-03
ES2101583T3 (es) 1997-07-01
NZ270316A (en) 1996-08-27
ATE151416T1 (de) 1997-04-15
RU95100773A (ru) 1996-10-27
CN1043349C (zh) 1999-05-12
FI950127A7 (fi) 1995-07-15
UA42696C2 (uk) 2001-11-15
HUT72412A (en) 1996-04-29
EP0663391B1 (de) 1997-04-09
IL112284A (en) 1998-10-30
US5521160A (en) 1996-05-28
TW308598B (enExample) 1997-06-21
DE59500162D1 (de) 1997-05-15
CA2139720A1 (en) 1995-07-15
RU2139854C1 (ru) 1999-10-20
CN1109889A (zh) 1995-10-11
AU685196B2 (en) 1998-01-15
CZ8395A3 (en) 1995-11-15
NO950137D0 (no) 1995-01-13
NO302817B1 (no) 1998-04-27
JPH07206803A (ja) 1995-08-08
FI950127A0 (fi) 1995-01-11
AU1010695A (en) 1995-07-27
FI950127L (fi) 1995-07-15
IL112284A0 (en) 1995-03-30
EP0663391A1 (de) 1995-07-19
NO950137L (no) 1995-07-17
GR3024012T3 (en) 1997-10-31

Similar Documents

Publication Publication Date Title
ATE151416T1 (de) Schwefelsäureester von zuckeralkoholen zur behandlung von arteriosklerotischen gefässwandveränderungen
ES2067036T3 (es) Productos de alcoxilacion de derivados de acidos carboxilicos y/o acidos carboxilicos que contienen grupos oh.
EE9700073A (et) Pulbiseebist saadavad steroolsed kompositsioonid
ATE170513T1 (de) Diastereomeres salz von optisch aktiver chinolinmevalonsäure
ATE174604T1 (de) Lipopeptide aus actinoplanes sp. mit pharmakologischer wirkung, verfahren zu ihrer herstellung und verwendung derselben
ES2091324T3 (es) Proceso para la preparacion de aspartama a partir de una dicetopiperazina y nuevos compuestos intermedios y derivados para dicho proceso.
ES2104766T3 (es) Agentes tensioactivos derivados de esteres de acido sulfosuccinico.
FR2723946B1 (fr) Procede de fabrication d'un diester de l'acide 2,5-furane dicarboxylique
FR2780968B1 (fr) Procede de preparation de l'acide hydroxymethylthiobutyrique
IT1255486B (it) Processo per preparare gli acidi biliari coniugati con la taurina
FI921334A7 (fi) Menetelmä puhdistetun alkaanisulfonihapon valmistamiseksi
DK0640614T3 (da) Stereoselektiv fremgangsmåde til fremstilling af beta-anomerberigede 2-deoxy-2,2-difluor-D-ribofuranosyl-3,5-hydroxybeskyttede 1-alkyl- og arylsulfonatmellemprodukter
EP0801131A4 (en) METHOD FOR PRODUCING A D-N-CARBAMOYL ALPHA AMINO ACID
EP0692539A3 (en) Process for the production of optically active gamma-hydroxy-L-glutamic acid
FR2656549B1 (fr) Procede pour la fabrication d'un coude et coude fabrique suivant ce procede.
BR0005323A (pt) Processo para preparar sais de metal alcalino de ácido l-ascórbico
ATE224373T1 (de) Verfahren zur herstellung von alkylimidazolidinon(meth)acrylaten
DE69008653D1 (de) Verfahren zur Racemisierung von optisch aktiven 4-Phenylbuttersäureestern.
ES2153124T3 (es) Nuevos derivados de acidos carboxilicos, su obtencion y empleo.
ATE17470T1 (de) Aliphatische ether des cyclododecen-2-ols, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von riechstoffkompositionen.
EP0770611A3 (en) Fungicidal 2- (4-pyrazolyloxypyrimidin-5-yl) acetic acid derivatives
BE875071A (fr) Procede de fabrication de l'acide hydroxy-4, dimethoxy-3,5 benzoique a partir de l'acide trimethoxy-3,4,5 benzoique
FR2687657B1 (fr) Procede de fabrication d'acide phosphorique marchand a tres basse teneur en cadmium.
FR2780399B1 (fr) Procede de fabrication d'esters d'alkyles par transesterification ou alcoolyse
DK0450491T3 (da) Fremgangsmåde til fremstilling af d-isocitronsyre ved fermentation