DK0643704T3 - Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister - Google Patents

Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister

Info

Publication number
DK0643704T3
DK0643704T3 DK93900550T DK93900550T DK0643704T3 DK 0643704 T3 DK0643704 T3 DK 0643704T3 DK 93900550 T DK93900550 T DK 93900550T DK 93900550 T DK93900550 T DK 93900550T DK 0643704 T3 DK0643704 T3 DK 0643704T3
Authority
DK
Denmark
Prior art keywords
receptor antagonists
synthesis
acid intermediates
methods
tetrazolylphenylboronic acid
Prior art date
Application number
DK93900550T
Other languages
Danish (da)
English (en)
Inventor
Young Sek Lo
Lucius Thomas Rossano
Robert D Larsen
Anthony O King
Original Assignee
Merck & Co Inc
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/793,514 external-priority patent/US5130439A/en
Priority claimed from US07/911,812 external-priority patent/US5310928A/en
Priority claimed from US07/911,813 external-priority patent/US5206374A/en
Application filed by Merck & Co Inc, Du Pont filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0643704T3 publication Critical patent/DK0643704T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK93900550T 1991-11-18 1992-11-18 Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister DK0643704T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/793,514 US5130439A (en) 1991-11-18 1991-11-18 Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US07/911,812 US5310928A (en) 1991-11-18 1992-07-10 Process for preparing biphenyltetrazole compounds
US07/911,813 US5206374A (en) 1991-11-18 1992-07-10 Process for preparing tetrazolylphenylboronic acid intermediates
PCT/US1992/009979 WO1993010106A1 (en) 1991-11-18 1992-11-18 Tetrazolylphenylboronic acid intermediates for the synthesis of aii receptor antagonists

Publications (1)

Publication Number Publication Date
DK0643704T3 true DK0643704T3 (da) 2004-01-19

Family

ID=27419904

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93900550T DK0643704T3 (da) 1991-11-18 1992-11-18 Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister

Country Status (14)

Country Link
EP (2) EP0643704B1 (cs)
JP (1) JPH08500323A (cs)
KR (2) KR100212257B1 (cs)
AT (2) ATE250043T1 (cs)
AU (1) AU665388B2 (cs)
CA (1) CA2123900C (cs)
CZ (1) CZ283954B6 (cs)
DE (2) DE69233208T2 (cs)
DK (1) DK0643704T3 (cs)
ES (1) ES2203614T3 (cs)
FI (1) FI112945B (cs)
NO (1) NO307932B1 (cs)
SK (1) SK280887B6 (cs)
WO (1) WO1993010106A1 (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
DE69507887T2 (de) * 1994-09-20 1999-06-17 Wakunaga Seiyaku K.K., Osaka Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
ES2173433T3 (es) 1996-10-29 2002-10-16 Merck & Co Inc Procedimiento para la cristalizacion de losartan.
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19916222A1 (de) * 1999-04-10 2000-10-19 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung von Biarylen
JP4507294B2 (ja) * 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
JP2001226372A (ja) 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
SK722003A3 (en) * 2001-05-18 2003-12-02 Aurobindo Pharma Ltd Process for the crystallization of losartan potassium
ATE487478T1 (de) * 2003-01-30 2010-11-15 Lek Pharmaceuticals Herstellung eines neuen pharmazeutisch geeigneten losartan-salzes und von seinen formen mittels neuer reinigungs- und isolationsverfahren
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
EP1660463B1 (en) * 2003-08-08 2007-12-05 Dipharma Francis S.r.l. A process for the preparation of phenyltetrazole derivatives
ITMI20032069A1 (it) * 2003-10-23 2005-04-24 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di derivati benzilmidazolici.
DE102004060699A1 (de) * 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
FR2879601B1 (fr) * 2004-12-22 2007-01-19 Galderma Res & Dev Nouveaux composes derives d'acide phenyl-boronique et leur procede de preparation
ES2308591T3 (es) * 2004-12-22 2008-12-01 Algry Quimica, S.L Intermedios para la preparacion de antagonistas de los receptores de la angiotensina ii.
WO2007005967A2 (en) * 2005-07-05 2007-01-11 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
ES2300175B1 (es) * 2006-02-14 2009-06-08 Inke, S.A. Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo.
CN101812029B (zh) * 2010-04-29 2012-02-15 南通市华峰化工有限责任公司 5-卤代直链烷基四氮唑的生产方法
CN105906614A (zh) * 2016-05-12 2016-08-31 山东罗欣药业集团股份有限公司 一种奥美沙坦酯的制备方法
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
CN114181048B (zh) * 2021-12-20 2024-06-21 宁夏清研高分子新材料有限公司 一种高产率的4-氟联苯酚的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
IE914572A1 (en) * 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
TW226375B (cs) * 1991-10-24 1994-07-11 American Home Prod
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
FR2688507B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Derives de l'acide tetrazolylbenzeneboronique, leur preparation et leur utilisation comme intermediaires de synthese.
FR2688505B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Nouveau procede de preparation de 4-pyrimidinones.
US5655009A (en) * 1992-03-19 1997-08-05 Fujitsu Limited Modem unit

Also Published As

Publication number Publication date
WO1993010106A1 (en) 1993-05-27
SK57994A3 (en) 1995-02-08
NO941857L (no) 1994-07-18
SK280887B6 (sk) 2000-09-12
DE69233208D1 (de) 2003-10-23
CZ120594A3 (en) 1995-02-15
EP1384717A3 (en) 2004-02-04
EP1384717B1 (en) 2008-05-14
EP0643704A4 (en) 1995-04-12
NO941857D0 (no) 1994-05-18
AU3179293A (en) 1993-06-15
DE69233734D1 (de) 2008-06-26
JPH08500323A (ja) 1996-01-16
FI942282A0 (fi) 1994-05-17
AU665388B2 (en) 1996-01-04
CZ283954B6 (cs) 1998-07-15
CA2123900C (en) 1998-07-14
CA2123900A1 (en) 1993-05-27
EP0643704B1 (en) 2003-09-17
KR100212257B1 (ko) 1999-08-02
KR100212405B1 (ko) 2000-03-15
DE69233208T2 (de) 2004-07-08
ES2203614T3 (es) 2004-04-16
FI112945B (fi) 2004-02-13
NO307932B1 (no) 2000-06-19
FI942282L (fi) 1994-05-17
ATE250043T1 (de) 2003-10-15
ATE395341T1 (de) 2008-05-15
EP0643704A1 (en) 1995-03-22
EP1384717A2 (en) 2004-01-28

Similar Documents

Publication Publication Date Title
DK0643704T3 (da) Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister
NO882241D0 (no) Tetrazol-mellomprodukter for fremstilling av antihypertensive forbindelser.
NO902954L (no) Fremgangsmaate for fremstilling av substituerte kinazolinoner som angiotensin ii-antagonister.
CA2037630A1 (en) Nitrogen-containing heterocylic compounds, their production and use
ES545885A0 (es) Un metodo para preparar 4-(4-(dimetilamino)-1-(4'-fluoro- fenil)-1-hidroxibutil)-3-(hidroximetil)-benzonitrilo
RU94045915A (ru) Производные индола, способ их получения, фармкомпозиция
EP0249224A3 (en) Novel antihypertensive agent
DK0455510T3 (da) Anvendelse af 5HT1A-receptoragonist til inhibering af mavesyresekretion
ES2095907T3 (es) Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos.
DE69808093D1 (de) Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung
RU92004509A (ru) Замещенные фенилфенольные соединения, фармацевтическая композиция, способ получения
DK0850231T3 (da) Fremgangsmåde til fremstilling af en 2-chlor-5-chlormethyl-thiazolforbindelse
ATE183732T1 (de) Verfahren zur herstellung von biphenylderivaten
DK0594666T3 (da) Fremgangsmåde til fremstilling af sertralin
NO930205D0 (no) Benzimidazoler, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
ES2191621T3 (es) Tienocicloalqu(en)ilamino-1,3,5-triazinas substituidas.
FI972530A0 (fi) Menetelmä substituoitujen 4-etyyli-piperidiinien valmistamiseksi ja niiden valmistuksessa käytettävä välituote
EP0549352A3 (en) Tricyclic compounds as angiotensin ii antagonists
DK158729C (da) N-(3-trifluormethylphenyl)-n'-propargylpiperazin, farmaceutiske praeparater, der indeholder det, dets anvendelse, samt en fremgangsmaade til fremstilling af et farmaceutisk praeparat
DK0664802T3 (da) N-Arylheteroarylalkyl-1-phenyl-imidazol-2-on-forbindelser til behandling af kredsløbssygdomme
DK0614890T3 (da) Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazoler.
FI932206A0 (fi) Nya heterocykliska foereningar som antagonister mot excitatoriska aminosyrareceptorer, foerfaranden foer deras framstaellning och anvaendning av desamma
DK0614892T3 (da) Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazol-4-carbaldehyder
DK0539330T3 (da) Fremgangsmåde til fremstilling af substituerede indoler
SE8204641L (sv) Aminosyraderivat