DK0607334T3 - Cycliske urinstoffer og analoger anvendelige som retrovirale proteasehæmmere - Google Patents

Cycliske urinstoffer og analoger anvendelige som retrovirale proteasehæmmere

Info

Publication number
DK0607334T3
DK0607334T3 DK92922262.8T DK92922262T DK0607334T3 DK 0607334 T3 DK0607334 T3 DK 0607334T3 DK 92922262 T DK92922262 T DK 92922262T DK 0607334 T3 DK0607334 T3 DK 0607334T3
Authority
DK
Denmark
Prior art keywords
protease inhibitors
cyclic urea
retroviral protease
analogs useful
useful
Prior art date
Application number
DK92922262.8T
Other languages
Danish (da)
English (en)
Inventor
Prabhakar Kondaji Jadhav
Carl Nicholas Hodge
Patrick Yuk-Sun Lam
Charles Joseph Eyermann
George Vincent Delucca
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Application granted granted Critical
Publication of DK0607334T3 publication Critical patent/DK0607334T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/06—Seven-membered rings having the hetero atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/04—Seven-membered rings not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK92922262.8T 1991-10-11 1992-10-13 Cycliske urinstoffer og analoger anvendelige som retrovirale proteasehæmmere DK0607334T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77649191A 1991-10-11 1991-10-11
US88394492A 1992-05-15 1992-05-15
US95327292A 1992-09-29 1992-09-29

Publications (1)

Publication Number Publication Date
DK0607334T3 true DK0607334T3 (da) 1998-02-16

Family

ID=27419722

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92922262.8T DK0607334T3 (da) 1991-10-11 1992-10-13 Cycliske urinstoffer og analoger anvendelige som retrovirale proteasehæmmere

Country Status (19)

Country Link
EP (3) EP0607334B1 (de)
JP (1) JP3208140B2 (de)
KR (1) KR100268694B1 (de)
AT (2) ATE216371T1 (de)
AU (2) AU2871592A (de)
BR (1) BR9206623A (de)
CA (1) CA2120925A1 (de)
CZ (1) CZ284872B6 (de)
DE (2) DE69221309T2 (de)
DK (1) DK0607334T3 (de)
ES (1) ES2104946T3 (de)
FI (1) FI941649A (de)
GR (1) GR3025005T3 (de)
HK (1) HK1002257A1 (de)
HU (1) HU221816B1 (de)
NO (1) NO306720B1 (de)
RU (1) RU2131420C1 (de)
SK (1) SK280882B6 (de)
WO (1) WO1993007128A1 (de)

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ES2123065T3 (es) 1992-08-25 1999-01-01 Searle & Co Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
AU703962B2 (en) * 1993-02-26 1999-04-01 Du Pont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives
US5637780A (en) 1993-03-30 1997-06-10 The Dupont Merck Pharmaceutical Company Method for preparing alkylating agents and their use for alkylating cyclic ureas
EP0708760A1 (de) * 1993-07-14 1996-05-01 Novartis AG Cyclische hydrazin-verbindungen
US5616578A (en) * 1993-08-26 1997-04-01 The Dupont Merck Pharmaceutical Company Method of treating human immunodeficiency virus infection using a cyclic protease inhibitor in combination with a reverse transcriptase inhibitor
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US5559110A (en) * 1994-03-09 1996-09-24 The Dupont Merck Pharmaceutical Company Pharmaceutical formulations of cyclic urea type compounds
US5508400A (en) * 1994-04-20 1996-04-16 The Du Pont Merck Pharmaceutical Company Preparation of cyclic urea compounds
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US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
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CA2026832A1 (fr) 1990-10-03 1992-04-04 Nouredine Haouas Systeme demontable d'attache rapide pour objets tridimensionnels entre eux

Also Published As

Publication number Publication date
ATE216371T1 (de) 2002-05-15
GR3025005T3 (en) 1998-01-30
HU9401020D0 (en) 1994-07-28
HUT67285A (en) 1995-03-28
RU2131420C1 (ru) 1999-06-10
DE69221309T2 (de) 1997-12-11
WO1993007128A1 (en) 1993-04-15
JP3208140B2 (ja) 2001-09-10
NO941278L (no) 1994-06-10
AU2871592A (en) 1993-05-03
ATE156123T1 (de) 1997-08-15
CZ81494A3 (en) 1994-11-16
AU694417B2 (en) 1998-07-23
EP0765873B1 (de) 2002-04-17
DE69232568T2 (de) 2002-12-19
DE69221309D1 (de) 1997-09-04
FI941649A (fi) 1994-05-31
EP0765873A1 (de) 1997-04-02
FI941649A0 (fi) 1994-04-08
KR100268694B1 (ko) 2000-10-16
AU6180894A (en) 1994-07-07
CA2120925A1 (en) 1993-04-15
SK40794A3 (en) 1994-12-07
HU221816B1 (hu) 2003-01-28
HK1002257A1 (en) 1998-08-07
NO306720B1 (no) 1999-12-13
EP1153921A3 (de) 2001-11-21
EP0607334A1 (de) 1994-07-27
JPH07500324A (ja) 1995-01-12
EP0607334B1 (de) 1997-07-30
SK280882B6 (sk) 2000-08-14
CZ284872B6 (cs) 1999-03-17
NO941278D0 (no) 1994-04-08
ES2104946T3 (es) 1997-10-16
EP1153921A2 (de) 2001-11-14
BR9206623A (pt) 1995-05-02
DE69232568D1 (de) 2002-05-23

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