DE3686248D1 - Piperidinderivat, seine verwendung und diese enthaltende pharmazeutische zusammensetzung. - Google Patents
Piperidinderivat, seine verwendung und diese enthaltende pharmazeutische zusammensetzung.Info
- Publication number
- DE3686248D1 DE3686248D1 DE8686118045T DE3686248T DE3686248D1 DE 3686248 D1 DE3686248 D1 DE 3686248D1 DE 8686118045 T DE8686118045 T DE 8686118045T DE 3686248 T DE3686248 T DE 3686248T DE 3686248 D1 DE3686248 D1 DE 3686248D1
- Authority
- DE
- Germany
- Prior art keywords
- derivative
- sup
- piperide
- pharmaceutical composition
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29388585 | 1985-12-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3686248D1 true DE3686248D1 (de) | 1992-09-03 |
DE3686248T2 DE3686248T2 (de) | 1992-12-17 |
Family
ID=17800410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686118045T Expired - Lifetime DE3686248T2 (de) | 1985-12-27 | 1986-12-24 | Piperidinderivat, seine verwendung und diese enthaltende pharmazeutische zusammensetzung. |
Country Status (13)
Country | Link |
---|---|
US (7) | US4849431A (de) |
EP (1) | EP0229391B1 (de) |
JP (2) | JP2597559B2 (de) |
KR (1) | KR910002562B1 (de) |
AT (1) | ATE78813T1 (de) |
AU (1) | AU600458B2 (de) |
CA (1) | CA1279317C (de) |
DE (1) | DE3686248T2 (de) |
DK (1) | DK623586A (de) |
ES (1) | ES2044836T3 (de) |
GR (1) | GR3005315T3 (de) |
NZ (1) | NZ218786A (de) |
PH (1) | PH23739A (de) |
Families Citing this family (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
GB2196251B (en) * | 1986-09-08 | 1990-07-04 | Nat Res Dev | Anxiolytic compositions containing dioxopiperidine derivatives |
JP2573195B2 (ja) * | 1986-09-30 | 1997-01-22 | エーザイ株式会社 | 環状アミン誘導体 |
EP0294183B1 (de) * | 1987-06-02 | 1994-03-30 | Ajinomoto Co., Inc. | Verwendung von Äthylamin-Derivaten als antihypertensive Wirkstoffe |
FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
US4791121A (en) * | 1987-11-02 | 1988-12-13 | The Boc Group, Inc. | 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds |
JP2832979B2 (ja) * | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
EP0343307A1 (de) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinalkanamin-Derivate |
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US5177089A (en) * | 1988-06-01 | 1993-01-05 | Eisai Co., Ltd. | Butenoic or propenoic acid derivative |
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US5356891A (en) * | 1989-09-22 | 1994-10-18 | Witiak Donald T | Phenylalkyl amine derivatives having anti-ischaemic activity |
US5356906A (en) * | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
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US20080312281A1 (en) * | 2004-12-24 | 2008-12-18 | Matthew Colin Thor Fyfe | G-Protein Coupled Receptor (Gpr116) Agonists and Use Thereof for Treating Obesity and Diabetes |
EP1917262B1 (de) * | 2005-08-15 | 2011-12-14 | F. Hoffmann-La Roche AG | Piperidin- und piperazinderivate als p2x3-antagonisten |
EA017437B1 (ru) * | 2007-01-03 | 2012-12-28 | Ле Лаборатуар Сервье | 3-замещённое-[1,2,3]-бензотриазиноновое соединение для увеличения глутаматергических синаптических ответов |
CA2678248C (en) | 2007-03-08 | 2016-06-28 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp and tank inhibitors |
WO2009053373A1 (en) | 2007-10-26 | 2009-04-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp inhibitors |
ES2529545T3 (es) | 2008-03-27 | 2015-02-23 | Janssen Pharmaceutica, N.V. | Tetrahidrofenantridinonas y tetrahidrociclopentaquinolinonas como inhibidores de la polimerización de tubulina y PARP |
JP5464609B2 (ja) | 2008-03-27 | 2014-04-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チューブリン重合阻害剤としてのキナゾリノン誘導体 |
CN109134350A (zh) * | 2017-06-13 | 2019-01-04 | 中国药科大学 | 多奈哌齐-bht杂合体、其制备方法及其用于治疗阿尔茨海默症 |
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US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
US3729270A (en) * | 1970-09-19 | 1973-04-24 | Tsukasa Felt Shoji Kk | Writing nib |
GB1507462A (en) * | 1974-03-21 | 1978-04-12 | Gallardo Antonio Sa | N-heterocyclic substituted benzamides methods for their preparation and compositions containing them |
US4158060A (en) * | 1974-12-18 | 1979-06-12 | Synthelabo | 2-Methoxy-benzamide derivatives |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
US4360531A (en) * | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
US4559343A (en) * | 1982-09-07 | 1985-12-17 | Alcon Laboratories, Inc. | Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therapeutic agents |
FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
US4604393A (en) * | 1984-01-30 | 1986-08-05 | Cornu Pierre Jean | Phenyloxoalkyl piperidines and the pharmaceutical compositions containing them |
US4810703A (en) * | 1984-10-19 | 1989-03-07 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
DE3541428A1 (de) * | 1985-11-23 | 1987-05-27 | Hoechst Ag | Neue basisch substituierte pyridinverbindungen, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
US5041547A (en) * | 1986-08-28 | 1991-08-20 | Appleton Papers Inc. | Chromogenic substituted 4,7-diazaphthalides |
US4791112A (en) * | 1987-02-02 | 1988-12-13 | The Boc Group, Inc. | N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds |
-
1986
- 1986-12-22 DK DK623586A patent/DK623586A/da not_active Application Discontinuation
- 1986-12-23 NZ NZ218786A patent/NZ218786A/xx unknown
- 1986-12-23 AU AU66906/86A patent/AU600458B2/en not_active Ceased
- 1986-12-24 EP EP86118045A patent/EP0229391B1/de not_active Expired - Lifetime
- 1986-12-24 DE DE8686118045T patent/DE3686248T2/de not_active Expired - Lifetime
- 1986-12-24 AT AT86118045T patent/ATE78813T1/de not_active IP Right Cessation
- 1986-12-24 US US06/946,459 patent/US4849431A/en not_active Expired - Lifetime
- 1986-12-24 PH PH34667A patent/PH23739A/en unknown
- 1986-12-24 ES ES86118045T patent/ES2044836T3/es not_active Expired - Lifetime
- 1986-12-24 CA CA000526282A patent/CA1279317C/en not_active Expired - Fee Related
- 1986-12-26 JP JP61309878A patent/JP2597559B2/ja not_active Expired - Lifetime
- 1986-12-27 KR KR1019860011334A patent/KR910002562B1/ko not_active IP Right Cessation
-
1989
- 1989-03-10 US US07/321,624 patent/US4942169A/en not_active Expired - Lifetime
-
1990
- 1990-02-14 US US07/479,948 patent/US5039681A/en not_active Expired - Fee Related
-
1991
- 1991-04-03 US US07/679,769 patent/US5118684A/en not_active Expired - Lifetime
- 1991-12-20 US US07/811,698 patent/US5306720A/en not_active Expired - Lifetime
-
1992
- 1992-07-30 GR GR920400881T patent/GR3005315T3/el unknown
-
1994
- 1994-01-05 US US08/177,440 patent/US5424318A/en not_active Expired - Lifetime
-
1995
- 1995-05-05 US US08/435,367 patent/US5654306A/en not_active Expired - Fee Related
-
1996
- 1996-05-27 JP JP8131521A patent/JP2716965B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK623586D0 (da) | 1986-12-22 |
ATE78813T1 (de) | 1992-08-15 |
US4942169A (en) | 1990-07-17 |
JP2716965B2 (ja) | 1998-02-18 |
US5424318A (en) | 1995-06-13 |
ES2044836T3 (es) | 1994-01-16 |
JPH08333255A (ja) | 1996-12-17 |
CA1279317C (en) | 1991-01-22 |
EP0229391A1 (de) | 1987-07-22 |
DE3686248T2 (de) | 1992-12-17 |
US5306720A (en) | 1994-04-26 |
EP0229391B1 (de) | 1992-07-29 |
US5118684A (en) | 1992-06-02 |
JPS62234065A (ja) | 1987-10-14 |
US5654306A (en) | 1997-08-05 |
KR910002562B1 (ko) | 1991-04-26 |
AU6690686A (en) | 1987-07-02 |
GR3005315T3 (de) | 1993-05-24 |
DK623586A (da) | 1987-06-28 |
NZ218786A (en) | 1989-01-06 |
US5039681A (en) | 1991-08-13 |
JP2597559B2 (ja) | 1997-04-09 |
US4849431A (en) | 1989-07-18 |
PH23739A (en) | 1989-11-03 |
KR870005994A (ko) | 1987-07-08 |
AU600458B2 (en) | 1990-08-16 |
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Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP |