ATE431364T1 - Inhibitoren der menschlichen elastase von neutrophilen - Google Patents

Inhibitoren der menschlichen elastase von neutrophilen

Info

Publication number
ATE431364T1
ATE431364T1 AT03000399T AT03000399T ATE431364T1 AT E431364 T1 ATE431364 T1 AT E431364T1 AT 03000399 T AT03000399 T AT 03000399T AT 03000399 T AT03000399 T AT 03000399T AT E431364 T1 ATE431364 T1 AT E431364T1
Authority
AT
Austria
Prior art keywords
proteins
elastasis
inhibitors
human neutrophil
compositions
Prior art date
Application number
AT03000399T
Other languages
English (en)
Inventor
Arthur Charles Ley
Robert Charles Ladner
Sonia Kosow Guterman
Bruce Lindsay Roberts
William Markland
Rachel Baribault Kent
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/664,989 external-priority patent/US5223409A/en
Application filed by Dyax Corp filed Critical Dyax Corp
Application granted granted Critical
Publication of ATE431364T1 publication Critical patent/ATE431364T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03000399T 1991-03-01 1992-02-28 Inhibitoren der menschlichen elastase von neutrophilen ATE431364T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/664,989 US5223409A (en) 1988-09-02 1991-03-01 Directed evolution of novel binding proteins
US71583491A 1991-06-17 1991-06-17

Publications (1)

Publication Number Publication Date
ATE431364T1 true ATE431364T1 (de) 2009-05-15

Family

ID=27099103

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03000399T ATE431364T1 (de) 1991-03-01 1992-02-28 Inhibitoren der menschlichen elastase von neutrophilen
AT92908481T ATE243710T1 (de) 1991-03-01 1992-02-28 Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT92908481T ATE243710T1 (de) 1991-03-01 1992-02-28 Hemmstoffe für menschliche neutrophile elastase und menschliches kathepsin g

Country Status (9)

Country Link
EP (2) EP1325931B1 (de)
JP (1) JP3819931B2 (de)
AT (2) ATE431364T1 (de)
AU (1) AU1581692A (de)
CA (1) CA2105304C (de)
DE (3) DE69233760D1 (de)
DK (1) DK0573603T3 (de)
ES (1) ES2124203T3 (de)
WO (1) WO1992015605A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US7078383B2 (en) * 1988-09-02 2006-07-18 Dyax Corp. ITI-D1 Kunitz domain mutants as HNE inhibitors
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
ES2287206T3 (es) 1991-03-01 2007-12-16 Dyax Corporation Proceso para el desarrollo de mini-proteinas de union.
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
JP2769083B2 (ja) * 1993-02-22 1998-06-25 日清食品株式会社 エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
HU221310B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
HU221311B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use
EP0699750A1 (de) * 1994-06-07 1996-03-06 Gesellschaft für biotechnologische Forschung mbH (GBF) Eine Sammling an Phagemiden, eine Sammling von Escherichia coli Zellen die diese Phagemide tragen, eine Sammling an Phagemid-Partikeln die daraus hergestellt würden und Phagemid-Partikel die durch dieses Verfahren erhalten würden
US5885577A (en) * 1994-09-21 1999-03-23 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
CA2200684A1 (en) * 1994-09-21 1996-03-28 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
TR199801794T2 (xx) 1996-03-11 2000-07-21 Bayer Corporation �nsan bikunini.
ATE407694T1 (de) * 1998-12-22 2008-09-15 Bayer Ag Methode zur beschleunigung der schleimauflöserate
GB9908195D0 (en) 1999-04-09 1999-06-02 Microbiological Res Authority Treatment of intracellular infection
EP1201249A1 (de) * 2000-10-31 2002-05-02 Debiopharm S.A. Suspension von EPI-HNE-4, daraus hergestelltes Trockenpulveraerosol, Herstellungsverfahren und Arzneimittel enthaltend diese Suspension- oder Aerosolzubereitung und ihre Verwendung
DK1223972T3 (da) * 2000-10-31 2003-11-03 Debiopharm Sa Suspension af et EPI-hNE protein, fremgangsmåde til fremstilling deraf, tør pulveraerosol fremstillet deraf, farmaceutiske præparater indeholdende denne suspension eller aerosol samt anvendelser af disse
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
KR20070041749A (ko) * 2004-07-13 2007-04-19 바이엘 파마슈티칼스 코포레이션 개선된 아프로티닌 변이체
WO2008077478A1 (en) * 2006-12-22 2008-07-03 Bayer Schering Pharma Aktiengesellschaft Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene
US20110275535A1 (en) 2008-12-16 2011-11-10 Novartis Ag Yeast Display Systems
CN110055221B (zh) * 2019-04-16 2021-10-08 清华大学 一种基于细胞三维打印技术的类脑疾病治疗组织模型及其制备方法与应用
US20220354833A1 (en) 2019-09-17 2022-11-10 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
DK4106757T3 (da) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
CN118265527A (zh) 2021-10-20 2024-06-28 美莱奥生物制药第四有限公司 用于治疗纤维化的中性粒细胞弹性蛋白酶抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
IL77748A (en) * 1985-02-04 1991-11-21 Merrell Dow Pharma Amino acid and peptide derivatives as peptidase inhibitors
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DE768377T1 (de) * 1988-09-02 1998-01-02 Dyax Corp Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
DK0401508T3 (da) * 1989-05-13 1995-05-15 Bayer Ag Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf

Also Published As

Publication number Publication date
EP1325931B1 (de) 2009-05-13
DE573603T1 (de) 1999-05-06
ATE243710T1 (de) 2003-07-15
WO1992015605A2 (en) 1992-09-17
JPH06510522A (ja) 1994-11-24
CA2105304C (en) 2005-10-04
DE69233760D1 (de) 2009-06-25
DE69233108T2 (de) 2004-04-29
AU1581692A (en) 1992-10-06
EP0573603A1 (de) 1993-12-15
DK0573603T3 (da) 2003-10-20
CA2105304A1 (en) 1992-09-02
DE69233108D1 (de) 2003-07-31
WO1992015605A3 (en) 1992-12-23
ES2124203T3 (es) 2004-04-16
ES2124203T1 (es) 1999-02-01
EP0573603B1 (de) 2003-06-25
EP1325931A1 (de) 2003-07-09
JP3819931B2 (ja) 2006-09-13

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties