DK0597107T3 - Lignananalog, fremstilling deraf og hypolipidæmisk medikament - Google Patents
Lignananalog, fremstilling deraf og hypolipidæmisk medikamentInfo
- Publication number
- DK0597107T3 DK0597107T3 DK92921331.2T DK92921331T DK0597107T3 DK 0597107 T3 DK0597107 T3 DK 0597107T3 DK 92921331 T DK92921331 T DK 92921331T DK 0597107 T3 DK0597107 T3 DK 0597107T3
- Authority
- DK
- Denmark
- Prior art keywords
- lower alkyl
- chem
- formula
- ring
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/22—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one naphthalene or hydrogenated naphthalene ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29811991 | 1991-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0597107T3 true DK0597107T3 (da) | 1996-07-29 |
Family
ID=17855421
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92921331.2T DK0597107T3 (da) | 1991-10-17 | 1992-10-15 | Lignananalog, fremstilling deraf og hypolipidæmisk medikament |
| DK95117572T DK0701991T3 (da) | 1991-10-17 | 1992-10-15 | Fremgangsmåde til fremstilling af lignananaloger og udgangsmaterialer dertil |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95117572T DK0701991T3 (da) | 1991-10-17 | 1992-10-15 | Fremgangsmåde til fremstilling af lignananaloger og udgangsmaterialer dertil |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US5420333A (ko) |
| EP (2) | EP0701991B1 (ko) |
| JP (1) | JP2839805B2 (ko) |
| KR (1) | KR100252428B1 (ko) |
| AT (2) | ATE175954T1 (ko) |
| DE (2) | DE69211994T2 (ko) |
| DK (2) | DK0597107T3 (ko) |
| ES (2) | ES2129733T3 (ko) |
| GR (1) | GR3020461T3 (ko) |
| HU (1) | HU211296A9 (ko) |
| TW (1) | TW209215B (ko) |
| WO (1) | WO1993008155A1 (ko) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488134A (en) * | 1993-04-16 | 1996-01-30 | Shionogi & Co., Ltd. | Preparation of compounds of lignan series |
| FR2707980B1 (fr) * | 1993-07-20 | 1995-09-01 | Adir | Nouveaux cyclohept[b]indoles et cyclooct[b]indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| WO1995035291A1 (fr) * | 1994-06-22 | 1995-12-28 | Shionogi & Co., Ltd. | Procede de production d'un compose de phtalide |
| ID18046A (id) * | 1996-08-20 | 1998-02-19 | Takeda Chemical Industries Ltd | Senyawa siklik campuran, pembuatan dan penngunaannya. |
| CA2350213A1 (en) * | 1998-11-12 | 2000-05-18 | Alteon, Inc. | Glucose and lipid lowering compounds |
| KR100352269B1 (ko) * | 1999-10-08 | 2002-09-12 | 한국생명공학연구원 | 저밀도 지질 단백질에 대해 항산화 활성을 갖는 리그난계 화합물 |
| FR2800738B1 (fr) | 1999-11-04 | 2002-02-08 | Corning Sa | Naphtopyranes ayant un substituant perfluoroalkyle en position 5, preparation et compositions et matrices (co)polymeres les renfermant |
| US6770024B1 (en) * | 2000-03-28 | 2004-08-03 | Stony Brook Surgical Innovations, Inc. | Implantable counterpulsation cardiac assist device |
| TWI241195B (en) * | 2000-04-10 | 2005-10-11 | Shionogi & Co | Preventive agent for bile acidic diarrhea |
| CN1466465A (zh) * | 2000-08-01 | 2004-01-07 | ��Ұ����ҩ��ʽ���� | 肥胖或脂肪肝的预防或治疗药物 |
| AU2003271115A1 (en) * | 2002-10-08 | 2004-05-04 | Shionogi And Co., Ltd. | Process for producing enone ester |
| US7152611B2 (en) * | 2002-12-30 | 2006-12-26 | International Tape Partners, Llc | Coated multifilament dental devices overcoated with imbedded particulate |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| EP2771003B1 (en) | 2011-10-28 | 2017-04-19 | Lumena Pharmaceuticals LLC | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| EP2770990A4 (en) | 2011-10-28 | 2015-03-11 | Lumena Pharmaceuticals Inc | Gallic acid refluxing agent for the treatment of hypertension and chronic liver disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| WO2014144485A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| BR112021015815A2 (pt) | 2019-02-12 | 2022-01-18 | Mirum Pharmaceuticals Inc | Métodos para tratar colestase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4771072A (en) * | 1985-01-10 | 1988-09-13 | Tanabe Seiyaku Co., Ltd. | Alkoxynaphthalene derivatives |
| JPS6310746A (ja) * | 1986-07-01 | 1988-01-18 | Tanabe Seiyaku Co Ltd | ナフタレン誘導体 |
| JPH0372422A (ja) * | 1989-05-16 | 1991-03-27 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
-
1992
- 1992-10-15 JP JP4277151A patent/JP2839805B2/ja not_active Expired - Fee Related
- 1992-10-15 ES ES95117572T patent/ES2129733T3/es not_active Expired - Lifetime
- 1992-10-15 EP EP95117572A patent/EP0701991B1/en not_active Expired - Lifetime
- 1992-10-15 US US08/078,205 patent/US5420333A/en not_active Expired - Lifetime
- 1992-10-15 EP EP92921331A patent/EP0597107B1/en not_active Expired - Lifetime
- 1992-10-15 AT AT95117572T patent/ATE175954T1/de not_active IP Right Cessation
- 1992-10-15 DE DE69211994T patent/DE69211994T2/de not_active Expired - Fee Related
- 1992-10-15 DK DK92921331.2T patent/DK0597107T3/da active
- 1992-10-15 AT AT92921331T patent/ATE139990T1/de not_active IP Right Cessation
- 1992-10-15 KR KR1019930701814A patent/KR100252428B1/ko not_active IP Right Cessation
- 1992-10-15 ES ES92921331T patent/ES2091488T3/es not_active Expired - Lifetime
- 1992-10-15 WO PCT/JP1992/001342 patent/WO1993008155A1/ja active IP Right Grant
- 1992-10-15 DK DK95117572T patent/DK0701991T3/da active
- 1992-10-15 DE DE69228262T patent/DE69228262D1/de not_active Expired - Fee Related
- 1992-10-17 TW TW081108267A patent/TW209215B/zh active
-
1994
- 1994-09-07 US US08/301,996 patent/US5449814A/en not_active Expired - Lifetime
-
1995
- 1995-04-18 US US08/423,346 patent/US5731455A/en not_active Expired - Fee Related
- 1995-05-22 US US08/445,506 patent/US5502216A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00635P patent/HU211296A9/hu unknown
-
1996
- 1996-07-04 GR GR960401618T patent/GR3020461T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69228262D1 (de) | 1999-03-04 |
| US5449814A (en) | 1995-09-12 |
| DE69211994D1 (de) | 1996-08-08 |
| US5420333A (en) | 1995-05-30 |
| KR100252428B1 (ko) | 2000-04-15 |
| ES2129733T3 (es) | 1999-06-16 |
| JPH05310634A (ja) | 1993-11-22 |
| EP0701991B1 (en) | 1999-01-20 |
| TW209215B (ko) | 1993-07-11 |
| WO1993008155A1 (en) | 1993-04-29 |
| ATE175954T1 (de) | 1999-02-15 |
| EP0701991A1 (en) | 1996-03-20 |
| EP0597107B1 (en) | 1996-07-03 |
| US5731455A (en) | 1998-03-24 |
| US5502216A (en) | 1996-03-26 |
| HU211296A9 (en) | 1995-11-28 |
| KR930703236A (ko) | 1993-11-29 |
| DK0701991T3 (da) | 1999-09-13 |
| GR3020461T3 (en) | 1996-10-31 |
| ATE139990T1 (de) | 1996-07-15 |
| DE69211994T2 (de) | 1997-02-20 |
| EP0597107A4 (en) | 1994-02-03 |
| EP0597107A1 (en) | 1994-05-18 |
| JP2839805B2 (ja) | 1998-12-16 |
| ES2091488T3 (es) | 1996-11-01 |
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