DK0652962T3 - Ekspression af rekombinante fusionsproteiner i attenuerede bakterier - Google Patents
Ekspression af rekombinante fusionsproteiner i attenuerede bakterierInfo
- Publication number
- DK0652962T3 DK0652962T3 DK93917957T DK93917957T DK0652962T3 DK 0652962 T3 DK0652962 T3 DK 0652962T3 DK 93917957 T DK93917957 T DK 93917957T DK 93917957 T DK93917957 T DK 93917957T DK 0652962 T3 DK0652962 T3 DK 0652962T3
- Authority
- DK
- Denmark
- Prior art keywords
- expression
- fusion proteins
- recombinant fusion
- attenuated bacteria
- attenuated
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 230000002238 attenuated effect Effects 0.000 title 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108010044241 tetanus toxin fragment C Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
- C12N9/1088—Glutathione transferase (2.5.1.18)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929216317A GB9216317D0 (en) | 1992-07-31 | 1992-07-31 | Vaccines |
GB939306398A GB9306398D0 (en) | 1993-03-26 | 1993-03-26 | Vaccines |
PCT/GB1993/001617 WO1994003615A1 (fr) | 1992-07-31 | 1993-07-30 | Expression de proteines recombinantes fusionnees dans des bacteries attenuees |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0652962T3 true DK0652962T3 (da) | 1999-08-23 |
Family
ID=26301354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93917957T DK0652962T3 (da) | 1992-07-31 | 1993-07-30 | Ekspression af rekombinante fusionsproteiner i attenuerede bakterier |
Country Status (14)
Country | Link |
---|---|
US (1) | US6680182B1 (fr) |
EP (2) | EP0863211A1 (fr) |
JP (1) | JP3633933B2 (fr) |
KR (1) | KR950702635A (fr) |
AT (1) | ATE174628T1 (fr) |
AU (1) | AU4719393A (fr) |
CA (1) | CA2141427C (fr) |
DE (1) | DE69322645T2 (fr) |
DK (1) | DK0652962T3 (fr) |
ES (1) | ES2127829T3 (fr) |
FI (1) | FI950396A (fr) |
GR (1) | GR3029498T3 (fr) |
NO (1) | NO318018B1 (fr) |
WO (1) | WO1994003615A1 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9401787D0 (en) | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccine compositions |
CA2168459C (fr) * | 1993-07-30 | 2002-10-01 | Mohammed Anjam Khan | Proteines de fusion contenant le c-terminal de la toxine du tetanos liee a une proteine heterologue |
GB9401795D0 (en) * | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccines |
GB2295394B (en) * | 1994-01-31 | 1997-09-24 | Medeva Holdings Bv | DNA encoding a fusion protein comprising the C fragment of tetanus toxin |
GB9511909D0 (en) * | 1995-06-12 | 1995-08-09 | Microbiological Res Authority | Vaccine |
CA2216425C (fr) | 1996-03-23 | 2003-08-12 | The Research Foundation For Microbial Diseases Of Osaka University | Antigene a fragment fonctionnel de la toxine du tetanos, et vaccin contre le tetanos |
GB9608106D0 (en) * | 1996-04-19 | 1996-06-26 | Univ Newcastle | Animal Vaccines |
GB9621091D0 (en) * | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
GB9720033D0 (en) * | 1997-09-19 | 1997-11-19 | Medeva Plc | Hepatitis B virus polypeptides |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US6710226B1 (en) | 1997-12-02 | 2004-03-23 | Neuralab Limited | Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
US6923964B1 (en) | 1997-12-02 | 2005-08-02 | Neuralab Limited | Active immunization of AScr for prion disorders |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
US6905691B1 (en) | 1997-12-11 | 2005-06-14 | Celltech Pharma Europe Limited | Vaccines containing attenuated bacteria |
GB9726233D0 (en) * | 1997-12-11 | 1998-02-11 | Medeva Europ Ltd | Vaccines containing attenuated bacteria |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US7026155B2 (en) * | 1999-02-02 | 2006-04-11 | Regents Of The University Of California | Method of reducing bacterial proliferation |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
EP1790358A1 (fr) * | 2005-11-23 | 2007-05-30 | Université de Reims Champagne-Ardennes | Constructions protéiques concues pour cibler et lyser des cellules |
WO2009017467A1 (fr) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Traitement de maladies amyloïdogéniques |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
EP2062974B1 (fr) * | 2006-08-21 | 2015-08-12 | National University Corporation Kobe University | Procédé de production d'une protéine de fusion |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
WO2009133882A1 (fr) * | 2008-05-02 | 2009-11-05 | 出光興産株式会社 | Vaccin de toxine bactérienne |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
EP2788021B1 (fr) | 2011-12-09 | 2017-01-18 | Bavarian Nordic A/S | Vecteur du poxvirus codant des antigènes bactériens lié à le fragment c de la toxine tétanique |
WO2014146663A1 (fr) | 2013-03-18 | 2014-09-25 | Statens Serum Institut | Vaccins contre chlamydia sp. |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8516442D0 (en) | 1985-06-28 | 1985-07-31 | Wellcome Found | Cloned antigen |
AU613583B2 (en) * | 1986-08-22 | 1991-08-08 | Transgene S.A. | Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity |
EP0399001B1 (fr) * | 1988-02-01 | 1994-07-27 | Praxis Biologics, Inc. | Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues |
US4970147A (en) * | 1988-03-17 | 1990-11-13 | The General Hospital Corporation | Oxygen regulatable gene expression |
GB8912330D0 (en) * | 1989-05-30 | 1989-07-12 | Wellcome Found | Live vaccines |
GB8914122D0 (en) * | 1989-06-20 | 1989-08-09 | Wellcome Found | Polypeptide expression |
GB8924438D0 (en) * | 1989-10-31 | 1989-12-20 | Hoffmann La Roche | Vaccine composition |
IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
ATE93271T1 (de) * | 1989-11-28 | 1993-09-15 | Wellcome Found | Vakzine. |
CA2031468A1 (fr) * | 1989-12-08 | 1991-06-09 | Mitchell S. Gross | Vaccin contre la malaria |
FR2656626B1 (fr) * | 1989-12-29 | 1994-08-12 | Pasteur Institut | Fragment peptidique comprenant une sequence issue de la proteine 28 kda de schistosoma mansoni et compositions vaccinantes et/ou therapeutiques comprenant ledit fragment. |
ES2131069T3 (es) * | 1991-03-05 | 1999-07-16 | Wellcome Found | Expresion de proteinas recombinantes en bacterias atenuadas. |
SE468050C (sv) | 1991-03-15 | 1998-04-27 | Pharmacia & Upjohn Ab | Rekombinant derivat av human faktor VIII |
GB9112553D0 (en) * | 1991-06-11 | 1991-07-31 | Wellcome Found | Fusion proteins |
US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
EP0815235B1 (fr) * | 1995-03-13 | 2003-01-15 | The Secretary of State for Defence | Vaccins contre la peste |
US5877159A (en) * | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
US6190669B1 (en) * | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
US6142433A (en) * | 1999-08-18 | 2000-11-07 | Novelty Manufacturing Co. | Window sash hanger |
-
1993
- 1993-07-30 DE DE69322645T patent/DE69322645T2/de not_active Expired - Fee Related
- 1993-07-30 CA CA002141427A patent/CA2141427C/fr not_active Expired - Fee Related
- 1993-07-30 WO PCT/GB1993/001617 patent/WO1994003615A1/fr active IP Right Grant
- 1993-07-30 AT AT93917957T patent/ATE174628T1/de not_active IP Right Cessation
- 1993-07-30 EP EP98104783A patent/EP0863211A1/fr not_active Withdrawn
- 1993-07-30 EP EP93917957A patent/EP0652962B1/fr not_active Expired - Lifetime
- 1993-07-30 KR KR1019950700271A patent/KR950702635A/ko not_active Application Discontinuation
- 1993-07-30 JP JP50510294A patent/JP3633933B2/ja not_active Expired - Fee Related
- 1993-07-30 ES ES93917957T patent/ES2127829T3/es not_active Expired - Lifetime
- 1993-07-30 DK DK93917957T patent/DK0652962T3/da active
- 1993-07-30 US US08/379,611 patent/US6680182B1/en not_active Expired - Fee Related
- 1993-07-30 AU AU47193/93A patent/AU4719393A/en not_active Abandoned
-
1995
- 1995-01-30 NO NO950348A patent/NO318018B1/no not_active IP Right Cessation
- 1995-01-30 FI FI950396A patent/FI950396A/fi not_active IP Right Cessation
-
1999
- 1999-02-26 GR GR990400595T patent/GR3029498T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP3633933B2 (ja) | 2005-03-30 |
EP0652962B1 (fr) | 1998-12-16 |
US6680182B1 (en) | 2004-01-20 |
GR3029498T3 (en) | 1999-05-28 |
CA2141427A1 (fr) | 1994-02-17 |
ES2127829T3 (es) | 1999-05-01 |
NO950348D0 (no) | 1995-01-30 |
WO1994003615A1 (fr) | 1994-02-17 |
FI950396A0 (fi) | 1995-01-30 |
FI950396A (fi) | 1995-01-30 |
EP0863211A1 (fr) | 1998-09-09 |
AU4719393A (en) | 1994-03-03 |
CA2141427C (fr) | 2008-07-22 |
JPH08503602A (ja) | 1996-04-23 |
NO950348L (no) | 1995-03-28 |
DE69322645T2 (de) | 1999-05-20 |
DE69322645D1 (de) | 1999-01-28 |
KR950702635A (ko) | 1995-07-29 |
NO318018B1 (no) | 2005-01-24 |
ATE174628T1 (de) | 1999-01-15 |
EP0652962A1 (fr) | 1995-05-17 |
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