ES8501979A1 - Procedimiento para preparar un concentrado de factor antihemofilico - Google Patents

Procedimiento para preparar un concentrado de factor antihemofilico

Info

Publication number
ES8501979A1
ES8501979A1 ES524768A ES524768A ES8501979A1 ES 8501979 A1 ES8501979 A1 ES 8501979A1 ES 524768 A ES524768 A ES 524768A ES 524768 A ES524768 A ES 524768A ES 8501979 A1 ES8501979 A1 ES 8501979A1
Authority
ES
Spain
Prior art keywords
ahf
concentrate
preparation
highly purified
radius
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524768A
Other languages
English (en)
Other versions
ES524768A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of ES8501979A1 publication Critical patent/ES8501979A1/es
Publication of ES524768A0 publication Critical patent/ES524768A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Abstract

PROCEDIMIENTO PARA PREPARAR UN CONCENTRADO DE FACTOR ANTIHEMOFILICO.COMPRENDE: A) OBTENER UN CONCENTRADO DE FACTOR ANTIHEMOFILICO TOTAL O PARCIALMENTE EXENTO DE PROTEINAS COMPLEJAS DE PROTOMBINA, FIBRONOGENO Y ALBUMINA; B) SOMETER EL CONCENTRADO DE FACTOR ANTIHEMOFILICO A SEPARACION EN BASE DEL RADIO DE STOKE ELEVADO, DE OTRAS PROTEINAS; C) TRATAR EL CONCENTRADO DE FACTOR ANTIHEMOFILICO PARA COMBINAR EL RADIO EFECTIVO DE STOKE DE LA MOLECULA DE FACTOR ANTIHEMOFILICO A UN VALOR BAJO; D) SOMETER EL CONCENTRADO DE FACTOR ANTIHEMOFILICO A SEPARACION EN BASE DEL RADIO DE STOKE PARA SEPARAR, DE LAS OTRAS PROTEINAS, FACTOR ANTIHEMOFILICO DE VALOR DE RADIO DE STOKE BAJO; Y E) SOMETER EL CONCENTRADO DE FACTOR ANTIHEMOFILICO A CROMATOGRAFIA EN UN MEDIO DE INTERCAMBIO DE ANIONES PARA OBTENER EL CONCENTRADO HOMOGENEO Y ALTAMENTE PURIFICADO.
ES524768A 1982-08-05 1983-08-05 Procedimiento para preparar un concentrado de factor antihemofilico Granted ES524768A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/405,456 US4495175A (en) 1982-08-05 1982-08-05 Preparation of highly purified human antihemophilic factor

Publications (2)

Publication Number Publication Date
ES8501979A1 true ES8501979A1 (es) 1984-12-16
ES524768A0 ES524768A0 (es) 1984-12-16

Family

ID=23603775

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524768A Granted ES524768A0 (es) 1982-08-05 1983-08-05 Procedimiento para preparar un concentrado de factor antihemofilico

Country Status (8)

Country Link
US (1) US4495175A (es)
EP (1) EP0104356B1 (es)
JP (1) JPS5944322A (es)
AU (1) AU567683B2 (es)
CA (1) CA1213214A (es)
DE (1) DE3369143D1 (es)
ES (1) ES524768A0 (es)
MX (1) MX7309E (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614795A (en) * 1982-08-05 1986-09-30 University Of Rochester Deglycosylated Human Factor VIII:C
US4650858A (en) * 1983-03-21 1987-03-17 Nordisk Gentofte A/S Concentrate of the antihemophilic factor VIII and a process for producing it
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US5043428A (en) * 1984-08-31 1991-08-27 Behringwerke Aktiengesellschaft Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
GB8505882D0 (en) * 1985-03-07 1985-04-11 Central Blood Lab Authority Purification of blood coagulation factor viii
JPS61280866A (ja) * 1985-06-07 1986-12-11 アルフア・セラピユ−テイツク・コ−ポレイシヨン 人血液凝固第８因子の分離方法
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
ATE112287T1 (de) * 1987-12-21 1994-10-15 Miles Inc Faktor viii- gelfiltration.
US5177191A (en) * 1987-12-21 1993-01-05 Miles, Inc. Gel filtration of factor VIII
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
ATE85221T1 (de) 1988-11-05 1993-02-15 Octapharma Ag Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie.
FR2644064B1 (fr) * 1989-02-17 1994-05-27 Aquitaine Dev Transf Sanguine Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant
DE3926034C3 (de) * 1989-08-07 1996-11-21 Behringwerke Ag Verfahren zur Herstellung eines stabilen Faktors VIII
FR2651437A1 (fr) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.
DK162233C (da) * 1989-11-09 1992-03-16 Novo Nordisk As Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii
IT1248723B (it) * 1990-06-12 1995-01-26 Scalvo S P A Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo
FR2681867B1 (fr) * 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.
US5516509A (en) * 1993-03-31 1996-05-14 International Beauty Design, Inc. Quick-drying nail coating for use over nail polish
US5407666A (en) * 1993-04-05 1995-04-18 International Beauty Design, Inc. Removable, hard, durable, nail coating
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9501040D0 (en) * 1995-01-19 1995-03-08 Quadrant Holdings Cambridge Dried composition
US7253262B2 (en) * 1995-01-19 2007-08-07 Quandrant Drug Delivery Limited Dried blood factor composition comprising trehalose
US7244824B2 (en) * 1995-01-19 2007-07-17 Quadrant Drug Delivery Limited Dried blood factor composition comprising trehalose
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
ES2252986T3 (es) 1998-10-07 2006-05-16 Trinity Biotech Manufacturing Ltd. Reactivos de tromboplastina y metodos para preparar y usar tales reactivos.
PT2130554E (pt) 1999-02-22 2012-11-19 Univ Connecticut Formulações de factor viii isentas de albumina
US20100168018A1 (en) * 2008-11-07 2010-07-01 Baxter International Inc. Factor viii formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188318A (en) * 1975-06-16 1980-02-12 Edward Shanbrom Simplified method for preparation of high yield, high purity Factor VIII concentrate
US4278594A (en) * 1979-06-19 1981-07-14 David Amrani Process for separation and isolation of AHF, von Willebrand's ristocetin cofactor (VWF:RCF) and fibronectin from blood plasma
US4364861A (en) * 1980-05-27 1982-12-21 Cutter Laboratories, Inc. Blood-coagulation-promoting products and methods of preparing them
CA1178887A (en) * 1981-10-01 1984-12-04 Gail A. Rock Factor viii concentrates prepared from heparinized plasma by the application of a cold precipitation technique
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
AU555305B2 (en) * 1982-09-29 1986-09-18 Bayer Corporation Antihemophilic factor concentrate

Also Published As

Publication number Publication date
US4495175A (en) 1985-01-22
DE3369143D1 (en) 1987-02-19
MX7309E (es) 1988-05-10
ES524768A0 (es) 1984-12-16
EP0104356B1 (en) 1987-01-14
EP0104356A1 (en) 1984-04-04
AU1747283A (en) 1984-02-09
JPS5944322A (ja) 1984-03-12
CA1213214A (en) 1986-10-28
AU567683B2 (en) 1987-12-03

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