KR890011606A - 항응고제 - Google Patents
항응고제 Download PDFInfo
- Publication number
- KR890011606A KR890011606A KR1019890000792A KR890000792A KR890011606A KR 890011606 A KR890011606 A KR 890011606A KR 1019890000792 A KR1019890000792 A KR 1019890000792A KR 890000792 A KR890000792 A KR 890000792A KR 890011606 A KR890011606 A KR 890011606A
- Authority
- KR
- South Korea
- Prior art keywords
- anticoagulant
- heparin
- protein
- activated protein
- activity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Paper (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 단백질 C의 농도와 응고시간과의 상관 그래프이다.
Claims (3)
- 단백질 C또는 활성화된 단백질 C 및 헤파린을 함유하는 항응고제.
- 제1항에 있어서, 부가적으로 안티트롬빈 Ⅲ을 함유하는 항응고제.
- 응혈 장해 치료용 약제를 생성하기 위한 제1항 또는 2항에 따른 항응고제의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63-15761 | 1988-01-28 | ||
JP63015761A JP2739050B2 (ja) | 1988-01-28 | 1988-01-28 | 抗血液凝固剤 |
JP?63-15761 | 1988-01-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890011606A true KR890011606A (ko) | 1989-08-21 |
KR0127754B1 KR0127754B1 (ko) | 1998-04-01 |
Family
ID=11897770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890000792A KR0127754B1 (ko) | 1988-01-28 | 1989-01-26 | 항응고제 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5084273A (ko) |
EP (1) | EP0326014B1 (ko) |
JP (1) | JP2739050B2 (ko) |
KR (1) | KR0127754B1 (ko) |
AT (1) | ATE74273T1 (ko) |
AU (1) | AU607303B2 (ko) |
CA (1) | CA1330299C (ko) |
DE (1) | DE68901098D1 (ko) |
DK (1) | DK37789A (ko) |
ES (1) | ES2039709T3 (ko) |
GR (1) | GR3005040T3 (ko) |
IE (1) | IE63528B1 (ko) |
PT (1) | PT89534B (ko) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8822147D0 (en) * | 1988-09-21 | 1988-10-26 | Ciba Geigy Ag | Pharmaceutically active combination |
SE464135B (sv) * | 1989-07-14 | 1991-03-11 | Kabivitrum Ab | Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov |
US5571786A (en) * | 1990-08-16 | 1996-11-05 | Immuno Aktiengesellschaft | Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation |
AT402260B (de) * | 1990-08-16 | 1997-03-25 | Immuno Ag | Protein c-hältige pharmazeutische präparation |
FR2671973A1 (fr) * | 1991-01-25 | 1992-07-31 | Fondation Nale Transfusion San | Utilisation de la proteine c activee comme agent anti-agregant plaquettaire. |
AT402263B (de) * | 1991-06-20 | 1997-03-25 | Immuno Ag | Pharmazeutische präparation enthaltend eine thrombolytisch wirkende substanz |
EP0651655A4 (en) | 1992-07-24 | 1996-05-29 | Oklahoma Med Res Found | REDUCTION OF MICROVASCULAR BLEEDING DURING SURGERY BY BLOCKING PROTEIN C ACTIVATION |
US5589516A (en) * | 1993-04-05 | 1996-12-31 | The Green Cross Corporation | Liquid preparation of antithrombin-III and stabilizing method therefor |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
US5516889A (en) * | 1993-06-21 | 1996-05-14 | University Technologies International, Inc. | Synthetic thrombin receptor peptides |
WO1995030429A1 (en) * | 1994-05-04 | 1995-11-16 | Board Of Trustees Of The University Of Arkansas | Novel ophthalmologic uses of protein c |
JPH08224227A (ja) * | 1995-02-22 | 1996-09-03 | Internatl Reagents Corp | 血液採血管 |
US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US6491965B1 (en) | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
US6630137B1 (en) | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
IL132502A0 (en) * | 1997-04-28 | 2001-03-19 | Lilly Co Eli | Improved methods for processing activated protein c |
ID23908A (id) * | 1997-06-05 | 2000-05-25 | Lilly Co Eli | Metode pengobatan dari penyakit trombosis |
GB9711927D0 (en) * | 1997-06-09 | 1997-08-06 | Bristol Myers Squibb Co | Compositions useful as fibrin sealants |
US7204981B2 (en) | 2000-03-28 | 2007-04-17 | Eli Lilly And Company | Methods of treating diseases with activated protein C |
JP2004511428A (ja) | 2000-05-24 | 2004-04-15 | イーライ・リリー・アンド・カンパニー | 凝固亢進状態を処置するための製剤および方法 |
DE10045047A1 (de) * | 2000-09-12 | 2002-03-21 | Beate Kehrel | Arzneimittel enthaltend aktiviertes Antithrombin III |
JP2004535461A (ja) * | 2001-07-19 | 2004-11-25 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | プロテインcの不活性化を抑制するための銅キレート剤の使用 |
CA2475738A1 (en) * | 2002-03-08 | 2003-09-18 | Eli Lilly And Company | Activated protein c formulations |
WO2009096445A1 (ja) * | 2008-01-29 | 2009-08-06 | Kyowa Hakko Kirin Co., Ltd. | 神経幹細胞増殖促進剤 |
WO2024003418A1 (en) | 2022-07-01 | 2024-01-04 | Universiteit Maastricht | Improved downregulation of histone cytotoxicity by complex of negatively charged polysaccharide and protease |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8319538D0 (en) * | 1983-07-20 | 1983-08-24 | Beecham Group Plc | Compounds |
-
1988
- 1988-01-28 JP JP63015761A patent/JP2739050B2/ja not_active Expired - Fee Related
-
1989
- 1989-01-19 DE DE8989100852T patent/DE68901098D1/de not_active Revoked
- 1989-01-19 EP EP89100852A patent/EP0326014B1/en not_active Expired - Lifetime
- 1989-01-19 ES ES198989100852T patent/ES2039709T3/es not_active Expired - Lifetime
- 1989-01-19 AT AT89100852T patent/ATE74273T1/de not_active IP Right Cessation
- 1989-01-26 KR KR1019890000792A patent/KR0127754B1/ko not_active IP Right Cessation
- 1989-01-26 PT PT89534A patent/PT89534B/pt not_active IP Right Cessation
- 1989-01-27 IE IE26989A patent/IE63528B1/en not_active IP Right Cessation
- 1989-01-27 DK DK037789A patent/DK37789A/da not_active Application Discontinuation
- 1989-01-27 AU AU28855/89A patent/AU607303B2/en not_active Ceased
- 1989-01-27 CA CA000589391A patent/CA1330299C/en not_active Expired - Fee Related
-
1990
- 1990-12-21 US US07/630,754 patent/US5084273A/en not_active Expired - Lifetime
-
1992
- 1992-06-26 GR GR920400795T patent/GR3005040T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3005040T3 (ko) | 1993-05-24 |
PT89534B (pt) | 2001-05-31 |
ATE74273T1 (de) | 1992-04-15 |
IE63528B1 (en) | 1995-05-03 |
AU2885589A (en) | 1989-08-03 |
CA1330299C (en) | 1994-06-21 |
DK37789D0 (da) | 1989-01-27 |
DK37789A (da) | 1989-07-29 |
EP0326014A1 (en) | 1989-08-02 |
JP2739050B2 (ja) | 1998-04-08 |
US5084273A (en) | 1992-01-28 |
IE890269L (en) | 1989-07-28 |
KR0127754B1 (ko) | 1998-04-01 |
JPH01193229A (ja) | 1989-08-03 |
AU607303B2 (en) | 1991-02-28 |
DE68901098D1 (de) | 1992-05-07 |
ES2039709T3 (es) | 1993-10-01 |
EP0326014B1 (en) | 1992-04-01 |
PT89534A (pt) | 1989-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20041012 Year of fee payment: 8 |
|
LAPS | Lapse due to unpaid annual fee |