DK0655089T3 - Virkninger af actinfilamenter på fibrinkoagulatstruktur og -lyse - Google Patents

Virkninger af actinfilamenter på fibrinkoagulatstruktur og -lyse

Info

Publication number
DK0655089T3
DK0655089T3 DK93919997T DK93919997T DK0655089T3 DK 0655089 T3 DK0655089 T3 DK 0655089T3 DK 93919997 T DK93919997 T DK 93919997T DK 93919997 T DK93919997 T DK 93919997T DK 0655089 T3 DK0655089 T3 DK 0655089T3
Authority
DK
Denmark
Prior art keywords
actin
lysis
effects
actin filaments
coagulate
Prior art date
Application number
DK93919997T
Other languages
Danish (da)
English (en)
Inventor
Thomas P Stossel
Paul A Janmey
Jennifer A Lamb
Stuart E Lind
Original Assignee
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital filed Critical Brigham & Womens Hospital
Application granted granted Critical
Publication of DK0655089T3 publication Critical patent/DK0655089T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/106664—Blood serum or blood plasma standard or control

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK93919997T 1992-08-14 1993-08-13 Virkninger af actinfilamenter på fibrinkoagulatstruktur og -lyse DK0655089T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/929,203 US5691160A (en) 1992-08-14 1992-08-14 Effects of actin filaments of fibrin clot structure and lysis
PCT/US1993/007584 WO1994004704A1 (fr) 1992-08-14 1993-08-13 Effets de filaments d'actine sur la structure et la lyse de caillots de fibrine

Publications (1)

Publication Number Publication Date
DK0655089T3 true DK0655089T3 (da) 2001-02-12

Family

ID=25457479

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93919997T DK0655089T3 (da) 1992-08-14 1993-08-13 Virkninger af actinfilamenter på fibrinkoagulatstruktur og -lyse

Country Status (11)

Country Link
US (1) US5691160A (fr)
EP (1) EP0655089B1 (fr)
JP (1) JPH08500488A (fr)
AT (1) ATE197478T1 (fr)
CA (1) CA2142121C (fr)
DE (1) DE69329652T2 (fr)
DK (1) DK0655089T3 (fr)
ES (1) ES2151517T3 (fr)
GR (1) GR3034823T3 (fr)
PT (1) PT655089E (fr)
WO (1) WO1994004704A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I
US6391343B1 (en) 1991-01-15 2002-05-21 Hemosphere, Inc. Fibrinogen-coated particles for therapeutic use
AU7726598A (en) * 1997-06-05 1998-12-21 Hemosphere, Inc. Modification of platelet action by fibrinogen-coated particles
CA2294494A1 (fr) 1997-06-05 1998-12-10 Richard C. K. Yen Microspheres enrobees de fibrinogene
FR2781055B1 (fr) * 1998-07-09 2000-10-13 Immunotech Sa Reactif et methode pour la permeabilisation et l'identification des erythrocytes
CA2380972A1 (fr) * 1999-08-13 2001-02-22 Hemodyne, Inc. Procede d'utilisation de la force de contraction des plaquettes sanguines et du module d'elasticite des caillots de sang total comme marqueurs cliniques
US7301020B2 (en) * 2003-06-19 2007-11-27 Wisconsin Alumni Research Foundation Macrolide analogs and methods for identifying same
US20070238655A1 (en) * 2003-11-12 2007-10-11 The Trustees Of The University Of Pennsylvania Methods of Using Gelsolin to Treat or Prevent Bacterial Sepsis
US9408891B2 (en) * 2003-11-12 2016-08-09 The Trustees Of The University Of Pennsylvania Methods of using gelsolin to treat or prevent bacterial sepsis
EP2335722B1 (fr) * 2004-05-12 2019-03-13 The Brigham and Women's Hospital, Inc. Utilisation de gelsoline pour traiter des infections
GB0507981D0 (en) * 2005-04-20 2005-05-25 Uws Ventures Ltd Method of determining the point at which coagulating blood forms a clot
DK3279663T3 (da) 2006-03-15 2021-10-18 Brigham & Womens Hospital Inc Anvendelse af gelsolin til diagnosticering og behandling af inflammationssygdomme
US8440622B2 (en) * 2006-03-15 2013-05-14 The Brigham And Women's Hospital, Inc. Use of gelsolin to treat multiple sclerosis and to diagnose neurologic disease (stossel)
US9575072B2 (en) * 2008-01-25 2017-02-21 The Brigham And Women's Hospital, Inc. Diagnostic and therapeutic uses of gelsolin in renal failure
EP3067431B1 (fr) * 2010-09-15 2019-07-24 Debiopharm International S.A. Dispositif comprenant des composants sanguins pour séparer des molécules cibles ou des particules à partir d'échantillons
KR101416954B1 (ko) * 2012-09-12 2014-07-16 한양대학교 산학협력단 조혈세포 분화 유도 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03500166A (ja) * 1987-06-19 1991-01-17 シラキューズ　ユニバーシティ チトカラシンの精製方法および組成物
US5326749A (en) * 1989-11-20 1994-07-05 Nobuto Yamamoto Macrophage activating factor from vitamin D binding protein
US5177002A (en) * 1989-11-20 1993-01-05 Nobuto Yamamoto In vitro enzymatic conversion of glycosylated human vitamin D binding protein to a potent macrophage activating factor
US5177001A (en) * 1989-11-20 1993-01-05 Nobuto Yamamoto In vitro enzymatic conversion of glycosylated mammalian vitamin D-binding protein to a potent macrophage activating factor
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I
DE69130289T2 (de) * 1990-04-11 1999-06-02 Brigham And Women's Hospital, Boston, Mass. Therapeutische verwendung von actin-bindenden verbindungen

Also Published As

Publication number Publication date
WO1994004704A1 (fr) 1994-03-03
EP0655089A4 (fr) 1997-04-02
US5691160A (en) 1997-11-25
DE69329652D1 (de) 2000-12-14
PT655089E (pt) 2001-04-30
ATE197478T1 (de) 2000-11-11
CA2142121A1 (fr) 1994-03-03
CA2142121C (fr) 2003-09-09
DE69329652T2 (de) 2001-06-13
JPH08500488A (ja) 1996-01-23
EP0655089B1 (fr) 2000-11-08
EP0655089A1 (fr) 1995-05-31
GR3034823T3 (en) 2001-02-28
ES2151517T3 (es) 2001-01-01

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