RU2139854C1 - Сложные эфиры серной кислоты сахарных спиртов или их соли, лекарственные средства и способ получения соединений - Google Patents

Сложные эфиры серной кислоты сахарных спиртов или их соли, лекарственные средства и способ получения соединений Download PDF

Info

Publication number
RU2139854C1
RU2139854C1 RU95100773A RU95100773A RU2139854C1 RU 2139854 C1 RU2139854 C1 RU 2139854C1 RU 95100773 A RU95100773 A RU 95100773A RU 95100773 A RU95100773 A RU 95100773A RU 2139854 C1 RU2139854 C1 RU 2139854C1
Authority
RU
Russia
Prior art keywords
glucit
bis
penta
sulfo
salt
Prior art date
Application number
RU95100773A
Other languages
English (en)
Russian (ru)
Other versions
RU95100773A (ru
Inventor
Куколовски Александр
Фингерле Юрген
Иберг Нигги
Петер Мэрки Ганс
Мюллер Рита
Пех Михаель
Руж Марианн
Шмид Жерар
Чепп Томас
Петер Вессель Ганс
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of RU95100773A publication Critical patent/RU95100773A/ru
Application granted granted Critical
Publication of RU2139854C1 publication Critical patent/RU2139854C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/06—Hydrogenosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Laser Surgery Devices (AREA)
  • Seasonings (AREA)
  • Steroid Compounds (AREA)
RU95100773A 1994-01-14 1995-01-11 Сложные эфиры серной кислоты сахарных спиртов или их соли, лекарственные средства и способ получения соединений RU2139854C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH114/94 1994-01-14
CH11494 1994-01-14
CH3315/94 1994-11-07
CH331594 1994-11-07

Publications (2)

Publication Number Publication Date
RU95100773A RU95100773A (ru) 1996-10-27
RU2139854C1 true RU2139854C1 (ru) 1999-10-20

Family

ID=25683559

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95100773A RU2139854C1 (ru) 1994-01-14 1995-01-11 Сложные эфиры серной кислоты сахарных спиртов или их соли, лекарственные средства и способ получения соединений

Country Status (21)

Country Link
US (1) US5521160A (enExample)
EP (1) EP0663391B1 (enExample)
JP (1) JP2862489B2 (enExample)
KR (1) KR950032111A (enExample)
CN (1) CN1043349C (enExample)
AT (1) ATE151416T1 (enExample)
AU (1) AU685196B2 (enExample)
CA (1) CA2139720A1 (enExample)
CZ (1) CZ8395A3 (enExample)
DE (1) DE59500162D1 (enExample)
DK (1) DK0663391T3 (enExample)
ES (1) ES2101583T3 (enExample)
FI (1) FI950127L (enExample)
GR (1) GR3024012T3 (enExample)
HU (1) HUT72412A (enExample)
IL (1) IL112284A (enExample)
NO (1) NO302817B1 (enExample)
NZ (1) NZ270316A (enExample)
RU (1) RU2139854C1 (enExample)
TW (1) TW308598B (enExample)
UA (1) UA42696C2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2174583A1 (en) * 1995-05-05 1996-11-06 Alexander Chucholowski Sulfuric acid esters of sugar alcohols
CA2174582A1 (en) * 1995-05-05 1996-11-06 Alexander Chucholowski Sulphuric acid esters of amino-sugars
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
WO2000015214A1 (en) * 1998-09-11 2000-03-23 Ilexus Pty Limited Fc RECEPTOR MODULATORS AND USES THEREOF
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6635786B2 (en) * 2001-01-16 2003-10-21 Guilford Pharmaceuticals, Inc. Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use
GB0228410D0 (en) 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
JP4466373B2 (ja) * 2002-12-11 2010-05-26 日産化学工業株式会社 新規なジアミノベンゼン誘導体、それを用いたポリイミド前駆体およびポリイミド、並びに液晶配向剤
JP6051998B2 (ja) * 2012-03-30 2016-12-27 日油株式会社 マルチアーム型ポリエチレングリコール誘導体、その中間体及び製造方法
EP2852387A2 (en) * 2012-05-22 2015-04-01 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Selective inhibitors of undifferentiated cells
CN110092737B (zh) * 2018-01-31 2022-06-17 海思美域(深圳)科技有限公司 一种抗静电化合物、材料的表面处理方法及改性材料

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621796A5 (en) * 1976-06-28 1981-02-27 Hoffmann La Roche Process for the preparation of an antibiotic

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DE3734853A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Bis-aldonsaeureamide und verfahren zu ihrer herstellung
US5298616A (en) * 1990-10-03 1994-03-29 Hoffmann-La Roche Inc. Sulfated O-polysaccharide-trehaloses
CA2061370A1 (en) * 1991-03-13 1992-09-14 Markus Hosang Pharmaceutical preparations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621796A5 (en) * 1976-06-28 1981-02-27 Hoffmann La Roche Process for the preparation of an antibiotic

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Машковский М.Д. Лекарственные средства. -М.: Медицина, 1972, ч.2, с. 46 - 49. *

Also Published As

Publication number Publication date
EP0663391B1 (de) 1997-04-09
NZ270316A (en) 1996-08-27
KR950032111A (ko) 1995-12-20
ES2101583T3 (es) 1997-07-01
FI950127A7 (fi) 1995-07-15
CA2139720A1 (en) 1995-07-15
UA42696C2 (uk) 2001-11-15
CZ8395A3 (en) 1995-11-15
CN1109889A (zh) 1995-10-11
RU95100773A (ru) 1996-10-27
FI950127L (fi) 1995-07-15
DK0663391T3 (da) 1997-10-20
FI950127A0 (fi) 1995-01-11
JPH07206803A (ja) 1995-08-08
TW308598B (enExample) 1997-06-21
US5521160A (en) 1996-05-28
DE59500162D1 (de) 1997-05-15
IL112284A0 (en) 1995-03-30
NO302817B1 (no) 1998-04-27
IL112284A (en) 1998-10-30
JP2862489B2 (ja) 1999-03-03
HUT72412A (en) 1996-04-29
EP0663391A1 (de) 1995-07-19
AU685196B2 (en) 1998-01-15
GR3024012T3 (en) 1997-10-31
ATE151416T1 (de) 1997-04-15
CN1043349C (zh) 1999-05-12
AU1010695A (en) 1995-07-27
NO950137L (no) 1995-07-17
NO950137D0 (no) 1995-01-13

Similar Documents

Publication Publication Date Title
RU2139854C1 (ru) Сложные эфиры серной кислоты сахарных спиртов или их соли, лекарственные средства и способ получения соединений
AU730248B2 (en) Aryloxyarylsulfonylamino hydroxamic acid derivatives
EP0933372B1 (en) Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors
CA2089440C (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicaments containing them
RU2252214C2 (ru) 2'-замещенные 1,1'-бифенил-2-карбонамиды, способы их получения, их применение в качестве лекарственного средства, а также содержащие их фармацевтические композиции
EP0791006B1 (en) Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation
WO1998034915A1 (en) N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
IL202633A (en) History of sulfonamides and the pharmaceutical preparations that feed them
US5830920A (en) Sulfuric acid esters of sugar alcohols
EP0895988B1 (en) Arylsulfonylamino hydroxamic acid derivatives
EP0791004B1 (en) Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation
JPH07206823A (ja) 置換１−オキソ−１，２−ジヒドロイソキノリノイルグアニジン類及び１，１−ジオキソ−２ｈ−１，２−ベンゾチアジノイルグアニジン類
MXPA97002966A (en) Bencilglycosides accided as inhibitors of laproliferation of muscle cells
US5767268A (en) Sulfuric acid esters of amino sugars
PL180273B1 (en) Novel sulphuric esters of sugar alcohols, method of obtaining them and therapeutic agent containing such esters
AU4973500A (en) Alpha-amino-beta-sulfonyl hydroxamic acid compounds
CA2169695C (en) Substituted benzenesulfonylureas and -thioureas, processes for their preparation, their use for the production of pharmaceutical preparations and medicaments containing them
US5773420A (en) Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation
HU221851B1 (hu) Fluor-alkil-csoporttal szubsztituált benzoil-guanidin-származékok, eljárás előállításukra, gyógyszerként történő alkalmazásuk, és ezeket tartalmazó gyógyszerkészítmények
US6107337A (en) Arylsulfonylamino hydroxamic acid derivatives
US4275076A (en) Substituted naphthoic acids
EP0013784B1 (en) C-substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them
US4291169A (en) Substituted naphthoic acids
MXPA96001656A (en) New esters of sulfuric acid of amino azuca
HK1021737B (en) Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors