DK0621899T3 - Ekspression af signalpeptidfrie stafylokinaser - Google Patents

Ekspression af signalpeptidfrie stafylokinaser

Info

Publication number
DK0621899T3
DK0621899T3 DK93902129.1T DK93902129T DK0621899T3 DK 0621899 T3 DK0621899 T3 DK 0621899T3 DK 93902129 T DK93902129 T DK 93902129T DK 0621899 T3 DK0621899 T3 DK 0621899T3
Authority
DK
Denmark
Prior art keywords
pct
expression
free
staphylocinases
signal peptide
Prior art date
Application number
DK93902129.1T
Other languages
Danish (da)
English (en)
Inventor
Detlev Behnke
Bernhard Schlott
Karl-Heinz Guehrs
Manfred Hartmann
Original Assignee
Medac Ges F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4143279A external-priority patent/DE4143279A1/de
Priority claimed from DE4240801A external-priority patent/DE4240801A1/de
Application filed by Medac Ges F filed Critical Medac Ges F
Application granted granted Critical
Publication of DK0621899T3 publication Critical patent/DK0621899T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK93902129.1T 1991-12-30 1992-12-28 Ekspression af signalpeptidfrie stafylokinaser DK0621899T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4143279A DE4143279A1 (de) 1991-12-30 1991-12-30 Neue plasminogenaktivatoren, die sie kodierenden dna-sequenzen, zugehoerige expressionsplasmide und rekombinante escherichia coli-staemme, verfahren zur produktion dieser proteine und ihre verwendung
DE4220516 1992-06-22
DE4240801A DE4240801A1 (de) 1992-12-01 1992-12-01 Reife methioninfreie Staphylokinasen, die sie kodierenden DNA-Sequenzen, zugehörige Expressionsplasmide und rekombinante Escherichia coli-Stämme, Verfahren zur Herstellung dieser Proteine und ihre Verwendung

Publications (1)

Publication Number Publication Date
DK0621899T3 true DK0621899T3 (da) 1996-10-28

Family

ID=27203268

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93902129.1T DK0621899T3 (da) 1991-12-30 1992-12-28 Ekspression af signalpeptidfrie stafylokinaser

Country Status (14)

Country Link
US (2) US5801037A (el)
EP (1) EP0621899B1 (el)
JP (1) JP3310672B2 (el)
KR (1) KR100221150B1 (el)
AT (1) ATE139570T1 (el)
AU (1) AU669149B2 (el)
DE (1) DE59206628D1 (el)
DK (1) DK0621899T3 (el)
ES (1) ES2089784T3 (el)
FI (1) FI943146A (el)
GR (1) GR3020529T3 (el)
HK (1) HK1005886A1 (el)
HU (1) HU218043B (el)
WO (1) WO1993013209A1 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3310672B2 (ja) * 1991-12-30 2002-08-05 トロンブ−イックス・ナムローゼ・フェンノートシャップ シグナルペプチドを有さないスタフィロキナーゼの発現
CN1035192C (zh) * 1994-04-04 1997-06-18 上海医科大学 一种重组葡激酶的制备方法
ATE290598T1 (de) * 1995-01-06 2005-03-15 Leuven Res & Dev Vzw Neue staphylokinase derivate
EP0721982A1 (en) * 1995-01-06 1996-07-17 Leuven Research & Development V.Z.W. New staphylokinase derivatives
JPH08289790A (ja) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw 新規なスタフィロキナーゼ誘導体
US5846943A (en) * 1996-11-08 1998-12-08 Synsorb Biotech, Inc. Solid support matricles containing a toxin binding oligosaccharide
CN1059926C (zh) * 1997-07-19 2000-12-27 张其玖 葡激酶基因及其高表达工程菌株
ATE294865T1 (de) * 1998-02-04 2005-05-15 Thromb X N V Identifizierung, produktion und verwendung von staphylokinase derivaten mit reduzierter immunogenizität und/oder reduzierter 'clearance'
US7781209B2 (en) * 2005-09-25 2010-08-24 Multispan, Inc. GPCR-expressing cell lines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5867181A (ja) * 1981-10-16 1983-04-21 Yakult Honsha Co Ltd スタフイロキナーゼ産生遺伝情報を担うｄｎａ断片組み換え体ｄｎａおよびそれを導入した大腸菌
WO1987002732A1 (en) * 1985-11-01 1987-05-07 Vaughan Thomas L Hanger assembly
US5475089A (en) * 1990-12-17 1995-12-12 Kabushiki Kaisha Yakult Honsha Thrombolytic peptide, production thereof, and thrombolytic agent
DE69124370T2 (de) * 1991-06-28 1997-05-15 Desire Jose Collen Verwendung von Staphylokinase für die Herstellung einer Zusammensetzung für die Behandlung von Gefässthrombose
JP3310672B2 (ja) * 1991-12-30 2002-08-05 トロンブ−イックス・ナムローゼ・フェンノートシャップ シグナルペプチドを有さないスタフィロキナーゼの発現

Also Published As

Publication number Publication date
EP0621899A1 (de) 1994-11-02
DE59206628D1 (en) 1996-07-25
HK1005886A1 (en) 1999-01-29
JPH07502652A (ja) 1995-03-23
ATE139570T1 (de) 1996-07-15
FI943146A0 (fi) 1994-06-30
KR940703920A (ko) 1994-12-12
WO1993013209A1 (de) 1993-07-08
US6010897A (en) 2000-01-04
KR100221150B1 (ko) 1999-10-01
HU218043B (hu) 2000-05-28
HUT68067A (en) 1995-05-29
AU3347293A (en) 1993-07-28
JP3310672B2 (ja) 2002-08-05
US5801037A (en) 1998-09-01
AU669149B2 (en) 1996-05-30
HU9401949D0 (en) 1994-11-28
EP0621899B1 (de) 1996-06-19
FI943146A (fi) 1994-06-30
GR3020529T3 (en) 1996-10-31
ES2089784T3 (es) 1996-10-01

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