DK0624371T3 - Mikrokapsler til kontrolleret frigivelse af acetylsalicylsyre - Google Patents

Mikrokapsler til kontrolleret frigivelse af acetylsalicylsyre

Info

Publication number
DK0624371T3
DK0624371T3 DK94420126T DK94420126T DK0624371T3 DK 0624371 T3 DK0624371 T3 DK 0624371T3 DK 94420126 T DK94420126 T DK 94420126T DK 94420126 T DK94420126 T DK 94420126T DK 0624371 T3 DK0624371 T3 DK 0624371T3
Authority
DK
Denmark
Prior art keywords
microcapsules
controlled release
acetylsalicylic acid
forming polymer
relates
Prior art date
Application number
DK94420126T
Other languages
Danish (da)
English (en)
Inventor
Olga Burguiere
Ahmad Yassine
Jean-Philippe Selles
Original Assignee
Flamel Technologies Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Technologies Sa filed Critical Flamel Technologies Sa
Application granted granted Critical
Publication of DK0624371T3 publication Critical patent/DK0624371T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK94420126T 1993-04-19 1994-04-19 Mikrokapsler til kontrolleret frigivelse af acetylsalicylsyre DK0624371T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9304560A FR2704146B1 (fr) 1993-04-19 1993-04-19 Microcapsules d'acide acétylsalicylique à libération contrôlée.

Publications (1)

Publication Number Publication Date
DK0624371T3 true DK0624371T3 (da) 2000-10-02

Family

ID=9446180

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94420126T DK0624371T3 (da) 1993-04-19 1994-04-19 Mikrokapsler til kontrolleret frigivelse af acetylsalicylsyre

Country Status (10)

Country Link
US (2) US5603957A (pt)
EP (1) EP0624371B1 (pt)
JP (2) JP4067137B2 (pt)
AT (1) ATE193448T1 (pt)
DE (1) DE69424718D1 (pt)
DK (1) DK0624371T3 (pt)
ES (1) ES2148300T3 (pt)
FR (1) FR2704146B1 (pt)
GR (1) GR3034231T3 (pt)
PT (1) PT624371E (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2704146B1 (fr) * 1993-04-19 1995-07-13 Cripdom Microcapsules d'acide acétylsalicylique à libération contrôlée.
DE29502547U1 (de) * 1995-02-16 1995-03-30 Roehm Gmbh Thermoplastisches Überzugs- und Bindemittel für Arzneiformen
US6953593B2 (en) * 2000-02-01 2005-10-11 Lipoprotein Technologies, Inc. Sustained-release microencapsulated delivery system
FR2811571B1 (fr) * 2000-07-11 2002-10-11 Flamel Tech Sa Composition pharmaceutique orale, permettant la liberation controlee et l'absorption prolongee d'un principe actif
US6929884B2 (en) * 2001-04-19 2005-08-16 Zinc Matrix Power, Inc. Method for manufacture of films containing insoluble solids embedded in cellulose-based films
US6663896B1 (en) * 2001-08-01 2003-12-16 Alvin S. Blum Delayed release aspirin for vascular obstruction prophylaxis
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US20100041079A1 (en) * 2002-03-24 2010-02-18 Mcmaster University Method for predicting cardiovascular events
WO2003084517A2 (fr) * 2002-04-09 2003-10-16 Flamel Technologies Suspension orale de microcapsules d’amoxicilline
CN100553625C (zh) 2002-04-09 2009-10-28 弗拉梅技术公司 活性成分微囊的口服混悬液
US7008979B2 (en) * 2002-04-30 2006-03-07 Hydromer, Inc. Coating composition for multiple hydrophilic applications
WO2007036809A2 (en) * 2005-05-24 2007-04-05 Flamel Technologies S.A. Novel acetylsalicylic acid formulations
FR2886150B1 (fr) * 2005-05-24 2007-08-24 Flamel Technologies Sa Forme pharmaceutique orale a base d'au moins un principe actif dont la solubilite varie en fonction des conditions de ph gastrique
EP1726300A1 (en) * 2005-05-24 2006-11-29 Flamel Technologies Oral pharmaceutical formulation for the prevention and/or the treatment of cardiovascular and inflammatory diseases
EP1726301A1 (en) * 2005-05-24 2006-11-29 Flamel Technologies Oral pharmaceutical composition for treating a COX-2 mediated condition
WO2006133733A1 (en) * 2005-06-13 2006-12-21 Flamel Technologies Oral dosage form comprising an antimisuse system
US8652529B2 (en) * 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
NZ589469A (en) * 2008-05-20 2012-08-31 Cerenis Therapeutics Holding S A Niacin and NSAID combination for reducing niacin-induced flushing
US8828953B2 (en) * 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
AU2010239311B2 (en) 2009-04-20 2014-05-22 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US9901551B2 (en) 2009-04-20 2018-02-27 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies
KR100978583B1 (ko) * 2009-09-02 2010-08-27 (주)바이오제닉스 화장품용 색조캡슐 조성물, 이의 제조방법 및 이를 이용한 화장품 제제
CA2811202A1 (en) 2010-09-13 2012-03-22 Bev-Rx, Inc. Aqueous drug delivery system comprising off-flavor masking agent
KR20140114736A (ko) 2010-10-19 2014-09-29 엘셀릭스 테라퓨틱스 인코포레이티드 화학감각 수용체 리간드-기반 요법
RS61153B1 (sr) 2011-01-07 2020-12-31 Anji Pharma Us Llc Ligand hemosenzornog receptora-osnovne terapije
US9795792B2 (en) 2011-02-25 2017-10-24 Medtronic, Inc. Emergency mode switching for non-pacing modes
CN110693868A (zh) 2012-01-06 2020-01-17 埃尔舍利克斯治疗公司 双胍组合物和治疗代谢性病症的方法
KR102231554B1 (ko) 2012-01-06 2021-03-23 앤지 파마 유에스 엘엘씨 대사 장애를 치료하는 조성물 및 방법
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
EP2872127A1 (en) 2012-07-11 2015-05-20 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
KR102229492B1 (ko) 2013-01-05 2021-03-17 앤지 파마 유에스 엘엘씨 바이구아나이드를 포함하는 지연-방출 조성물
WO2019027459A1 (en) * 2017-08-03 2019-02-07 Sklar Pharma Llc PROLONGED RELEASE OF NITRIC OXIDE INTO THE INTESTINAL TRACT
CN110893179A (zh) * 2019-12-13 2020-03-20 沈阳东星医药科技有限公司 一种阿司匹林缓释胶囊及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892769A (en) * 1973-07-20 1975-07-01 Merck & Co Inc Acetaminophen esters of aryl salicylic acids
US4308251A (en) * 1980-01-11 1981-12-29 Boots Pharmaceuticals, Inc. Controlled release formulations of orally-active medicaments
LU85943A1 (fr) * 1985-06-12 1987-01-13 Galephar Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation
US4693896A (en) * 1985-10-07 1987-09-15 Fmc Corporation Ethylcellulose-coated, gastric-disintegrable aspirin tablet
DE3810757A1 (de) * 1988-03-30 1989-10-26 Freudenberg Carl Fa Verfahren zur herstellung einer mikroporoesen folie
AU632602B2 (en) * 1989-08-02 1993-01-07 John David Arnold Method and preparation for reducing risk of myocardial infarction
NZ233975A (en) * 1989-08-16 1992-06-25 Sterling Drug Inc Aspirin granules coated with a gastroprotectant
US5248516A (en) * 1989-12-19 1993-09-28 Fmc Corporation Film-forming composition: method of producing same and use for coating pharmaceuticals and foods and the like
US5206030A (en) * 1990-02-26 1993-04-27 Fmc Corporation Film-forming composition and use for coating pharmaceuticals, foods and the like
IT1246383B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per il mascheramento del sapore di farmaci
FR2704146B1 (fr) * 1993-04-19 1995-07-13 Cripdom Microcapsules d'acide acétylsalicylique à libération contrôlée.

Also Published As

Publication number Publication date
JPH07138164A (ja) 1995-05-30
ES2148300T3 (es) 2000-10-16
EP0624371B1 (fr) 2000-05-31
US5603957A (en) 1997-02-18
GR3034231T3 (en) 2000-12-29
JP4067137B2 (ja) 2008-03-26
EP0624371A1 (fr) 1994-11-17
JP2008019274A (ja) 2008-01-31
PT624371E (pt) 2000-11-30
ATE193448T1 (de) 2000-06-15
DE69424718D1 (de) 2000-07-06
FR2704146B1 (fr) 1995-07-13
FR2704146A1 (fr) 1994-10-28
US5846566A (en) 1998-12-08

Similar Documents

Publication Publication Date Title
DK0624371T3 (da) Mikrokapsler til kontrolleret frigivelse af acetylsalicylsyre
DE68902145D1 (de) Gegenstand mit einer nicht-haftenden beschichtung, verfahren zu dessen herstellung und zusammensetzung, verwendet in diesem verfahren.
NL189464C (nl) Verknoping teweegbrengende verbinding, mengsels die zo'n verbinding bevatten, thermisch hardbare polymeermengsels, verpompbare suspensies en werkwijze voor het vormen van een geconsolideerde mantel van deeltjesvormig materiaal om de verbuizing van een boorput.
CA2021580A1 (en) Polysiloxane-grafted copolymer topical binder composition with novel fluorochemical comonomer and method of coating therewith
DE69421799T2 (de) Mit einem trockenmittel überzogenes substrat und methode zur dessen herstellung
ATE18511T1 (de) Verfahren zur zerstaeubungs-mikroeinkapselung und dazu verwendbare zusammensetzung.
ATE145131T1 (de) Ueberzogene zusammensetzung sowie verfahren zu ihrer herstellung
DK21991A (da) Tryk-modtagelig belaegning samt en polymer-filmdannende sammensaetning til fremstilling af en saadan
EP0396425A3 (en) Extended release pharmaceutical formulations
DE69231177T2 (de) Landwirtschaftliche Mikrokapseln und ihre Herstellung
GB8913889D0 (en) New compositions of matter
DE69310402T2 (de) Beschichtungszusammensetzung und Verfahren zu ihrer Herstellung
PT84372B (pt) Processo para a preparacao de composicoes polimericas controlavel e rapidamente degradaveis contendo um polimero vinilico e de peliculas e outros objectos que as contem
IS1620B (is) Aðferð til framleiðslu á lyfjablöndum sem innihalda nifedipine
BR9307564A (pt) Composição curável método para revestir um artigo artigo revestido e polianidrido
IE820177L (en) Coated coloured intagliated articles.
BR9300473A (pt) Processo para a preparacao de uma composicao de polimero de multiplos estagios
DE69401736T2 (de) Vernetzbare Polymertrennmittelbeschichtungszusammensetzung
DE69506854T2 (de) Härtbare harzzusammensetzung, beschichtungszusammensetzung, beschichtungsmethode und beschichteter gegenstand
ES2090043T3 (es) Un procedimiento para producir un producto polimero reticulado, el producto obtenido y composiciones acuosas que contienen dicho producto.
ATE124425T1 (de) Vernetzbare oberflächenüberzugsmittel und verfahren zu ihrer herstellung.
DE58904703D1 (de) Flaechengebilde aus einem substrat und einem ueberzug und verfahren zu seiner herstellung.
ES2158155T3 (es) Agente de recubrimiento y aglutinante termoplastico para formas farmaceuticas.
ATE189492T1 (de) Zusammensetzungen aus bleichmittelvorläufern enthaltend eine beschichtete peroxysäure
DE3881067D1 (de) Waessrige filmbildende zusammensetzungen zur steuerung der wirkstofffreisetzung und verfahren zu deren herstellung.